{"id":"https://openalex.org/W4292309536","doi":"https://doi.org/10.3390/biom12081124","title":"HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas","display_name":"HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas","publication_year":2022,"publication_date":"2022-08-16","ids":{"openalex":"https://openalex.org/W4292309536","doi":"https://doi.org/10.3390/biom12081124","pmid":"https://pubmed.ncbi.nlm.nih.gov/36009018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9406048"},"language":"en","primary_location":{"id":"doi:10.3390/biom12081124","doi":"https://doi.org/10.3390/biom12081124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12081124","pdf_url":"https://www.mdpi.com/2218-273X/12/8/1124/pdf?version=1660705918","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/12/8/1124/pdf?version=1660705918","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015750970","display_name":"Hongbo Michael Xie","orcid":"https://orcid.org/0000-0003-2223-0029","observed_orcids":["https://orcid.org/0000-0003-2223-0029"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbo Michael Xie","raw_affiliation_strings":["Department of Bioinformatics and Health Informatics (DBHI), Children\u2019s Hospital of Philadelphia, Philadelphia, PA","Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia, Philadelphia, PA","Department of Bioinformatics and Health Informatics (DBHI), Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA","Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, CTRB 3064, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Health Informatics (DBHI), Children\u2019s Hospital of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Bioinformatics and Health Informatics (DBHI), Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, CTRB 3064, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081097548","display_name":"Kathrin Maria Bernt","orcid":"https://orcid.org/0000-0002-0691-356X","observed_orcids":["https://orcid.org/0000-0002-0691-356X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathrin M. Bernt","raw_affiliation_strings":["Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and Abramson Cancer Center, Philadelphia, PA","Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia, Philadelphia, PA","Abramson Cancer Center, Philadelphia, PA 19106, USA","Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA","Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, CTRB 3064, Philadelphia, PA 19104, USA"],"raw_orcid":"https://orcid.org/0000-0002-0691-356X","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and Abramson Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Abramson Cancer Center, Philadelphia, PA 19106, USA","institution_ids":["https://openalex.org/I4390039297"]},{"raw_affiliation_string":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, CTRB 3064, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081097548"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I4390039297","https://openalex.org/I79576946"],"apc_list":{"value":2100,"currency":"CHF","value_usd":2199},"apc_paid":{"value":2100,"currency":"CHF","value_usd":2199},"fwci":1.1522,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79212933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"8","first_page":"1124","last_page":"1124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiosarcoma","display_name":"angiosarcoma","score":1.0},{"id":"https://openalex.org/keywords/hoxa-cluster","display_name":"HOXA cluster","score":0.628000020980835},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.7689999938011169},{"id":"https://openalex.org/keywords/kdr","display_name":"KDR","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-angiosarcoma","display_name":"breast angiosarcoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cutaneous-angiosarcoma","display_name":"cutaneous angiosarcoma","score":0.8550000190734863},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6439999938011169},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2779217266","wikidata":"https://www.wikidata.org/wiki/Q2619091","display_name":"Angiosarcoma","level":2,"score":0.8905677795410156},{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.6302409768104553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5116499066352844},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5034865736961365},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49067938327789307},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4468975365161896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43024179339408875},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33954527974128723},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24750187993049622},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2232780158519745},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16488683223724365}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005801","descriptor_name":"Genes, Homeobox","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/biom12081124","doi":"https://doi.org/10.3390/biom12081124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12081124","pdf_url":"https://www.mdpi.com/2218-273X/12/8/1124/pdf?version=1660705918","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"doi:10.1101/2022.05.06.22274708","doi":"https://doi.org/10.1101/2022.05.06.22274708","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.05.06.22274708","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/05/07/2022.05.06.22274708.