{"id":"https://openalex.org/W4291197745","doi":"https://doi.org/10.1002/pro.4403","title":"Dynamic regulation of Zn( II ) sequestration by calgranulin C","display_name":"Dynamic regulation of Zn( II ) sequestration by calgranulin C","publication_year":2022,"publication_date":"2022-08-13","ids":{"openalex":"https://openalex.org/W4291197745","doi":"https://doi.org/10.1002/pro.4403","pmid":"https://pubmed.ncbi.nlm.nih.gov/36367084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9650546"},"language":"en","primary_location":{"id":"doi:10.1002/pro.4403","doi":"https://doi.org/10.1002/pro.4403","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pro.4403","pdf_url":null,"source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9650546","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100391139","display_name":"Qian Wang","orcid":"https://orcid.org/0000-0003-1109-7699","observed_orcids":["https://orcid.org/0000-0003-1109-7699"]},"institutions":[{"id":"https://openalex.org/I142393192","display_name":"College of Staten Island","ror":"https://ror.org/02p179j44","country_code":"US","type":"education","lineage":["https://openalex.org/I142393192"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Wang","raw_affiliation_strings":["Department of Chemistry, College of Staten Island, City University of New York, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0003-1109-7699","affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Staten Island, City University of New York, New York, New York, USA","institution_ids":["https://openalex.org/I142393192","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046071334","display_name":"Deniz Kuci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142393192","display_name":"College of Staten Island","ror":"https://ror.org/02p179j44","country_code":"US","type":"education","lineage":["https://openalex.org/I142393192"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deniz Kuci","raw_affiliation_strings":["Department of Chemistry, College of Staten Island, City University of New York, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Staten Island, City University of New York, New York, New York, USA","institution_ids":["https://openalex.org/I142393192","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000660156","display_name":"Shibani Bhattacharya","orcid":"https://orcid.org/0000-0002-7706-9167","observed_orcids":["https://orcid.org/0000-0002-7706-9167"]},"institutions":[{"id":"https://openalex.org/I4210096322","display_name":"New York Structural Biology Center","ror":"https://ror.org/00new7409","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210096322"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shibani Bhattacharya","raw_affiliation_strings":["New York Structural Biology Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-7706-9167","affiliations":[{"raw_affiliation_string":"New York Structural Biology Center, New York, New York, USA","institution_ids":["https://openalex.org/I4210096322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056514842","display_name":"Jodi A. Hadden\u2010Perilla","orcid":"https://orcid.org/0000-0003-4685-8291","observed_orcids":["https://orcid.org/0000-0003-4685-8291"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jodi A. Hadden\u2010Perilla","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA"],"raw_orcid":"https://orcid.org/0000-0003-4685-8291","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007977669","display_name":"Rupal Gupta","orcid":"https://orcid.org/0000-0001-8637-6129","observed_orcids":["https://orcid.org/0000-0001-8637-6129"]},"institutions":[{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I142393192","display_name":"College of Staten Island","ror":"https://ror.org/02p179j44","country_code":"US","type":"education","lineage":["https://openalex.org/I142393192"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rupal Gupta","raw_affiliation_strings":["Department of Chemistry, College of Staten Island, City University of New York, New York, New York, USA","Ph.D. Programs in Biochemistry and Chemistry, The Graduate Center of the City University of New York, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-8637-6129","affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Staten Island, City University of New York, New York, New York, USA","institution_ids":["https://openalex.org/I142393192","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Ph.D. Programs in Biochemistry and Chemistry, The Graduate Center of the City University of New York, New York, New York, USA","institution_ids":["https://openalex.org/I121847817","https://openalex.org/I174216632"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000660156","https://openalex.org/A5007977669","https://openalex.org/A5056514842"],"corresponding_institution_ids":["https://openalex.org/I121847817","https://openalex.org/I142393192","https://openalex.org/I174216632","https://openalex.org/I4210096322","https://openalex.org/I86501945"],"apc_list":{"value":3950,"currency":"USD","value_usd":3950},"apc_paid":null,"fwci":0.2437,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.41175244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"9","first_page":"e4403","last_page":"e4403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.241799995303154,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100a12","display_name":"S100A12","score":0.9990000128746033},{"id":"https://openalex.org/keywords/zinc-sequestration","display_name":"zinc sequestration","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ef-hand-motifs","display_name":"EF-hand motifs","score":0.6940000057220459},{"id":"https://openalex.org/keywords/calcium-binding","display_name":"calcium