{"id":"https://openalex.org/W4292333050","doi":"https://doi.org/10.1158/0008-5472.195.65.1","title":"Implication of STAT3 Signaling in Human Colonic Cancer Cells during Intestinal Trefoil Factor 3 (TFF3) \u2013 and Vascular Endothelial Growth Factor\u2013Mediated Cellular Invasion and Tumor Growth","display_name":"Implication of STAT3 Signaling in Human Colonic Cancer Cells during Intestinal Trefoil Factor 3 (TFF3) \u2013 and Vascular Endothelial Growth Factor\u2013Mediated Cellular Invasion and Tumor Growth","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W4292333050","doi":"https://doi.org/10.1158/0008-5472.195.65.1","mag":"1675904792","pmid":"https://pubmed.ncbi.nlm.nih.gov/15665295"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.195.65.1","doi":"https://doi.org/10.1158/0008-5472.195.65.1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.195.65.1","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/1/195/2529724/195.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/65/1/195/2529724/195.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081606844","display_name":"Christine Rivat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rivat Christine","raw_affiliation_strings":["1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034128979","display_name":"Sylvie Rodrigues-Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rodrigues Sylvie","raw_affiliation_strings":["1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039299879","display_name":"Bruyneel Erik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bruyneel Erik","raw_affiliation_strings":["2Laboratory of Experimental Cancerology, University Hospital, Gent, Belgium; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Laboratory of Experimental Cancerology, University Hospital, Gent, Belgium; and","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081222252","display_name":"Genevi\u00e8ve Pi\u00e9tu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pie\u0301tu Genevie\u0300ve","raw_affiliation_strings":["3CEA, Service de Ge\u0301nomique Fonctionnelle, Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3CEA, Service de Ge\u0301nomique Fonctionnelle, Evry, France","institution_ids":["https://openalex.org/I2738703131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102489308","display_name":"Robert Am\u00e9lie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Robert Ame\u0301lie","raw_affiliation_strings":["3CEA, Service de Ge\u0301nomique Fonctionnelle, Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3CEA, Service de Ge\u0301nomique Fonctionnelle, Evry, France","institution_ids":["https://openalex.org/I2738703131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109058190","display_name":"G\u00e9rard Redeuilh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Redeuilh Ge\u0301rard","raw_affiliation_strings":["1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000927871","display_name":"Marc Bracke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bracke Marc","raw_affiliation_strings":["1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052850973","display_name":"Christian P. Gespach","orcid":"https://orcid.org/0000-0003-4397-1555","observed_orcids":["https://orcid.org/0000-0003-4397-1555"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gespach Christian","raw_affiliation_strings":["1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210102928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076483582","display_name":"Samir Attoub","orcid":"https://orcid.org/0000-0001-5862-9512","observed_orcids":["https://orcid.org/0000-0001-5862-9512"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Attoub Samir","raw_affiliation_strings":["1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sante et de la Recherche Medicale U482, Ho\u0302pital Saint-Antoine, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210102928"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4077,"has_fulltext":true,"cited_by_count":123,"citation_normalized_percentile":{"value":0.92960539,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"65","issue":"1","first_page":"195","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/trefoil-factor-3","display_name":"TFF3","score":0.9330000281333923},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/flt-1","display_name":"Flt-1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/neuropilins","display_name":"neuropilins","score":0.8320000171661377},{"id":"https://openalex.org/keywords/id2","display_name":"Id2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cucurbitacins","display_name":"cucurbitacins","score":0.8119999766349792},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8450000286102295},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.6998355388641357},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6507002711296082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6035838723182678},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5321295261383057},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5284842252731323},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.518170952796936},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48521044850349426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33889201283454895},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071165","descriptor_name":"Trefoil Factor-3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.195.65.1","doi":"https://doi.org/10.1158/0008-5472.195.65.1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.195.65.1","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/1/195/2529724/195.