{"id":"https://openalex.org/W4292004335","doi":"https://doi.org/10.1021/acs.jmedchem.2c00911","title":"Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity","display_name":"Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity","publication_year":2022,"publication_date":"2022-08-16","ids":{"openalex":"https://openalex.org/W4292004335","doi":"https://doi.org/10.1021/acs.jmedchem.2c00911","pmid":"https://pubmed.ncbi.nlm.nih.gov/35972998","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9421656"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.2c00911","doi":"https://doi.org/10.1021/acs.jmedchem.2c00911","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.2c00911","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00911","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00911","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050213616","display_name":"Simona Musella","orcid":"https://orcid.org/0000-0001-8312-4241","observed_orcids":["https://orcid.org/0000-0001-8312-4241"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Musella","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017061959","display_name":"Lidia Carotenuto","orcid":"https://orcid.org/0000-0003-4053-0957","observed_orcids":["https://orcid.org/0000-0003-4053-0957"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lidia Carotenuto","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074044188","display_name":"Nunzio Iraci","orcid":"https://orcid.org/0000-0002-1359-8684","observed_orcids":["https://orcid.org/0000-0002-1359-8684"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nunzio Iraci","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, Viale Ferdinando Stagno d\u2019Alcontres 31, Messina 98166, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1359-8684","affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, Viale Ferdinando Stagno d\u2019Alcontres 31, Messina 98166, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045075161","display_name":"Giulia Baroli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Baroli","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003767871","display_name":"Tania Ciaglia","orcid":"https://orcid.org/0000-0002-6592-4373","observed_orcids":["https://orcid.org/0000-0002-6592-4373"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tania Ciaglia","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079671054","display_name":"Piera Nappi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piera Nappi","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040050950","display_name":"Manuela Giovanna Basilicata","orcid":"https://orcid.org/0000-0003-2736-1044","observed_orcids":["https://orcid.org/0000-0003-2736-1044"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manuela Giovanna Basilicata","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039496274","display_name":"Emanuela Salviati","orcid":"https://orcid.org/0000-0003-2867-2784","observed_orcids":["https://orcid.org/0000-0003-2867-2784"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuela Salviati","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019225802","display_name":"Vincenzo Barrese","orcid":"https://orcid.org/0000-0001-8721-8843","observed_orcids":["https://orcid.org/0000-0001-8721-8843"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Barrese","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047003794","display_name":"Vincenzo Vestuto","orcid":"https://orcid.org/0000-0002-3603-5526","observed_orcids":["https://orcid.org/0000-0002-3603-5526"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Vestuto","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061843273","display_name":"Giuseppe Pignataro","orcid":"https://orcid.org/0000-0002-7290-4397","observed_orcids":["https://orcid.org/0000-0002-7290-4397"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Pignataro","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054372400","display_name":"Giacomo Pepe","orcid":"https://orcid.org/0000-0002-7561-2023","observed_orcids":["https://orcid.org/0000-0002-7561-2023"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giacomo Pepe","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7561-2023","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082023445","display_name":"Eduardo Sommella","orcid":"https://orcid.org/0000-0001-8654-6431","observed_orcids":["https://orcid.org/0000-0001-8654-6431"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eduardo Sommella","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040913282","display_name":"Veronica Di Sarno","orcid":"https://orcid.org/0000-0002-1397-5240","observed_orcids":["https://orcid.org/0000-0002-1397-5240"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Veronica Di Sarno","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043164400","display_name":"Michele Manfra","orcid":"https://orcid.org/0000-0002-3320-972X","observed_orcids":["https://orcid.org/0000-0002-3320-972X"]},"institutions":[{"id":"https://openalex.org/I20272500","display_name":"University of Basilicata","ror":"https://ror.org/03tc05689","country_code":"IT","type":"education","lineage":["https://openalex.org/I20272500"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Manfra","raw_affiliation_strings":["Department of Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, Potenza 85100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, Potenza 85100, Italy","institution_ids":["https://openalex.org/I20272500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074768676","display_name":"Pietro Campiglia","orcid":"https://orcid.org/0000-0002-1069-2181","observed_orcids":["https://orcid.org/0000-0002-1069-2181"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Campiglia","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1069-2181","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050246182","display_name":"Isabel