{"id":"https://openalex.org/W4292115336","doi":"https://doi.org/10.3389/fimmu.2022.916491","title":"Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy","display_name":"Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy","publication_year":2022,"publication_date":"2022-08-17","ids":{"openalex":"https://openalex.org/W4292115336","doi":"https://doi.org/10.3389/fimmu.2022.916491","pmid":"https://pubmed.ncbi.nlm.nih.gov/36059475","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9430023"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.916491","doi":"https://doi.org/10.3389/fimmu.2022.916491","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.916491","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.916491/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.916491/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089324119","display_name":"Jennifer Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jennifer Zimmermann","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064032175","display_name":"Alexandra Goretzki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Goretzki","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085710772","display_name":"Clara Meier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clara Meier","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040999588","display_name":"Sonja Wolfheimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sonja Wolfheimer","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065485399","display_name":"Yen\u2010Ju Lin","orcid":"https://orcid.org/0000-0002-0761-9506","observed_orcids":["https://orcid.org/0000-0002-0761-9506"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yen-Ju Lin","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051884500","display_name":"Hannah Rainer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannah Rainer","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018543142","display_name":"Maren Krause","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maren Krause","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111149956","display_name":"Saskia Wedel","orcid":"https://orcid.org/0009-0004-6562-4575","observed_orcids":["https://orcid.org/0009-0004-6562-4575"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Saskia Wedel","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067794688","display_name":"Gerd Spies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd Spies","raw_affiliation_strings":["Z6 Occupational Safety, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Z6 Occupational Safety, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071057352","display_name":"Frank F\u00fchrer","orcid":"https://orcid.org/0009-0002-7761-1793","observed_orcids":["https://orcid.org/0009-0002-7761-1793"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank F\u00fchrer","raw_affiliation_strings":["Division of Allergology, Batch Control and Allergen Analytics, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergology, Batch Control and Allergen Analytics, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026230972","display_name":"Stefan Vieths","orcid":"https://orcid.org/0000-0003-3826-6704","observed_orcids":["https://orcid.org/0000-0003-3826-6704"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Vieths","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019714610","display_name":"Stephan Scheurer","orcid":"https://orcid.org/0000-0002-2859-562X","observed_orcids":["https://orcid.org/0000-0002-2859-562X"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Scheurer","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039122343","display_name":"Stefan Sch\u00fclke","orcid":"https://orcid.org/0000-0002-9674-5116","observed_orcids":["https://orcid.org/0000-0002-9674-5116"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Sch\u00fclke","raw_affiliation_strings":["Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President\u00b4s Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039122343"],"corresponding_institution_ids":["https://openalex.org/I884002606"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.9358,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.67773603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"916491","last_page":"916491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/myeloid-dendritic-cells","display_name":"myeloid dendritic cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dendritic-cell-metabolism","display_name":"dendritic cell metabolism","score":0.9390000104904175},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/aluminium-adjuvants","display_name":"alum adjuvant","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7350000143051147},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.8700000047683716},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.5889999866485596},{"id":"https://openalex.org/keywords/glutamine-deficiency","display_name":"glutamine deficiency","score":0.753000020980835},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6420000195503235},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.607059121131897},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4756309986114502},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.4703167974948883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.443437784910202},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4424351155757904},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4419862926006317},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4370110332965851},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.3701058030128479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.357180118560791},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.35277557373046875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29264920949935913},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27857139706611633},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.26475563645362854}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000277","descriptor_name":"Adjuvants, Pharmaceutic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000277","descriptor_name":"Adjuvants, Pharmaceutic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2022.916491","doi":"https://doi.org/10.3389/fimmu.2022.916491","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.916491","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.916491/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:36059475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36059475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9430023","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9430023/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:587e4ac925034b488b25d9fe6bff272a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/587e4ac925034b488b25d9fe6bff272a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.916491","doi":"https://doi.org/10.3389/fimmu.2022.916491","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.916491","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.916491/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4348922801","display_name":null,"funder_award_id":"DFG SCHU2951/4","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6254501140","display_name":null,"funder_award_id":"DFG SCHE637/4","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292115336.pdf","grobid_xml":"https://content.openalex.org/works/W4292115336.