{"id":"https://openalex.org/W4291908320","doi":"https://doi.org/10.1101/2022.08.12.503453","title":"Time-of-day defines the efficacy of NAD + to treat diet-induced metabolic disease by adjusting oscillations of the hepatic circadian clock","display_name":"Time-of-day defines the efficacy of NAD + to treat diet-induced metabolic disease by adjusting oscillations of the hepatic circadian clock","publication_year":2022,"publication_date":"2022-08-15","ids":{"openalex":"https://openalex.org/W4291908320","doi":"https://doi.org/10.1101/2022.08.12.503453"},"language":"en","primary_location":{"id":"doi:10.1101/2022.08.12.503453","doi":"https://doi.org/10.1101/2022.08.12.503453","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.12.503453","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/15/2022.08.12.503453.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/15/2022.08.12.503453.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087871897","display_name":"Quetzalc\u00f3atl Escalante\u2010Covarrubias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Q Escalante-Covarrubias","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019252768","display_name":"Luc\u00eda Mendoza-Viveros","orcid":"https://orcid.org/0000-0001-9707-859X","observed_orcids":["https://orcid.org/0000-0001-9707-859X"]},"institutions":[{"id":"https://openalex.org/I4210110970","display_name":"National Institute of Genomic Medicine","ror":"https://ror.org/01qjckx08","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210110970"]},{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"L Mendoza-Viveros","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","Laboratorio de Cronobiolog\u00eda y Metabolismo, Instituto Nacional de Medicina Gen\u00f3mica, 14610 Mexico City, Mexico","Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Laboratorio de Cronobiolog\u00eda y Metabolismo, Instituto Nacional de Medicina Gen\u00f3mica, 14610 Mexico City, Mexico","institution_ids":["https://openalex.org/I4210110970"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103196833","display_name":"Mirna Gonz\u00e1lez-Su\u00e1rez","orcid":"https://orcid.org/0000-0001-9017-9814","observed_orcids":["https://orcid.org/0000-0001-9017-9814"]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M Gonz\u00e1lez-Su\u00e1rez","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091625214","display_name":"Fernando Becerril-P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"F Becerril-P\u00e9rez","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066865961","display_name":"Ignacio Pacheco-Bernal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"I Pacheco-Bernal","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006074172","display_name":"Erick Carre\u00f1o\u2010V\u00e1zquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110970","display_name":"National Institute of Genomic Medicine","ror":"https://ror.org/01qjckx08","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210110970"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"E Carre\u00f1o-V\u00e1zquez","raw_affiliation_strings":["Laboratorio de Cronobiolog\u00eda y Metabolismo, Instituto Nacional de Medicina Gen\u00f3mica, 14610 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Cronobiolog\u00eda y Metabolismo, Instituto Nacional de Medicina Gen\u00f3mica, 14610 Mexico City, Mexico","institution_ids":["https://openalex.org/I4210110970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050231458","display_name":"Paola Berenice Mass Sanchez","orcid":"https://orcid.org/0000-0001-9185-7613","observed_orcids":["https://orcid.org/0000-0001-9185-7613"]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"P Mass-S\u00e1nchez","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006207875","display_name":"Marcia Bustamante-Zepeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M Bustamante-Zepeda","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013754150","display_name":"Ricardo Orozco-Sol\u00eds","orcid":"https://orcid.org/0000-0003-1494-7281","observed_orcids":["https://orcid.org/0000-0003-1494-7281"]},"institutions":[{"id":"https://openalex.org/I4210110970","display_name":"National Institute of Genomic Medicine","ror":"https://ror.org/01qjckx08","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210110970"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"R Orozco-Sol\u00eds","raw_affiliation_strings":["Laboratorio de Cronobiolog\u00eda y Metabolismo, Instituto Nacional de Medicina Gen\u00f3mica, 14610 Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Cronobiolog\u00eda y Metabolismo, Instituto Nacional de Medicina Gen\u00f3mica, 14610 Mexico City, Mexico","institution_ids":["https://openalex.org/I4210110970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047742036","display_name":"Lorena Aguilar\u2010Arnal","orcid":"https://orcid.org/0000-0003-4473-4471","observed_orcids":["https://orcid.org/0000-0003-4473-4471"]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"L Aguilar-Arnal","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-4473-4471","affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 0450 Mexico City, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047742036"],"corresponding_institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinamide-adenine-dinucleotide","display_name":"NAD+","score":0.9150000214576721},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9089999794960022},{"id":"https://openalex.org/keywords/time-of-day","display_name":"time