{"id":"https://openalex.org/W4292670565","doi":"https://doi.org/10.24171/j.phrp.2022.0150","title":"The effect of photodynamic therapy using Radachlorin on biofilm-forming multidrug-resistant bacteria","display_name":"The effect of photodynamic therapy using Radachlorin on biofilm-forming multidrug-resistant bacteria","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4292670565","doi":"https://doi.org/10.24171/j.phrp.2022.0150","pmid":"https://pubmed.ncbi.nlm.nih.gov/36097751","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9468690"},"language":"en","primary_location":{"id":"doi:10.24171/j.phrp.2022.0150","doi":"https://doi.org/10.24171/j.phrp.2022.0150","is_oa":true,"landing_page_url":"https://doi.org/10.24171/j.phrp.2022.0150","pdf_url":null,"source":{"id":"https://openalex.org/S2765061833","display_name":"Osong Public Health and Research Perspectives","issn_l":"2210-9099","issn":["2210-9099","2233-6052"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong Public Health and Research Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.24171/j.phrp.2022.0150","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018484510","display_name":"Choong-Won Seo","orcid":"https://orcid.org/0000-0002-6863-2034","observed_orcids":["https://orcid.org/0000-0002-6863-2034"]},"institutions":[{"id":"https://openalex.org/I4405284686","display_name":"Dong-Eui Institute of Technology","ror":"https://ror.org/04189hf20","country_code":"KR","type":"education","lineage":["https://openalex.org/I4405284686"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Choong-Won Seo","raw_affiliation_strings":["Department of Biomedical Laboratory Science, Dong-Eui Institute of Technology, Busan, Korea"],"raw_orcid":"https://orcid.org/0000-0002-6863-2034","affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, Dong-Eui Institute of Technology, Busan, Korea","institution_ids":["https://openalex.org/I4405284686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073269228","display_name":"Young-Kwon Kim","orcid":"https://orcid.org/0000-0002-5029-4962","observed_orcids":["https://orcid.org/0000-0002-5029-4962","https://orcid.org/0000-0003-2585-1226"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Kwon Kim","raw_affiliation_strings":["Department of Health Sciences, The Graduate School of Konyang University, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0002-5029-4962","affiliations":[{"raw_affiliation_string":"Department of Health Sciences, The Graduate School of Konyang University, Daejeon, Korea","institution_ids":["https://openalex.org/I165028127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057836453","display_name":"Jeong-Lib An","orcid":"https://orcid.org/0000-0003-1292-4772","observed_orcids":["https://orcid.org/0000-0003-1292-4772"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong-Lib An","raw_affiliation_strings":["Department of Health Sciences, The Graduate School of Konyang University, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1292-4772","affiliations":[{"raw_affiliation_string":"Department of Health Sciences, The Graduate School of Konyang University, Daejeon, Korea","institution_ids":["https://openalex.org/I165028127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057995109","display_name":"Jong-Sook Kim","orcid":"https://orcid.org/0000-0002-0615-5244","observed_orcids":["https://orcid.org/0000-0002-0615-5244"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Sook Kim","raw_affiliation_strings":["Department of Health Sciences, The Graduate School of Konyang University, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0002-0615-5244","affiliations":[{"raw_affiliation_string":"Department of Health Sciences, The Graduate School of Konyang University, Daejeon, Korea","institution_ids":["https://openalex.org/I165028127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041090277","display_name":"Pil Seung Kwon","orcid":"https://orcid.org/0000-0002-9808-4200","observed_orcids":["https://orcid.org/0000-0002-9808-4200"]},"institutions":[{"id":"https://openalex.org/I4210108896","display_name":"WonKwang Health Science University","ror":"https://ror.org/01m84dy33","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210108896"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Pil-Seung