{"id":"https://openalex.org/W4292566478","doi":"https://doi.org/10.31254/phyto.2022.11405","title":"Hepatoprotective activity of Amalakyadi Gana, a polyherbal ayurvedic formulation in paracetamol-induced hepatotoxicity in mice","display_name":"Hepatoprotective activity of Amalakyadi Gana, a polyherbal ayurvedic formulation in paracetamol-induced hepatotoxicity in mice","publication_year":2022,"publication_date":"2022-08-15","ids":{"openalex":"https://openalex.org/W4292566478","doi":"https://doi.org/10.31254/phyto.2022.11405"},"language":"en","primary_location":{"id":"doi:10.31254/phyto.2022.11405","doi":"https://doi.org/10.31254/phyto.2022.11405","is_oa":true,"landing_page_url":"https://doi.org/10.31254/phyto.2022.11405","pdf_url":"https://doi.org/10.31254/phyto.2022.11405","source":{"id":"https://openalex.org/S4210208595","display_name":"The Journal of Phytopharmacology","issn_l":"2320-480X","issn":["2320-480X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Phytopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.31254/phyto.2022.11405","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047891251","display_name":"Shreyosi Ray","orcid":"https://orcid.org/0000-0002-0121-5391","observed_orcids":["https://orcid.org/0000-0002-0121-5391"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shreyosi Ray","raw_affiliation_strings":["Department of Dravyaguna, Raghunath Ayurved Mahavidyalaya and Hospital, Contai, Purba Medinipur-721401, West Bengal, India","Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road 700009, Kolkata, India"],"raw_orcid":"https://orcid.org/0000-0002-0121-5391","affiliations":[{"raw_affiliation_string":"Department of Dravyaguna, Raghunath Ayurved Mahavidyalaya and Hospital, Contai, Purba Medinipur-721401, West Bengal, India","institution_ids":[]},{"raw_affiliation_string":"Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road 700009, Kolkata, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082744111","display_name":"Amit Kumar Taraphdar","orcid":"https://orcid.org/0000-0001-7117-3222","observed_orcids":["https://orcid.org/0000-0001-7117-3222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit K. Taraphdar","raw_affiliation_strings":["Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road 700009, Kolkata, India","Department of Dravyaguna, Raghunath Ayurved Mahavidyalaya and Hospital, Contai, Purba Medinipur-721401, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0001-7117-3222","affiliations":[{"raw_affiliation_string":"Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road 700009, Kolkata, India","institution_ids":[]},{"raw_affiliation_string":"Department of Dravyaguna, Raghunath Ayurved Mahavidyalaya and Hospital, Contai, Purba Medinipur-721401, West Bengal, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084849733","display_name":"Mradu Gupta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mradu Gupta","raw_affiliation_strings":["Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road 700009, Kolkata, India","Department of Dravyaguna, Raghunath Ayurved Mahavidyalaya and Hospital, Contai, Purba Medinipur-721401, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road 700009, Kolkata, India","institution_ids":[]},{"raw_affiliation_string":"Department of Dravyaguna, Raghunath Ayurved Mahavidyalaya and Hospital, Contai, Purba Medinipur-721401, West Bengal, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4342,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.48645334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"4","first_page":"255","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9750000238418579},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/polyherbal-formulation","display_name":"polyherbal formulation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ayurveda","display_name":"Ayurveda","score":0.8149999976158142},{"id":"https://openalex.org/keywords/phyllanthus-emblica","display_name":"Phyllanthus emblica","score":0.9710000157356262},{"id":"https://openalex.org/keywords/terminalia-chebula","display_name":"Terminalia chebula","score":1.0},{"id":"https://openalex.org/keywords/piper-longum","display_name":"Piper longum","score":1.0},{"id":"https://openalex.org/keywords/plumbago-zeylanica","display_name":"Plumbago zeylanica","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-function-markers","display_name":"liver function markers","score":0.800000011920929},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.8949999809265137},{"id":"https://openalex.org/keywords/silymarin","display_name":"silymarin","score":0.7360000014305115},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C3020366999","wikidata":"https://www.wikidata.org/wiki/Q3595915","display_name":"Terminalia chebula","level":2,"score":0.8198444843292236},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.722920298576355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6201733350753784},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5972321629524231},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5354243516921997},{"id":"https://openalex.org/C2993709057","wikidata":"https://www.wikidata.org/wiki/Q1349821","display_name":"Liver