{"id":"https://openalex.org/W4291885404","doi":"https://doi.org/10.3390/ijms23169061","title":"How Hydroxyurea Alters the Gut Microbiome: A Longitudinal Study Involving Angolan Children with Sickle Cell Anemia","display_name":"How Hydroxyurea Alters the Gut Microbiome: A Longitudinal Study Involving Angolan Children with Sickle Cell Anemia","publication_year":2022,"publication_date":"2022-08-13","ids":{"openalex":"https://openalex.org/W4291885404","doi":"https://doi.org/10.3390/ijms23169061","pmid":"https://pubmed.ncbi.nlm.nih.gov/36012325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9409137"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23169061","doi":"https://doi.org/10.3390/ijms23169061","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23169061","pdf_url":"https://www.mdpi.com/1422-0067/23/16/9061/pdf?version=1660542620","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/16/9061/pdf?version=1660542620","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076934093","display_name":"Mariana Delgadinho","orcid":"https://orcid.org/0000-0003-0586-9154","observed_orcids":["https://orcid.org/0000-0003-0586-9154"]},"institutions":[{"id":"https://openalex.org/I203847022","display_name":"Universidade Polit\u00e9cnica de Lisboa","ror":"https://ror.org/04ea70f07","country_code":"PT","type":"education","lineage":["https://openalex.org/I203847022"]},{"id":"https://openalex.org/I4405256770","display_name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Tecnologia","ror":"https://ror.org/04gzz8859","country_code":"PT","type":"facility","lineage":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Mariana Delgadinho","raw_affiliation_strings":["H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-0586-9154","affiliations":[{"raw_affiliation_string":"H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal","institution_ids":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088877098","display_name":"Catarina Ginete","orcid":"https://orcid.org/0000-0002-2334-782X","observed_orcids":["https://orcid.org/0000-0002-2334-782X"]},"institutions":[{"id":"https://openalex.org/I203847022","display_name":"Universidade Polit\u00e9cnica de Lisboa","ror":"https://ror.org/04ea70f07","country_code":"PT","type":"education","lineage":["https://openalex.org/I203847022"]},{"id":"https://openalex.org/I4405256770","display_name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Tecnologia","ror":"https://ror.org/04gzz8859","country_code":"PT","type":"facility","lineage":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina Ginete","raw_affiliation_strings":["H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-2334-782X","affiliations":[{"raw_affiliation_string":"H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal","institution_ids":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101303099","display_name":"Br\u00edgida Santos","orcid":"https://orcid.org/0009-0003-6270-7255","observed_orcids":["https://orcid.org/0009-0003-6270-7255"]},"institutions":[{"id":"https://openalex.org/I4405260078","display_name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola","ror":"https://ror.org/036qche57","country_code":"AO","type":"government","lineage":["https://openalex.org/I4405258564","https://openalex.org/I4405260078"]}],"countries":["AO"],"is_corresponding":false,"raw_author_name":"Br\u00edgida Santos","raw_affiliation_strings":["Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola (CISA), Hospital Geral do Bengo, Bengo 9999, Angola","Hospital Pedi\u00e1trico David Bernardino (HPDB), Luanda 3067, Angola"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola (CISA), Hospital Geral do Bengo, Bengo 9999, Angola","institution_ids":["https://openalex.org/I4405260078"]},{"raw_affiliation_string":"Hospital Pedi\u00e1trico David Bernardino (HPDB), Luanda 3067, Angola","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Carolina Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203847022","display_name":"Universidade Polit\u00e9cnica de Lisboa","ror":"https://ror.org/04ea70f07","country_code":"PT","type":"education","lineage":["https://openalex.org/I203847022"]},{"id":"https://openalex.org/I4405256770","display_name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Tecnologia","ror":"https://ror.org/04gzz8859","country_code":"PT","type":"facility","lineage":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carolina Fernandes","raw_affiliation_strings":["H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal","institution_ids":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070017275","display_name":"Carina Silva","orcid":"https://orcid.org/0000-0003-1021-7935","observed_orcids":["https://orcid.org/0000-0003-1021-7935"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I203847022","display_name":"Universidade Polit\u00e9cnica de Lisboa","ror":"https://ror.org/04ea70f07","country_code":"PT","type":"education","lineage":["https://openalex.org/I203847022"]},{"id":"https://openalex.org/I4405255504","display_name":"Centro de Estat\u00edstica e Aplica\u00e7\u00f5es","ror":"https://ror.org/03302rx63","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405255504"]},{"id":"https://openalex.org/I4405256770","display_name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Tecnologia","ror":"https://ror.org/04gzz8859","country_code":"PT","type":"facility","lineage":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carina Silva","raw_affiliation_strings":["Centro de Estat\u00edstica e Aplica\u00e7\u00f5es, Universidade de Lisboa, 1749-016 Lisbon, Portugal","H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estat\u00edstica e Aplica\u00e7\u00f5es, Universidade de Lisboa, 1749-016 Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405255504"]},{"raw_affiliation_string":"H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal","institution_ids":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062640529","display_name":"Armandina