{"id":"https://openalex.org/W4292168377","doi":"https://doi.org/10.1111/ced.15371","title":"Efficacy of MitoHeal\u00ae supplementation on adult skin quality and patient satisfaction: a randomized, double-blind, placebo-controlled, pilot study","display_name":"Efficacy of MitoHeal\u00ae supplementation on adult skin quality and patient satisfaction: a randomized, double-blind, placebo-controlled, pilot study","publication_year":2022,"publication_date":"2022-08-17","ids":{"openalex":"https://openalex.org/W4292168377","doi":"https://doi.org/10.1111/ced.15371","pmid":"https://pubmed.ncbi.nlm.nih.gov/35973827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10092201"},"language":"en","primary_location":{"id":"doi:10.1111/ced.15371","doi":"https://doi.org/10.1111/ced.15371","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ced.15371","pdf_url":"https://academic.oup.com/ced/article-pdf/47/12/2269/48531166/ced2269.pdf","source":{"id":"https://openalex.org/S80252431","display_name":"Clinical and Experimental Dermatology","issn_l":"0307-6938","issn":["0307-6938","1365-2230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/ced/article-pdf/47/12/2269/48531166/ced2269.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112710657","display_name":"Stephanie L. Hooper","orcid":"https://orcid.org/0000-0002-9731-6516","observed_orcids":["https://orcid.org/0000-0002-9731-6516"]},"institutions":[{"id":"https://openalex.org/I36075867","display_name":"Jacksonville University","ror":"https://ror.org/050rkhq40","country_code":"US","type":"education","lineage":["https://openalex.org/I36075867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephanie Hooper","raw_affiliation_strings":["Center for Health and Human Performance Academic Health Sciences Building Jacksonville FL USA","Department of Kinesiology, Brooks Rehabilitation College of Healthcare Sciences Jacksonville University Jacksonville FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health and Human Performance Academic Health Sciences Building Jacksonville FL USA","institution_ids":[]},{"raw_affiliation_string":"Department of Kinesiology, Brooks Rehabilitation College of Healthcare Sciences Jacksonville University Jacksonville FL USA","institution_ids":["https://openalex.org/I36075867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072543916","display_name":"Heather Ann Hausenblas","orcid":"https://orcid.org/0000-0002-0127-9184","observed_orcids":["https://orcid.org/0000-0002-0127-9184"]},"institutions":[{"id":"https://openalex.org/I36075867","display_name":"Jacksonville University","ror":"https://ror.org/050rkhq40","country_code":"US","type":"education","lineage":["https://openalex.org/I36075867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather A. Hausenblas","raw_affiliation_strings":["Center for Health and Human Performance Academic Health Sciences Building Jacksonville FL USA","Department of Kinesiology, Brooks Rehabilitation College of Healthcare Sciences Jacksonville University Jacksonville FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health and Human Performance Academic Health Sciences Building Jacksonville FL USA","institution_ids":[]},{"raw_affiliation_string":"Department of Kinesiology, Brooks Rehabilitation College of Healthcare Sciences Jacksonville University Jacksonville FL USA","institution_ids":["https://openalex.org/I36075867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041714880","display_name":"Carena Winters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36075867","display_name":"Jacksonville University","ror":"https://ror.org/050rkhq40","country_code":"US","type":"education","lineage":["https://openalex.org/I36075867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carena Winters","raw_affiliation_strings":["Center for Health and Human Performance Academic Health Sciences Building Jacksonville FL USA","Department of Kinesiology, Brooks Rehabilitation College of Healthcare Sciences Jacksonville University Jacksonville FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health and Human Performance Academic Health Sciences Building Jacksonville FL USA","institution_ids":[]},{"raw_affiliation_string":"Department of Kinesiology, Brooks Rehabilitation College of Healthcare Sciences Jacksonville University Jacksonville FL USA","institution_ids":["https://openalex.org/I36075867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112710657"],"corresponding_institution_ids":["https://openalex.org/I36075867"],"apc_list":{"value":2329,"currency":"GBP","value_usd":2881},"apc_paid":{"value":2329,"currency":"GBP","value_usd":2881},"fwci":0.2386,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44007506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"47","issue":"12","first_page":"2269","last_page":"2272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.781000018119812},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/skin-quality","display_name":"skin quality","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cosmetic-outcome","display_name":"cosmetic