{"id":"https://openalex.org/W4291237996","doi":"https://doi.org/10.1007/s12035-022-02976-3","title":"Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review","display_name":"Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review","publication_year":2022,"publication_date":"2022-08-13","ids":{"openalex":"https://openalex.org/W4291237996","doi":"https://doi.org/10.1007/s12035-022-02976-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/35963926"},"language":"en","primary_location":{"id":"doi:10.1007/s12035-022-02976-3","doi":"https://doi.org/10.1007/s12035-022-02976-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12035-022-02976-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12035-022-02976-3.pdf","source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12035-022-02976-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012969863","display_name":"Andrea de Bartolomeis","orcid":"https://orcid.org/0000-0002-3188-5652","observed_orcids":["https://orcid.org/0000-0002-3188-5652","https://orcid.org/0000-0001-9266-280X"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Andrea de Bartolomeis","raw_affiliation_strings":["Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy. adebarto@unina.it","Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy. adebarto@unina.it","Laboratory of Molecular  and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy. adebarto@unina.it","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy. adebarto@unina.it","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Laboratory of Molecular  and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041378239","display_name":"Annarita Barone","orcid":"https://orcid.org/0000-0002-2751-5683","observed_orcids":["https://orcid.org/0000-0002-2751-5683"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annarita Barone","raw_affiliation_strings":["Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy","Laboratory of Molecular  and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Laboratory of Molecular  and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047370784","display_name":"Licia Vellucci","orcid":"https://orcid.org/0000-0001-5301-405X","observed_orcids":["https://orcid.org/0000-0001-5301-405X"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Licia Vellucci","raw_affiliation_strings":["Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy","Laboratory of Molecular  and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Laboratory of Molecular  and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077840701","display_name":"Benedetta Mazza","orcid":"https://orcid.org/0000-0002-3574-2325","observed_orcids":["https://orcid.org/0000-0002-3574-2325"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Benedetta Mazza","raw_affiliation_strings":["Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108216036","display_name":"Mark C. Austin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106969075","display_name":"Idaho State University","ror":"https://ror.org/0162z8b04","country_code":"US","type":"education","lineage":["https://openalex.org/I106969075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark C. Austin","raw_affiliation_strings":["Clinical Psychopharmacology Program, College of Pharmacy, Idaho State University (ISU), Pocatello, ID, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Psychopharmacology Program, College of Pharmacy, Idaho State University (ISU), Pocatello, ID, USA","institution_ids":["https://openalex.org/I106969075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048387587","display_name":"Felice Iasevoli","orcid":"https://orcid.org/0000-0002-7051-5013","observed_orcids":["https://orcid.org/0000-0002-7051-5013"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Felice Iasevoli","raw_affiliation_strings":["Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054945518","display_name":"Mariateresa Ciccarelli","orcid":"https://orcid.org/0000-0001-8944-414X","observed_orcids":["https://orcid.org/0000-0001-8944-414X"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariateresa Ciccarelli","raw_affiliation_strings":["Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy","Laboratory of Molecular  and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Laboratory of Molecular  and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012969863"],"corresponding_institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.8476,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.84782609,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"59","issue":"10","first_page":"6460","last_page":"6501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/dopamine-glutamate-interaction","display_name":"dopamine-glutamate