{"id":"https://openalex.org/W4292210285","doi":"https://doi.org/10.1002/slct.202201406","title":"Novel Curcumin Mimics: Design, Synthesis, Biological Properties and Computational Studies of Piperidone\u2010Piperazine Conjugates","display_name":"Novel Curcumin Mimics: Design, Synthesis, Biological Properties and Computational Studies of Piperidone\u2010Piperazine Conjugates","publication_year":2022,"publication_date":"2022-08-18","ids":{"openalex":"https://openalex.org/W4292210285","doi":"https://doi.org/10.1002/slct.202201406"},"language":"en","primary_location":{"id":"doi:10.1002/slct.202201406","doi":"https://doi.org/10.1002/slct.202201406","is_oa":false,"landing_page_url":"https://doi.org/10.1002/slct.202201406","pdf_url":null,"source":{"id":"https://openalex.org/S4210221416","display_name":"ChemistrySelect","issn_l":"2365-6549","issn":["2365-6549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemistrySelect","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101945168","display_name":"Mohamed Adel Youssef","orcid":"https://orcid.org/0000-0001-8592-9676","observed_orcids":["https://orcid.org/0000-0001-8592-9676"]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"M. Adel Youssef","raw_affiliation_strings":["Department of Chemistry Faculty of Science Helwan University  Helwan Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Faculty of Science Helwan University  Helwan Egypt","institution_ids":["https://openalex.org/I84058292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018294904","display_name":"Siva S. Panda","orcid":"https://orcid.org/0000-0003-3668-104X","observed_orcids":["https://orcid.org/0000-0003-3668-104X"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siva S. Panda","raw_affiliation_strings":["Department of Chemistry and Physics Augusta University  Augusta GA 30912 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Physics Augusta University  Augusta GA 30912 USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061012341","display_name":"Dalia R. Aboshouk","orcid":"https://orcid.org/0000-0003-0038-0835","observed_orcids":["https://orcid.org/0000-0003-0038-0835"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Dalia R. Aboshouk","raw_affiliation_strings":["Department of Pesticide Chemistry National Research Centre Dokki  Giza 12622 Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pesticide Chemistry National Research Centre Dokki  Giza 12622 Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110137678","display_name":"Mona F. Said","orcid":"https://orcid.org/0000-0002-9169-3847","observed_orcids":["https://orcid.org/0000-0002-9169-3847"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mona F. Said","raw_affiliation_strings":["Department of Pharmaceutical Chemistry Faculty of Pharmacy Cairo University  Cairo 11562 Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Cairo University  Cairo 11562 Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ahmed El Taweel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed El Taweel","raw_affiliation_strings":["Center of Scientific Excellence for Influenza Viruses National Research Centre Dokki  Giza 12622 Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Scientific Excellence for Influenza Viruses National Research Centre Dokki  Giza 12622 Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103133080","display_name":"Mohamed GabAllah","orcid":"https://orcid.org/0000-0001-9882-9199","observed_orcids":["https://orcid.org/0000-0001-9882-9199"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed GabAllah","raw_affiliation_strings":["Center of Scientific Excellence for Influenza Viruses National Research Centre Dokki  Giza 12622 Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Scientific Excellence for Influenza Viruses National Research Centre Dokki  Giza 12622 Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070645919","display_name":"Walid Fayad","orcid":"https://orcid.org/0000-0002-7975-0343","observed_orcids":["https://orcid.org/0000-0002-7975-0343"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Walid Fayad","raw_affiliation_strings":["Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department National Research Centre  Dokki, Giza 12622 Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department National Research Centre  Dokki, Giza 12622 Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044798952","display_name":"Ahmed F. Soliman","orcid":"https://orcid.org/0000-0002-8401-1553","observed_orcids":["https://orcid.org/0000-0002-8401-1553"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed F. Soliman","raw_affiliation_strings":["Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department National Research Centre  Dokki, Giza 12622 Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department National Research