{"id":"https://openalex.org/W3186478710","doi":"https://doi.org/10.2147/dddt.s316247","title":"Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation","display_name":"Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3186478710","doi":"https://doi.org/10.2147/dddt.s316247","mag":"3186478710","pmid":"https://pubmed.ncbi.nlm.nih.gov/34321865","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8311472"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s316247","doi":"https://doi.org/10.2147/dddt.s316247","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s316247","pdf_url":"https://www.dovepress.com/getfile.php?fileID=71816","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=71816","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000298653","display_name":"Ebtesam A. Mohamad","orcid":"https://orcid.org/0000-0001-5296-896X","observed_orcids":["https://orcid.org/0000-0001-5296-896X"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ebtesam A Mohamad","raw_affiliation_strings":["Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101151798","display_name":"Aya A. Aly","orcid":"https://orcid.org/0000-0003-2446-7871","observed_orcids":["https://orcid.org/0000-0003-2446-7871"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aya A Aly","raw_affiliation_strings":["Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011013389","display_name":"Aya A Khalaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aya A Khalaf","raw_affiliation_strings":["Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111128322","display_name":"Mona Ibrahim Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mona I Ahmed","raw_affiliation_strings":["Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056343388","display_name":"Reham M. Kamel","orcid":"https://orcid.org/0000-0003-0227-3750","observed_orcids":["https://orcid.org/0000-0003-0227-3750"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Reham M Kamel","raw_affiliation_strings":["Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057514160","display_name":"Sherouk M Abdelnaby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sherouk M Abdelnaby","raw_affiliation_strings":["Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077365504","display_name":"Yasmine H Abdelzaher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Yasmine H Abdelzaher","raw_affiliation_strings":["Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024671616","display_name":"Marize G Sedrak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Marize G Sedrak","raw_affiliation_strings":["Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology/Biomolecular Chemistry Program, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032045966","display_name":"Shaker A. Mousa","orcid":"https://orcid.org/0000-0002-9294-015X","observed_orcids":["https://orcid.org/0000-0002-9294-015X"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaker A Mousa","raw_affiliation_strings":["The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-9294-015X","affiliations":[{"raw_affiliation_string":"The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA","institution_ids":["https://openalex.org/I365282"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032045966"],"corresponding_institution_ids":["https://openalex.org/I365282"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":5.7617,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.97013279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"Volume 15","issue":null,"first_page":"3151","last_page":"3162"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/punicalagin","display_name":"punicalagin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/niosomes","display_name":"niosomes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pomegranate","display_name":"Punica granatum","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/human-dermal-fibroblasts","display_name":"human dermal fibroblasts","score":0.8479999899864197},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.5799999833106995},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.8220000267028809},{"id":"https://openalex.org/keywords/timp-3","display_name":"TIMP-3","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7210000157356262},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.6460000276565552},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C2909910311","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Skin Aging","level":2,"score":0.7078046202659607},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6689161062240601},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.61590576171875},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.6018433570861816},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5461503267288208},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.5276022553443909},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5143450498580933},{"id":"https://openalex.org/C72918618","wikidata":"https://www.wikidata.org/wiki/Q1993211","display_name":"Niosome","level":4,"score":0.48701149225234985},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.4814440608024597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45349395275115967},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3815557360649109},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.38115841150283813},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.34134405851364136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22570431232452393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14248839020729065},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.06310167908668518},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D047348","descriptor_name":"Hydrolyzable