of day","score":0.7540000081062317},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.753000020980835},{"id":"https://openalex.org/keywords/ampk-signaling","display_name":"AMPK signaling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"nutrient sensing","score":0.7319999933242798},{"id":"https://openalex.org/keywords/insulin-tolerance","display_name":"insulin tolerance","score":0.6570000052452087},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.7139999866485596},{"id":"https://openalex.org/keywords/chronotherapy","display_name":"chronotherapy","score":0.6290000081062317},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.857445240020752},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6822905540466309},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6394065022468567},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.6392237544059753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6020997166633606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45395156741142273},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.43242499232292175},{"id":"https://openalex.org/C2779910239","wikidata":"https://www.wikidata.org/wiki/Q7539765","display_name":"Chronotherapy (sleep phase)","level":3,"score":0.42039811611175537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31664037704467773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19536882638931274},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08646729588508606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.08.12.503453","doi":"https://doi.org/10.1101/2022.08.12.503453","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.12.503453","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/15/2022.08.12.503453.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.08.12.503453","doi":"https://doi.org/10.1101/2022.08.12.503453","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.12.503453","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/15/2022.08.12.503453.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327956","display_name":"Instituto Nacional de Medicina Gen\u00f3mica","ror":"https://ror.org/01qjckx08"},{"id":"https://openalex.org/F4320337011","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291908320.pdf","grobid_xml":"https://content.openalex.org/works/W4291908320.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W15715521","https://openalex.org/W1534360145","https://openalex.org/W1706803842","https://openalex.org/W1760023500","https://openalex.org/W1852699976","https://openalex.org/W1911639929","https://openalex.org/W1964031474","https://openalex.org/W1965036088","https://openalex.org/W1966490808","https://openalex.org/W1968890500","https://openalex.org/W1969408132","https://openalex.org/W1994994441","https://openalex.org/W1995496043","https://openalex.org/W1995579184","https://openalex.org/W1997151200","https://openalex.org/W2000487298","https://openalex.org/W2004849589","https://openalex.org/W2012352157","https://openalex.org/W2013256245","https://openalex.org/W2014677321","https://openalex.org/W2019240387","https://openalex.org/W2022475610","https://openalex.org/W2028769116","https://openalex.org/W2032660293","https://openalex.org/W2036020955","https://openalex.org/W2038011036","https://openalex.org/W2042500733","https://openalex.org/W2044458189","https://openalex.org/W2045333877","https://openalex.org/W2046938310","https://openalex.org/W2050906228","https://openalex.org/W2063041018","https://openalex.org/W2064949318","https://openalex.org/W2066445380","https://openalex.org/W2067136301","https://openalex.org/W2073144689","https://openalex.org/W2073742199","https://openalex.org/W2079580613","https://openalex.org/W2082393205","https://openalex.org/W2087076407","https://openalex.org/W2087376237","https://openalex.org/W2090843533","https://openalex.org/W2091531174","https://openalex.org/W2096498454","https://openalex.org/W2097813112","https://openalex.org/W2104734659","https://openalex.org/W2110702262","https://openalex.org/W2113136381","https://openalex.org/W2113349786","https://openalex.org/W2114382609","https://openalex.org/W2115228849","https://openalex.org/W2116756810","https://openalex.org/W2119914706","https://openalex.org/W2122927821","https://openalex.org/W2123068849","https://openalex.org/W2123319274","https://openalex.org/W2125666085","https://openalex.org/W2125718576","https://openalex.org/W2130410032","https://openalex.org/W2133918896","https://openalex.org/W2134377844","https://openalex.org/W2134787700","https://openalex.org/W2135151215","https://openalex.org/W2135704900","https://openalex.org/W2143210222","https://openalex.org/W2150076905","https://openalex.org/W2153399820","https://openalex.org/W2157296254","https://openalex.org/W2160700740","https://openalex.org/W2161197995","https://openalex.org/W2161932769","https://openalex.org/W2164628441","https://openalex.org/W2166771618","https://openalex.org/W2173681478","https://openalex.org/W2175842441","https://openalex.org/W2179683104","https://openalex.org/W2214074259","https://openalex.org/W2230973995","https://openalex.org/W2239653845","https://openalex.org/W2263654516","https://openalex.org/W2301828156","https://openalex.org/W2328246325","https://openalex.org/W2332254719","