Centre  Dokki, Giza 12622 Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107910392","display_name":"Ahmed Mostafa","orcid":"https://orcid.org/0000-0002-2878-5714","observed_orcids":["https://orcid.org/0000-0002-2878-5714"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Mostafa","raw_affiliation_strings":["Center of Scientific Excellence for Influenza Viruses National Research Centre Dokki  Giza 12622 Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Scientific Excellence for Influenza Viruses National Research Centre Dokki  Giza 12622 Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103010154","display_name":"Nehmedo G. Fawzy","orcid":"https://orcid.org/0000-0002-5786-7778","observed_orcids":["https://orcid.org/0000-0002-5786-7778"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nehmedo G. Fawzy","raw_affiliation_strings":["Department of Pesticide Chemistry National Research Centre Dokki  Giza 12622 Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pesticide Chemistry National Research Centre Dokki  Giza 12622 Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084441438","display_name":"Adel S. Girgis","orcid":"https://orcid.org/0000-0003-4407-9745","observed_orcids":["https://orcid.org/0000-0003-4407-9745"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Adel S. Girgis","raw_affiliation_strings":["Department of Pesticide Chemistry National Research Centre Dokki  Giza 12622 Egypt"],"raw_orcid":"https://orcid.org/0000-0003-4407-9745","affiliations":[{"raw_affiliation_string":"Department of Pesticide Chemistry National Research Centre Dokki  Giza 12622 Egypt","institution_ids":["https://openalex.org/I4210131959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084441438"],"corresponding_institution_ids":["https://openalex.org/I4210131959"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.2995,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.76947738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":"31","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0723000019788742,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperidin-4-ones","display_name":"piperidin-4-ones","score":0.8519999980926514},{"id":"https://openalex.org/keywords/antiproliferative-agents","display_name":"antiproliferative agents","score":0.8080000281333923},{"id":"https://openalex.org/keywords/topoisomerase-ii-alpha","display_name":"TOP2A","score":0.847000002861023},{"id":"https://openalex.org/keywords/topoisomerase-i","display_name":"topoisomerase I","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-sars-cov-2-activity","display_name":"anti-SARS-CoV-2 activity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/qsar","display_name":"QSAR","score":0.703000009059906},{"id":"https://openalex.org/keywords/dehydrohalogenation","display_name":"dehydrohalogenation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/n-methylpiperazine","display_name":"N-methylpiperazine","score":0.7770000100135803},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2776201271","wikidata":"https://www.wikidata.org/wiki/Q409292","display_name":"Piperazine","level":2,"score":0.7237356305122375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5973767042160034},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.495569109916687},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.48581647872924805},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4526132047176361},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.44941645860671997},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.44820737838745117},{"id":"https://openalex.org/C2781269603","wikidata":"https://www.wikidata.org/wiki/Q899683","display_name":"Isoxazole","level":2,"score":0.4100455343723297},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3503080904483795},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3482446074485779},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2972714900970459},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24098455905914307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19371604919433594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14971083402633667},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09916767477989197}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/slct.202201406","doi":"https://doi.org/10.1002/slct.202201406","is_oa":false,"landing_page_url":"https://doi.org/10.1002/slct.202201406","pdf_url":null,"source":{"id":"https://openalex.org/S4210221416","display_name":"ChemistrySelect","issn_l":"2365-6549","issn":["2365-6549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemistrySelect","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1138664098","https://openalex.org/W1972246768","https://openalex.org/W1982861164","https://openalex.org/W1991199800","https://openalex.org/W1996808708