Maria Gomez-Monterrey","orcid":"https://orcid.org/0000-0001-6688-2606","observed_orcids":["https://orcid.org/0000-0001-6688-2606","https://orcid.org/0000-0003-0001-8748"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Isabel Gomez-Monterrey","raw_affiliation_strings":["Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, Naples 80131, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6688-2606","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069089232","display_name":"Alessia Bertamino","orcid":"https://orcid.org/0000-0002-5482-6276","observed_orcids":["https://orcid.org/0000-0002-5482-6276"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Bertamino","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5482-6276","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057579624","display_name":"Maurizio Taglialatela","orcid":"https://orcid.org/0000-0002-8202-0560","observed_orcids":["https://orcid.org/0000-0002-8202-0560"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maurizio Taglialatela","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8202-0560","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020033317","display_name":"Carmine Ostacolo","orcid":"https://orcid.org/0000-0003-3715-8680","observed_orcids":["https://orcid.org/0000-0003-3715-8680"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Carmine Ostacolo","raw_affiliation_strings":["Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, Naples 80131, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3715-8680","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021427652","display_name":"Francesco Miceli","orcid":"https://orcid.org/0000-0002-5393-1402","observed_orcids":["https://orcid.org/0000-0002-5393-1402"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Miceli","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020033317","https://openalex.org/A5057579624"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":2.2059,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.89835431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"65","issue":"16","first_page":"11340","last_page":"11364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.10869999974966049,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kv7-channels","display_name":"Kv7 channels","score":0.871999979019165},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9020000100135803},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.949999988079071},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8659999966621399},{"id":"https://openalex.org/keywords/retigabine","display_name":"retigabine","score":0.5699999928474426},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.9200000166893005},{"id":"https://openalex.org/keywords/photostability","display_name":"photostability","score":0.6380000114440918},{"id":"https://openalex.org/keywords/kv7-2","display_name":"Kv7.2","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.8122131824493408},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7866271138191223},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.7155247926712036},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5927634835243225},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.51178377866745},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.41804876923561096},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2408333718776703},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.23760342597961426},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14543795585632324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1433873176574707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11662861704826355},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.07589581608772278}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010655","descriptor_name":"Phenylenediamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010655","descriptor_name":"Phenylenediamines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010655","descriptor_name":"Phenylenediamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051658","descriptor_name":"KCNQ2 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051659","descriptor_name":"KCNQ3 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jmedchem.2c00911","doi":"https://doi.org/10.1021/acs.jmedchem.2c00911","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.2c00911","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00911","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9421656","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9421656","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Chem","raw_type":"Text"},{"id":"pmid:35972998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35972998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unibas.it:11563/160007","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11563/160007","pdf_url":null,"source":{"id":"https://openalex.org/S4377196360","display_name":"CINECA IRIS Institutional Research Information System (University of Basilicata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20272500","host_organization_name":"University of Basilicata","host_organization_lineage":["https://openalex.org/I20272500"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1021/acs.jmedchem.2c00911","doi":"https://doi.org/10.1021/acs.jmedchem.2c00911","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.2c00911","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00911","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1364686276","display_name":null,"funder_award_id":"PRIN 