{"id":"https://openalex.org/W4292560331","doi":"https://doi.org/10.1002/cbin.11887","title":"DPCPX induces Bim\u2010dependent apoptosis in nasopharyngeal carcinoma cells","display_name":"DPCPX induces Bim\u2010dependent apoptosis in nasopharyngeal carcinoma cells","publication_year":2022,"publication_date":"2022-08-21","ids":{"openalex":"https://openalex.org/W4292560331","doi":"https://doi.org/10.1002/cbin.11887","pmid":"https://pubmed.ncbi.nlm.nih.gov/35989488"},"language":"en","primary_location":{"id":"doi:10.1002/cbin.11887","doi":"https://doi.org/10.1002/cbin.11887","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbin.11887","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083206631","display_name":"Suming Pan","orcid":"https://orcid.org/0000-0002-1942-3869","observed_orcids":["https://orcid.org/0000-0002-1942-3869"]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Suming Pan","raw_affiliation_strings":["Department of Radiation Oncology Yue Bei People's Hospital Shaoguan China"],"raw_orcid":"https://orcid.org/0000-0002-1942-3869","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology Yue Bei People's Hospital Shaoguan China","institution_ids":["https://openalex.org/I4210109945"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiangguo Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangguo Zhang","raw_affiliation_strings":["Department of Radiation Oncology Yue Bei People's Hospital Shaoguan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology Yue Bei People's Hospital Shaoguan China","institution_ids":["https://openalex.org/I4210109945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041899187","display_name":"Yugan Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yugan Guo","raw_affiliation_strings":["Department of Radiation Oncology Yue Bei People's Hospital Shaoguan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology Yue Bei People's Hospital Shaoguan China","institution_ids":["https://openalex.org/I4210109945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100451104","display_name":"Yin Li","orcid":"https://orcid.org/0000-0001-7826-3167","observed_orcids":["https://orcid.org/0000-0001-7826-3167"]},"institutions":[{"id":"https://openalex.org/I3130751423","display_name":"Shaoguan University","ror":"https://ror.org/0286g6711","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130751423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Li","raw_affiliation_strings":["Faculty of education Shaoguan University Shaoguan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of education Shaoguan University Shaoguan China","institution_ids":["https://openalex.org/I3130751423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083206631"],"corresponding_institution_ids":["https://openalex.org/I4210109945"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":0.4146,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.39633508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"46","issue":"12","first_page":"2050","last_page":"2059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dpcpx","display_name":"DPCPX","score":1.0},{"id":"https://openalex.org/keywords/adenosine-a1-receptor-antagonist","display_name":"adenosine A1 receptor antagonist","score":0.8859999775886536},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.8460000157356262},{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/building-information-modeling","display_name":"building information modeling","score":0.8149999976158142},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/p53-independent-apoptosis","display_name":"p53-independent apoptosis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9890000224113464},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7099710702896118},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.6352891325950623},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6028347611427307},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5763154029846191},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5488737225532532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48205241560935974},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4752728044986725},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4324271082878113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3847123384475708},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3439558744430542},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29235750436782837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2884168028831482},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.057850271463394165},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbin.11887","doi":"https://doi.org/10.1002/cbin.11887","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbin.11887","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},{"id":"pmid:35989488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35989488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1414004483","https://openalex.org/W2001605681","https://openalex.org/W2025457067","https://openalex.org/W2033251175","https://openalex.org/W2064815984","https://openalex.org/W2095596429","https://openalex.org/W2098584395","https://openalex.org/W2106229202","https://openalex.org/W2111788554","https://openalex.org/W2165179086","https://openalex.org/W2165823586","https://openalex.org/W2301231478","https://openalex.org/W2308538306","https://openalex.org/W2401298790","https://openalex.org/W2465435645","https://openalex.org/W2590612424","https://openalex.org/W2626786480","https://openalex.org/W2739819331","https://openalex.org/W2766023905","https://openalex.org/W2767731740","https://openalex.org/W2769631482","https://openalex.org/W2789220621","https://openalex.org/W2791998267","https://openalex.org/W2801274882","https://openalex.org/W2804985859","https://openalex.org/W2805539079","https://openalex.org/W2808615008","https://openalex.org/W2884963512","https://openalex.org/W2890414229","https://openalex.org/W2894268253","https://openalex.org/W2896744886","https://openalex.org/W2900933518","https://openalex.org/W2902048219","https://openalex.org/W2911079687","https://openalex.org/W2915054797","https://openalex.org/W2919393250","https://openalex.org/W2933248657","https://openalex.org/W2947747173","https://openalex.org/W2979320780","https://openalex.org/W2984955289","https://openalex.org/W2994080338","https://openalex.org/W2996719003","https://openalex.org/W3010989256","https://openalex.org/W3011900210","https://openalex.org/W3014057721","https://openalex.org/W3017080436","https://openalex.org/W3021394574","https://openalex.org/W3021836841","https://openalex.org/W3024756905","https://openalex.org/W3108687974","https://openalex.org/W3158456927"],"related_works":["https://openalex.org/W3158456927","https://openalex.org/W3085187219","https://openalex.org/W2768722721","https://openalex.org/W2380220730","https://openalex.org/W2339338287","https://openalex.org/W3175946098","https://openalex.org/W2624651286","https://openalex.org/W7100338805","https://openalex.org/W3199937822","https://openalex.org/W2058285191"],"abstract_inverted_index":{"ADORA1":[0,18],"promotes":[1,59],"tumor":[2],"growth":[3,62],"and":[4,91,106],"development":[5],"in":[6,24,33,68,93,102,120,126],"multiple":[7],"cancers.":[8],"DPCPX":[9,32,51,58,64,83,125],"(a":[10],"selective":[11],"adenosine":[12],"A1":[13],"receptor":[14],"antagonist),":[15],"a":[16,117],"specific":[17],"antagonist,":[19],"has":[20],"shown":[21],"antitumor":[22,86,107],"effects":[23,123],"many":[25],"cancer":[26],"types.":[27],"Nevertheless,":[28],"the":[29,47,76,85,113,121],"function":[30],"of":[31,50,72,88,100,109,124],"nasopharyngeal":[34],"carcinoma":[35],"(NPC)":[36],"still":[37],"remains":[38],"to":[39],"be":[40],"unraveled.":[41],"In":[42,111],"this":[43],"study,":[44],"we":[45],"investigated":[46],"functional":[48],"role":[49,119],"on":[52],"NPC":[53,60,69],"cells.":[54],"We":[55],"found":[56],"that":[57,98],"cells":[61,70],"inhibition.":[63,81],"induced":[65],"Bim-dependent":[66],"apoptosis":[67,105],"irrespective":[71],"p53":[73],"status":[74],"via":[75],"FoxO3a":[77],"pathway":[78],"following":[79],"PI3K/AKT":[80],"Furthermore,":[82],"enhanced":[84],"effect":[87],"cisplatin,":[89],"5-FU":[90],"Paclitaxel":[92],"NPC.":[94,127],"Xenograft":[95],"experiment":[96],"revealed":[97],"deficiency":[99],"Bim":[101],"vivo":[103],"stalls":[104],"activity":[108],"DPCPX.":[110],"conclusion,":[112],"PI3K/AKT/FoxO3a/Bim":[114],"axis":[115],"plays":[116],"critical":[118],"anticancer":[122]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-22T00:00:00"}
