{"id":"https://openalex.org/W4291474593","doi":"https://doi.org/10.1136/ejhpharm-2022-eahp.109","title":"4CPS-072 Bezlotoxumab for the prevention of Clostridioides difficile recurrence: study in the real world","display_name":"4CPS-072 Bezlotoxumab for the prevention of Clostridioides difficile recurrence: study in the real world","publication_year":2022,"publication_date":"2022-03-01","ids":{"openalex":"https://openalex.org/W4291474593","doi":"https://doi.org/10.1136/ejhpharm-2022-eahp.109"},"language":"en","primary_location":{"id":"doi:10.1136/ejhpharm-2022-eahp.109","doi":"https://doi.org/10.1136/ejhpharm-2022-eahp.109","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ejhpharm-2022-eahp.109","pdf_url":"https://ejhp.bmj.com/content/ejhpharm/29/Suppl_1/A52.1.full.pdf","source":{"id":"https://openalex.org/S3012707348","display_name":"European Journal of Hospital Pharmacy","issn_l":"2047-9956","issn":["2047-9956","2047-9964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Section 4: Clinical pharmacy services","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ejhp.bmj.com/content/ejhpharm/29/Suppl_1/A52.1.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Herrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S Herrero","raw_affiliation_strings":["General University Hospital Gregorio Mara\u00f1on, Pharmacy, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General University Hospital Gregorio Mara\u00f1on, Pharmacy, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001006820","display_name":"C Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C Rodriguez","raw_affiliation_strings":["General University Hospital Gregorio Mara\u00f1on, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General University Hospital Gregorio Mara\u00f1on, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112902798","display_name":"Esther Chamorro","orcid":"https://orcid.org/0000-0002-2654-7165","observed_orcids":["https://orcid.org/0000-0002-2654-7165"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E Chamorro","raw_affiliation_strings":["General University Hospital Gregorio Mara\u00f1on, Pharmacy, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General University Hospital Gregorio Mara\u00f1on, Pharmacy, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026528067","display_name":"M Valerio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M Valerio","raw_affiliation_strings":["General University Hospital Gregorio Mara\u00f1on, Microbiology Department, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General University Hospital Gregorio Mara\u00f1on, Microbiology Department, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025775425","display_name":"Marco Antonio Santiago Olmedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M Olmedo","raw_affiliation_strings":["General University Hospital Gregorio Mara\u00f1on, Microbiology Department, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General University Hospital Gregorio Mara\u00f1on, Microbiology Department, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081663241","display_name":"Ana Bel\u00e9n L\u00f3pez Herranz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Herranz","raw_affiliation_strings":["General University Hospital Gregorio Mara\u00f1on, Pharmacy, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General University Hospital Gregorio Mara\u00f1on, Pharmacy, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007327573","display_name":"M Sanjurjo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M Sanjurjo","raw_affiliation_strings":["General University Hospital Gregorio Mara\u00f1on, Pharmacy, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General University Hospital Gregorio Mara\u00f1on, Pharmacy, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2960094004"],"apc_list":null,"apc_paid":null,"fwci":3.5637,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.89770642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"A52.1","last_page":"A52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bezlotoxumab","display_name":"bezlotoxumab","score":0.8059999942779541},{"id":"https://openalex.org/keywords/clostridium-difficile-infection","display_name":"Clostridium difficile infection","score":0.9959999918937683},{"id":"https://openalex.org/keywords/recurrence-prevention","display_name":"recurrence prevention","score":0.8040000200271606},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.859000027179718},{"id":"https://openalex.org/keywords/risk-factors-for-recurrence","display_name":"recurrence risk factors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8539999723434448},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.7129999995231628},{"id":"https://openalex.org/keywords/fidaxomicin","display_name":"fidaxomicin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/severe-infection","display_name":"serious infections","score":0.6169999837875366},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.722000002861023},{"id":"https://openalex.org/keywords/clinical-cure","display_name":"clinical cure","score":0.6909999847412109},{"id":"https://openalex.org/keywords/spain","display_name":"Spain","score":0.4569999873638153},{"id":"https://openalex.org/keywords/population-aged-65-and-over","display_name":"age over 65","score":0.5659999847412109},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.3370000123977661},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8989925384521484},{"id":"https://openalex.org/C2910067853","wikidata":"https://www.wikidata.org/wiki/Q27438828","display_name":"Clostridioides","level":2,"score":0.8439266681671143},{"id":"https://openalex.org/C2776644030","wikidata":"https://www.wikidata.org/wiki/Q25324519","display_name":"Hospital