toxicity","level":3,"score":0.4827117621898651},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.46630823612213135},{"id":"https://openalex.org/C2910151965","wikidata":"https://www.wikidata.org/wiki/Q310050","display_name":"Phyllanthus emblica","level":2,"score":0.4360968768596649},{"id":"https://openalex.org/C2776718122","wikidata":"https://www.wikidata.org/wiki/Q310927","display_name":"Phyllanthus","level":2,"score":0.4320603609085083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0906728208065033}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31254/phyto.2022.11405","doi":"https://doi.org/10.31254/phyto.2022.11405","is_oa":true,"landing_page_url":"https://doi.org/10.31254/phyto.2022.11405","pdf_url":"https://doi.org/10.31254/phyto.2022.11405","source":{"id":"https://openalex.org/S4210208595","display_name":"The Journal of Phytopharmacology","issn_l":"2320-480X","issn":["2320-480X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Phytopharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31254/phyto.2022.11405","doi":"https://doi.org/10.31254/phyto.2022.11405","is_oa":true,"landing_page_url":"https://doi.org/10.31254/phyto.2022.11405","pdf_url":"https://doi.org/10.31254/phyto.2022.11405","source":{"id":"https://openalex.org/S4210208595","display_name":"The Journal of Phytopharmacology","issn_l":"2320-480X","issn":["2320-480X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Phytopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292566478.pdf","grobid_xml":"https://content.openalex.org/works/W4292566478.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1210618818","https://openalex.org/W1504644673","https://openalex.org/W1527821398","https://openalex.org/W1957278093","https://openalex.org/W1996657555","https://openalex.org/W2028432508","https://openalex.org/W2039107480","https://openalex.org/W2077094342","https://openalex.org/W2170705413","https://openalex.org/W2183257107","https://openalex.org/W2189549443","https://openalex.org/W2290311699","https://openalex.org/W2293512153","https://openalex.org/W2405650916","https://openalex.org/W2547896973","https://openalex.org/W2610536898","https://openalex.org/W2770940062","https://openalex.org/W3152434232","https://openalex.org/W4232186080","https://openalex.org/W6828634874"],"related_works":["https://openalex.org/W4244892585","https://openalex.org/W2559841133","https://openalex.org/W2177543660","https://openalex.org/W2051538064","https://openalex.org/W3025531626","https://openalex.org/W2186849043","https://openalex.org/W2150944431","https://openalex.org/W2189297672","https://openalex.org/W4408283282","https://openalex.org/W4402054513"],"abstract_inverted_index":{"Since":[0],"ancient":[1],"times,":[2],"Amalakyadi":[3,96],"Gana,":[4,97],"a":[5,110],"polyherbal":[6],"formulation":[7,27,49,143,198],"of":[8,22,29,31,41,47,84,91,95,117,172,189],"Susruta":[9],"Samhita":[10],"(6th":[11],"century":[12],"BCE),":[13],"has":[14],"been":[15],"used":[16],"for":[17],"the":[18,39,53,81,92,115,126,139,148,157,163,170,190],"prevention":[19],"and":[20,38],"treatment":[21],"numerous":[23],"gastrointestinal":[24],"diseases.":[25],"This":[26,142,197],"consists":[28],"fruits":[30],"Phyllanthus":[32],"emblica,":[33],"Terminalia":[34],"chebula,":[35],"Piper":[36],"longum,":[37],"root":[40],"Plumbago":[42],"zeylanica.":[43],"The":[44,64,180],"hepatoprotective":[45,65,107,201],"efficacy":[46,66],"this":[48],"was":[50,67,185],"evaluated":[51],"following":[52],"acute":[54],"toxicity":[55,205],"study":[56],"in":[57,72,79,109,121,138,146,162,206],"mice":[58],"to":[59,125,177,187],"validate":[60],"its":[61],"ayurvedic":[62],"uses.":[63],"assessed":[68],"using":[69],"paracetamol-induced":[70],"hepatotoxicity":[71],"Swiss":[73],"albino":[74],"mice.":[75,122,207],"Research":[76],"drug":[77,165],"exhibited":[78,144],"normalizing":[80,147],"PCM-dependent":[82],"rise":[83],"serum":[85],"liver":[86,140,149,159],"function":[87],"markers.":[88],"After":[89],"administration":[90],"aqueous":[93],"extract":[94],"relevant":[98],"blood":[99],"biochemical":[100],"measures":[101],"showed":[102],"significant":[103,129,200],"(P":[104],"<":[105,131],"0.05)":[106,132],"activity":[108,184,202],"dosage-dependent":[111],"manner,":[112],"especially":[113],"at":[114,169],"dose":[116,171],"700":[118,173],"mg/kg":[119],"orally":[120],"When":[123],"compared":[124],"control":[127],"group,":[128],"(p":[130],"histological":[133],"alterations":[134],"were":[135],"also":[136],"observed":[137],"tissues.":[141],"results":[145],"architecture":[150],"by":[151],"decreasing":[152],"necrotic":[153],"foci":[154],"along":[155],"with":[156],"normal":[158],"parenchymal":[160],"structure":[161],"research":[164,181],"pre-treated":[166],"groups":[167],"mainly":[168],"mg/kg,":[174,193],"caused":[175],"due":[176],"paracetamol":[178],"toxicity.":[179],"drug's":[182],"sustained":[183],"comparable":[186],"that":[188],"silymarin":[191],"(200":[192],"p.o.)":[194],"reference":[195],"medicine.":[196],"possesses":[199],"without":[203],"any":[204]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-08-22T00:00:00"}
