{"id":"https://openalex.org/W4292387359","doi":"https://doi.org/10.1200/jco.22.01470","title":"Reply to R. Sun et al","display_name":"Reply to R. Sun et al","publication_year":2022,"publication_date":"2022-08-19","ids":{"openalex":"https://openalex.org/W4292387359","doi":"https://doi.org/10.1200/jco.22.01470","pmid":"https://pubmed.ncbi.nlm.nih.gov/35985006"},"language":"fr","primary_location":{"id":"doi:10.1200/jco.22.01470","doi":"https://doi.org/10.1200/jco.22.01470","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.22.01470","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.01470?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.01470?role=tab","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038489185","display_name":"Andrew J. Armstrong","orcid":"https://orcid.org/0000-0001-7012-1754","observed_orcids":["https://orcid.org/0000-0001-7012-1754"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Armstrong","raw_affiliation_strings":["Andrew J. Armstrong, MD, ScM, Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University, Durham, NC; Brad Rosbrook, MS, Pfizer Inc, New York, NY; and Shunsuke Yamada, MEng, Astellas Pharma Inc, Northbrook, IL","Bayer, Dendreon,","Constellation Pharmaceuticals (Inst), Merck (Inst), AstraZeneca (Inst), BeiGene (Inst), Amgen (Inst), FORMA Therapeutics (Inst)","Janssen Oncology (Inst), Astellas Pharma (Inst), Gilead Sciences (Inst), Roche/ Genentech (Inst), Bristol Myers Squibb (Inst),","Pfizer, Astellas Scientific and Medical Affairs Inc, AstraZeneca, Merck, Bristol Myers Squibb, Janssen, FORMA Therapeutics, Novartis, Exelixis, Myovant Sciences, GoodRx Research Funding: Dendreon (Inst), Bayer (Inst), Pfizer (Inst), Novartis (Inst),"],"raw_orcid":"https://orcid.org/0000-0001-7012-1754","affiliations":[{"raw_affiliation_string":"Andrew J. Armstrong, MD, ScM, Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University, Durham, NC; Brad Rosbrook, MS, Pfizer Inc, New York, NY; and Shunsuke Yamada, MEng, Astellas Pharma Inc, Northbrook, IL","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]},{"raw_affiliation_string":"Bayer, Dendreon,","institution_ids":[]},{"raw_affiliation_string":"Constellation Pharmaceuticals (Inst), Merck (Inst), AstraZeneca (Inst), BeiGene (Inst), Amgen (Inst), FORMA Therapeutics (Inst)","institution_ids":[]},{"raw_affiliation_string":"Janssen Oncology (Inst), Astellas Pharma (Inst), Gilead Sciences (Inst), Roche/ Genentech (Inst), Bristol Myers Squibb (Inst),","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Pfizer, Astellas Scientific and Medical Affairs Inc, AstraZeneca, Merck, Bristol Myers Squibb, Janssen, FORMA Therapeutics, Novartis, Exelixis, Myovant Sciences, GoodRx Research Funding: Dendreon (Inst), Bayer (Inst), Pfizer (Inst), Novartis (Inst),","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032105752","display_name":"Brad Rosbrook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Rosbrook","raw_affiliation_strings":["Andrew J. Armstrong, MD, ScM, Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University, Durham, NC; Brad Rosbrook, MS, Pfizer Inc, New York, NY; and Shunsuke Yamada, MEng, Astellas Pharma Inc, Northbrook, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew J. Armstrong, MD, ScM, Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University, Durham, NC; Brad Rosbrook, MS, Pfizer Inc, New York, NY; and Shunsuke Yamada, MEng, Astellas Pharma Inc, Northbrook, IL","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071001904","display_name":"Shunsuke Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shunsuke Yamada","raw_affiliation_strings":["Andrew J. Armstrong, MD, ScM, Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University, Durham, NC; Brad Rosbrook, MS, Pfizer Inc, New York, NY; and Shunsuke Yamada, MEng, Astellas Pharma Inc, Northbrook, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew J. Armstrong, MD, ScM, Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University, Durham, NC; Brad Rosbrook, MS, Pfizer Inc, New York, NY; and Shunsuke Yamada, MEng, Astellas Pharma Inc, Northbrook, IL","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]}]},{"author_position":"last","author":{"id":null,"display_name":"On behalf of the ARCHES authors","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"On behalf of the ARCHES authors","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"36","first_page":"4279","last_page":"4280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.796999990940094},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8560000061988831},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"hazard