","https://openalex.org/W1997690734","https://openalex.org/W2005243501","https://openalex.org/W2011142811","https://openalex.org/W2030278693","https://openalex.org/W2050946288","https://openalex.org/W2091149866","https://openalex.org/W2093904463","https://openalex.org/W2095324891","https://openalex.org/W2102192655","https://openalex.org/W2108556797","https://openalex.org/W2151101177","https://openalex.org/W2153289658","https://openalex.org/W2161387798","https://openalex.org/W2162799606","https://openalex.org/W2165061736","https://openalex.org/W2289200220","https://openalex.org/W2396839272","https://openalex.org/W2524578182","https://openalex.org/W2531437765","https://openalex.org/W2566094495","https://openalex.org/W2579340176","https://openalex.org/W2757433189","https://openalex.org/W2767076259","https://openalex.org/W2790446723","https://openalex.org/W2807500538","https://openalex.org/W2810788886","https://openalex.org/W2811011079","https://openalex.org/W2905360468","https://openalex.org/W2912993657","https://openalex.org/W2913817144","https://openalex.org/W2925848620","https://openalex.org/W2940282309","https://openalex.org/W2946625724","https://openalex.org/W2967102877","https://openalex.org/W2969263723","https://openalex.org/W2972693248","https://openalex.org/W2980164919","https://openalex.org/W2981286239","https://openalex.org/W2996735769","https://openalex.org/W3008222633","https://openalex.org/W3015635512","https://openalex.org/W3016473145","https://openalex.org/W3017321583","https://openalex.org/W3026690391","https://openalex.org/W3094092853","https://openalex.org/W3096614986","https://openalex.org/W3102446254","https://openalex.org/W3112586040","https://openalex.org/W3128646645","https://openalex.org/W3164811968","https://openalex.org/W3174283291","https://openalex.org/W3176298565","https://openalex.org/W3190616317","https://openalex.org/W3197191231","https://openalex.org/W3211097250","https://openalex.org/W4200124851"],"related_works":["https://openalex.org/W3211097250","https://openalex.org/W2940282309","https://openalex.org/W4282826748","https://openalex.org/W4411628938","https://openalex.org/W2023431192","https://openalex.org/W2390430596","https://openalex.org/W2033154574","https://openalex.org/W2384068640","https://openalex.org/W2237775868","https://openalex.org/W4416329654"],"abstract_inverted_index":{"Abstract":[0],"3,5\u2010Di[(":[1],"E":[2,87,95,124],")\u2010arylidene]\u20101\u2010[3\u2010(4\u2010methylpiperazin\u20101\u2010yl)alkyl]piperidin\u20104\u2010ones":[3],"7":[4,98,127],"a\u2212k":[5,13],"were":[6,23,117],"synthesized":[7,29,50,121,135,145],"through":[8],"dehydrohalogenation":[9],"of":[10,27,53,85,140],"1\u2010(2\u2010chloroacyl)piperidin\u20104\u2010ones":[11],"5":[12,90],"with":[14,62,136],"N":[15],"\u2010methylpiperazine":[16],"(":[17,89,97,126],"6":[18],").":[19],"High":[20],"antiproliferation":[21,79],"potencies":[22],"observed":[24,78,118],"by":[25,119],"most":[26,132],"the":[28,43,77,83,103,131,141,153],"agents":[30,51],"against":[31,56,65,156],"both":[32],"HCT116":[33,104],"(colon)":[34],"and":[35,47,59,81,93,110,148,159,166],"MCF7":[36],"(breast)":[37],"cancer":[38],"cell":[39,73,105],"lines":[40],"relative":[41],"to":[42,101,152],"standard":[44],"references":[45],"(sunitinib":[46],"5\u2010fluorouracil).":[48],"The":[49],"are":[52],"dual":[54],"activity":[55],"topoisomerases":[57],"I":[58],"II\u03b1":[60,67],"however,":[61],"higher":[63],"efficacy":[64],"topoisomerase":[66,70],"rather":[68],"than":[69],"I.":[71],"Flow\u2010cytometry":[72],"cycle":[74,106],"studies":[75],"support":[76,168],"properties":[80,116],"exhibit":[82],"capability":[84],"1\u2010(2\u2010chloroacetyl)\u20103,5\u2010bis[(":[86],")\u20104\u2010chlorobenzylidene]piperidin\u20104\u2010one":[88],"e":[91],")":[92,100,129],"3,5\u2010bis[(":[94],")\u20104\u2010bromobenzylidene]\u20101\u2010[2\u2010(4\u2010methylpiperazin\u20101\u2010yl)acetyl]piperidin\u20104\u2010one":[96],"g":[99],"arrest":[102],"progression":[107],"at":[108],"G1/S":[109],"G1":[111],"phases,":[112],"respectively.":[113],"Noticeable":[114],"anti\u2010SARS\u2010CoV\u20102":[115,134,149],"many":[120],"agents.":[122],"3,5\u2010Bis[(":[123],")\u20104\u2010chlorobenzylidene]\u20101\u2010[3\u2010(4\u2010methylpiperazin\u20101\u2010yl)propanoyl]piperidin\u20104\u2010one":[125],"f":[128],"is":[130,150],"effective":[133,143],"high":[137],"SI.":[138],"Applicability":[139],"highly":[142],"candidates":[144],"as":[146],"antitumor":[147],"due":[151],"safety":[154],"observations":[155],"normal":[157],"(RPE1":[158],"VERO\u2010E6)":[160],"cells.":[161],"QSAR":[162],"models":[163],"validated":[164],"internally":[165],"externally,":[167],"their":[169],"possibility":[170],"for":[171],"optimizing":[172],"more":[173],"hits/leads.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-18T00:00:00"}