interaction","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.8889999985694885},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"postsynaptic density","score":0.7269999980926514},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8199999928474426},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/maternal-immune-activation","display_name":"maternal immune activation","score":0.972000002861023},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasma-inflammatory-markers","display_name":"plasma inflammatory markers","score":0.7789999842643738},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.968999981880188},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7919999957084656},{"id":"https://openalex.org/keywords/antipsychotic-resistance","display_name":"antipsychotic resistance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.8140000104904175},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6793698072433472},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6243501305580139},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6197205185890198},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5822889804840088},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.49728110432624817},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4918968677520752},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.471321165561676},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.42189279198646545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3683513402938843},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3334583044052124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2662658095359802},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18158993124961853},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15694066882133484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14561069011688232}],"mesh":[{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s12035-022-02976-3","doi":"https://doi.org/10.1007/s12035-022-02976-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12035-022-02976-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12035-022-02976-3.pdf","source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},{"id":"pmid:35963926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35963926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular neurobiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9463235","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9463235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Neurobiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12035-022-02976-3","doi":"https://doi.org/10.1007/s12035-022-02976-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12035-022-02976-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12035-022-02976-3.pdf","source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309590","display_name":"Universit\u00e0 degli Studi di Napoli Federico II","ror":"https://ror.org/05290cv24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291237996.pdf","grobid_xml":"https://content.openalex.org/works/W4291237996.grobid-xml"},"referenced_works_count":325,"referenced_works":["https://openalex.org/W203709983","https://openalex.org/W756325778","https://openalex.org/W890438156","https://openalex.org/W969274875","https://openalex.org/W1515682008","https://openalex.org/W1524847211","https://openalex.org/W1568207206","https://openalex.org/W1606923904","https://openalex.org/W1621815751","https://openalex.org/W1699799016","https://openalex.org/W1757694062","https://openalex.org/W1785970105","https://openalex.org/W1839257070","https://openalex.org/W1865026600","https://openalex.org/W1871930545","https://openalex.org/W1879552006","https://openalex.org/W1965530749","https://openalex.org/W1967449806","https://openalex.org/W1968536001","https://openalex.org/W1968910133","https://openalex.org/W1970164806","https://openalex.org/W1972578501","https://openalex.org/W1973461459","https://openalex.org/W1973478979","https://openalex.org/W1973794580","https://openalex.org/W1974003946","https://openalex.org/W1974251035","https://openalex.org/W1975682905","https://openalex.org/W1975952150","https://openalex.org/W1977917668","https://openalex.org/W1978815393","https://openalex.org/W1980126775","https://openalex.org/W1980302503","https://openalex.org/W1980789245","https://openalex.org/W1981164474","https://openalex.org/W1982656322","https://