{"id":"https://openalex.org/W4291498113","doi":"https://doi.org/10.55730/1300-0144.5388","title":"The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19","display_name":"The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4291498113","doi":"https://doi.org/10.55730/1300-0144.5388","pmid":"https://pubmed.ncbi.nlm.nih.gov/36326397","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10388126"},"language":"en","primary_location":{"id":"doi:10.55730/1300-0144.5388","doi":"https://doi.org/10.55730/1300-0144.5388","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5388","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=5416&context=medical","source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=5416&context=medical","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113987362","display_name":"H\u00fclya U\u00e7ary\u0131lmaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00dcLYA U\u00c7ARYILMAZ","raw_affiliation_strings":["Department of Medical Biology , Faculty of Medicine , Sel\u00e7uk University , Konya , Turkey","Department of Medical Biology , of , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology , Faculty of Medicine , Sel\u00e7uk University , Konya , Turkey","institution_ids":["https://openalex.org/I137996928"]},{"raw_affiliation_string":"Department of Medical Biology , of , , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042728722","display_name":"Dilek Erg\u00fcn","orcid":"https://orcid.org/0000-0002-9890-2250","observed_orcids":["https://orcid.org/0000-0002-9890-2250"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"D\u0130LEK ERG\u00dcN","raw_affiliation_strings":["Department of Chest Disease, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey","of , of , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Disease, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]},{"raw_affiliation_string":"of , of , , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029876637","display_name":"H\u00fcsamettin Vatansev","orcid":"https://orcid.org/0000-0002-0230-3414","observed_orcids":["https://orcid.org/0000-0002-0230-3414"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00dcSAMETT\u0130N VATANSEV","raw_affiliation_strings":["Department of Medical Biochemistry, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey","of , of , , , of of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]},{"raw_affiliation_string":"of , of , , , of of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077786768","display_name":"Hande K\u00f6ksal","orcid":"https://orcid.org/0000-0002-9668-7913","observed_orcids":["https://orcid.org/0000-0002-9668-7913"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"HANDE K\u00d6KSAL","raw_affiliation_strings":["Department of General Surgery, Hamidiye Faculty of Medicine, University of Health Sciences, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Hamidiye Faculty of Medicine, University of Health Sciences, Konya, Turkey","institution_ids":["https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004037115","display_name":"Onur Ural","orcid":"https://orcid.org/0000-0003-1355-7572","observed_orcids":["https://orcid.org/0000-0003-1355-7572"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"ONUR URAL","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091415791","display_name":"U\u011eUR ARSLAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"U\u011eUR ARSLAN","raw_affiliation_strings":["Department of Medical Microbiology, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039246008","display_name":"Hasibe Arta\u00e7","orcid":"https://orcid.org/0000-0002-9807-2605","observed_orcids":["https://orcid.org/0000-0002-9807-2605"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"HAS\u0130BE ARTA\u00c7","raw_affiliation_strings":["Department of Pediatric Immunology and Allergy, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Immunology and Allergy, Faculty of Medicine, Sel\u00e7uk University, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039246008"],"corresponding_institution_ids":["https://openalex.org/I137996928"],"apc_list":null,"apc_paid":null,"fwci":0.3809,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57883081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"52","issue":"4","first_page":"888","last_page":"898"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd8-regulatory-t-cells","display_name":"CD8+ regulatory T cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/regulatory-b-cells","display_name":"regulatory B cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.9330000281333923},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7960000038146973},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.6269999742507935},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/plasmablasts","display_name":"plasmablasts","score":0.9010000228881836},{"id":"https://openalex.org/keywords/naive-b-cells","display_name":"naive B cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7390000224113464},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8750117421150208},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7228702902793884},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.7052954435348511},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6368331909179688},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6191949248313904},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5091456770896912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48762694001197815},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48359745740890503},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.4824822247028351},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4662913680076599},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41064804792404175},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.33421459794044495},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3159084916114807},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.55730/1300-0144.5388","doi":"https://doi.org/10.55730/1300-0144.5388","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5388","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=5416&context=medical","source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10388126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10388126","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10388126/pdf/turkjmedsci-52-4-888.