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1749037810","https://openalex.org/W1975556592","https://openalex.org/W1990702493","https://openalex.org/W1995251646","https://openalex.org/W2000323986","https://openalex.org/W2010498205","https://openalex.org/W2011211981","https://openalex.org/W2013887826","https://openalex.org/W2014462255","https://openalex.org/W2017826746","https://openalex.org/W2020561761","https://openalex.org/W2024849509","https://openalex.org/W2048899027","https://openalex.org/W2049923433","https://openalex.org/W2052817467","https://openalex.org/W2069499619","https://openalex.org/W2072347337","https://openalex.org/W2076272449","https://openalex.org/W2087759162","https://openalex.org/W2092194474","https://openalex.org/W2099728359","https://openalex.org/W2110395890","https://openalex.org/W2120404094","https://openalex.org/W2124488542","https://openalex.org/W2128897591","https://openalex.org/W2210729715","https://openalex.org/W2289080497","https://openalex.org/W2302299923","https://openalex.org/W2547382465","https://openalex.org/W2568354677","https://openalex.org/W2606946633","https://openalex.org/W2731589462","https://openalex.org/W2733201199","https://openalex.org/W2738554310","https://openalex.org/W2753400412","https://openalex.org/W2801227320","https://openalex.org/W2809943059","https://openalex.org/W2891693819","https://openalex.org/W2896373487","https://openalex.org/W2909866259","https://openalex.org/W2972915830","https://openalex.org/W2991840702","https://openalex.org/W3088083318","https://openalex.org/W3201883319","https://openalex.org/W4221076514"],"related_works":["https://openalex.org/W2909866259","https://openalex.org/W4307262654","https://openalex.org/W2972915830","https://openalex.org/W7128048086","https://openalex.org/W4405954322","https://openalex.org/W2775575445","https://openalex.org/W3191655421","https://openalex.org/W2000323986","https://openalex.org/W3173319442","https://openalex.org/W6888886231"],"abstract_inverted_index":{"Background:":[0],"Recently,":[1],"bacterial":[2],"components":[3],"were":[4,72,108,136,293],"shown":[5,294],"to":[6,143,150,279,295,325],"enhance":[7],"immune":[8,12,40,300,320],"responses":[9,301,321],"by":[10,105,302],"shifting":[11],"cell":[13,41,63,99,153,263,317],"metabolism":[14,42,65,181,253,318],"towards":[15],"glycolysis":[16],"and":[17,36,66,87,91,102,124,170,182,213,218,233,239,250,286,319,330],"lactic":[18],"acid":[19],"production,":[20],"also":[21,205,257],"known":[22],"as":[23,271],"the":[24,28,49,128,145,151,165,175,207,224,260,290,297,304,311,314],"Warburg":[25,180,228],"Effect.":[26],"Currently,":[27],"effect":[29,50],"of":[30,51,98,147,156,209,244,266,273,299,307],"allergen":[31],"products":[32,53,78],"for":[33,93,259],"immunotherapy":[34],"(AIT)":[35],"commercial":[37,171,287],"vaccines":[38,90,288],"on":[39,60,190],"is":[43],"mostly":[44],"unknown.":[45],"Objective:":[46],"To":[47],"investigate":[48,144],"AIT":[52,77,130,160,167,177,191,198,225,267,284],"(adjuvanted":[54],"with":[55,74,81,85,110,127,138,159],"either":[56,111],"MPLA":[57,292],"or":[58,113,116,120],"Alum)":[59,86],"myeloid":[61],"dendritic":[62],"(mDC)":[64],"activation.":[67],"Methods:":[68],"Bone":[69],"marrow-derived":[70],"mDCs":[71,107,135,157,255],"stimulated":[73,126,158],"five":[75],"allergoid-based":[76],"(one":[79],"adjuvanted":[80,84],"MPLA,":[82],"four":[83],"two":[88],"MPLA-adjuvanted":[89],"analyzed":[92],"their":[94,277],"metabolic":[95,114,148,305],"activation,":[96],"expression":[97],"surface":[100],"markers,":[101],"cytokine":[103],"secretion":[104,184,208,243],"ELISA.":[106],"pre-incubated":[109],"immunological":[112],"inhibitors":[115],"cultured":[117],"in":[118,185,254],"glucose-":[119,238],"glutamine-free":[121],"culture":[122],"media":[123],"subsequently":[125],"MPLA-containing":[129,166],"product":[131,133,161,168,192,199,226,268,285],"(AIT":[132],"1).":[134],"co-cultured":[137],"allergen-specific":[139],"CD4+":[140],"T":[141,152,262],"cells":[142],"contribution":[146],"pathways":[149],"priming":[154,264],"capacity":[155,265],"1.":[162,193],"Results:":[163],"Both":[164,215],"1":[169,200],"vaccines,":[172],"but":[173],"not":[174],"Alum-adjuvanted":[176],"products,":[178],"activated":[179],"TNF-\u03b1":[183,234],"mDCs.":[186,308],"Further":[187],"experiments":[188],"focused":[189],"Metabolic":[194],"analysis":[195],"showed":[196],"that":[197],"increased":[201],"glycolytic":[202],"activity":[203],"while":[204],"inducing":[206],"IL-1\u03b2,":[210],"IL-10,":[211,249],"IL-12,":[212],"TNF-\u03b1.":[214],"rapamycin":[216],"(mTOR-inhibitor)":[217],"SP600125":[219],"(SAP/JNK":[220],"MAPK-inhibitor)":[221],"dose-dependently":[222],"suppressed":[223,242],"1-induced":[227],"Effect,":[229],"glucose":[230],"consumption,":[231],"IL-10-,":[232],"secretion.":[235],"Moreover,":[236],"both":[237],"glutamine":[240],"deficiency":[241],"all":[245],"investigated":[246],"cytokines":[247],"(IL-1\u03b2,":[248],"TNF-\u03b1).":[251],"Glucose":[252],"was":[256],"critical":[258],"(Th1-biased)":[261],"1-stimulated":[269],"mDCs,":[270],"inhibition":[272],"mTOR":[274],"signaling":[275],"abrogated":[276],"ability":[278],"induce":[280],"Th1-responses.":[281],"Conclusion:":[282],"The":[283],"containing":[289],"adjuvant":[291],"modulate":[296],"induction":[298],"changing":[303],"state":[306],"Better":[309],"understanding":[310],"mechanisms":[312],"underlying":[313],"interactions":[315],"between":[316],"will":[322],"allow":[323],"us":[324],"further":[326],"improve":[327],"vaccine":[328],"development":[329],"AIT.":[331]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-17T00:00:00"}