{"id":"https://openalex.org/W4292332849","doi":"https://doi.org/10.3389/fcvm.2022.976083","title":"Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury","display_name":"Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury","publication_year":2022,"publication_date":"2022-08-19","ids":{"openalex":"https://openalex.org/W4292332849","doi":"https://doi.org/10.3389/fcvm.2022.976083","pmid":"https://pubmed.ncbi.nlm.nih.gov/36061560","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9437585"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2022.976083","doi":"https://doi.org/10.3389/fcvm.2022.976083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.976083","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcvm.2022.976083/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcvm.2022.976083/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076387463","display_name":"Podsawee Mongkolpathumrat","orcid":"https://orcid.org/0000-0002-9836-0324","observed_orcids":["https://orcid.org/0000-0002-9836-0324"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Podsawee Mongkolpathumrat","raw_affiliation_strings":["Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011112460","display_name":"Nitirut Nernpermpisooth","orcid":"https://orcid.org/0000-0002-5017-9980","observed_orcids":["https://orcid.org/0000-0002-5017-9980"]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Nitirut Nernpermpisooth","raw_affiliation_strings":["Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand","Integrative Biomedical Research Unit (IBRU), Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand","institution_ids":["https://openalex.org/I66200439"]},{"raw_affiliation_string":"Integrative Biomedical Research Unit (IBRU), Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand","institution_ids":["https://openalex.org/I66200439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025483055","display_name":"Anusak Kijtawornrat","orcid":"https://orcid.org/0000-0002-7872-3183","observed_orcids":["https://orcid.org/0000-0002-7872-3183"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Anusak Kijtawornrat","raw_affiliation_strings":["Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047453604","display_name":"Faprathan Pikwong","orcid":"https://orcid.org/0000-0002-3259-9770","observed_orcids":["https://orcid.org/0000-0002-3259-9770"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Faprathan Pikwong","raw_affiliation_strings":["Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008701567","display_name":"Wannapat Chouyratchakarn","orcid":"https://orcid.org/0000-0002-6727-7210","observed_orcids":["https://orcid.org/0000-0002-6727-7210"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Wannapat Chouyratchakarn","raw_affiliation_strings":["Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012252642","display_name":"Rungrueang Yodsheewan","orcid":"https://orcid.org/0000-0002-6371-3679","observed_orcids":["https://orcid.org/0000-0002-6371-3679"]},"institutions":[{"id":"https://openalex.org/I198105771","display_name":"Kasetsart University","ror":"https://ror.org/05gzceg21","country_code":"TH","type":"education","lineage":["https://openalex.org/I198105771"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Rungrueang Yodsheewan","raw_affiliation_strings":["Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand","institution_ids":["https://openalex.org/I198105771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089029212","display_name":"Sasimanas Unajak","orcid":"https://orcid.org/0000-0002-3242-3978","observed_orcids":["https://orcid.org/0000-0002-3242-3978"]},"institutions":[{"id":"https://openalex.org/I198105771","display_name":"Kasetsart University","ror":"https://ror.org/05gzceg21","country_code":"TH","type":"education","lineage":["https://openalex.org/I198105771"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sasimanas Unajak","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand","institution_ids":["https://openalex.org/I198105771"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015967411","display_name":"Sarawut Kumphune","orcid":"https://orcid.org/0000-0003-4940-7103","observed_orcids":["https://orcid.org/0000-0003-4940-7103"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]},{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Sarawut Kumphune","raw_affiliation_strings":["Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand","Integrative Biomedical Research Unit (IBRU), Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]},{"raw_affiliation_string":"Integrative Biomedical Research Unit (IBRU), Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand","institution_ids":["https://openalex.org/I66200439"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015967411"],"corresponding_institution_ids":["https://openalex.org/I48076826","https://openalex.org/I66200439"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.8627,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71652312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"9","issue":null,"first_page":"976083","last_page":"976083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-leukocyte-protease-inhibitor","display_name":"secretory leukocyte protease inhibitor","score":0.996999979019165},{"id":"https://openalex.org/keywords/aav9-vector","display_name":"AAV9 vector","score":0.7120000123977661},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8759999871253967},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.6679999828338623},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.574999988079071},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/ischemia-modified-albumin","display_name":"ischemia-modified albumin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2777090344","wikidata":"https://www.wikidata.org/wiki/Q18031590","display_name":"SLPI","level":3,"score":0.6656663417816162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6039398312568665},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.5965573191642761},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5832422971725464},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5007984638214111},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4795396327972412},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4455976188182831},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.43875136971473694},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.426118940114975},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3900730311870575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36941903829574585},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.24025756120681763}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fcvm.2022.976083","doi":"https://doi.org/10.3389/fcvm.2022.976083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.976083","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcvm.2022.976083/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmid:36061560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36061560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9437585","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9437585/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:759b867eb1e6488bae27a0e6afb2d5b4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/759b867eb1e6488bae27a0e6afb2d5b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 9 (2022)","raw_type":"article"},{"id":"doi:10.60692/1dam3-nek14","doi":"https://doi.org/10.60692/1dam3-nek14","is_oa":true,"landing_page_url":"https://doi.org/10.60692/1dam3-nek14","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/dkapz-xh735","doi":"https://doi.org/10.60692/dkapz-xh735","is_oa":true,"landing_page_url":"https://doi.org/10.60692/dkapz-xh735","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2022.976083","doi":"https://doi.org/10.3389/fcvm.2022.976083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.976083","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcvm.2022.976083/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3539389433","display_name":null,"funder_award_id":"N42A650305","funder_id":"https://openalex.org/F4320322817","funder_display_name":"National Research Council of Thailand"},{"id":"https://openalex.org/G4385613656","display_name":null,"funder_award_id":"R2564B013","funder_id":"https://openalex.org/F4320322817","funder_display_name":"National Research Council of Thailand"},{"id":"https://openalex.org/G8050010294","display_name":null,"funder_award_id":"N42A650305","funder_id":"https://openalex.org/F4320321529","funder_display_name":"Chiang Mai University"}],"funders":[{"id":"https://openalex.org/F4320321529","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25"},{"id":"https://openalex.org/F4320321557","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58"},{"id":"https://openalex.org/F4320322817","display_name":"National Research Council of Thailand","ror":"https://ror.org/018wfhg78"},{"id":"https://openalex.org/F4320323020","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292332849.pdf","grobid_xml":"https://content.openalex.org/works/W4292332849.