Miranda","orcid":"https://orcid.org/0000-0002-4763-1227","observed_orcids":["https://orcid.org/0000-0002-4763-1227"]},"institutions":[{"id":"https://openalex.org/I4210142220","display_name":"National Institute of Health Dr. Ricardo Jorge","ror":"https://ror.org/03mx8d427","country_code":"PT","type":"other","lineage":["https://openalex.org/I4210117458","https://openalex.org/I4210142220","https://openalex.org/I4210157859"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Armandina Miranda","raw_affiliation_strings":["Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge (INSA), 1649-016 Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge (INSA), 1649-016 Lisbon, Portugal","institution_ids":["https://openalex.org/I4210142220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013419348","display_name":"Jocelyne Neto de Vasconcelos","orcid":"https://orcid.org/0000-0002-7318-693X","observed_orcids":["https://orcid.org/0000-0002-7318-693X"]},"institutions":[{"id":"https://openalex.org/I4405260078","display_name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola","ror":"https://ror.org/036qche57","country_code":"AO","type":"government","lineage":["https://openalex.org/I4405258564","https://openalex.org/I4405260078"]}],"countries":["AO"],"is_corresponding":false,"raw_author_name":"Jocelyne Neto de Vasconcelos","raw_affiliation_strings":["Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola (CISA), Hospital Geral do Bengo, Bengo 9999, Angola"],"raw_orcid":"https://orcid.org/0000-0002-7318-693X","affiliations":[{"raw_affiliation_string":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola (CISA), Hospital Geral do Bengo, Bengo 9999, Angola","institution_ids":["https://openalex.org/I4405260078"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065467974","display_name":"Miguel Brito","orcid":"https://orcid.org/0000-0001-6394-658X","observed_orcids":["https://orcid.org/0000-0001-6394-658X"]},"institutions":[{"id":"https://openalex.org/I203847022","display_name":"Universidade Polit\u00e9cnica de Lisboa","ror":"https://ror.org/04ea70f07","country_code":"PT","type":"education","lineage":["https://openalex.org/I203847022"]},{"id":"https://openalex.org/I4405256770","display_name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Tecnologia","ror":"https://ror.org/04gzz8859","country_code":"PT","type":"facility","lineage":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]},{"id":"https://openalex.org/I4405260078","display_name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola","ror":"https://ror.org/036qche57","country_code":"AO","type":"government","lineage":["https://openalex.org/I4405258564","https://openalex.org/I4405260078"]}],"countries":["AO","PT"],"is_corresponding":true,"raw_author_name":"Miguel Brito","raw_affiliation_strings":["Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola (CISA), Hospital Geral do Bengo, Bengo 9999, Angola","H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-6394-658X","affiliations":[{"raw_affiliation_string":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola (CISA), Hospital Geral do Bengo, Bengo 9999, Angola","institution_ids":["https://openalex.org/I4405260078"]},{"raw_affiliation_string":"H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal","institution_ids":["https://openalex.org/I203847022","https://openalex.org/I4405256770"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065467974"],"corresponding_institution_ids":["https://openalex.org/I203847022","https://openalex.org/I4405256770","https://openalex.org/I4405260078"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.6571,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.58677856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"16","first_page":"9061","last_page":"9061"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.925000011920929},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.9049999713897705},{"id":"https://openalex.org/keywords/faecalibacterium","display_name":"Faecalibacterium","score":0.8299999833106995},{"id":"https://openalex.org/keywords/clostridium","display_name":"Clostridium","score":0.7540000081062317},{"id":"https://openalex.org/keywords/microbial-diversity","display_name":"microbial diversity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2776706654","wikidata":"https://www.wikidata.org/wiki/Q3941444","display_name":"Roseburia","level":4,"score":0.9271743893623352},{"id":"https://openalex.org/C2780027724","wikidata":"https://www.wikidata.org/wiki/Q288892","display_name":"Ruminococcus","level":3,"score":0.7036632299423218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.683285117149353},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5828850269317627},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5407751202583313},{"id":"https://openalex.org/C2780092757","wikidata":"https://www.wikidata.org/wiki/Q5405346","display_name":"Eubacterium","level":3,"score":0.5326558947563171},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5151930451393127},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4146432876586914},{"id":"https://openalex.org/C2775980262","wikidata":"https://www.wikidata.org/wiki/Q218870","display_name":"Prebiotic","level":2,"score":0.4109107255935669},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3711971640586853},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3525785207748413},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33838963508605957},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3276914358139038},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.29289644956588745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22013872861862183},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11793652176856995},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07527455687522888},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms23169061","doi":"https://doi.org/10.3390/ijms23169061","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23169061","pdf_url":"https://www.mdpi.com/1422-0067/23/16/9061/pdf?version=1660542620","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:36012325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36012325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9409137","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9409137/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7fbb4b7d3f0a46d198d14214b634004b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7fbb4b7d3f0a46d198d14214b634004b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 