2017YH3SXK","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G2422427483","display_name":null,"funder_award_id":"RF-2019-12370491","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G3157836466","display_name":"Up-scaling the global univocal identification of medicines","funder_award_id":"875299","funder_id":"https://openalex.org/F4320338342","funder_display_name":"H2020 Health"},{"id":"https://openalex.org/G5136116722","display_name":null,"funder_award_id":"PRIN 2017ALCR7C","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G5566881147","display_name":null,"funder_award_id":"PRIN 2020L45ZW4","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G8975055903","display_name":"European Joint Programme on Rare Diseases","funder_award_id":"825575","funder_id":"https://openalex.org/F4320338342","funder_display_name":"H2020 Health"}],"funders":[{"id":"https://openalex.org/F4320309590","display_name":"Universit\u00e0 degli Studi di Napoli Federico II","ror":"https://ror.org/05290cv24"},{"id":"https://openalex.org/F4320309746","display_name":"Compagnia di San Paolo","ror":"https://ror.org/00d1b1c41"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320338342","display_name":"H2020 Health","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292004335.pdf"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1208303706","https://openalex.org/W1638684638","https://openalex.org/W1952128844","https://openalex.org/W1963298781","https://openalex.org/W1975440733","https://openalex.org/W1975691556","https://openalex.org/W1991001144","https://openalex.org/W1991601482","https://openalex.org/W1997537641","https://openalex.org/W2011198932","https://openalex.org/W2011379762","https://openalex.org/W2023459069","https://openalex.org/W2027408247","https://openalex.org/W2029667189","https://openalex.org/W2031167141","https://openalex.org/W2031168104","https://openalex.org/W2032475347","https://openalex.org/W2036281957","https://openalex.org/W2049069390","https://openalex.org/W2051381895","https://openalex.org/W2051920240","https://openalex.org/W2052127460","https://openalex.org/W2055766784","https://openalex.org/W2059083767","https://openalex.org/W2063663785","https://openalex.org/W2077775082","https://openalex.org/W2083974405","https://openalex.org/W2125801651","https://openalex.org/W2130004182","https://openalex.org/W2130479394","https://openalex.org/W2140831051","https://openalex.org/W2142318256","https://openalex.org/W2147905547","https://openalex.org/W2153629931","https://openalex.org/W2157952220","https://openalex.org/W2159579442","https://openalex.org/W2162891493","https://openalex.org/W2170598431","https://openalex.org/W2302590860","https://openalex.org/W2318319321","https://openalex.org/W2337718384","https://openalex.org/W2464200492","https://openalex.org/W2587096332","https://openalex.org/W2889380993","https://openalex.org/W2909765711","https://openalex.org/W2911226018","https://openalex.org/W2918867724","https://openalex.org/W2922427931","https://openalex.org/W2944151862","https://openalex.org/W2987069034","https://openalex.org/W2995146830","https://openalex.org/W3011242618","https://openalex.org/W3033726198","https://openalex.org/W3040895919","https://openalex.org/W3046802571","https://openalex.org/W3082138276","https://openalex.org/W3106910265","https://openalex.org/W3149078497","https://openalex.org/W3158803573","https://openalex.org/W4245660285","https://openalex.org/W4296816736"],"related_works":["https://openalex.org/W2995146830","https://openalex.org/W4401577374","https://openalex.org/W7057298980","https://openalex.org/W4409668907","https://openalex.org/W6981000060","https://openalex.org/W7072192112","https://openalex.org/W4413506374","https://openalex.org/W2077775082","https://openalex.org/W7100609347","https://openalex.org/W2084690108"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Neuronal":[7],"Kv7":[8,23,76,98,146],"channels":[9],"represent":[10],"important":[11],"pharmacological":[12],"targets":[13],"for":[14,27,74,141,148],"hyperexcitability":[15,152],"disorders":[16],"including":[17],"epilepsy.":[18],"Retigabine":[19],"is":[20],"the":[21,46,142,149],"prototype":[22],"activator":[24],"clinically":[25],"approved":[26],"seizure":[28,126],"treatment;":[29],"however,":[30],"severe":[31],"side":[32],"effects":[33,122],"associated":[34],"with":[35,54],"long-term":[36],"use":[37],"have":[38],"led":[39],"to":[40,102],"its":[41],"market":[42],"discontinuation.":[43],"Building":[44],"upon":[45],"recently":[47],"described":[48],"cryoEM":[49],"structure":[50],"of":[51,65,144,151],"Kv7.2":[52],"complexed":[53],"retigabine":[55,66],"and":[56,72,82,94,116,119],"on":[57],"previous":[58],"structure\u2013activity":[59],"relationship":[60],"studies,":[61],"a":[62,92,107,112,137],"small":[63],"library":[64],"analogues":[67],"has":[68],"been":[69],"designed,":[70],"synthesized,":[71],"characterized":[73],"their":[75],"opening":[77],"ability":[78],"using":[79],"both":[80],"fluorescence-":[81],"electrophysiology-based":[83],"assays.":[84],"Among":[85],"all":[86],"tested":[87],"compounds,":[88],"60":[89,105,135],"emerged":[90],"as":[91,136],"potent":[93,118],"photochemically":[95],"stable":[96],"neuronal":[97],"channel":[99],"activator.":[100],"Compared":[101],"retigabine,":[103],"compound":[104,134,140],"displayed":[106],"higher":[108],"brain/plasma":[109],"distribution":[110],"ratio,":[111],"longer":[113],"elimination":[114],"half-life,":[115],"more":[117],"effective":[120],"anticonvulsant":[121],"in":[123,128],"an":[124],"acute":[125],"model":[127],"mice.":[129],"Collectively,":[130],"these":[131],"data":[132],"highlight":[133],"promising":[138],"lead":[139],"development":[143],"novel":[145],"activators":[147],"treatment":[150],"diseases.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-08-16T00:00:00"}
