{"id":"https://openalex.org/W4291639848","doi":"https://doi.org/10.1083/jcb.202208015","title":"Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse","display_name":"Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse","publication_year":2022,"publication_date":"2022-08-15","ids":{"openalex":"https://openalex.org/W4291639848","doi":"https://doi.org/10.1083/jcb.202208015","pmid":"https://pubmed.ncbi.nlm.nih.gov/35969858","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9375141"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.202208015","doi":"https://doi.org/10.1083/jcb.202208015","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.202208015","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1083/jcb.202208015","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062380202","display_name":"Mitchell S. Wang","orcid":"https://orcid.org/0000-0002-6851-3596","observed_orcids":["https://orcid.org/0000-0002-6851-3596"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell S. Wang","raw_affiliation_strings":["Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 1","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035129988","display_name":"Morgan Huse","orcid":"https://orcid.org/0000-0001-9941-7719","observed_orcids":["https://orcid.org/0000-0001-9941-7719"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Morgan Huse","raw_affiliation_strings":["Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 1"],"raw_orcid":"https://orcid.org/0000-0001-9941-7719","affiliations":[{"raw_affiliation_string":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 1","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035129988"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":0.4775,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.54054281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"221","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.13120000064373016,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9490000009536743},{"id":"https://openalex.org/keywords/actin-dynamics","display_name":"actin dynamics","score":0.7799999713897705},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/inpp5b","display_name":"INPP5B","score":0.906000018119812},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.9470000267028809},{"id":"https://openalex.org/keywords/lipid-phosphatase","display_name":"lipid phosphatase","score":0.8500000238418579},{"id":"https://openalex.org/keywords/phosphoinositide-signaling","display_name":"phosphoinositide signaling","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.927588939666748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8538947105407715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6161723732948303},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6123442649841309},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5462517142295837},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5089113712310791},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.45588549971580505},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.42329761385917664},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42111656069755554},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.40769124031066895},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2706853747367859},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21382009983062744},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1685439944267273},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16601452231407166},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.141200989484787},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.09529897570610046}],"mesh":[{"descriptor_ui":"D000099182","descriptor_name":"Phosphoinositide 5-Phosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.202208015","doi":"https://doi.org/10.1083/jcb.202208015","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.202208015","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9375141","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9375141","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:35969858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35969858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1083/jcb.202208015","doi":"https://doi.org/10.1083/jcb.202208015","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.202208015","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W31480411","https://openalex.org/W1983090571","https://openalex.org/W2005252392","https://openalex.org/W2034306306","https://openalex.org/W2037871133","https://openalex.org/W2051341672","https://openalex.org/W2082024168","https://openalex.org/W2153604838","https://openalex.org/W2769182821","https://openalex.org/W2884166686","https://openalex.org/W2885287769","https://openalex.org/W2995443875","https://openalex.org/W4281611229","https://openalex.org/W4287837689"],"related_works":["https://openalex.org/W4287837689","https://openalex.org/W2915756396","https://openalex.org/W7080350339","https://openalex.org/W2586974243","https://openalex.org/W7213909029","https://openalex.org/W4211149574","https://openalex.org/W3047185358","https://openalex.org/W4386448111","https://openalex.org/W3154003478","https://openalex.org/W4312863991"],"abstract_inverted_index":{"Actin":[0],"remodeling":[1],"promotes":[2],"B":[3,8],"cell":[4,9],"activation":[5],"by":[6,36,46],"enabling":[7],"antigen":[10],"receptor":[11],"clustering":[12],"in":[13],"the":[14,18,37],"immune":[15],"synapse.":[16],"In":[17],"current":[19],"issue":[20],"of":[21],"JCB,":[22],"Droubi":[23],"et":[24],"al.":[25],"(2022.":[26],"J.":[27],"Cell":[28],"Biol.https://doi.org/10.1083/jcb.202112018)":[29],"find":[30],"that":[31],"this":[32],"process":[33],"is":[34],"initiated":[35],"lipid":[38],"phosphatase":[39],"INPP5B,":[40],"which":[41],"shapes":[42],"synaptic":[43],"actin":[44],"architecture":[45],"locally":[47],"depleting":[48],"phosphatidylinositol":[49],"4,5":[50],"bisphosphate.":[51]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-15T00:00:00"}