{"id":"https://openalex.org/W4292265804","doi":"https://doi.org/10.1021/acscatal.2c01134","title":"Review on Recent Developments in Biocatalysts for Friedel\u2013Crafts Reactions","display_name":"Review on Recent Developments in Biocatalysts for Friedel\u2013Crafts Reactions","publication_year":2022,"publication_date":"2022-08-17","ids":{"openalex":"https://openalex.org/W4292265804","doi":"https://doi.org/10.1021/acscatal.2c01134"},"language":"en","primary_location":{"id":"doi:10.1021/acscatal.2c01134","doi":"https://doi.org/10.1021/acscatal.2c01134","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acscatal.2c01134","pdf_url":null,"source":{"id":"https://openalex.org/S37391459","display_name":"ACS Catalysis","issn_l":"2155-5435","issn":["2155-5435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Catalysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034439500","display_name":"Vajinder Kumar","orcid":"https://orcid.org/0000-0002-8825-3517","observed_orcids":["https://orcid.org/0000-0002-8825-3517"]},"institutions":[{"id":"https://openalex.org/I3132890203","display_name":"Akal University","ror":"https://ror.org/01r7w2j21","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132890203"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vajinder Kumar","raw_affiliation_strings":["Department of Chemistry, Akal University, Talwandi Sabo, Bathinda, Punjab 151302, India"],"raw_orcid":"https://orcid.org/0000-0002-8825-3517","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Akal University, Talwandi Sabo, Bathinda, Punjab 151302, India","institution_ids":["https://openalex.org/I3132890203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063640449","display_name":"W. Bruce Turnbull","orcid":"https://orcid.org/0000-0002-7352-0360","observed_orcids":["https://orcid.org/0000-0002-7352-0360"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. Bruce Turnbull","raw_affiliation_strings":["School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K"],"raw_orcid":"https://orcid.org/0000-0002-7352-0360","affiliations":[{"raw_affiliation_string":"School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074265545","display_name":"Avneesh Kumar","orcid":"https://orcid.org/0000-0002-8907-9047","observed_orcids":["https://orcid.org/0000-0002-8907-9047"]},"institutions":[{"id":"https://openalex.org/I3132890203","display_name":"Akal University","ror":"https://ror.org/01r7w2j21","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132890203"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Avneesh Kumar","raw_affiliation_strings":["Department of Botany, Akal University, Talwandi Sabo, Bathinda, Punjab 151302, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany, Akal University, Talwandi Sabo, Bathinda, Punjab 151302, India","institution_ids":["https://openalex.org/I3132890203"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034439500"],"corresponding_institution_ids":["https://openalex.org/I3132890203"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.9853,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88058709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"12","issue":"17","first_page":"10742","last_page":"10763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/friedel-crafts-reaction","display_name":"Friedel-Crafts reaction","score":0.8920000195503235},{"id":"https://openalex.org/keywords/biocatalysis","display_name":"biocatalysis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/asymmetric-friedel-crafts-reaction","display_name":"asymmetric Friedel-Crafts reaction","score":0.8289999961853027},{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"enzyme catalysis","score":0.5339999794960022},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/enantioselectivity","display_name":"enantioselectivity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chemo-and-regioselectivity","display_name":"chemo- and regioselectivity","score":0.824999988079071},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.5889999866485596},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.7289999723434448},{"id":"https://openalex.org/keywords/biocatalyst-design","display_name":"biocatalyst design","score":0.7490000128746033},{"id":"https://openalex.org/keywords/process-scale-up","display_name":"process scale-up","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.8040432929992676},{"id":"https://openalex.org/C202224193","wikidata":"https://www.wikidata.org/wiki/Q649999","display_name":"Friedel\u2013Crafts