{"id":"https://openalex.org/W4292745296","doi":"https://doi.org/10.2217/fon-2022-0656","title":"LIBRETTO-432, a Phase III Study of Adjuvant Selpercatinib or Placebo in Stage IB-IIIA RET Fusion-Positive Non-Small-Cell Lung Cancer","display_name":"LIBRETTO-432, a Phase III Study of Adjuvant Selpercatinib or Placebo in Stage IB-IIIA RET Fusion-Positive Non-Small-Cell Lung Cancer","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4292745296","doi":"https://doi.org/10.2217/fon-2022-0656","pmid":"https://pubmed.ncbi.nlm.nih.gov/35950566"},"language":"en","primary_location":{"id":"doi:10.2217/fon-2022-0656","doi":"https://doi.org/10.2217/fon-2022-0656","is_oa":true,"landing_page_url":"https://doi.org/10.2217/fon-2022-0656","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2217/fon-2022-0656","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045498137","display_name":"Masahiro Tsuboi","orcid":"https://orcid.org/0000-0003-3031-5807","observed_orcids":["https://orcid.org/0000-0003-3031-5807"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Tsuboi","raw_affiliation_strings":["National Cancer Center Hospital East,\rKashiwa,\rJapan"],"raw_orcid":"https://orcid.org/0000-0003-3031-5807","affiliations":[{"raw_affiliation_string":"National Cancer Center Hospital East,\rKashiwa,\rJapan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036134937","display_name":"Jonathan Wade Goldman","orcid":"https://orcid.org/0000-0002-4925-8243","observed_orcids":["https://orcid.org/0000-0002-4925-8243"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan W Goldman","raw_affiliation_strings":["David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632072","display_name":"Yi-Long Lung Cancer Wu","orcid":"https://orcid.org/0000-0002-3611-0258","observed_orcids":["https://orcid.org/0000-0002-3611-0258"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Long Wu","raw_affiliation_strings":["Guangdong Lung Cancer Institute,Guangdong Provincial People\u2019s Hospital & Guangdong Academy of Medical Sciences,\rGuangzhou,\rChina"],"raw_orcid":"https://orcid.org/0000-0002-3611-0258","affiliations":[{"raw_affiliation_string":"Guangdong Lung Cancer Institute,Guangdong Provincial People\u2019s Hospital & Guangdong Academy of Medical Sciences,\rGuangzhou,\rChina","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049294543","display_name":"Melissa Lynne Johnson","orcid":"https://orcid.org/0000-0001-9874-1314","observed_orcids":["https://orcid.org/0000-0001-9874-1314"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa L Johnson","raw_affiliation_strings":["Sarah Cannon Research Institute, Nashville, TN 37203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I4210100810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052765751","display_name":"Luis G Paz-Ares","orcid":"https://orcid.org/0000-0002-1947-3364","observed_orcids":["https://orcid.org/0000-0002-1947-3364"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Paz-Ares","raw_affiliation_strings":["Department of Medical Oncology,Hospital Universitario 12 de Octubre,H120-CNIO Lung Cancer Unit,Universidad Complutense & Ciberonc,\rMadrid,\rSpain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology,Hospital Universitario 12 de Octubre,H120-CNIO Lung Cancer Unit,Universidad Complutense & Ciberonc,\rMadrid,\rSpain","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"James Chih-Hsin Yang","raw_affiliation_strings":["Department of Oncology,National Taiwan University Hospital & Graduate Institute of Oncology,National Taiwan University,\rTaipei,\rTaiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,National Taiwan University Hospital & Graduate Institute of Oncology,National Taiwan University,\rTaipei,\rTaiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023794502","display_name":"Benjamin Besse","orcid":"https://orcid.org/0000-0001-5090-8189","observed_orcids":["https://orcid.org/0000-0001-5090-8189"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Besse","raw_affiliation_strings":["Gustave Roussy,Villejuif France & Paris Saclay University,\rFrance"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gustave Roussy,Villejuif France & Paris Saclay University,\rFrance","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084001176","display_name":"Weiji Su","orcid":"https://orcid.org/0000-0002-5426-9764","observed_orcids":["https://orcid.org/0000-0002-5426-9764"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiji Su","raw_affiliation_strings":["Eli Lilly & Company,\rIndianapolis,\rIN 46225,\rUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly & Company,\rIndianapolis,\rIN 46225,\rUSA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028800670","display_name":"Bo H. Chao","orcid":"https://orcid.org/0000-0003-2335-5579","observed_orcids":["https://orcid.org/0000-0003-2335-5579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo H Chao","raw_affiliation_strings":["Eli Lilly & Company,\rNew York,\rNY 10016,\rUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly & Company,\rNew York,\rNY 10016,\rUSA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063199354","display_name":"Alexander Edward Dela Cruz Drilon","orcid":"https://orcid.org/0000-0001-6806-9061","observed_orcids":["https://orcid.org/0000-0001-6806-9061"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Drilon","raw_affiliation_strings":["Department of Medicine,Memorial Sloan-Kettering Cancer Center & Weill Cornell Medical College,\rNew York,\rNY 10065,\rUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,Memorial Sloan-Kettering Cancer Center & Weill Cornell Medical College,\rNew York,\rNY 