Kwon","raw_affiliation_strings":["Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan, Korea"],"raw_orcid":"https://orcid.org/0000-0002-9808-4200","affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan, Korea","institution_ids":["https://openalex.org/I4210108896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059556930","display_name":"Young-Bin Yu","orcid":"https://orcid.org/0000-0002-6913-9735","observed_orcids":["https://orcid.org/0000-0002-6913-9735"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young-Bin Yu","raw_affiliation_strings":["Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0002-6913-9735","affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea","institution_ids":["https://openalex.org/I165028127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059556930"],"corresponding_institution_ids":["https://openalex.org/I165028127"],"apc_list":null,"apc_paid":null,"fwci":0.4359,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.47654006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"4","first_page":"290","last_page":"297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":1.0},{"id":"https://openalex.org/keywords/radachlorin","display_name":"Radachlorin","score":0.996999979019165},{"id":"https://openalex.org/keywords/acinetobacter-baumannii","display_name":"Acinetobacter baumannii","score":0.9290000200271606},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.640999972820282},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.9430000185966492},{"id":"https://openalex.org/keywords/oxa-23","display_name":"OXA-23","score":0.8519999980926514},{"id":"https://openalex.org/keywords/oxa-51","display_name":"OXA-51","score":0.9850000143051147},{"id":"https://openalex.org/keywords/class-d-beta-lactamase","display_name":"class D beta-lactamase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/light-emitting-diodes","display_name":"light-emitting diodes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cell-membrane-damage","display_name":"cell membrane damage","score":0.6510000228881836},{"id":"https://openalex.org/keywords/antibiotic-alternatives","display_name":"antibiotic alternatives","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8748122453689575},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7453274130821228},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.6547703742980957},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6058773994445801},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.45931461453437805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45385536551475525},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2819329798221588},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26119858026504517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25439751148223877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.24171/j.phrp.2022.0150","doi":"https://doi.org/10.24171/j.phrp.2022.0150","is_oa":true,"landing_page_url":"https://doi.org/10.24171/j.phrp.2022.0150","pdf_url":null,"source":{"id":"https://openalex.org/S2765061833","display_name":"Osong Public Health and Research Perspectives","issn_l":"2210-9099","issn":["2210-9099","2233-6052"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong Public Health and Research Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9468690","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9468690/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9468690/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong Public Health Res Perspect","raw_type":"Text"},{"id":"pmid:36097751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36097751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong public health and research perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8c98ac7e5b3349ef9d70122d7c2958c3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c98ac7e5b3349ef9d70122d7c2958c3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osong Public Health and Research Perspectives, Vol 13, Iss 4, Pp 290-297 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.24171/j.phrp.2022.0150","doi":"https://doi.org/10.24171/j.phrp.2022.0150","is_oa":true,"landing_page_url":"https://doi.org/10.24171/j.phrp.2022.0150","pdf_url":null,"source":{"id":"https://openalex.org/S2765061833","display_name":"Osong Public Health and Research Perspectives","issn_l":"2210-9099","issn":["2210-9099","2233-6052"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong Public Health and Research Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G403884510","display_name":null,"funder_award_id":"20A0088","funder_id":"https://openalex.org/F4320321252","funder_display_name":"Konyang University"}],"funders":[{"id":"https://openalex.org/F4320321252","display_name":"Konyang University","ror":"https://ror.org/02v8yp068"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292670565.pdf","grobid_xml":"https://content.openalex.org/works/W4292670565.