{"id":"https://openalex.org/W4291972500","doi":"https://doi.org/10.1038/s42255-022-00635-4","title":"Publisher Correction: Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study","display_name":"Publisher Correction: Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study","publication_year":2022,"publication_date":"2022-08-16","ids":{"openalex":"https://openalex.org/W4291972500","doi":"https://doi.org/10.1038/s42255-022-00635-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/35974248"},"language":"en","primary_location":{"id":"doi:10.1038/s42255-022-00635-4","doi":"https://doi.org/10.1038/s42255-022-00635-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42255-022-00635-4","pdf_url":"https://www.nature.com/articles/s42255-022-00635-4.pdf","source":{"id":"https://openalex.org/S4210232714","display_name":"Nature Metabolism","issn_l":"2522-5812","issn":["2522-5812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Metabolism","raw_type":"journal-article"},"volume":null,"type":"erratum","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/s42255-022-00635-4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086688599","display_name":"Marja Kaarina Puurunen","orcid":"https://orcid.org/0000-0003-3810-5687","observed_orcids":["https://orcid.org/0000-0003-3810-5687"]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marja K. Puurunen","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA. marja@synlogictx.com","Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3810-5687","affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA. marja@synlogictx.com","institution_ids":["https://openalex.org/I4210100181"]},{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025162900","display_name":"Jerry E. Vockley","orcid":"https://orcid.org/0000-0002-8180-6457","observed_orcids":["https://orcid.org/0000-0002-8180-6457"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Vockley","raw_affiliation_strings":["UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA","University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067414076","display_name":"Shawn L. Searle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I920293368","display_name":"PRA Health Sciences","ror":"https://ror.org/02k5t6c64","country_code":"US","type":"facility","lineage":["https://openalex.org/I920293368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn L. Searle","raw_affiliation_strings":["PRA Health Sciences, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PRA Health Sciences, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I920293368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053773798","display_name":"Stephanie J. Sacharow","orcid":"https://orcid.org/0000-0001-5249-5840","observed_orcids":["https://orcid.org/0000-0001-5249-5840"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie J. Sacharow","raw_affiliation_strings":["Boston Children's Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John A. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Phillips","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041025811","display_name":"William S. Denney","orcid":"https://orcid.org/0000-0002-5759-428X","observed_orcids":["https://orcid.org/0000-0002-5759-428X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William S. Denney","raw_affiliation_strings":["Human Predictions LLC, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5759-428X","affiliations":[{"raw_affiliation_string":"Human Predictions LLC, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079250170","display_name":"Benjamin D. Goodlett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D. Goodlett","raw_affiliation_strings":["Boston Children's Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101823735","display_name":"David A. Wagner","orcid":"https://orcid.org/0000-0003-4438-626X","observed_orcids":["https://orcid.org/0000-0003-4438-626X"]},"institutions":[{"id":"https://openalex.org/I4210106720","display_name":"Metabolic Solutions","ror":"https://ror.org/019br0e98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Wagner","raw_affiliation_strings":["Metabolic Solutions, Nashua, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Solutions, Nashua, NH, USA","institution_ids":["https://openalex.org/I4210106720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029994962","display_name":"Larry A. Blankstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry Blankstein","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045334180","display_name":"Mary Joan Castillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary J. Castillo","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053831021","display_name":"Mark R. Charbonneau","orcid":"https://orcid.org/0000-0003-4893-8244","observed_orcids":["https://orcid.org/0000-0003-4893-8244"]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Charbonneau","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4893-8244","affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048259931","display_name":"Vincent M. Isabella","orcid":"https://orcid.org/0000-0002-5849-3149","observed_orcids":["https://orcid.org/0000-0002-5849-3149"]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent M. Isabella","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056043634","display_name":"Vasu V. Sethuraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasu V. Sethuraman","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072429797","display_name":"Richard J. Riese","orcid":"https://orcid.org/0009-0000-3657-6229","observed_orcids":["https://orcid.org/0009-0000-3657-6229"]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Riese","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068196876","display_name":"Caroline B. Kurtz","orcid":"https://orcid.org/0000-0001-7192-6116","observed_orcids":["https://orcid.org/0000-0001-7192-6116"]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline B. Kurtz","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7192-6116","affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047910418","display_name":"Aoife M. Brennan","orcid":"https://orcid.org/0000-0002-3413-4723","observed_orcids":["https://orcid.org/0000-0002-3413-4723"]},"institutions":[{"id":"https://openalex.org/I4210100181","display_name":"Synlogic (United States)","ror":"https://ror.org/019hezp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aoife M. Brennan","raw_affiliation_strings":["Synlogic, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synlogic, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210100181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5086688599"],"corresponding_institution_ids":["https://openalex.org/I4210100181"],"apc_list":{"value":11390,"currency":"USD","value_usd":11390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"9","first_page":"1214","last_page":"1214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.15860000252723694,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylketonuria","display_name":"phenylketonuria","score":0.9110000133514404},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8859999775886536},{"id":"https://openalex.org/keywords/phenylalanine","display_name":"phenylalanine","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7976551651954651},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.4761911928653717},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44977614283561707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4069676399230957},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32655662298202515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2424165904521942},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2088126838207245},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s42255-022-00635-4","doi":"https://doi.org/10.1038/s42255-022-00635-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42255-022-00635-4","pdf_url":"https://www.nature.com/articles/s42255-022-00635-4.pdf","source":{"id":"https://openalex.org/S4210232714","display_name":"Nature Metabolism","issn_l":"2522-5812","issn":["2522-5812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Metabolism","raw_type":"journal-article"},{"id":"pmid:35974248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35974248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature metabolism","raw_type":"Published Erratum"}],"best_oa_location":{"id":"doi:10.1038/s42255-022-00635-4","doi":"https://doi.org/10.1038/s42255-022-00635-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42255-022-00635-4","pdf_url":"https://www.nature.com/articles/s42255-022-00635-4.pdf","source":{"id":"https://openalex.org/S4210232714","display_name":"Nature Metabolism","issn_l":"2522-5812","issn":["2522-5812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291972500.pdf","grobid_xml":"https://content.openalex.org/works/W4291972500.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3183633755","https://openalex.org/W4387140966","https://openalex.org/W2039649401","https://openalex.org/W2404145152","https://openalex.org/W4252583829","https://openalex.org/W2401567716","https://openalex.org/W2397362460","https://openalex.org/W100443781","https://openalex.org/W4408532667","https://openalex.org/W2164951749"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-16T00:00:00"}