{"id":"https://openalex.org/W4291335293","doi":"https://doi.org/10.1016/j.lpmope.2022.100030","title":"The remaining role and feasibility of detoxification in opioid addiction after 30 years of medication for opioid use disorder: A systematic review","display_name":"The remaining role and feasibility of detoxification in opioid addiction after 30 years of medication for opioid use disorder: A systematic review","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4291335293","doi":"https://doi.org/10.1016/j.lpmope.2022.100030"},"language":"en","primary_location":{"id":"doi:10.1016/j.lpmope.2022.100030","doi":"https://doi.org/10.1016/j.lpmope.2022.100030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lpmope.2022.100030","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590250422000084/pdf","source":{"id":"https://openalex.org/S4210239372","display_name":"La Presse M\u00e9dicale Open","issn_l":"2590-2504","issn":["2590-2504"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Presse M\u00e9dicale Open","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2590250422000084/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036004339","display_name":"Paolo Di Patrizio","orcid":"https://orcid.org/0000-0003-2412-1301","observed_orcids":["https://orcid.org/0000-0003-2412-1301"]},"institutions":[{"id":"https://openalex.org/I4387155006","display_name":"InterPsy","ror":"https://ror.org/0495mzm65","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387155006","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Paolo Di Patrizio","raw_affiliation_strings":["Director of General Practice Department, D\u00e9partement de m\u00e9decine G\u00e9n\u00e9rale, Faculty of Medicine, University of Lorraine, France","D\u00e9partement Grand Est de recherche en soins Primaires, Faculty of Medicine, University of Lorraine, France","EA 4432 Interpsy Laboratory, University of Lorraine, France","Nancy Psychotherapy Centre, Laxou, France"],"raw_orcid":"https://orcid.org/0000-0003-2412-1301","affiliations":[{"raw_affiliation_string":"Director of General Practice Department, D\u00e9partement de m\u00e9decine G\u00e9n\u00e9rale, Faculty of Medicine, University of Lorraine, France","institution_ids":["https://openalex.org/I90183372"]},{"raw_affiliation_string":"D\u00e9partement Grand Est de recherche en soins Primaires, Faculty of Medicine, University of Lorraine, France","institution_ids":["https://openalex.org/I90183372"]},{"raw_affiliation_string":"EA 4432 Interpsy Laboratory, University of Lorraine, France","institution_ids":["https://openalex.org/I4387155006","https://openalex.org/I90183372"]},{"raw_affiliation_string":"Nancy Psychotherapy Centre, Laxou, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010867137","display_name":"Christophe Clesse","orcid":"https://orcid.org/0000-0003-3042-0770","observed_orcids":["https://orcid.org/0000-0003-3042-0770"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christophe Clesse","raw_affiliation_strings":["Psychotherapist, research fellow, Queen Mary University of London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychotherapist, research fellow, Queen Mary University of London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040739168","display_name":"Laura Bernard","orcid":"https://orcid.org/0000-0002-3858-5783","observed_orcids":["https://orcid.org/0000-0002-3858-5783"]},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laura Bernard","raw_affiliation_strings":["Faculty of Psychology, University of Lorraine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Psychology, University of Lorraine, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023499346","display_name":"Martine Batt","orcid":"https://orcid.org/0000-0002-5091-9213","observed_orcids":["https://orcid.org/0000-0002-5091-9213"]},"institutions":[{"id":"https://openalex.org/I4387155006","display_name":"InterPsy","ror":"https://ror.org/0495mzm65","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387155006","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martine Batt","raw_affiliation_strings":["EA 4432 Interpsy Laboratory, University of Lorraine, France","Faculty of Psychology, University of Lorraine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA 4432 Interpsy Laboratory, University of Lorraine, France","institution_ids":["https://openalex.org/I4387155006","https://openalex.org/I90183372"]},{"raw_affiliation_string":"Faculty of Psychology, University of Lorraine, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111792421","display_name":"G. Kanny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I4387155006","display_name":"InterPsy","ror":"https://ror.org/0495mzm65","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387155006","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gis\u00e8le Kanny","raw_affiliation_strings":["D\u00e9partement