9061, p 9061 (2022)","raw_type":"article"},{"id":"pmh:oai:repositorio.insa.pt:10400.18/8515","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.18/8515","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:repositorio.ipl.pt:10400.21/14922","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.21/14922","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3390/ijms23169061","doi":"https://doi.org/10.3390/ijms23169061","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23169061","pdf_url":"https://www.mdpi.com/1422-0067/23/16/9061/pdf?version=1660542620","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291885404.pdf","grobid_xml":"https://content.openalex.org/works/W4291885404.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1584253018","https://openalex.org/W1592407962","https://openalex.org/W1858794626","https://openalex.org/W1964030232","https://openalex.org/W2035127684","https://openalex.org/W2065727769","https://openalex.org/W2108860293","https://openalex.org/W2110235509","https://openalex.org/W2115701239","https://openalex.org/W2130880789","https://openalex.org/W2153109441","https://openalex.org/W2273646766","https://openalex.org/W2328023807","https://openalex.org/W2495182816","https://openalex.org/W2535360044","https://openalex.org/W2558417198","https://openalex.org/W2579533542","https://openalex.org/W2585053973","https://openalex.org/W2591857450","https://openalex.org/W2736538047","https://openalex.org/W2778831181","https://openalex.org/W2797498165","https://openalex.org/W2802324602","https://openalex.org/W2803050835","https://openalex.org/W2896473060","https://openalex.org/W2904509656","https://openalex.org/W2908210684","https://openalex.org/W2957585395","https://openalex.org/W2972627544","https://openalex.org/W2980356966","https://openalex.org/W2988521256","https://openalex.org/W3016889019","https://openalex.org/W3027958678","https://openalex.org/W3112267312","https://openalex.org/W3177838279","https://openalex.org/W3187821926","https://openalex.org/W3205545067","https://openalex.org/W4200335445","https://openalex.org/W4205394221","https://openalex.org/W4214875183","https://openalex.org/W4230740560","https://openalex.org/W4297489987","https://openalex.org/W6741368106"],"related_works":["https://openalex.org/W4364365676","https://openalex.org/W4291493188","https://openalex.org/W6982092152","https://openalex.org/W4390347142","https://openalex.org/W4297489987","https://openalex.org/W4365144078","https://openalex.org/W7169764506","https://openalex.org/W4385442036","https://openalex.org/W4210278847","https://openalex.org/W6982091976"],"abstract_inverted_index":{"Sickle":[0],"cell":[1],"anemia":[2],"(SCA)":[3],"is":[4,22],"an":[5,60],"inherited":[6],"hematological":[7],"disorder":[8],"and":[9,66,81,96,160,180,193],"a":[10,151],"serious":[11],"global":[12],"health":[13],"problem,":[14],"especially":[15],"in":[16,94],"Sub-Saharan":[17],"Africa.":[18],"Although":[19],"hydroxyurea":[20],"(HU)":[21],"the":[23,33,44,56,84,105,169,173,177],"leading":[24],"treatment":[25],"for":[26,83,104,108,190],"patients":[27],"with":[28,98],"SCA,":[29],"its":[30],"effects":[31],"on":[32,176],"gut":[34,57,178],"microbiome":[35,58,179],"have":[36],"not":[37],"yet":[38],"been":[39],"explored.":[40],"In":[41,145],"this":[42,47,52],"context,":[43],"aim":[45],"of":[46,59,70,75,101,120,154,172],"study":[48,167],"was":[49,150],"to":[50],"investigate":[51],"association":[53],"by":[54],"characterizing":[55],"Angolan":[61],"SCA":[62],"pediatric":[63],"population":[64],"before":[65,147],"after":[67,115],"6":[68],"months":[69],"HU":[71,116,148,174,194],"treatment.":[72],"A":[73],"total":[74],"66":[76],"stool":[77],"samples":[78],"were":[79,92],"obtained":[80],"sequenced":[82],"16S":[85],"rRNA":[86],"gene":[87],"(V3-V4":[88],"regions).":[89],"Significant":[90],"associations":[91],"observed":[93],"alpha":[95],"beta-diversity,":[97],"higher":[99,118,152],"values":[100],"species":[102],"richness":[103],"children":[106,114],"na\u00efve":[107],"HU.":[109],"We":[110],"also":[111],"noticed":[112],"that":[113,184],"had":[117],"proportions":[119],"several":[121,182],"beneficial":[122],"bacteria,":[123],"mostly":[124],"short-chain":[125],"fatty":[126],"acids":[127],"(SCFAs)":[128],"producing":[129],"species,":[130],"such":[131],"as":[132],"Blautia":[133],"luti,":[134],"Roseburia":[135],"inulinivorans,":[136],"Eubacterium":[137],"halli,":[138],"Faecalibacterium,":[139],"Ruminococcus,":[140],"Lactobacillus":[141],"rogosae,":[142],"among":[143],"others.":[144],"addition,":[146],"there":[149],"abundance":[153],"Clostridium_g24,":[155],"which":[156],"includes":[157],"C.":[158,161],"bolteae":[159],"clostridioforme,":[162],"both":[163],"considered":[164,187],"pathogenic.":[165],"This":[166],"provides":[168],"first":[170],"evidence":[171],"effect":[175],"unravels":[181],"microorganisms":[183],"could":[185],"be":[186],"candidate":[188],"biomarkers":[189],"disease":[191],"severity":[192],"efficacy.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-16T00:00:00"}