{"id":"https://openalex.org/W4292337575","doi":"https://doi.org/10.1055/s-0038-1648972","title":"\u03b11-Antitrypsin Pittsburgh (Met358 \u2192 Arg) Inhibits the Contact Pathway of Intrinsic Coagulation and Alters the Release of Human Neutrophil Elastase during Simulated Extracorporeal Circulation","display_name":"\u03b11-Antitrypsin Pittsburgh (Met358 \u2192 Arg) Inhibits the Contact Pathway of Intrinsic Coagulation and Alters the Release of Human Neutrophil Elastase during Simulated Extracorporeal Circulation","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W4292337575","doi":"https://doi.org/10.1055/s-0038-1648972"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1648972","doi":"https://doi.org/10.1055/s-0038-1648972","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1648972","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109108387","display_name":"Yanina T. Wachtfogel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanina T Wachtfogel","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center and the Hematology Division, Departments of Medicine and Physiology, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center and the Hematology Division, Departments of Medicine and Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006922451","display_name":"Rainer Bischoff","orcid":"https://orcid.org/0000-0001-9849-0121","observed_orcids":["https://orcid.org/0000-0001-9849-0121"]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rainer Bischoff","raw_affiliation_strings":["Transgene SA, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgene SA, Strasbourg, France","institution_ids":["https://openalex.org/I152238723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ross Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross Bauer","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Harrison Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Harrison Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080558143","display_name":"C. Erik Hack","orcid":"https://orcid.org/0009-0000-7281-8002","observed_orcids":["https://orcid.org/0009-0000-7281-8002"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C Erik Hack","raw_affiliation_strings":["Central Laboratory of The Netherlands Red Cross, Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory of The Netherlands Red Cross, Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110574052","display_name":"Jan H. Nuijens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116086","display_name":"Pharming Group (Netherlands)","ror":"https://ror.org/0233s3730","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210116086"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan H Nuijens","raw_affiliation_strings":["Gene Pharming Europe BV, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Pharming Europe BV, Leiden, The Netherlands","institution_ids":["https://openalex.org/I4210116086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038021583","display_name":"Umberto Kucich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801219303","display_name":"Graduate Hospital","ror":"https://ror.org/0116mdr21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801219303","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umberto Kucich","raw_affiliation_strings":["Research Division, Department of Medicine, The Graduate Hospital, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Department of Medicine, The Graduate Hospital, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801219303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023230653","display_name":"Stefan Niewiarowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Niewiarowski","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center and the Hematology Division, Departments of Medicine and Physiology, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center and the Hematology Division, Departments of Medicine and Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112177995","display_name":"L. Henry Edmunds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Henry Edmunds","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Harrison Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Harrison Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W Colman","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center and the Hematology Division, Departments of Medicine and Physiology, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center and the Hematology Division, Departments of Medicine and Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.43089182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"72","issue":"06","first_page":"843","last_page":"847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.49239999055862427,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.49239999055862427,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.1770000010728836,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.8980000019073486},{"id":"https://openalex.org/keywords/extracorporeal-circulation","display_name":"extracorporeal circulation","score":0.871999979019165},{"id":"https://openalex.org/keywords/kallikrein","display_name":"kallikrein","score":0.7319999933242798},{"id":"https://openalex.org/keywords/contact-pathway","display_name":"contact pathway","score":0.515999972820282},{"id":"https://openalex.org/keywords/intrinsic-coagulation-pathway","display_name":"intrinsic coagulation