{"id":"https://openalex.org/W4291270784","doi":"https://doi.org/10.1016/b978-0-12-821618-7.00221-2","title":"CDK Inhibitors in Normal and Malignant Cells","display_name":"CDK Inhibitors in Normal and Malignant Cells","publication_year":2022,"publication_date":"2022-08-13","ids":{"openalex":"https://openalex.org/W4291270784","doi":"https://doi.org/10.1016/b978-0-12-821618-7.00221-2"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-821618-7.00221-2","doi":"https://doi.org/10.1016/b978-0-12-821618-7.00221-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-821618-7.00221-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Cell Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4309944387","display_name":"Encyclopedia of Cell Biology"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111922723","display_name":"Alexandra H. Besser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Besser","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044737202","display_name":"Joyce M. Slingerland","orcid":"https://orcid.org/0000-0003-1487-8554","observed_orcids":["https://orcid.org/0000-0003-1487-8554"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Slingerland","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL, United States","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"243","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.9739999771118164},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":1.0},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9879999756813049},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9800000190734863},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cell-motility-and-invasion","display_name":"cell motility and invasion","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.656000018119812},{"id":"https://openalex.org/keywords/targeted-therapy-response","display_name":"targeted therapy response","score":0.5360000133514404},{"id":"https://openalex.org/keywords/oncogenic-pathway-activation","display_name":"oncogenic pathway activation","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.877388596534729},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5739953517913818},{"id":"https://openalex.org/C2778298596","wikidata":"https://www.wikidata.org/wiki/Q17143494","display_name":"CDK inhibitor","level":5,"score":0.5649492740631104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5586627721786499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5264131426811218},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4727310240268707},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.4574029743671417},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4531068205833435},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4144141674041748},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41079115867614746},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3596610426902771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14162585139274597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05884909629821777}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-12-821618-7.00221-2","doi":"https://doi.org/10.1016/b978-0-12-821618-7.00221-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-821618-7.00221-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Cell Biology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":118,"referenced_works":["https://openalex.org/W169454248","https://openalex.org/W310321113","https://openalex.org/W1565041471","https://openalex.org/W1605269201","https://openalex.org/W1834547194","https://openalex.org/W1859252938","https://openalex.org/W1964742508","https://openalex.org/W1970430170","https://openalex.org/W1971233705","https://openalex.org/W1975324295","https://openalex.org/W1975825917","https://openalex.org/W1976369107","https://openalex.org/W1979946545","https://openalex.org/W1982108368","https://openalex.org/W1991517695","https://openalex.org/W1993702697","https://openalex.org/W1996413533","https://openalex.org/W1996926240","https://openalex.org/W1997073961","https://openalex.org/W1998770945","https://openalex.org/W2002405735","https://openalex.org/W2003907692","https://openalex.org/W2007772649","https://openalex.org/W2008474877","https://openalex.org/W2008789097","https://openalex.org/W2010938071","https://openalex.org/W2014462533","https://openalex.org/W2015519364","https://openalex.org/W2016153631","https://openalex.org/W2025935112","https://openalex.org/W2026004604","https://openalex.org/W2027558915","https://openalex.org/W2031682344","https://openalex.org/W2033156691","https://openalex.org/W2034277114","https://openalex.org/W2035532250","https://openalex.org/W2036817346","https://openalex.org/W2037611415","https://openalex.org/W2039284226","https://openalex.org/W2039818183","https://openalex.org/W2040412126","https://openalex.org/W2046577405","https://openalex.org/W2048315213","https://openalex.org/W2049085719","https://openalex.org/W2049283940","https://openalex.org/W2050551830","https://openalex.org/W2052022100","https://openalex.org/W2052032939","https://openalex.org/W2056495027","https://openalex.org/W2065494505","https://openalex.org/W2065891752","https://openalex.org/W2066267678","https://openalex.org/W2066700256","https://openalex.org/W2066848701","https://openalex.org/W2067613861","https://openalex.org/W2071266945","https://openalex.org/W2071275928","https://openalex.org/W2071734901","https://openalex.org/W2071870936","https://openalex.org/W2078050605","https://openalex.org/W2079777624","https://openalex.org/W2086773265","https://openalex.org/W2089218510","https://openalex.org/W2091729097","https://openalex.org/W2092967525","https://openalex.org/W2096890855","https://openalex.org/W2098157104","https://openalex.org/W2101076673","https://openalex.org/W2103732635","https://openalex.org/W2110511887","https://openalex.org/W2111750063","https://openalex.org/W2115279938","https://openalex.org/W2115847932","https://openalex.org/W2118040139","https://openalex.org/W2118782338","https://openalex.org/W2120064499","https://openalex.org/W2121619780","https://openalex.org/W2123408027","https://openalex.org/W2124565099","https://openalex.org/W2125143689","https://openalex.org/W2126610931","https://openalex.org/W2128705810","https://openalex.org/W2131847309","https://openalex.org/W2131954674","https://openalex.org/W2135687675","https://openalex.org/W2138314001","https://openalex.org/W2147242002","https://openalex.org/W2150170782","https://openalex.org/W2152398347","https://openalex.org/W2153056550","https://openalex.org/W2153281546","https://openalex.org/W2153488262","https://openalex.org/W2155147356","https://openalex.org/W2155454155","https://openalex.org/W2157033538","https://openalex.org/W2157330585","https://openalex.org/W2157540307","https://openalex.org/W2158865822","https://openalex.org/W2159023635","https://openalex.org/W2161378573","https://openalex.org/W2162262059","https://openalex.org/W2162741492","https://openalex.org/W2165439041","https://openalex.org/W2166529745","https://openalex.org/W2168675070","https://openalex.org/W2170331239","https://openalex.org/W2181478018","https://openalex.org/W2210620858","https://openalex.org/W2230896985","https://openalex.org/W2267718012","https://openalex.org/W2322060655","https://openalex.org/W4232123484","https://openalex.org/W6610839458","https://openalex.org/W6683387562","https://openalex.org/W6684782675","https://openalex.org/W6685196429","https://openalex.org/W6689205003","https://openalex.org/W7099811773"],"related_works":["https://openalex.org/W4319304236","https://openalex.org/W2249107744","https://openalex.org/W4237122597","https://openalex.org/W2049283940","https://openalex.org/W2414175864","https://openalex.org/W2991831049","https://openalex.org/W4236064824","https://openalex.org/W2026004604","https://openalex.org/W1813513289","https://openalex.org/W2423450923"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-14T00:00:00"}