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:15665295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15665295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1675904792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15665295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1158/0008-5472.195.65.1","doi":"https://doi.org/10.1158/0008-5472.195.65.1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.195.65.1","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/1/195/2529724/195.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292333050.pdf","grobid_xml":"https://content.openalex.org/works/W4292333050.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W435481956","https://openalex.org/W1444350329","https://openalex.org/W1495457417","https://openalex.org/W1520149501","https://openalex.org/W1584223654","https://openalex.org/W1595383321","https://openalex.org/W1649526546","https://openalex.org/W1917630072","https://openalex.org/W1928129824","https://openalex.org/W1933735120","https://openalex.org/W1976552319","https://openalex.org/W1977455794","https://openalex.org/W1985111087","https://openalex.org/W1998767340","https://openalex.org/W2007897471","https://openalex.org/W2024282024","https://openalex.org/W2024584640","https://openalex.org/W2030307027","https://openalex.org/W2047425800","https://openalex.org/W2051638902","https://openalex.org/W2058792197","https://openalex.org/W2074242397","https://openalex.org/W2074356752","https://openalex.org/W2074622849","https://openalex.org/W2080778311","https://openalex.org/W2083044332","https://openalex.org/W2083867249","https://openalex.org/W2084150021","https://openalex.org/W2093689205","https://openalex.org/W2107631090","https://openalex.org/W2113060812","https://openalex.org/W2147018670","https://openalex.org/W2148719225","https://openalex.org/W2148883613","https://openalex.org/W2150162161","https://openalex.org/W2159511823","https://openalex.org/W2160703339","https://openalex.org/W2172166956","https://openalex.org/W2172326429","https://openalex.org/W2180795626","https://openalex.org/W2330829715"],"related_works":["https://openalex.org/W2104573766","https://openalex.org/W3025978112","https://openalex.org/W3196135301","https://openalex.org/W2387214733","https://openalex.org/W4306361937","https://openalex.org/W3085030546","https://openalex.org/W2018769559","https://openalex.org/W2149946192","https://openalex.org/W1972728205","https://openalex.org/W2091433642"],"abstract_inverted_index":{"Signal":[0],"transducer":[1],"and":[2,18,44,64,79,96,110,114,144,146,167,198],"activator":[3],"of":[4,15,33,40,76,83,89,99,118,135,149,204],"transcription":[5],"(STAT)":[6],"3":[7],"is":[8],"overexpressed":[9],"or":[10,104],"activated":[11],"in":[12,50,122,156,181],"most":[13],"types":[14],"human":[16,51,182],"tumors":[17],"has":[19],"been":[20],"classified":[21],"as":[22],"an":[23],"oncogene.":[24],"In":[25],"the":[26,31,34,37,90,116,138,147,157,168,202],"present":[27],"study,":[28],"we":[29],"investigated":[30],"contribution":[32],"STAT3s":[35],"to":[36],"proinvasive":[38,176],"activity":[39,177],"trefoil":[41,61],"factors":[42],"(TFF)":[43],"vascular":[45],"endothelial":[46],"growth":[47,117],"factor":[48],"(VEGF)":[49],"colorectal":[52,183,205],"cancer":[53,184,206],"cells":[54],"HCT8/S11":[55,119],"expressing":[56],"VEGF":[57,139],"receptors.":[58],"Both":[59],"intestinal":[60],"peptide":[62,107],"(TFF3)":[63],"VEGF,":[65],"but":[66],"not":[67],"pS2":[68],"(TFF1),":[69],"activate":[70],"STAT3":[71,84,105,179,193],"signaling":[72,85,180,194],"through":[73,178],"Tyr(705)":[74],"phosphorylation":[75,101],"both":[77],"STAT3alpha":[78],"STAT3beta":[80,136],"isoforms.":[81],"Blockade":[82],"by":[86,93,102,195],"STAT3beta,":[87],"depletion":[88],"STAT3alpha/beta":[91,100],"isoforms":[92],"RNA":[94,199],"interference,":[95],"pharmacologic":[97,196],"inhibition":[98],"cucurbitacin":[103],"inhibitory":[106],"abrogates":[108],"TFF-":[109],"VEGF-induced":[111],"cellular":[112],"invasion":[113],"reduces":[115],"tumor":[120,170],"xenografts":[121],"athymic":[123],"mice.":[124],"Differential":[125],"gene":[126,153],"expression":[127],"analysis":[128],"using":[129],"DNA":[130,150],"microarrays":[131],"revealed":[132],"that":[133,165],"overexpression":[134],"down-regulates":[137],"receptors":[140],"Flt-1,":[141],"neuropilins":[142],"1":[143],"2,":[145],"inhibitor":[148],"binding/differentiation":[151],"(Id-2)":[152],"product":[154],"involved":[155],"neoplastic":[158],"transformation.":[159],"Taken":[160],"together,":[161],"our":[162],"data":[163],"suggest":[164],"TFF3":[166],"essential":[169],"angiogenesis":[171],"regulator":[172],"VEGF(165)":[173],"exert":[174],"potent":[175],"cells.":[185],"We":[186],"also":[187],"validate":[188],"new":[189],"therapeutic":[190],"strategies":[191],"targeting":[192],"inhibitors":[197],"interference":[200],"for":[201],"treatment":[203],"patients.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-19T00:00:00"}