pathway","score":0.8029999732971191},{"id":"https://openalex.org/keywords/neutrophil-elastase-release","display_name":"neutrophil elastase release","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/thrombin-inhibition","display_name":"thrombin inhibition","score":0.7149999737739563},{"id":"https://openalex.org/keywords/kallikrein-kinin-system","display_name":"kallikrein-kinin system","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.7204743027687073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6662370562553406},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6613885164260864},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6564688086509705},{"id":"https://openalex.org/C2994232697","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal circulation","level":2,"score":0.6199468374252319},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.5938119292259216},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.482749879360199},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.47014811635017395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3704996109008789},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35447388887405396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3496376872062683},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3001234531402588},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21940886974334717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19264566898345947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1845252811908722},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09188765287399292}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0038-1648972","doi":"https://doi.org/10.1055/s-0038-1648972","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1648972","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/b05b4886-46ea-4d8d-8199-410ae6c9accc","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/b05b4886-46ea-4d8d-8199-410ae6c9accc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wachtfogel, Y T, Bischoff, R, Bauer, R, Hack, C E, Nuijens, J H, Kucich, U, Niewiarowski, S, Edmunds, Jr., L H & Colman, R W 1994, 'Alpha 1-antitrypsin Pittsburgh (Met358-- >Arg) inhibits the contact pathway of intrinsic coagulation and alters the release of human neutrophil elastase during simulated extracorporeal circulation', Journal of Thrombosis and Haemostasis, vol. 72, no. 6, pp. 843 - 847.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2343088591","https://openalex.org/W2144197274","https://openalex.org/W2463862959","https://openalex.org/W2107657427","https://openalex.org/W1592226092","https://openalex.org/W2008706609","https://openalex.org/W1634475175","https://openalex.org/W2889356691","https://openalex.org/W2395461310","https://openalex.org/W83208118"],"abstract_inverted_index":{"Summary":[0],"Cardiopulmonary":[1],"bypass":[2],"prolongs":[3],"bleeding":[4],"time,":[5],"increases":[6],"postoperative":[7],"blood":[8,19,31],"loss,":[9],"and":[10,18,38,45,49,74],"triggers":[11],"activation":[12,93,189,198],"of":[13,30,65,71,112,127,133,142,175,187,193,212],"plasma":[14,72],"proteolytic":[15],"enzyme":[16],"systems":[17],"cells":[20],"referred":[21],"to":[22,36],"as":[23,86,88],"the":[24,103,117,131,146,173,191,200,204],"\u201cwhole":[25],"body":[26],"inflammatory":[27],"response\u201d.":[28],"Contact":[29,48],"with":[32],"synthetic":[33],"surfaces":[34],"leads":[35],"qualitative":[37],"quantitative":[39],"alterations":[40],"in":[41,106,120,190],"platelets,":[42],"neutrophils,":[43],"contact":[44,89],"complement":[46,50,197],"systems.":[47],"pathway":[51],"proteins":[52],"both":[53],"induce":[54],"neutrophil":[55,92,181,188,213],"activation,":[56,85],"a":[57,63,68,209],"j-antitrypsin":[58],"Pittsburgh":[59],"(Met358":[60],"\u2192":[61],"Arg),":[62],"mutant":[64,81],"\u03b11-antitrypsin,":[66],"is":[67,208],"potent":[69],"inhibitor":[70,147],"kalli-krein":[73],"thrombin.":[75],"We":[76],"investigated":[77],"whether":[78],"this":[79],"recombinant":[80],"protein":[82],"inhibited":[83],"platelet":[84,107,122,152],"well":[87],"and/or":[90],"complement-induced":[91],"during":[94,215],"simulated":[95],"extracorporeal":[96],"circulation.":[97],"Arg358":[98,155,170],"\u03b11-antitrypsin":[99,171],"did":[100,114],"not":[101,115,164],"prevent":[102],"34%":[104],"drop":[105],"count":[108],"at":[109,124,139],"5":[110],"min":[111,126,141],"recirculation,":[113,128],"block":[116],"50%":[118],"decrease":[119],"ADP-induced":[121],"aggregation":[123],"120":[125,140],"nor":[129],"inhibit":[130],"release":[132,174],"6.06":[134],"\u03b1":[135,177],"1.07":[136],"\u00b5g/ml":[137,179],"(3-thromboglobulin":[138],"recirculation":[143],"suggesting":[144],"that":[145,206],"had":[148],"little":[149],"effect":[150,195],"on":[151,196],"activation.":[153],"However,":[154],"\u03b11":[156],"arantitrypsin":[157],"totally":[158],"blocked":[159],"kallikrein-Cl-in-hibitor":[160],"complex":[161,166],"formation":[162],"but":[163],"Cl-Cl-inhibitor":[165],"formation.":[167],"Most":[168],"importantly,":[169],"decreased":[172],"1.11":[176],"0.16":[178],"human":[180],"elastase":[182],"by":[183],"43%.":[184],"The":[185],"attenuation":[186],"absence":[192],"an":[194],"via":[199],"classical":[201],"pathway,":[202],"supports":[203],"concept":[205],"kallikrein":[207],"major":[210],"mediator":[211],"degranulation":[214],"cardiopulmonary":[216],"bypass.":[217]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-08-19T00:00:00"}