outcome","score":0.578000009059906},{"id":"https://openalex.org/keywords/adult-skin","display_name":"adult skin","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8592024445533752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8577131032943726},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6469835638999939},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6214765310287476},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.5711147785186768},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.41997361183166504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33519187569618225},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2549862265586853},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.19143247604370117},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017060","descriptor_name":"Patient Satisfaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/ced.15371","doi":"https://doi.org/10.1111/ced.15371","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ced.15371","pdf_url":"https://academic.oup.com/ced/article-pdf/47/12/2269/48531166/ced2269.pdf","source":{"id":"https://openalex.org/S80252431","display_name":"Clinical and Experimental Dermatology","issn_l":"0307-6938","issn":["0307-6938","1365-2230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Dermatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10092201","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10092201","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10092201/pdf/CED-47-2269.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Dermatol","raw_type":"Text"},{"id":"pmid:35973827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35973827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental dermatology","raw_type":"Randomized Controlled Trial"}],"best_oa_location":{"id":"doi:10.1111/ced.15371","doi":"https://doi.org/10.1111/ced.15371","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ced.15371","pdf_url":"https://academic.oup.com/ced/article-pdf/47/12/2269/48531166/ced2269.pdf","source":{"id":"https://openalex.org/S80252431","display_name":"Clinical and Experimental Dermatology","issn_l":"0307-6938","issn":["0307-6938","1365-2230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292168377.pdf","grobid_xml":"https://content.openalex.org/works/W4292168377.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2039364304","https://openalex.org/W2048335872","https://openalex.org/W2160942583","https://openalex.org/W2204976166","https://openalex.org/W2566397109","https://openalex.org/W2901509642","https://openalex.org/W3134526290","https://openalex.org/W3176618967","https://openalex.org/W3214861431","https://openalex.org/W4250928742"],"related_works":["https://openalex.org/W7163390871","https://openalex.org/W123352722","https://openalex.org/W2794974036","https://openalex.org/W3005393980","https://openalex.org/W4408884613","https://openalex.org/W3185796","https://openalex.org/W3172147938","https://openalex.org/W4389258062","https://openalex.org/W3015249232","https://openalex.org/W7221599750"],"abstract_inverted_index":{"Abstract":[0],"Aim":[1],"Polyphenols,":[2],"the":[3,35,152],"most":[4],"abundant":[5],"natural":[6],"biochemicals":[7],"found":[8],"in":[9,97,99],"fruits,":[10],"vegetables":[11],"seeds,":[12],"red":[13],"wine,":[14],"cocoa,":[15],"coffee":[16],"and":[17,22,73,81,86,102,139,145,159],"spices,":[18],"may":[19],"have":[20],"cosmetic":[21],"health":[23],"effects.":[24],"Methods":[25],"This":[26],"was":[27],"a":[28,112],"1-month":[29],"randomized,":[30],"placebo-controlled":[31],"study,":[32],"approved":[33],"by":[34],"institutional":[36],"review":[37],"board.":[38],"In":[39],"total,":[40],"40":[41],"adults":[42],"(mean":[43],"age":[44],"44.65":[45],"years)":[46],"were":[47,64,123],"randomized":[48],"to":[49,108,150],"one":[50],"of":[51,67,70,154],"three":[52],"groups:":[53],"MitoHeal\u00ae":[54,57],"500":[55],"mg/day,":[56],"1000":[58],"mg/day":[59],"or":[60],"placebo":[61],"drink.":[62],"Measurements":[63],"expert":[65],"rating":[66],"professional":[68],"photos":[69],"skin":[71,76,100,137],"quality":[72,101,138],"patient":[74,103,140],"self-reported":[75],"satisfaction":[77,104],"at":[78],"Days":[79],"0":[80,107],"30.":[82],"Results":[83],"The":[84],"photographs":[85],"self-report":[87],"assessments":[88],"revealed":[89,128],"that,":[90],"compared":[91],"with":[92,111],"placebo,":[93],"MitoHeal":[94,130,155],"supplementation":[95,131,156],"resulted":[96],"improvements":[98],"from":[105],"Day":[106,109],"30,":[110],"dose\u2013response":[113],"relationship":[114],"often":[115],"evidenced":[116],"(P":[117],"<":[118],"0.05).":[119],"No":[120],"adverse":[121],"events":[122],"reported.":[124],"Conclusion":[125],"Pilot":[126],"data":[127],"that":[129],"might":[132],"be":[133],"effective":[134],"for":[135],"improving":[136],"satisfaction.":[141],"Larger":[142],"sample":[143],"sizes":[144],"trial":[146],"durations":[147],"are":[148],"needed":[149],"determine":[151],"effects":[153],"on":[157],"beauty":[158],"overall":[160],"health.":[161]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-18T00:00:00"}