de m\u00e9decine interne, CHRU de Nancy, France","EA 4432 Interpsy Laboratory, University of Lorraine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de m\u00e9decine interne, CHRU de Nancy, France","institution_ids":["https://openalex.org/I4210100260"]},{"raw_affiliation_string":"EA 4432 Interpsy Laboratory, University of Lorraine, France","institution_ids":["https://openalex.org/I4387155006","https://openalex.org/I90183372"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036004339"],"corresponding_institution_ids":["https://openalex.org/I4387155006","https://openalex.org/I90183372"],"apc_list":{"value":1710,"currency":"USD","value_usd":1710},"apc_paid":{"value":1710,"currency":"USD","value_usd":1710},"fwci":0.1649,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.21658508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"3","issue":null,"first_page":"100030","last_page":"100030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.7789999842643738},{"id":"https://openalex.org/keywords/opioid-detoxification","display_name":"opioid detoxification","score":0.8999999761581421},{"id":"https://openalex.org/keywords/opioid-withdrawal","display_name":"opioid withdrawal","score":0.7210000157356262},{"id":"https://openalex.org/keywords/replacement-therapy","display_name":"replacement therapy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.8690000176429749},{"id":"https://openalex.org/keywords/transcutaneous-electrical-acupoint-stimulation","display_name":"transcutaneous electrical acupoint stimulation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/12-step-programs","display_name":"12-step programs","score":0.9210000038146973},{"id":"https://openalex.org/keywords/narcotics-anonymous","display_name":"Narcotics Anonymous","score":0.800000011920929},{"id":"https://openalex.org/keywords/follow-up-care","display_name":"follow-up care","score":0.527999997138977},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.7820000052452087},{"id":"https://openalex.org/keywords/nursing-staff-training","display_name":"nursing staff training","score":0.7829999923706055},{"id":"https://openalex.org/keywords/abstinence","display_name":"abstinence","score":0.6570000052452087},{"id":"https://openalex.org/keywords/social-costs","display_name":"social costs","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.9701008796691895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6738553643226624},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.6622309684753418},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.5967356562614441},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.5007846355438232},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.45598533749580383},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.43361955881118774},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4309844374656677},{"id":"https://openalex.org/C124306116","wikidata":"https://www.wikidata.org/wiki/Q2512965","display_name":"Ambulatory care","level":3,"score":0.4299369752407074},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.42942094802856445},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.2564274072647095},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.19510674476623535},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08132022619247437},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lpmope.2022.100030","doi":"https://doi.org/10.1016/j.lpmope.2022.100030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lpmope.2022.100030","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590250422000084/pdf","source":{"id":"https://openalex.org/S4210239372","display_name":"La Presse M\u00e9dicale Open","issn_l":"2590-2504","issn":["2590-2504"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Presse M\u00e9dicale Open","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-04296582v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04296582v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"La Presse M\u00e9dicale Open, 2022, 3, pp.100030. ⟨10.1016/j.lpmope.2022.100030⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.lpmope.2022.100030","doi":"https://doi.org/10.1016/j.lpmope.2022.100030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lpmope.2022.100030","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590250422000084/pdf","source":{"id":"https://openalex.org/S4210239372","display_name":"La Presse M\u00e9dicale Open","issn_l":"2590-2504","issn":["2590-2504"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Presse M\u00e9dicale Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291335293.pdf","grobid_xml":"https://content.openalex.org/works/W4291335293.