reaction","level":3,"score":0.7900922298431396},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5480348467826843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5386704206466675},{"id":"https://openalex.org/C59759590","wikidata":"https://www.wikidata.org/wiki/Q2275927","display_name":"Regioselectivity","level":3,"score":0.5127440690994263},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.48814424872398376},{"id":"https://openalex.org/C105289051","wikidata":"https://www.wikidata.org/wiki/Q1930094","display_name":"Pillar","level":2,"score":0.46537846326828003},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4480224847793579},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.34127867221832275},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2926112711429596},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19288888573646545},{"id":"https://openalex.org/C65024703","wikidata":"https://www.wikidata.org/wiki/Q373406","display_name":"Reaction mechanism","level":3,"score":0.18914064764976501},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0915994942188263},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acscatal.2c01134","doi":"https://doi.org/10.1021/acscatal.2c01134","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acscatal.2c01134","pdf_url":null,"source":{"id":"https://openalex.org/S37391459","display_name":"ACS Catalysis","issn_l":"2155-5435","issn":["2155-5435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Catalysis","raw_type":"journal-article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:190174","doi":null,"is_oa":false,"landing_page_url":"https://eprints.whiterose.ac.uk/190174/1/Kumar%20et%20al%20ACS%20Catalysis%202022%20author%20accepte_Bruce%20Turnbull.pdf","pdf_url":"https://eprints.whiterose.ac.uk/190174/1/Kumar%20et%20al%20ACS%20Catalysis%202022%20author%20accepte_Bruce%20Turnbull.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W58193929","https://openalex.org/W1612553237","https://openalex.org/W1652052270","https://openalex.org/W1757331726","https://openalex.org/W1898639147","https://openalex.org/W1966811777","https://openalex.org/W1971107713","https://openalex.org/W1972206605","https://openalex.org/W1974862878","https://openalex.org/W1977106710","https://openalex.org/W1981888951","https://openalex.org/W1984180361","https://openalex.org/W1988277588","https://openalex.org/W1991240905","https://openalex.org/W1992139828","https://openalex.org/W1992223332","https://openalex.org/W1992971778","https://openalex.org/W1995730727","https://openalex.org/W1996991816","https://openalex.org/W1998524371","https://openalex.org/W1998880343","https://openalex.org/W2009170287","https://openalex.org/W2010450283","https://openalex.org/W2013621961","https://openalex.org/W2015232449","https://openalex.org/W2015306414","https://openalex.org/W2016524118","https://openalex.org/W2016598460","https://openalex.org/W2017422430","https://openalex.org/W2023321919","https://openalex.org/W2024057169","https://openalex.org/W2024258233","https://openalex.org/W2024535467","https://openalex.org/W2024687417","https://openalex.org/W2026823120","https://openalex.org/W2027265711","https://openalex.org/W2036185563","https://openalex.org/W2037172159","https://openalex.org/W2045226520","https://openalex.org/W2045489285","https://openalex.org/W2047412920","https://openalex.org/W2049888624","https://openalex.org/W2051858226","https://openalex.org/W2052044977","https://openalex.org/W2055725578","https://openalex.org/W2057095795","https://openalex.org/W2057976910","https://openalex.org/W2062726106","https://openalex.org/W2065967474","https://openalex.org/W2066249088","https://openalex.org/W2068269663","https://openalex.org/W2083910101","https://openalex.org/W2084852025","https://openalex.org/W2085358206","https://openalex.org/W2086717660","https://openalex.org/W2087572200","https://openalex.org/W2088286639","https://openalex.org/W2088626356","https://openalex.org/W2100071542","https://openalex.org/W2101195941","https://openalex.org/W2106531843","https://openalex.org/W2109623962","https://openalex.org/W2110260818","https://openalex.org/W2110466770","https://openalex.org/W2112580008","https://openalex.org/W2112726919","https://openalex.org/W2114003658","https://openalex.org/W2115056050","https://openalex.org/W2115917156","https://openalex.org/W2121140685","https://openalex.org/W2121915606","https://openalex.org/W2125178930","https://openalex.org/W2127666353","https://openalex.org/W2130244315","https://openalex.org/W2134988785","https://openalex.org/W2135598762","https://openalex.org/W2138097993","https://openalex.org/W2144825873","https://openalex.org/W2148778955","https://openalex.org/W2157680389","https://openalex.org/W2158381930","https://openalex.org/W2160726203","https://openalex.org/W2162709361","https://openalex.org/W2168937674","https://openalex.org/W2171830519","https://openalex.org/W2263707531","