Tannins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047348","descriptor_name":"Hydrolyzable Tannins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D047348","descriptor_name":"Hydrolyzable Tannins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/dddt.s316247","doi":"https://doi.org/10.2147/dddt.s316247","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s316247","pdf_url":"https://www.dovepress.com/getfile.php?fileID=71816","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8311472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8311472","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmid:34321865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34321865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"mag:3139394980","doi":null,"is_oa":false,"landing_page_url":"https://www.preprints.org/manuscript/202103.0610/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:bb36bccb3c59452c899a03b6c05b3eb0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bb36bccb3c59452c899a03b6c05b3eb0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Design, Development and Therapy, Vol Volume 15, Pp 3151-3162 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/dddt.s316247","doi":"https://doi.org/10.2147/dddt.s316247","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s316247","pdf_url":"https://www.dovepress.com/getfile.php?fileID=71816","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3186478710.pdf","grobid_xml":"https://content.openalex.org/works/W3186478710.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1500703123","https://openalex.org/W1596484490","https://openalex.org/W1975749301","https://openalex.org/W1984042925","https://openalex.org/W2018396727","https://openalex.org/W2028052095","https://openalex.org/W2044760813","https://openalex.org/W2057137099","https://openalex.org/W2059327477","https://openalex.org/W2068677193","https://openalex.org/W2072446382","https://openalex.org/W2097603366","https://openalex.org/W2098473006","https://openalex.org/W2098562002","https://openalex.org/W2103185389","https://openalex.org/W2113755029","https://openalex.org/W2117345120","https://openalex.org/W2121761828","https://openalex.org/W2145437034","https://openalex.org/W2146136320","https://openalex.org/W2421912663","https://openalex.org/W2502726215","https://openalex.org/W2566587919","https://openalex.org/W2568389087","https://openalex.org/W2571053339","https://openalex.org/W2607133225","https://openalex.org/W2620300588","https://openalex.org/W2625602643","https://openalex.org/W2768634176","https://openalex.org/W2783592753","https://openalex.org/W2802570850","https://openalex.org/W2886272186","https://openalex.org/W2904759666","https://openalex.org/W2913530571","https://openalex.org/W2940908985","https://openalex.org/W2943172598","https://openalex.org/W2954987929","https://openalex.org/W2955885901","https://openalex.org/W2982436252","https://openalex.org/W3004726103","https://openalex.org/W3011983070","https://openalex.org/W3012095658","https://openalex.org/W4299560702"],"related_works":["https://openalex.org/W3139394980","https://openalex.org/W1581685657","https://openalex.org/W4367856571","https://openalex.org/W4402221315","https://openalex.org/W4310597196","https://openalex.org/W3164832248","https://openalex.org/W4398785068","https://openalex.org/W2413884547","https://openalex.org/W4386475436","https://openalex.org/W4385236962"],"abstract_inverted_index":{"Introduction:":[0],"Skin":[1],"aging":[2,106,136],"is":[3,180],"a":[4,183],"normal":[5],"process":[6,137],"that":[7],"might":[8,51],"be":[9],"accelerated":[10],"or":[11],"delayed":[12],"by":[13,108],"altering":[14],"the":[15,26,42,134,149,158],"balance":[16],"between":[17],"antioxidants":[18],"and":[19,47,66,71,75,85,88,113,121,129,160,166],"free":[20],"radicals":[21],"due":[22],"to":[23,28,140,186],"increase":[24],"in":[25,93,133,147,175],"exposure":[27],"reactive":[29],"oxygen":[30],"species":[31],"(ROS)":[32],"into":[33],"skin":[34,135,176,189,193],"cells":[35,104],"via":[36],"UV":[37,55,114,197],"radiation.":[38,56,115],"Antioxidants":[39],"can":[40],"neutralize":[41],"harmful":[43],"effects":[44],"of":[45,68,152,157],"ROS,":[46],"secondary":[48],"plant":[49],"metabolites":[50],"help":[52],"protect":[53,187],"against":[54],"Methods:":[57],"In":[58],"this":[59],"study,":[60],"punicalagin":[61],"was":[62,81,96,119],"extracted":[63],"from":[64,190],"pomegranate,":[65],"concentrations":[67],"total":[69],"polyphenolics":[70],"flavonoids":[72],"were":[73,78,90,138],"determined,":[74],"antioxidant":[76,185],"activities":[77],"measured.":[79],"Punicalagin":[80,145,170,179],"loaded":[82],"onto":[83],"niosomes,":[84,196],"its":[86],"morphology":[87],"release":[89],"studied.":[91],"An":[92],"vitro":[94],"study":[95],"performed":[97],"on":[98],"human":[99,172,188],"fibroblast":[100],"cell":[101],"line":[102],"HFB4":[103,153],"with":[105],"induced":[107],"H":[109],"2":[110,112],"O":[111],"Cell":[116],"cycle":[117],"arrest":[118,151],"studied,":[120],"different":[122],"genes":[123],"(":[124],"MMP3,":[125],"Col1A1,":[126],"Timp3":[127,161],",":[128],"TERT":[130,173],")":[131],"involved":[132],"selected":[139],"measure":[141],"punicalagin\u2019s":[142],"effect.":[143],"Results:":[144],"succeeded":[146],"reducing":[148],"growth":[150],"cells,":[154],"activated":[155],"production":[156],"Col1A1":[159],"genes,":[162],"maintained":[163],"collagen":[164,199],"level,":[165],"lowered":[167],"MMP3":[168],".":[169],"increased":[171],"concentration":[174],"cells.":[177],"Discussion:":[178],"promising":[181],"as":[182],"natural":[184],"aging.":[191],"Keywords:":[192],"aging,":[194],"punicalagin,":[195],"radiation,":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-02T00:00:00"}