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1510703988","https://openalex.org/W1604489494","https://openalex.org/W1767669749","https://openalex.org/W1852873638","https://openalex.org/W1973888009","https://openalex.org/W1975776257","https://openalex.org/W1990743173","https://openalex.org/W1991369935","https://openalex.org/W2022264240","https://openalex.org/W2062971972","https://openalex.org/W2094931992","https://openalex.org/W2113589361","https://openalex.org/W2118130962","https://openalex.org/W2120030490","https://openalex.org/W2121821947","https://openalex.org/W2136714706","https://openalex.org/W2137633167","https://openalex.org/W2145092433","https://openalex.org/W2156325842","https://openalex.org/W2159558526","https://openalex.org/W2171397714","https://openalex.org/W2312438037","https://openalex.org/W2341168708","https://openalex.org/W2499185390","https://openalex.org/W2519105412","https://openalex.org/W2549631450","https://openalex.org/W2606264631","https://openalex.org/W2744082671","https://openalex.org/W2760696327","https://openalex.org/W2804283237","https://openalex.org/W2811466041","https://openalex.org/W2849276375","https://openalex.org/W2944263807","https://openalex.org/W2982461739","https://openalex.org/W2990648940","https://openalex.org/W3012261821","https://openalex.org/W3022903699","https://openalex.org/W4211145752","https://openalex.org/W4234458906","https://openalex.org/W4246429316","https://openalex.org/W4281264421","https://openalex.org/W4399625654","https://openalex.org/W6685146592"],"related_works":["https://openalex.org/W7165043359","https://openalex.org/W2625578722","https://openalex.org/W2166136560","https://openalex.org/W3121262223","https://openalex.org/W3171898288","https://openalex.org/W4281264421","https://openalex.org/W4251771636","https://openalex.org/W1967472403","https://openalex.org/W2500282627","https://openalex.org/W2121455553"],"abstract_inverted_index":{"In":[0],"last":[1,39],"thirty":[2],"years,":[3],"substitution":[4,200],"therapy":[5],"for":[6],"opiate-dependant":[7],"patients":[8,181,229],"has":[9,146],"been":[10],"widespread":[11],"in":[12,19,31,130,233],"general":[13,112],"practice":[14],"with":[15,142,157],"a":[16,96],"corresponding":[17],"decrease":[18],"detoxification":[20,27,156,168,183,194,217,226],"strategies.":[21],"Evaluate":[22],"the":[23,32,38,79,85,91,115,131,216],"remaining":[24],"role":[25],"of":[26,34,176,193,199,204,224],"and":[28,53,70,94,107,119,139,154,159,184,186,219],"its":[29],"feasibility":[30],"management":[33],"opioid":[35],"addiction":[36],"over":[37],"decade.":[40],"A":[41,202],"systematic":[42],"review":[43],"(PRISMA":[44],"criteria)":[45],"was":[46],"conducted":[47],"using":[48],"14":[49],"databases.":[50],"Both":[51],"English":[52],"French":[54],"keywords":[55],"(opioid,":[56],"withdrawal,":[57],"addiction,":[58],"detoxification)":[59],"were":[60,75,102],"used":[61],"to":[62,172,179],"find":[63],"research":[64],"papers":[65],"published":[66],"between":[67],"January":[68,71],"2010":[69],"2020.":[72],"The":[73,149,164,190,222],"data":[74],"exploited":[76],"by":[77,136,212],"applying":[78],"Synthesis":[80],"Without":[81],"Meta-analysis":[82],"protocol.":[83],"Of":[84],"282,865":[86],"screened":[87],"publications":[88],"identified":[89],"through":[90],"database":[92],"search,":[93],"following":[95],"bias":[97],"assessment,":[98],"11":[99],"quantitative":[100],"studies":[101],"selected":[103],"on":[104],"detoxification,":[105,210],"modalities":[106],"post-detoxification":[108],"support.":[109],"There":[110],"is":[111,195],"consensus":[113],"regarding":[114],"alpha2-adrenergic":[116],"drug":[117],"protocol":[118],"symptomatic":[120],"treatment.":[121],"Transcutaneous":[122],"electrical":[123],"acupoint":[124],"stimulation":[125],"alleviates":[126],"withdrawal":[127],"symptoms.":[128],"Involvement":[129],"Twelve":[132],"Step":[133],"program":[134],"recommended":[135],"Alcoholics":[137],"Anonymous":[138,141],"Narcotics":[140],"adapted":[143],"aftercare":[144],"accommodation":[145],"proved":[147],"effective.":[148],"results":[150],"gained":[151],"from":[152],"inpatient":[153],"outpatient":[155],"regular":[158],"prolonged":[160],"support":[161,173,180,214],"are":[162,169],"similar.":[163],"main":[165],"factors":[166],"facilitating":[167],"rapid":[170],"access":[171],"structures,":[174],"training":[175],"nursing":[177],"staff":[178],"during":[182,209],"post-detoxification,":[185],"age":[187],"(30-40":[188],"y.o.).":[189],"societal":[191],"cost":[192],"lower":[196],"than":[197],"that":[198],"therapy.":[201],"combination":[203],"primary":[205,239],"care,":[206],"psycho-social":[207],"intervention":[208],"followed":[211],"care":[213],"facilitates":[215],"process":[218],"long-term":[220],"abstinence.":[221],"promotion":[223],"opiate":[225],"among":[227],"eligible":[228],"must":[230],"be":[231],"encouraged":[232],"dedicated":[234],"medico-psychosocial":[235],"organisations":[236],"via":[237],"ambulatory":[238],"care.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-15T00:00:00"}