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W42844712","https://openalex.org/W204998232","https://openalex.org/W1809795104","https://openalex.org/W1824389368","https://openalex.org/W1973769490","https://openalex.org/W2001582636","https://openalex.org/W2008033906","https://openalex.org/W2009172879","https://openalex.org/W2015077604","https://openalex.org/W2023165472","https://openalex.org/W2026820190","https://openalex.org/W2030970158","https://openalex.org/W2050744280","https://openalex.org/W2051612765","https://openalex.org/W2067189573","https://openalex.org/W2067288493","https://openalex.org/W2087642160","https://openalex.org/W2089808477","https://openalex.org/W2093076255","https://openalex.org/W2097178825","https://openalex.org/W2116516363","https://openalex.org/W2128439338","https://openalex.org/W2136817003","https://openalex.org/W2139124675","https://openalex.org/W2157300834","https://openalex.org/W2159995125","https://openalex.org/W2161070498","https://openalex.org/W2165883566","https://openalex.org/W2221450513","https://openalex.org/W2242431214","https://openalex.org/W2409047346","https://openalex.org/W2484910684","https://openalex.org/W2583906917","https://openalex.org/W2588336639","https://openalex.org/W2594401612","https://openalex.org/W2596947530","https://openalex.org/W2612697984","https://openalex.org/W2755179889","https://openalex.org/W2764227811","https://openalex.org/W2789755071","https://openalex.org/W2801351680","https://openalex.org/W2801948364","https://openalex.org/W2911763292","https://openalex.org/W2930506919","https://openalex.org/W2951400985","https://openalex.org/W2990357695","https://openalex.org/W3002217545","https://openalex.org/W3038341522","https://openalex.org/W3083497145","https://openalex.org/W3084679119","https://openalex.org/W3113178943","https://openalex.org/W3155215791","https://openalex.org/W3195299366","https://openalex.org/W3199946890","https://openalex.org/W4210880791","https://openalex.org/W4248380489"],"related_works":["https://openalex.org/W2801351680","https://openalex.org/W3155215791","https://openalex.org/W2801948364","https://openalex.org/W4224861102","https://openalex.org/W2009172879","https://openalex.org/W2982453684","https://openalex.org/W2764227811","https://openalex.org/W3208711712","https://openalex.org/W4405791729","https://openalex.org/W4386799453"],"abstract_inverted_index":{"Protease":[0,17],"enzymes":[1],"contribute":[2],"to":[3,101,108,137,173],"the":[4,32,65,89,170],"initiation":[5],"of":[6,35,46,64,91,118,143,178],"cardiac":[7,124,139,163],"remodeling":[8],"and":[9,22,27,73,131,160,162],"heart":[10],"failure":[11],"after":[12],"myocardial":[13,183],"ischemic/reperfusion":[14],"(I/R)":[15],"injury.":[16,43],"inhibitors":[18],"attenuate":[19],"protease":[20,38,69],"activity":[21],"limit":[23],"left":[24],"ventricular":[25],"dysfunction":[26],"remodeling.":[28],"Previous":[29],"studies":[30],"showed":[31,114,145],"cardioprotective":[33],"effect":[34,75],"secretory":[36,67],"leukocyte":[37,68],"inhibitor":[39,70],"(SLPI)":[40],"against":[41,182],"I/R":[42,77,184],"However,":[44],"overexpression":[45,142],"SLPI":[47],"gene":[48,72,176],"in":[49,56,58,148,186,188],"cardiovascular":[50],"diseases":[51],"has":[52],"only":[53],"been":[54],"investigated":[55],"an":[57,187],"vitro":[59],"experiment.":[60],"Here,":[61],"cardiac-selective":[62,92,175],"expression":[63,93,117],"human":[66],"(hSLPI)":[71],"its":[74],"on":[76],"injury":[78,185],"were":[79],"investigated.":[80],"Adeno-associated":[81],"virus":[82],"(AAV)":[83],"serotype":[84],"9":[85],"carrying":[86],"hSLPI":[87,119,144,179],"under":[88],"control":[90],"promoter":[94],"(cardiac":[95],"troponin,":[96],"cTn)":[97],"was":[98],"intravenously":[99],"administered":[100],"Sprague\u2013Dawley":[102],"rats":[103],"for":[104],"4":[105],"weeks":[106],"prior":[107],"coronary":[109],"artery":[110],"ligation.":[111],"The":[112],"results":[113],"that":[115,134],"myocardial-selective":[116],"significantly":[120],"reduced":[121],"infarct":[122],"size,":[123],"troponin":[125],"I":[126],"(cTnI),":[127],"creatine":[128],"kinase-MB":[129],"(CK-MB),":[130],"myoglobin":[132],"levels":[133],"all":[135],"served":[136],"improve":[138],"function.":[140],"Moreover,":[141],"a":[146],"reduction":[147],"inflammatory":[149],"cytokines,":[150],"oxidatively":[151],"modified":[152],"protein":[153],"carbonyl":[154],"(PC)":[155],"content,":[156],"ischemia-modified":[157],"albumin":[158],"(IMA),":[159],"necrosis":[161],"tissue":[164],"degeneration.":[165],"In":[166],"conclusion,":[167],"this":[168],"is":[169],"first":[171],"study":[172],"demonstrate":[174],"delivery":[177],"providing":[180],"cardioprotection":[181],"vivo":[189],"model.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-19T00:00:00"}