openalex.org/W1983719168","https://openalex.org/W1984715501","https://openalex.org/W1985719886","https://openalex.org/W1987593166","https://openalex.org/W1988220982","https://openalex.org/W1988487044","https://openalex.org/W1988668472","https://openalex.org/W1990999239","https://openalex.org/W1994155561","https://openalex.org/W1995230642","https://openalex.org/W1996300729","https://openalex.org/W1997950587","https://openalex.org/W1998679999","https://openalex.org/W2000304680","https://openalex.org/W2002380965","https://openalex.org/W2004030802","https://openalex.org/W2004078557","https://openalex.org/W2006955019","https://openalex.org/W2007305673","https://openalex.org/W2009527574","https://openalex.org/W2009832071","https://openalex.org/W2009895267","https://openalex.org/W2010925631","https://openalex.org/W2012356934","https://openalex.org/W2012860638","https://openalex.org/W2014780789","https://openalex.org/W2016735402","https://openalex.org/W2018135697","https://openalex.org/W2020651859","https://openalex.org/W2020835355","https://openalex.org/W2021087861","https://openalex.org/W2022180773","https://openalex.org/W2022506737","https://openalex.org/W2022654189","https://openalex.org/W2022755347","https://openalex.org/W2022809683","https://openalex.org/W2022949524","https://openalex.org/W2023257087","https://openalex.org/W2024028366","https://openalex.org/W2025011978","https://openalex.org/W2028222586","https://openalex.org/W2029027341","https://openalex.org/W2029815010","https://openalex.org/W2030765669","https://openalex.org/W2030851291","https://openalex.org/W2031337229","https://openalex.org/W2031405035","https://openalex.org/W2032023453","https://openalex.org/W2032804593","https://openalex.org/W2033283555","https://openalex.org/W2033617297","https://openalex.org/W2035775618","https://openalex.org/W2035859458","https://openalex.org/W2038092706","https://openalex.org/W2039047987","https://openalex.org/W2039469943","https://openalex.org/W2040268226","https://openalex.org/W2040789766","https://openalex.org/W2041576587","https://openalex.org/W2042755650","https://openalex.org/W2043435297","https://openalex.org/W2045493616","https://openalex.org/W2045853555","https://openalex.org/W2045909419","https://openalex.org/W2046900303","https://openalex.org/W2050923395","https://openalex.org/W2055292959","https://openalex.org/W2055466946","https://openalex.org/W2058728768","https://openalex.org/W2058934183","https://openalex.org/W2059619057","https://openalex.org/W2060443295","https://openalex.org/W2062239841","https://openalex.org/W2062808587","https://openalex.org/W2062815109","https://openalex.org/W2063056653","https://openalex.org/W2063393311","https://openalex.org/W2063619823","https://openalex.org/W2064118110","https://openalex.org/W2064622297","https://openalex.org/W2066738717","https://openalex.org/W2067494870","https://openalex.org/W2068549596","https://openalex.org/W2068766837","https://openalex.org/W2069281265","https://openalex.org/W2072233684","https://openalex.org/W2072799517","https://openalex.org/W2073144071","https://openalex.org/W2079254246","https://openalex.org/W2079322979","https://openalex.org/W2081653475","https://openalex.org/W2082535880","https://openalex.org/W2084072056","https://openalex.org/W2084588595","https://openalex.org/W2085234560","https://openalex.org/W2085498887","https://openalex.org/W2089412776","https://openalex.org/W2089627897","https://openalex.org/W2090271911","https://openalex.org/W2090625429","https://openalex.org/W2091932664","https://openalex.org/W2092473589","https://openalex.org/W2095340735","https://openalex.org/W2095689910","https://openalex.org/W2098234649","https://openalex.org/W2098597355","https://openalex.org/W2102178526","https://openalex.org/W2102796622","https://openalex.org/W2104401681","https://openalex.org/W2105035544","https://openalex.org/W2108598556","https://openalex.org/W2108794450","https://openalex.org/W2110726313","https://openalex.org/W2113207193","https://openalex.org/W2116679423","https://openalex.org/W2118213304","https://openalex.org/W2120003285","https://openalex.org/W2121301324","https://openalex.org/W2121637331","https://openalex.org/W2121815237","https://openalex.org/W2122697202","https://openalex.org/W2124792922","https://openalex.org/W2125238755","https://openalex.org/W2125531274","https://openalex.org/W2126741688","https://openalex.org/W2127205775","https://openalex.org/W2129031013","https://openalex.org/W2131932927","https://openalex.org/W2133621398","https://openalex.org/W2139161910","https://openalex.org/W2140035683","https://