ratio","score":0.7580000162124634},{"id":"https://openalex.org/keywords/proportional-hazards-assumption","display_name":"proportional hazards assumption","score":0.972000002861023},{"id":"https://openalex.org/keywords/kaplan-meier-curves","display_name":"Kaplan-Meier curves","score":0.8759999871253967},{"id":"https://openalex.org/keywords/log-rank-test","display_name":"log-rank test","score":0.8740000128746033},{"id":"https://openalex.org/keywords/treatment-effect-interpretation","display_name":"treatment effect interpretation","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7643477916717529}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.22.01470","doi":"https://doi.org/10.1200/jco.22.01470","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.22.01470","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.01470?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:35985006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35985006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1200/jco.22.01470","doi":"https://doi.org/10.1200/jco.22.01470","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.22.01470","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.01470?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292387359.pdf","grobid_xml":"https://content.openalex.org/works/W4292387359.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2760699482","https://openalex.org/W2887933497","https://openalex.org/W3191733181","https://openalex.org/W4212801027","https://openalex.org/W4224078346","https://openalex.org/W4292358709"],"related_works":["https://openalex.org/W3202107108","https://openalex.org/W4410811223","https://openalex.org/W4212967167","https://openalex.org/W7127337907","https://openalex.org/W4224078346","https://openalex.org/W7162500292","https://openalex.org/W4297821480","https://openalex.org/W4225259966","https://openalex.org/W4389504780","https://openalex.org/W3157858132"],"abstract_inverted_index":{"We":[0],"recently":[1],"published":[2],"results":[3],"from":[4,99],"the":[5,14,79,84,87,100,104,107,127,141,145,152,156,166,190,193,198,201,217,229],"final":[6],"prespecified":[7],"analysis":[8],"of":[9,22,83,94,106,140,159,192,216],"overall":[10],"survival":[11],"(OS)":[12],"in":[13,52],"ARCHES":[15],"trial,":[16],"a":[17,45,92,111,137],"phase":[18],"III,":[19],"double-blind":[20],"study":[21],"enzalutamide":[23,41],"(160":[24],"mg":[25],"once":[26],"daily)":[27],"plus":[28,35,42,57],"androgen":[29],"deprivation":[30],"therapy":[31],"(ADT)":[32],"versus":[33],"placebo":[34,56],"ADT.":[36],"1":[37,179],"In":[38],"that":[39,103,117],"analysis,":[40,124],"ADT":[43,58],"demonstrated":[44],"clinically":[46,222],"meaningful":[47,223],"and":[48,72,81,91,115,144,169,176,187,196,204,213,226],"statistically":[49],"significant":[50],"increase":[51],"OS":[53,88],"compared":[54],"with":[55],"(hazard":[59],"ratio":[60],"[HR],":[61],"0.66;":[62],"95%":[63],"CI,":[64],"0.53":[65],"to":[66,131,224],"0.81;":[67],"log-rank":[68,199],"P":[69],",":[70],".001).Sun":[71],"Wei":[73],"2":[74],"have":[75],"raised":[76],"concerns":[77],"about":[78],"use":[80],"interpretation":[82],"HR":[85,108,153,181],"for":[86,184],"end":[89],"point":[90],"lack":[93],"median":[95],"Kaplan-Meier":[96],"(KM)":[97],"estimates":[98,172],"data.They":[101],"note":[102],"validity":[105],"depends":[109],"on":[110],"proportional":[112,128,210],"hazards":[113,129,211],"assumption":[114,119,130],"suggest":[116],"this":[118],"is":[120,154,182],"likely":[121],"invalid.In":[122],"our":[123],"we":[125,163],"considered":[126],"be":[132],"appropriate,":[133],"as":[134],"observed":[135],"by":[136,189,197,228],"visual":[138],"examination":[139],"log-log":[142],"plot":[143],"Kolmogorov-type":[146],"supremum":[147],"test":[148,206],"(P":[149],"5":[150],".4440).Furthermore,":[151],"not":[155,208],"sole":[157],"descriptor":[158],"treatment":[160],"effect":[161],"presented;":[162],"also":[164],"presented":[165],"KM":[167,171,194,202],"curve":[168],"provided":[170],"at":[173],"24,":[174],"36,":[175],"48":[177],"months.":[178],"The":[180],"appropriate":[183],"these":[185],"data":[186],"supported":[188],"summaries":[191],"curves":[195,203],"test;":[200],"logrank":[205],"do":[207],"require":[209],"assumptions":[212],"are":[214,221],"independent":[215],"Cox":[218],"HR.These":[219],"statistics":[220],"clinicians":[225],"well-understood":[227],"scientific":[230],"community.":[231]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-08-20T00:00:00"}