10065,\rUSA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.8025,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.97380471,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"18","issue":"28","first_page":"3133","last_page":"3141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selpercatinib","display_name":"selpercatinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ret-fusion-positive-non-small-cell-lung-cancer","display_name":"RET fusion-positive non-small cell lung cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ret-inhibitors","display_name":"RET inhibitors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/early-stage-lung-cancer","display_name":"early-stage lung cancer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cns-relapse","display_name":"central nervous system relapse","score":0.8429999947547913},{"id":"https://openalex.org/keywords/durvalumab","display_name":"durvalumab","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9051689505577087},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6306036114692688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5958285927772522},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5771386027336121},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.546358585357666},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5339848399162292},{"id":"https://openalex.org/C2777742743","wikidata":"https://www.wikidata.org/wiki/Q19904005","display_name":"Durvalumab","level":5,"score":0.5219539999961853},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4833769202232361},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.45732489228248596},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45079874992370605},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.43486836552619934},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.351091593503952},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18402352929115295},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.12948709726333618},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.06129530072212219},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D051096","descriptor_name":"Proto-Oncogene Proteins c-ret","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2217/fon-2022-0656","doi":"https://doi.org/10.2217/fon-2022-0656","is_oa":true,"landing_page_url":"https://doi.org/10.2217/fon-2022-0656","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},{"id":"pmid:35950566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35950566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future oncology (London, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2217/fon-2022-0656","doi":"https://doi.org/10.2217/fon-2022-0656","is_oa":true,"landing_page_url":"https://doi.org/10.2217/fon-2022-0656","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Partnerships for the goals","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/17"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1979840428","https://openalex.org/W2034407059","https://openalex.org/W2040865689","https://openalex.org/W2135631135","https://openalex.org/W2168404690","https://openalex.org/W2225799198","https://openalex.org/W2228221433","https://openalex.org/W2607970143","https://openalex.org/W2609444947","https://openalex.org/W2769006626","https://openalex.org/W2800393195","https://openalex.org/W2889243349","https://openalex.org/W2895926103","https://openalex.org/W2924277568","https://openalex.org/W2995682899","https://openalex.org/W3081278682","https://openalex.org/W3087210493","https://openalex.org/W3094659495","https://openalex.org/W3137057543","https://openalex.org/W3199241644","https://openalex.org/W4223502512","https://openalex.org/W4281261689"],"related_works":["https://openalex.org/W7163410629","https://openalex.org/W4408555229","https://openalex.org/W6995747031","https://openalex.org/W4393165832","https://openalex.org/W3094659495","https://openalex.org/W4401513681","https://openalex.org/W4403419897","https://openalex.org/W4296460186","https://openalex.org/W4407827967","https://openalex.org/W3207837598"],"abstract_inverted_index":{"Selpercatinib,":[0],"a":[1,33],"first-in-class,":[2],"highly":[3],"selective":[4],"and":[5,22,108],"potent":[6],"central":[7,116],"nervous":[8,117],"system-active":[9],"RET":[10,25,47,93],"kinase":[11],"inhibitor":[12],"demonstrated":[13],"clinically":[14],"meaningful":[15],"activity":[16],"with":[17,52],"manageable":[18],"toxicity":[19],"in":[20,44,86,102,114],"pretreated":[21],"treatment-naive":[23],"advanced/metastatic":[24],"fusion-positive":[26,48,94],"non-small-cell":[27],"lung":[28],"cancer":[29],"(NSCLC).":[30],"LIBRETTO-432":[31],"is":[32,81],"global,":[34],"randomized,":[35],"double-blind,":[36],"phase":[37],"III":[38],"trial":[39],"evaluating":[40],"selpercatinib":[41],"versus":[42],"placebo":[43],"stage":[45],"IB-IIIA,":[46],"NSCLC,":[49],"previously":[50],"treated":[51],"definitive":[53],"surgery":[54],"or":[55,66,68],"radiation;":[56],"participants":[57],"must":[58],"have":[59],"undergone":[60],"available":[61],"anti-cancer":[62],"therapy":[63],"(including":[64],"chemotherapy":[65],"durvalumab)":[67],"not":[69],"be":[70],"suitable":[71],"for":[72],"it,":[73],"per":[74],"investigator's":[75],"discretion.":[76],"The":[77],"primary":[78,88],"end":[79,98],"point":[80],"investigator-assessed":[82],"event-free":[83],"survival":[84],"(EFS)":[85],"the":[87,103,115],"analysis":[89],"population":[90],"(stage":[91],"II-IIIA":[92],"NSCLC).":[95],"Key":[96],"secondary":[97],"points":[99],"include":[100],"EFS":[101],"overall":[104,106],"population,":[105],"survival,":[107],"time":[109],"to":[110],"distant":[111],"disease":[112],"recurrence":[113],"system.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-23T00:00:00"}