openalex.org/W2142987488","https://openalex.org/W2143217444","https://openalex.org/W2145021390","https://openalex.org/W2146264275","https://openalex.org/W2146809691","https://openalex.org/W2147372806","https://openalex.org/W2151012511","https://openalex.org/W2151594453","https://openalex.org/W2153129892","https://openalex.org/W2154663864","https://openalex.org/W2154965665","https://openalex.org/W2159109510","https://openalex.org/W2159428631","https://openalex.org/W2161527093","https://openalex.org/W2164051789","https://openalex.org/W2164172573","https://openalex.org/W2165964582","https://openalex.org/W2166043067","https://openalex.org/W2167272363","https://openalex.org/W2168408561","https://openalex.org/W2168768495","https://openalex.org/W2169079754","https://openalex.org/W2170260565","https://openalex.org/W2170561948","https://openalex.org/W2171149822","https://openalex.org/W2171832535","https://openalex.org/W2176596376","https://openalex.org/W2208839622","https://openalex.org/W2219458178","https://openalex.org/W2234053937","https://openalex.org/W2239411622","https://openalex.org/W2254734101","https://openalex.org/W2255138985","https://openalex.org/W2258502568","https://openalex.org/W2261355986","https://openalex.org/W2288923216","https://openalex.org/W2295670844","https://openalex.org/W2295874056","https://openalex.org/W2296156098","https://openalex.org/W2314634699","https://openalex.org/W2324251075","https://openalex.org/W2334244908","https://openalex.org/W2335196723","https://openalex.org/W2343167511","https://openalex.org/W2343430620","https://openalex.org/W2409273775","https://openalex.org/W2415131480","https://openalex.org/W2493699314","https://openalex.org/W2529708574","https://openalex.org/W2533914879","https://openalex.org/W2534869317","https://openalex.org/W2546857529","https://openalex.org/W2549211016","https://openalex.org/W2582832945","https://openalex.org/W2587178939","https://openalex.org/W2592490726","https://openalex.org/W2592865134","https://openalex.org/W2603460853","https://openalex.org/W2605804632","https://openalex.org/W2605908960","https://openalex.org/W2613880574","https://openalex.org/W2619504931","https://openalex.org/W2622488119","https://openalex.org/W2722712192","https://openalex.org/W2733966599","https://openalex.org/W2737645448","https://openalex.org/W2738830741","https://openalex.org/W2742114583","https://openalex.org/W2743499986","https://openalex.org/W2753593979","https://openalex.org/W2765391558","https://openalex.org/W2768553970","https://openalex.org/W2789018622","https://openalex.org/W2790000715","https://openalex.org/W2792340030","https://openalex.org/W2799919475","https://openalex.org/W2803065697","https://openalex.org/W2809185781","https://openalex.org/W2809453362","https://openalex.org/W2811102313","https://openalex.org/W2834652095","https://openalex.org/W2884020101","https://openalex.org/W2886764984","https://openalex.org/W2888647009","https://openalex.org/W2892238272","https://openalex.org/W2892433402","https://openalex.org/W2892897550","https://openalex.org/W2895892932","https://openalex.org/W2896544938","https://openalex.org/W2898335363","https://openalex.org/W2900366804","https://openalex.org/W2909790138","https://openalex.org/W2911701742","https://openalex.org/W2920576114","https://openalex.org/W2921277284","https://openalex.org/W2921715866","https://openalex.org/W2922933095","https://openalex.org/W2923483102","https://openalex.org/W2927195072","https://openalex.org/W2929017669","https://openalex.org/W2939505143","https://openalex.org/W2946508416","https://openalex.org/W2949039677","https://openalex.org/W2954449729","https://openalex.org/W2969797731","https://openalex.org/W2970478205","https://openalex.org/W2970759956","https://openalex.org/W2980137384","https://openalex.org/W2980542075","https://openalex.org/W2989233097","https://openalex.org/W2990734695","https://openalex.org/W2997486288","https://openalex.org/W2997938254","https://openalex.org/W2998882607","https://openalex.org/W3005761959","https://openalex.org/W3007414154","https://openalex.org/W3011933438","https://openalex.org/W3012426459","https://openalex.org/W3014643812","https://openalex.org/W3020213801","https://openalex.org/W3020719306","https://openalex.org/W3024472781","https://openalex.org/W3028887807","https://openalex.org/W3033738615","https://openalex.org/W3081365535","https://openalex.org/W3081448604","https://openalex.org/W3086828095","https://openalex.org/W3093181376","https://openalex.org/W3094393488","https://openalex.org/W3112457725","https://openalex.org/W3128373070","https://