{"id":"https://openalex.org/W4291884530","doi":"https://doi.org/10.1101/2022.08.11.503674","title":"Antagonistic, synergistic, and social pleiotropy in microbial cheaters","display_name":"Antagonistic, synergistic, and social pleiotropy in microbial cheaters","publication_year":2022,"publication_date":"2022-08-14","ids":{"openalex":"https://openalex.org/W4291884530","doi":"https://doi.org/10.1101/2022.08.11.503674"},"language":"en","primary_location":{"id":"doi:10.1101/2022.08.11.503674","doi":"https://doi.org/10.1101/2022.08.11.503674","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.11.503674","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/14/2022.08.11.503674.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/14/2022.08.11.503674.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088645607","display_name":"Pauline Manhes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254264","display_name":"Institute of Integrative Biology","ror":"https://ror.org/01kwjhv40","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pauline Manhes","raw_affiliation_strings":["Institute of Integrative Biology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060501042","display_name":"Kaitlin A. Schaal","orcid":"https://orcid.org/0000-0001-9033-9646","observed_orcids":["https://orcid.org/0000-0001-9033-9646"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254264","display_name":"Institute of Integrative Biology","ror":"https://ror.org/01kwjhv40","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Kaitlin A. Schaal","raw_affiliation_strings":["Institute of Integrative Biology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9033-9646","affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076629790","display_name":"Gregory J. Velicer","orcid":"https://orcid.org/0000-0001-8721-1502","observed_orcids":["https://orcid.org/0000-0001-8721-1502"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254264","display_name":"Institute of Integrative Biology","ror":"https://ror.org/01kwjhv40","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gregory J. Velicer","raw_affiliation_strings":["Institute of Integrative Biology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8721-1502","affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060501042"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254264"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.048700001090765,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antagonistic-pleiotropy","display_name":"antagonistic pleiotropy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/myxococcus-xanthus","display_name":"Myxococcus xanthus","score":0.902999997138977},{"id":"https://openalex.org/keywords/fruiting-body-development","display_name":"fruiting body formation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sporulation","display_name":"sporulation","score":0.75},{"id":"https://openalex.org/keywords/csga","display_name":"CsgA","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cooperative-behavior","display_name":"cooperative behavior","score":0.5009999871253967},{"id":"https://openalex.org/keywords/stress-tolerance","display_name":"stress tolerance","score":0.6290000081062317},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ph-stress","display_name":"pH stress","score":0.8370000123977661},{"id":"https://openalex.org/keywords/multicellular-behavior","display_name":"multicellular behavior","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2778024590","wikidata":"https://www.wikidata.org/wiki/Q2357432","display_name":"Cheating","level":2,"score":0.8950968980789185},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.885942816734314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7309222221374512},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6238791942596436},{"id":"https://openalex.org/C2777120639","wikidata":"https://www.wikidata.org/wiki/Q142803","display_name":"Myxococcus xanthus","level":4,"score":0.5762271285057068},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5355970859527588},{"id":"https://openalex.org/C2910387474","wikidata":"https://www.wikidata.org/wiki/Q331710","display_name":"Genetic Fitness","level":3,"score":0.511709451675415},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.48454514145851135},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.37735849618911743},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37593936920166016},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3205784559249878},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.25939154624938965}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.08.11.503674","doi":"https://doi.org/10.1101/2022.08.11.503674","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.11.503674","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/14/2022.08.11.503674.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.08.11.503674","doi":"https://doi.org/10.1101/2022.08.11.503674","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.11.503674","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/14/2022.08.11.503674.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291884530.pdf","grobid_xml":"https://content.openalex.org/works/W4291884530.