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9406048","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9406048","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:36009018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36009018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:efb4fb125fff41fe9e4c433ddc2416e2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/efb4fb125fff41fe9e4c433ddc2416e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 12, Iss 8, p 1124 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom12081124","doi":"https://doi.org/10.3390/biom12081124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12081124","pdf_url":"https://www.mdpi.com/2218-273X/12/8/1124/pdf?version=1660705918","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310274","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116"},{"id":"https://openalex.org/F4320318896","display_name":"Emerson Collective","ror":"https://ror.org/04537p149"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292309536.pdf","grobid_xml":"https://content.openalex.org/works/W4292309536.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1537976626","https://openalex.org/W1979466366","https://openalex.org/W1983035953","https://openalex.org/W1983128071","https://openalex.org/W1987713796","https://openalex.org/W1992618206","https://openalex.org/W2012204251","https://openalex.org/W2020466593","https://openalex.org/W2034665525","https://openalex.org/W2039724178","https://openalex.org/W2039971642","https://openalex.org/W2052487490","https://openalex.org/W2053444552","https://openalex.org/W2059215767","https://openalex.org/W2068281991","https://openalex.org/W2069918359","https://openalex.org/W2076033933","https://openalex.org/W2081151890","https://openalex.org/W2091208410","https://openalex.org/W2091500124","https://openalex.org/W2099959716","https://openalex.org/W2100990361","https://openalex.org/W2103266497","https://openalex.org/W2114843025","https://openalex.org/W2120803742","https://openalex.org/W2149441684","https://openalex.org/W2192124831","https://openalex.org/W2556389398","https://openalex.org/W2755739102","https://openalex.org/W2769932985","https://openalex.org/W2802129476","https://openalex.org/W2809481277","https://openalex.org/W2908294545","https://openalex.org/W2937582753","https://openalex.org/W2988345755","https://openalex.org/W3005073090","https://openalex.org/W4241093998"],"related_works":["https://openalex.org/W3081692609","https://openalex.org/W2886881165","https://openalex.org/W7100769050","https://openalex.org/W4393073032","https://openalex.org/W2138955827","https://openalex.org/W1584137238","https://openalex.org/W2050152766","https://openalex.org/W4406338131","https://openalex.org/W2965852665","https://openalex.org/W2971640766"],"abstract_inverted_index":{"Abstract":[0],"Angiosarcoma":[1],"is":[2,128],"a":[3,16,51,129],"rare,":[4],"devastating":[5],"malignancy":[6],"with":[7,75],"few":[8],"curative":[9],"options":[10],"for":[11,150],"disseminated":[12],"disease.":[13],"We":[14],"analyzed":[15],"recently":[17],"published":[18],"genomic":[19],"data":[20,122],"set":[21],"of":[22,29,35,42,77],"48":[23],"angiosarcomas":[24,100,109],"and":[25,46,73,79,105,119,144],"noticed":[26],"recurrent":[27],"amplifications":[28,66,76,94],"HOXA":[30,37,58,65,71,93,125,151],"cluster":[31],"genes":[32,38,59,72],"in":[33,63,87,99,102,108,111,142],"33%":[34],"patients.":[36],"are":[39],"master":[40],"regulators":[41],"embryonic":[43],"vascular":[44],"development":[45],"adult":[47],"neovascularization,":[48],"which":[49],"provides":[50],"molecular":[52,131],"rationale":[53],"to":[54,134],"suspect":[55],"that":[56,124],"amplified":[57,126,152],"act":[60],"as":[61],"oncogenes":[62],"angiosarcoma.":[64,153],"typically":[67],"affected":[68],"multiple":[69],"pro-angiogenic":[70],"co-occurred":[74],"CD36":[78],"KDR":[80],",":[81],"whereas":[82],"the":[83,103,115],"overall":[84],"mutation":[85],"rate":[86],"these":[88],"tumors":[89],"was":[90],"relatively":[91],"low.":[92],"were":[95,106],"found":[96],"most":[97],"commonly":[98],"located":[101],"breast,":[104],"rare":[107],"arising":[110],"sun-exposed":[112],"areas":[113],"on":[114],"head,":[116],"neck,":[117],"face":[118],"scalp.":[120],"Our":[121],"suggest":[123],"angiosarcoma":[127],"distinct":[130],"subgroup.":[132],"Efforts":[133],"develop":[135],"therapies":[136],"targeting":[137],"oncogenic":[138],"HOX":[139],"gene":[140],"expression":[141],"AML":[143],"other":[145],"sarcomas":[146],"may":[147],"have":[148],"relevance":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-19T00:00:00"}