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turk J Med Sci","raw_type":"Text"},{"id":"pmid:36326397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36326397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish journal of medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.55730/1300-0144.5388","doi":"https://doi.org/10.55730/1300-0144.5388","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5388","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=5416&context=medical","source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324151","display_name":"Sel\u00e7uk \u00dcniversitesi","ror":"https://ror.org/045hgzm75"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291498113.pdf","grobid_xml":"https://content.openalex.org/works/W4291498113.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1558319006","https://openalex.org/W1566416470","https://openalex.org/W1973599173","https://openalex.org/W2007631222","https://openalex.org/W2009042953","https://openalex.org/W2072853625","https://openalex.org/W2096998441","https://openalex.org/W2114512094","https://openalex.org/W2121672225","https://openalex.org/W2144810538","https://openalex.org/W2146949490","https://openalex.org/W2155139751","https://openalex.org/W2548000951","https://openalex.org/W2616586501","https://openalex.org/W2923378509","https://openalex.org/W2945792041","https://openalex.org/W3001118548","https://openalex.org/W3001638293","https://openalex.org/W3002108456","https://openalex.org/W3007814559","https://openalex.org/W3009859788","https://openalex.org/W3014003872","https://openalex.org/W3015289726","https://openalex.org/W3016570462","https://openalex.org/W3018494531","https://openalex.org/W3024541652","https://openalex.org/W3030915969","https://openalex.org/W3098710536","https://openalex.org/W3212922389","https://openalex.org/W4392145873"],"related_works":["https://openalex.org/W4401043775","https://openalex.org/W4391338465","https://openalex.org/W3113773386","https://openalex.org/W3084453033","https://openalex.org/W4200511947","https://openalex.org/W4205553086","https://openalex.org/W3206616468","https://openalex.org/W3085935634","https://openalex.org/W4220848563","https://openalex.org/W4213435852"],"abstract_inverted_index":{"BACKGROUND:":[0],"Coronavirus":[1],"disease":[2],"2019":[3],"(COVID-19)":[4],"has":[5],"a":[6],"wide":[7],"clinical":[8],"spectrum":[9],"from":[10],"asymptomatic":[11],"to":[12,33,123,180,254],"mild,":[13],"moderate,":[14],"and":[15,39,43,68,105,129,153,173,225,248,257],"severe":[16,107,256],"cases.":[17],"There":[18],"are":[19],"still":[20],"many":[21],"unknowns":[22],"about":[23],"the":[24,125,142,154,166,207,212,231,234,243],"role":[25],"of":[26,49,117,144,168,209,236],"immunoregulatory":[27],"mechanisms":[28],"in":[29,81,190,211,223,233,260],"COVID-19.":[30,50,239],"We":[31],"aimed":[32],"study":[34],"regulatory":[35,169],"T":[36,146,201,224],"cells":[37,147,177,202],"(Tregs)":[38],"B":[40,170,176,226],"cell":[41,227],"subsets":[42,228],"evaluate":[44],"their":[45],"correlations":[46],"with":[47,56,140,160,194,206,238],"severity":[48,250],"METHODS:":[51],"In":[52,137,240],"total,":[53],"50":[54],"patients":[55,85,139,192,237],"COVID-19":[57,249,259],"confirmed":[58],"by":[59],"PCR":[60],"(mean":[61,72],"age":[62,73,92,100,109],"=":[63,74,93,101,110,151,163,215,218],"49.9":[64],"\u00b1":[65,76],"12.8":[66],"years)":[67,78,104],"40":[69],"healthy":[70],"control":[71,161],"47.9":[75],"14.7":[77],"were":[79,86,157,178,188,203],"included":[80],"this":[82,241],"study.":[83],"The":[84,221],"classified":[87],"as":[88],"14":[89,106],"mild":[90],"(median":[91,99,108],"35.5":[94],"[24-73]":[95],"years),":[96],"22":[97],"moderate":[98],"51.5":[102],"[28-67]":[103],"55.5":[111],"[42-67]":[112],"years).":[113],"Within":[114],"24":[115],"h":[116],"admission,":[118],"flow":[119],"cytometry":[120],"was":[121,148],"used":[122],"assess":[124],"lymphocyte":[126],"subsets,":[127],"Tregs":[128,156,247],"Bregs":[130],"without":[131],"receiving":[132],"any":[133],"relevant":[134],"medication.":[135],"RESULTS:":[136],"all":[138,191],"COVID-19,":[141],"proportion":[143],"CD3+CD8+":[145],"reduced":[149],"(p":[150,162,196],"0.004)":[152],"CD8+":[155,246],"increased":[158],"compared":[159,193],"0.001).":[164],"While":[165],"levels":[167,187],"cells,":[171],"plasmablasts,":[172],"mature":[174],"naive":[175],"found":[179],"be":[181],"significantly":[182],"high,":[183],"primarily":[184],"memory":[185],"B-cell":[186],"low":[189],"controls":[195],"<":[197],"0.05).":[198],"Total":[199],"CD3+":[200],"negatively":[204],"correlated":[205],"length":[208],"stay":[210],"hospital":[213],"(r":[214],"-0.286,":[216],"p":[217],"0.044).":[219],"DISCUSSION:":[220],"changes":[222],"may":[229,251],"show":[230],"dysregulation":[232],"immunity":[235],"context,":[242],"association":[244],"between":[245],"help":[252],"clinicians":[253],"predict":[255],"fatal":[258],"hospitalized":[261],"patients.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-15T00:00:00"}