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1480307447","https://openalex.org/W1491712856","https://openalex.org/W1567974406","https://openalex.org/W1635778238","https://openalex.org/W1792243108","https://openalex.org/W1860714877","https://openalex.org/W1942625694","https://openalex.org/W1966995391","https://openalex.org/W1974483110","https://openalex.org/W1977809773","https://openalex.org/W1979587114","https://openalex.org/W1979888857","https://openalex.org/W1979905261","https://openalex.org/W1980352067","https://openalex.org/W1992626069","https://openalex.org/W2007993714","https://openalex.org/W2009602749","https://openalex.org/W2015644418","https://openalex.org/W2019988542","https://openalex.org/W2020402841","https://openalex.org/W2022910577","https://openalex.org/W2024173763","https://openalex.org/W2029743581","https://openalex.org/W2036516886","https://openalex.org/W2052480626","https://openalex.org/W2053330332","https://openalex.org/W2062663664","https://openalex.org/W2063694547","https://openalex.org/W2066034383","https://openalex.org/W2077646289","https://openalex.org/W2077723503","https://openalex.org/W2080533051","https://openalex.org/W2081083195","https://openalex.org/W2084690556","https://openalex.org/W2088323801","https://openalex.org/W2088451270","https://openalex.org/W2092668948","https://openalex.org/W2094223277","https://openalex.org/W2123035125","https://openalex.org/W2123435633","https://openalex.org/W2123880126","https://openalex.org/W2126909084","https://openalex.org/W2131068496","https://openalex.org/W2141401164","https://openalex.org/W2150014559","https://openalex.org/W2150879418","https://openalex.org/W2152815488","https://openalex.org/W2154066472","https://openalex.org/W2154278889","https://openalex.org/W2156470286","https://openalex.org/W2164165249","https://openalex.org/W2164606163","https://openalex.org/W2164622275","https://openalex.org/W2167637616","https://openalex.org/W2169626923","https://openalex.org/W2170784505","https://openalex.org/W2204366321","https://openalex.org/W2410766695","https://openalex.org/W2494427789","https://openalex.org/W2558525467","https://openalex.org/W2582013619","https://openalex.org/W2590004837","https://openalex.org/W2809690985","https://openalex.org/W2898194682","https://openalex.org/W2948478831","https://openalex.org/W2953159327","https://openalex.org/W2954114611","https://openalex.org/W2979257221","https://openalex.org/W2990599707","https://openalex.org/W2992097690","https://openalex.org/W3120758456","https://openalex.org/W3122889152","https://openalex.org/W3126252525","https://openalex.org/W3159167168","https://openalex.org/W3189937028","https://openalex.org/W3215314120","https://openalex.org/W4229072953","https://openalex.org/W4281779331","https://openalex.org/W4283268351","https://openalex.org/W4378188247","https://openalex.org/W6725038865"],"related_works":["https://openalex.org/W1491712856","https://openalex.org/W3120758456","https://openalex.org/W1966076924","https://openalex.org/W4300594426","https://openalex.org/W2164606163","https://openalex.org/W2081083195","https://openalex.org/W2084690556","https://openalex.org/W6967144120","https://openalex.org/W1965743933","https://openalex.org/W2810136943"],"abstract_inverted_index":{"Abstract":[0],"Cooperation":[1],"is":[2,12,56],"widespread":[3],"among":[4],"microbes.":[5],"One":[6],"mechanism":[7],"proposed":[8],"to":[9,58,70,77,186],"constrain":[10],"cheating":[11,163,194],"antagonistic":[13,91],"pleiotropy,":[14,117],"wherein":[15],"mutations":[16],"that":[17,168],"cause":[18],"defection":[19],"from":[20,135],"cooperation,":[21],"while":[22,99],"potentially":[23],"under":[24,93,108,130],"positive":[25],"selection":[26],"for":[27],"this":[28],"effect,":[29],"reduce":[30],"fitness":[31],"at":[32,103],"other":[33],"traits.":[34],"The":[35],"bacterium":[36],"Myxococcus":[37],"xanthus":[38],"engages":[39],"in":[40,85,112,121,174,195],"pleiotropically":[41,171],"connected":[42],"complex":[43],"multicellular":[44],"behaviors,":[45],"including":[46],"motility,":[47],"predation,":[48],"and":[49,96,181,193],"starvation-induced":[50],"fruiting-body":[51],"development.":[52],"Sporulation":[53],"during":[54],"development":[55],"susceptible":[57],"cheating.":[59],"Here":[60],"we":[61],"investigate":[62],"pleiotropic":[63],"impacts":[64],"on":[65,153],"how":[66],"cheater":[67,81,101,126],"spores":[68,119],"respond":[69],"stressful":[71],"environmental":[72],"changes":[73],"after":[74],"development,":[75],"relative":[76],"cooperator":[78,118],"spores.":[79],"A":[80],"with":[82,123,141],"a":[83,100,113],"mutation":[84],"the":[86,124,144,154,188],"developmental-signaling":[87],"gene":[88],"asgB":[89,125],"shows":[90,105],"pleiotropy":[92,107,156,183],"both":[94],"heat":[95],"basic-pH":[97,109],"stress,":[98],"mutated":[102],"csgA":[104],"synergistic":[106],"stress.":[110],"Further,":[111],"social":[114,182,197],"form":[115],"of":[116,139,191],"formed":[120],"mixture":[122],"are":[127],"less":[128],"resilient":[129],"basic":[131],"pH":[132],"than":[133],"those":[134,178],"pure":[136],"groups;":[137],"interaction":[138],"cooperators":[140],"cheaters":[142],"reduces":[143],"cooperators\u2019":[145],"physical":[146],"robustness.":[147],"Our":[148],"results":[149],"indicate":[150],"that,":[151],"depending":[152],"mutation,":[155],"can":[157,170],"promote":[158],"as":[159,161],"well":[160],"limit":[162],"alleles.":[164,179],"They":[165],"additionally":[166],"demonstrate":[167],"alleles":[169],"alter":[172],"traits":[173],"organisms":[175],"not":[176],"carrying":[177],"Synergistic":[180],"may":[184],"contribute":[185],"shaping":[187],"evolutionary":[189],"dynamics":[190],"cooperation":[192],"many":[196],"systems.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-08-16T00:00:00"}