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1487174515","https://openalex.org/W1902535075","https://openalex.org/W1943216040","https://openalex.org/W1997495012","https://openalex.org/W2009828713","https://openalex.org/W2019623290","https://openalex.org/W2031321348","https://openalex.org/W2033533398","https://openalex.org/W2048218195","https://openalex.org/W2057373188","https://openalex.org/W2057607409","https://openalex.org/W2096618073","https://openalex.org/W2097700470","https://openalex.org/W2101464392","https://openalex.org/W2110256580","https://openalex.org/W2111725508","https://openalex.org/W2128578655","https://openalex.org/W2131727615","https://openalex.org/W2134877726","https://openalex.org/W2140455148","https://openalex.org/W2143405687","https://openalex.org/W2145645537","https://openalex.org/W2151496242","https://openalex.org/W2151790223","https://openalex.org/W2160868642","https://openalex.org/W2166606642"],"related_works":["https://openalex.org/W4385987433","https://openalex.org/W7120789079","https://openalex.org/W4413843304","https://openalex.org/W6906238613","https://openalex.org/W2489427773","https://openalex.org/W2573945359","https://openalex.org/W3015849911","https://openalex.org/W4384563186","https://openalex.org/W2909368356","https://openalex.org/W2134877726"],"abstract_inverted_index":{"OBJECTIVES:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,78,93,132,151,207],"test":[5,32,89],"the":[6,13,36,41,56,80,94,100,133,136,152,166,189,215],"effect":[7,82],"of":[8,17,40,53,58,83,116,135,160,168,192],"photodynamic":[9],"therapy":[10],"(PDT)":[11],"on":[12,188],"inhibition":[14],"and":[15,72,74,97,108,110,139,147,162,182,199],"removal":[16],"biofilms":[18,193],"containing":[19,194],"multidrug-resistant":[20,25,169,195],"Acinetobacter":[21],"baumannii.":[22,171],"METHODS:":[23],"Using":[24],"A.":[26,118,170],"baumannii":[27,119],"strains,":[28],"an":[29,51,128],"antibiotic":[30,87],"susceptibility":[31,88],"was":[33,106,184],"performed":[34],"using":[35,66,123,174],"Gram-negative":[37],"identification":[38],"card":[39],"Vitek":[42],"2":[43],"system":[44],"(bioM\u00e9rieux":[45],"Inc.,":[46],"France),":[47],"as":[48,50],"well":[49],"analysis":[52],"resistance":[54,92],"genes,":[55],"effects":[57],"treatment":[59,204],"with":[60,209],"a":[61,158,203],"light-emitting":[62],"diode":[63],"(LED)":[64],"array":[65],"Radachlorin":[67,163,183],"(RADA-PHARMA":[68],"Co.,":[69],"Ltd.,":[70],"Russia),":[71],"transmission":[73],"scanning":[75],"electron":[76,175],"microscopy":[77,176],"confirm":[79],"biofilm-inhibitory":[81],"PDT.":[84],"RESULTS:":[85],"The":[86],"revealed":[90,127],"multiple":[91],"antibiotics":[95,210],"imipenem":[96],"meropenem":[98],"in":[99,114,214],"carbapenem":[101],"class.":[102],"A":[103],"class-D-type":[104],"\u03b2-lactamase":[105],"found,":[107],"OXA-23":[109],"OXA-51":[111],"were":[112],"found":[113],"100%":[115],"15":[117],"strains.":[120],"After":[121],"PDT":[122,156,179],"Radachlorin,":[124],"morphological":[125,141],"observations":[126],"abnormal":[129],"structure":[130],"due":[131],"loss":[134],"cell":[137,153],"membrane":[138],"extensive":[140],"changes,":[142],"including":[143],"low":[144],"intracellular":[145],"visibility":[146],"small":[148],"vacuoles":[149],"attached":[150],"membrane.":[154],"CONCLUSION:":[155],"involving":[157],"combination":[159],"LED":[161,181],"significantly":[164],"eliminated":[165],"biofilm":[167],"Observations":[172],"made":[173],"showed":[177],"that":[178,202],"combining":[180],"effective.":[185],"Additional":[186],"studies":[187],"effective":[190],"elimination":[191],"bacteria":[196],"are":[197],"necessary,":[198],"we":[200],"hope":[201],"method":[205],"superior":[206],"sterilization":[208],"will":[211],"be":[212],"developed":[213],"future.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-08-23T00:00:00"}