readmission","level":2,"score":0.6014314889907837},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5813478827476501},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4220902621746063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40811780095100403},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35969269275665283},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3479961156845093},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.28692203760147095}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/ejhpharm-2022-eahp.109","doi":"https://doi.org/10.1136/ejhpharm-2022-eahp.109","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ejhpharm-2022-eahp.109","pdf_url":"https://ejhp.bmj.com/content/ejhpharm/29/Suppl_1/A52.1.full.pdf","source":{"id":"https://openalex.org/S3012707348","display_name":"European Journal of Hospital Pharmacy","issn_l":"2047-9956","issn":["2047-9956","2047-9964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Section 4: Clinical pharmacy services","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/ejhpharm-2022-eahp.109","doi":"https://doi.org/10.1136/ejhpharm-2022-eahp.109","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ejhpharm-2022-eahp.109","pdf_url":"https://ejhp.bmj.com/content/ejhpharm/29/Suppl_1/A52.1.full.pdf","source":{"id":"https://openalex.org/S3012707348","display_name":"European Journal of Hospital Pharmacy","issn_l":"2047-9956","issn":["2047-9956","2047-9964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Section 4: Clinical pharmacy services","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291474593.pdf","grobid_xml":"https://content.openalex.org/works/W4291474593.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4293230032","https://openalex.org/W4220969524","https://openalex.org/W3012186458","https://openalex.org/W4408376252","https://openalex.org/W4291298336","https://openalex.org/W3208721718","https://openalex.org/W4385458993","https://openalex.org/W3117645128","https://openalex.org/W2966743773","https://openalex.org/W4390973992"],"abstract_inverted_index":{"Background":[0],"and":[1,16,50,87,112,132,190,213,237,264,305,312,319],"importance":[2],"Clostridioides":[3],"difficile":[4,100],"is":[5,28,45,72,333],"the":[6,22,60,66,78,91,151,178,191,203,210,217,261,270,280,283,315,339,352],"most":[7],"common":[8],"cause":[9],"of":[10,25,68,80,93,98,120,123,142,153,168,249,273,282,297,314,327,347,354,363,367],"infectious":[11],"diarrhoea":[12],"in":[13,47,59,82,95,103,109,166,177,310,338,351],"hospitalised":[14],"patients":[15,104,124,137,174,199,223,258,355],"causes":[17],"great":[18],"morbidity":[19],"due":[20],"to":[21,36,40,55,58,65,74,335],"high":[23,42],"percentage":[24,152,163],"recurrence.":[26],"Bezlotoxumab":[27],"a":[29,48,106,116,121,139],"monoclonal":[30],"antibody":[31],"against":[32],"toxin":[33],"B,":[34],"intended":[35],"prevent":[37],"relapse.":[38],"Due":[39,64],"its":[41],"cost,":[43],"it":[44,71],"used":[46,234],"population":[49],"under":[51],"conditions":[52],"slightly":[53],"different":[54,169],"those":[56],"referred":[57],"MODIFY":[61],"clinical":[62,154,341],"trials.":[63],"scarcity":[67],"real-life":[69],"studies,":[70],"necessary":[73],"collect":[75],"data":[76],"on":[77],"effectiveness":[79,92],"bezlotoxumab":[81,94,127,143,201,250,328],"daily":[83],"hospital":[84,108],"practice.":[85],"Aim":[86],"objectives":[88],"To":[89],"determine":[90],"preventing":[96],"recurrences":[97,245,348],"C.":[99],"infection":[101,295],"(CDI)":[102],"from":[105,279],"tertiary":[107],"Spain.":[110],"Material":[111],"methods":[113],"We":[114],"conducted":[115],"longitudinal,":[117],"retrospective":[118],"study":[119],"cohort":[122],"treated":[125],"with":[126,356],"between":[128],"2":[129],"August":[130],"2018":[131],"31":[133],"March":[134],"2021.":[135],"All":[136],"received":[138,200,225],"single":[140],"infusion":[141],"at":[144,227,324],"10":[145],"mg/kg.":[146],"The":[147,180,286,321,344],"main":[148,287],"variable":[149],"was":[150,164,183,195,293,330,349],"cure":[155],"within":[156,246],"12":[157,247,271],"weeks.":[158],"As":[159],"secondary":[160],"variables,":[161],"this":[162],"analysed":[165],"terms":[167],"risk":[170,288],"factors.":[171],"Results":[172],"52":[173],"were":[175,188,242,277,308],"included":[176],"study.":[179],"median":[181,192],"age":[182,301],"73.5":[184],"years,":[185],"32":[186,222],"(61.5%)":[187],"women":[189],"Charlson":[193],"index":[194],"5.16.":[196],"??":[197],"(42.9%)":[198],"during":[202,209,216,230,260,269],"first":[204,211],"CDI":[205],"episode,":[206],"22":[207],"(30.8%)":[208],"recurrence":[212,284,291,322],"14":[214],"(26.4%)":[215],"second":[218],"or":[219],"later":[220],"recurrences.":[221],"(61.54%)":[224],"vancomycin":[226,235],"standard":[228],"dose":[229],"recurrence,":[231],"16":[232],"(30.77%)":[233],"tapering":[236],"4":[238],"(7.69%)":[239],"fidaxomicin.":[240],"There":[241],"9":[243],"(18.4%)":[244],"weeks":[248,272],"infusion.":[251],"It":[252],"should":[253],"be":[254],"noted":[255],"that":[256,336],"6":[257],"died":[259],"inpatient":[262],"stay":[263],"3":[265,325],"others":[266],"did":[267],"so":[268,275],"follow-up,":[274],"they":[276],"excluded":[278],"calculation":[281],"ratio.":[285],"factor":[289],"for":[290],"identified":[292,350],"severe":[294,357],"(77.8%":[296],"recurrences)":[298],"followed":[299],"by":[300],"above":[302],"65":[303],"years":[304],"immunosuppression,":[306],"which":[307,332],"present":[309],"66.7%":[311],"44.4%":[313],"recurrences,":[316],"respectively.":[317],"Conclusion":[318],"relevance":[320],"ratio":[323],"months":[326],"administration":[329],"20.9%,":[331],"similar":[334],"found":[337],"pivotal":[340],"trials":[342],"(16.5%).":[343],"highest":[345],"prevalence":[346],"subgroup":[353],"CDI.":[358],"References":[359],"and/or":[360],"acknowledgements":[361],"Conflict":[362],"interest":[364,368],"No":[365],"conflict":[366]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-15T00:00:00"}