https://openalex.org/W2285590503","https://openalex.org/W2314463646","https://openalex.org/W2319105559","https://openalex.org/W2319476709","https://openalex.org/W2338992754","https://openalex.org/W2400468982","https://openalex.org/W2412078865","https://openalex.org/W2419259432","https://openalex.org/W2494191766","https://openalex.org/W2554786884","https://openalex.org/W2555470883","https://openalex.org/W2567415926","https://openalex.org/W2583554723","https://openalex.org/W2598829434","https://openalex.org/W2599859268","https://openalex.org/W2603129210","https://openalex.org/W2619923059","https://openalex.org/W2704642493","https://openalex.org/W2735839143","https://openalex.org/W2755480631","https://openalex.org/W2790961542","https://openalex.org/W2798059242","https://openalex.org/W2802959587","https://openalex.org/W2803536627","https://openalex.org/W2809896272","https://openalex.org/W2810361637","https://openalex.org/W2890944115","https://openalex.org/W2893067032","https://openalex.org/W2896736304","https://openalex.org/W2900385456","https://openalex.org/W2906170671","https://openalex.org/W2910552588","https://openalex.org/W2913927383","https://openalex.org/W2914911203","https://openalex.org/W2915890876","https://openalex.org/W2952966302","https://openalex.org/W2975482714","https://openalex.org/W2987964167","https://openalex.org/W2997247320","https://openalex.org/W2997333704","https://openalex.org/W3005446012","https://openalex.org/W3012303600","https://openalex.org/W3016878001","https://openalex.org/W3035847987","https://openalex.org/W3038115123","https://openalex.org/W3041217629","https://openalex.org/W3047421331","https://openalex.org/W3087157678","https://openalex.org/W3119963450","https://openalex.org/W3164241068","https://openalex.org/W3165730573","https://openalex.org/W3211086965","https://openalex.org/W4200399827","https://openalex.org/W4210918323","https://openalex.org/W4220762206","https://openalex.org/W4247702607","https://openalex.org/W4248044179"],"related_works":["https://openalex.org/W4285026216","https://openalex.org/W2119984183","https://openalex.org/W2084852025","https://openalex.org/W2922066363","https://openalex.org/W4396804576","https://openalex.org/W2008161171","https://openalex.org/W1969951206","https://openalex.org/W3124129400","https://openalex.org/W2341443336","https://openalex.org/W2979109122"],"abstract_inverted_index":{"The":[0,56],"Friedel\u2013Crafts":[1],"(F\u2013C)":[2],"reaction":[3,54,61],"has":[4,76,101],"been":[5,43,92],"a":[6,35,78,147],"fundamental":[7],"pillar":[8],"of":[9,31,38,47,59,81,113,178],"both":[10],"academic":[11],"and":[12,29,40,49,73,75,89,119,139,176,180],"industrial":[13],"synthetic":[14],"organic":[15],"chemistry":[16],"since":[17],"its":[18],"discovery":[19],"in":[20,130,173],"1873.":[21],"Its":[22],"success":[23],"is":[24,151],"based":[25],"on":[26],"the":[27,60,68,102,106,114,125,158,174,185],"versatility":[28],"applicability":[30],"F\u2013C":[32,53,94,166,187],"reactions":[33,95],"for":[34,164,183],"wide":[36],"range":[37],"substrates,":[39],"there":[41],"have":[42,91,142,160],"an":[44],"impressive":[45],"number":[46],"publications":[48],"patents":[50],"describing":[51],"catalytic":[52,179],"methods.":[55],"asymmetric":[57,165,186],"version":[58],"was":[62],"discovered":[63],"about":[64],"100":[65],"years":[66],"after":[67],"seminal":[69],"work":[70],"by":[71,122],"Friedel":[72],"Crafts":[74],"become":[77],"major":[79],"area":[80],"research.":[82],"While":[83],"chemical":[84],"methods":[85],"with":[86],"much-improved":[87],"efficacies":[88],"scopes":[90],"discovered,":[93],"still":[96],"suffer":[97],"from":[98],"limitations.":[99],"Biocatalysis":[100],"potential":[103],"to":[104,109,144],"be":[105],"best":[107],"solution":[108],"this":[110],"challenge":[111],"because":[112],"excellent":[115],"selectivity":[116],"(enantio-,":[117],"chemo-,":[118],"regioselectivity)":[120],"displayed":[121],"enzymes.":[123],"In":[124],"last":[126],"two":[127],"decades,":[128],"advancements":[129],"molecular":[131],"biology":[132],"techniques,":[133],"bioinformatics,":[134],"high-throughput":[135],"screening,":[136],"directed":[137],"evolution,":[138],"process":[140],"scale-up":[141],"led":[143],"biocatalysis":[145],"becoming":[146],"mature":[148],"field.":[149],"It":[150],"therefore":[152],"not":[153],"surprising":[154],"that":[155],"researchers":[156],"around":[157],"globe":[159],"developed":[161],"several":[162],"biocatalysts":[163],"reactions.":[167,188],"Herein,":[168],"we":[169],"review":[170],"recent":[171],"developments":[172],"design":[175],"use":[177],"stereoselective":[181],"strategies":[182],"performing":[184]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-19T00:00:00"}