openalex.org/W3131982609","https://openalex.org/W3133745080","https://openalex.org/W3134867462","https://openalex.org/W3136955135","https://openalex.org/W3137546921","https://openalex.org/W3159635887","https://openalex.org/W3164459432","https://openalex.org/W3164699423","https://openalex.org/W3178376238","https://openalex.org/W3182714136","https://openalex.org/W3186792747","https://openalex.org/W3187832372","https://openalex.org/W3202917511","https://openalex.org/W3209008035","https://openalex.org/W3213228399","https://openalex.org/W3216009504","https://openalex.org/W3216918706","https://openalex.org/W3217448373","https://openalex.org/W4205145656","https://openalex.org/W4205161454","https://openalex.org/W4206965694","https://openalex.org/W4212952892","https://openalex.org/W4213436284","https://openalex.org/W4214925284","https://openalex.org/W4220697223","https://openalex.org/W4220806019","https://openalex.org/W4246854168"],"related_works":["https://openalex.org/W4390463473","https://openalex.org/W4221075899","https://openalex.org/W2807379694","https://openalex.org/W163337889","https://openalex.org/W2094568064","https://openalex.org/W2093078804","https://openalex.org/W2053807370","https://openalex.org/W2076034638","https://openalex.org/W1974963742","https://openalex.org/W2019163442"],"abstract_inverted_index":{"Evidence":[0],"from":[1],"clinical,":[2],"preclinical,":[3],"and":[4,23,27,37,71,77,104,121,129,145,154,175,207],"post-mortem":[5],"studies":[6,136],"supports":[7],"the":[8,17,20,33,38,48,63,99,125,212,218],"inflammatory/immune":[9,222],"hypothesis":[10],"of":[11,30,40,51,110,165,215,236],"schizophrenia":[12,31,116,143,196,237],"pathogenesis.":[13],"Less":[14],"evident":[15],"is":[16,87,131],"link":[18,126,219],"between":[19,127,220],"inflammatory":[21,90,112,190],"background":[22],"two":[24],"well-recognized":[25],"functional":[26,208],"structural":[28],"findings":[29,65],"pathophysiology:":[32],"dopamine-glutamate":[34],"aberrant":[35,68],"interaction":[36],"alteration":[39,164],"dendritic":[41],"spines":[42],"architecture,":[43],"both":[44],"believed":[45],"to":[46,61,96,182,199,211,241,246],"be":[47,97],"\"quantal\"":[49],"elements":[50],"cortical-subcortical":[52],"dysfunctional":[53],"network.":[54],"In":[55,160],"this":[56],"systematic":[57],"review,":[58],"we":[59],"tried":[60],"capture":[62],"major":[64],"linking":[66],"inflammation,":[67],"glutamate-dopamine":[69],"interaction,":[70],"post-synaptic":[72,166],"changes":[73],"under":[74],"a":[75,81,108,185],"direct":[76],"inverse":[78],"translational":[79],"perspective,":[80],"paramount":[82],"picture":[83],"that":[84,238],"at":[85,138],"present":[86],"lacking.":[88],"The":[89],"effects":[91],"on":[92],"dopaminergic":[93],"function":[94],"appear":[95],"bidirectional:":[98],"inflammation":[100,128],"influences":[101],"dopamine":[102,105],"release,":[103],"acts":[106],"as":[107,118],"regulator":[109],"discrete":[111],"processes":[113],"involved":[114],"in":[115,142,188,195],"such":[117],"dysregulated":[119],"interleukin":[120],"kynurenine":[122],"pathways.":[123],"Furthermore,":[124],"glutamate":[130,152],"strongly":[132],"supported":[133],"by":[134],"clinical":[135],"aimed":[137],"exploring":[139],"overactive":[140],"microglia":[141],"patients":[144,197],"maternal":[146],"immune":[147],"activation":[148],"models,":[149],"indicating":[150],"impaired":[151],"regulation":[153],"reduced":[155,204],"N-methyl-D-aspartate":[156],"receptor":[157],"(NMDAR)":[158],"function.":[159],"addition,":[161],"an":[162],"inflammatory/immune-induced":[163],"density":[167],"scaffold":[168],"proteins,":[169],"crucial":[170],"for":[171,233],"downstream":[172],"NMDAR":[173],"signaling":[174],"synaptic":[176],"efficacy,":[177],"has":[178,192],"been":[179,193],"demonstrated.":[180],"According":[181],"these":[183],"findings,":[184],"significant":[186],"increase":[187],"plasma":[189],"markers":[191],"found":[194],"compared":[198],"healthy":[200],"controls,":[201],"associated":[202],"with":[203],"cortical":[205],"integrity":[206],"connectivity,":[209],"relevant":[210,225],"cognitive":[213],"deficit":[214],"schizophrenia.":[216],"Finally,":[217],"altered":[221],"responses":[223],"raises":[224],"questions":[226],"regarding":[227],"potential":[228],"new":[229],"therapeutic":[230],"strategies":[231],"specifically":[232],"those":[234],"forms":[235],"are":[239],"resistant":[240],"canonical":[242],"antipsychotics":[243],"or":[244],"unresponsive":[245],"clozapine.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":30},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}