https://openalex.org/W2400466055","https://openalex.org/W2465287431","https://openalex.org/W2470982690","https://openalex.org/W2490476022","https://openalex.org/W2509657334","https://openalex.org/W2512293483","https://openalex.org/W2531686927","https://openalex.org/W2532941772","https://openalex.org/W2547963687","https://openalex.org/W2549026759","https://openalex.org/W2550846703","https://openalex.org/W2562261303","https://openalex.org/W2567503091","https://openalex.org/W2575018533","https://openalex.org/W2581413639","https://openalex.org/W2588342194","https://openalex.org/W2604689206","https://openalex.org/W2605280287","https://openalex.org/W2606513998","https://openalex.org/W2620612177","https://openalex.org/W2696298149","https://openalex.org/W2743588819","https://openalex.org/W2775008495","https://openalex.org/W2777887312","https://openalex.org/W2789456434","https://openalex.org/W2789621916","https://openalex.org/W2791758888","https://openalex.org/W2799887182","https://openalex.org/W2800314655","https://openalex.org/W2808580352","https://openalex.org/W2840330380","https://openalex.org/W2883902554","https://openalex.org/W2886229837","https://openalex.org/W2889254660","https://openalex.org/W2889487737","https://openalex.org/W2889913897","https://openalex.org/W2890832189","https://openalex.org/W2900310474","https://openalex.org/W2905294359","https://openalex.org/W2910084517","https://openalex.org/W2916163456","https://openalex.org/W2917295444","https://openalex.org/W2917520831","https://openalex.org/W2918133990","https://openalex.org/W2937950122","https://openalex.org/W2938768157","https://openalex.org/W2945270938","https://openalex.org/W2946109016","https://openalex.org/W2946781915","https://openalex.org/W2947105529","https://openalex.org/W2949358699","https://openalex.org/W2959497354","https://openalex.org/W2966001604","https://openalex.org/W2967786139","https://openalex.org/W2974124960","https://openalex.org/W2978622885","https://openalex.org/W2997222620","https://openalex.org/W3000157665","https://openalex.org/W3010443092","https://openalex.org/W3021486271","https://openalex.org/W3084174900","https://openalex.org/W3084435846","https://openalex.org/W3102558410","https://openalex.org/W3104775068","https://openalex.org/W3119677722","https://openalex.org/W3124083504","https://openalex.org/W3156374487","https://openalex.org/W3165186859","https://openalex.org/W3210312599"],"related_works":["https://openalex.org/W2351414818","https://openalex.org/W2404748302","https://openalex.org/W2188383195","https://openalex.org/W2140682486","https://openalex.org/W3215411460","https://openalex.org/W3196683579","https://openalex.org/W4285097245","https://openalex.org/W4282585009","https://openalex.org/W2090209293","https://openalex.org/W4318054768"],"abstract_inverted_index":{"SUMMARY":[0],"The":[1],"circadian":[2],"clock":[3],"is":[4,24,41],"a":[5,44,79,227],"time-tracking":[6],"endogenous":[7],"system":[8],"which":[9,23,188],"anticipates":[10],"and":[11,49,108,110,113,122,184,218],"coordinates":[12],"adaptation":[13],"to":[14,21,119,130],"daily":[15,57],"environmental":[16],"fluctuations.":[17],"Circadian":[18],"misalignment":[19],"leads":[20],"obesity,":[22],"accompanied":[25,177],"by":[26,178],"reduced":[27],"levels":[28,40],"of":[29,56,59,75,95,102,137,172,207,213,226],"the":[30,54,73,93,96,126,135,138,163,170,173,182,185,193,205,210,220,223],"clock-controlled":[31],"metabolite":[32],"NAD":[33,38,60,76,89,132,167,214],"+":[34,39,61,77,90,133,168,215],".":[35],"Concomitantly,":[36],"increasing":[37],"emerging":[42],"as":[43,78,105],"therapy":[45,80],"for":[46,81,222],"diet-induced":[47,82],"obesity":[48],"type":[50],"2":[51],"diabetes;":[52],"however,":[53],"impact":[55],"fluctuations":[58],"on":[62],"these":[63,143],"therapies":[64,217],"remains":[65],"unknown.":[66],"Here,":[67],"we":[68],"demonstrate":[69,203],"that":[70,204],"time-of-day":[71],"determines":[72,209],"efficacy":[74],"metabolic":[83,100],"disease":[84,103],"in":[85,157,192],"mice.":[86],"Restoring":[87],"regular":[88],"oscillations":[91,180],"at":[92,134,169],"onset":[94,136,171],"active":[97,164],"phase":[98,140,175,190],"ameliorates":[99],"markers":[101],"such":[104],"body":[106],"weight":[107],"glucose":[109],"insulin":[111],"tolerance,":[112],"restores":[114],"hepatic":[115,147,186],"gene":[116],"expression":[117],"related":[118],"inflammatory":[120],"response":[121],"lipid":[123],"metabolism.":[124],"However,":[125],"same":[127],"treatment":[128],"designed":[129],"increase":[131],"rest":[139,174],"severely":[141],"compromises":[142],"beneficial":[144,211],"responses.":[145],"Notably,":[146],"nutrient-sensing":[148],"mTOR,":[149],"AMPK":[150],"or":[151],"AKT":[152],"signaling,":[153],"became":[154],"rhythmic":[155],"specifically":[156],"obese":[158],"mice":[159],"treated":[160],"just":[161],"before":[162],"phase.":[165],"Remarkably,":[166],"was":[176],"uncoupled":[179],"between":[181],"SCN":[183],"clock,":[187],"were":[189],"inverted":[191],"liver,":[194],"while":[195],"keeping":[196],"behavioral":[197],"rhythms":[198],"largely":[199],"intact.":[200],"These":[201],"findings":[202],"time":[206],"day":[208],"effects":[212],"-based":[216],"pave":[219],"way":[221],"basic":[224],"strategy":[225],"chronobiology-based":[228],"therapeutic":[229],"approach.":[230]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2025-10-10T00:00:00"}