binding","score":0.9039999842643738},{"id":"https://openalex.org/keywords/conformational-exchange","display_name":"conformational exchange","score":0.7889999747276306},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7347272038459778},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6145392656326294},{"id":"https://openalex.org/C34742353","wikidata":"https://www.wikidata.org/wiki/Q842015","display_name":"Microsecond","level":2,"score":0.563599169254303},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.42990121245384216},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4169155955314636},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3239513039588928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21547681093215942},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.11384332180023193},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10666322708129883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08792877197265625},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020832","descriptor_name":"EF Hand Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039841","descriptor_name":"Leukocyte L1 Antigen Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/pro.4403","doi":"https://doi.org/10.1002/pro.4403","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pro.4403","pdf_url":null,"source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9650546","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9650546","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:36367084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36367084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"},{"id":"pmh:oai:udspace.udel.edu:19716/31287","doi":null,"is_oa":true,"landing_page_url":"https://udspace.udel.edu/handle/19716/31287","pdf_url":"https://udspace.udel.edu/bitstreams/8553d43f-a805-4af7-9bb6-a750c3aa23e0/download","source":{"id":"https://openalex.org/S4377196565","display_name":"Library, Museums and Press - UDSpace (University of Delaware)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86501945","host_organization_name":"University of Delaware","host_organization_lineage":["https://openalex.org/I86501945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9650546","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9650546","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1783228025","display_name":"Center on Macromolecular Dynamics by NMR Spectroscopy","funder_award_id":"P41GM118302","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2808982272","display_name":"Interdependence of Antimicrobial and Pro-inflammatory Activities Mediated by S100A12 in the Innate Immune Response","funder_award_id":"R15GM131338","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3037964080","display_name":"Discovery of Chemical Probes and Therapeutic Leads, Phase II","funder_award_id":"P20GM104316","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3620842080","display_name":null,"funder_award_id":"GM131338","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000154739","display_name":null,"funder_award_id":"GM118302","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000875138","display_name":"RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)","funder_award_id":"RM1GM145397","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320309102","display_name":"City University of New York","ror":"https://ror.org/00453a208"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W167277884","https://openalex.org/W205642993","https://openalex.org/W1489910389","https://openalex.org/W1542648807","https://openalex.org/W1601964977","https://openalex.org/W1853529910","https://openalex.org/W1888391017","https://openalex.org/W1964339096","https://openalex.org/W1964818207","https://openalex.org/W1974956783","https://openalex.org/W1976499671","https://openalex.org/W1979826536","https://openalex.org/W1981159786","https://openalex.org/W1987528091","https://openalex.org/W1987816685","https://openalex.org/W1996859443","https://openalex.org/W1997387109","https://openalex.org/W1999296295","https://openalex.org/W1999613945","https://openalex.org/W2000809907","https://openalex.org/W2001822779","https://openalex.org/W2011005794","https://openalex.org/W2018045909","https://openalex.org/W2029667189","https://openalex.org/W2040062153","https://openalex.org/W2047695660","https://openalex.org/W2048822589","https://openalex.org/W2050341653","https://openalex.org/W2054191418","https://openalex.org/W2056229694","https://openalex.org/W2082439356","https://openalex.org/W2083144176","https://openalex.org/W2097985410","https://openalex.org/W2110249446","https://openalex.org/W2123681603","https://openalex.org/W2127888335","https://openalex.org/W2129305902","https://openalex.org/W2132629607","https://openalex.org/W2133034601","https://openalex.org/W2153066330","https://openalex.org/W2154915448","https://openalex.org/W2157045527","https://openalex.org/W2164356619","https://openalex.org/W2165565773","https://openalex.org/W2169821755","https://openalex.org/W2223120317","https://openalex.org/W2295327469","https://openalex.org/W2311509164","https://openalex.org/W2313116527","https://openalex.org/W2332712348","https://openalex.org/W2333047204","https://openalex.org/W2404280981","https://openalex.org/W2609912642","https://openalex.org/W2621084800","https://openalex.org/W2738606079","https://openalex.org/W2809675229","https://openalex.org/W2940293665","https://openalex.org/W2951531210","https://openalex.org/W2994806190","https://openalex.org/W2996803842","https://openalex.org/W3030350434","https://openalex.org/W3063437788","https://openalex.org/W3093939119","https://openalex.org/W4232031254","https://openalex.org/W7073644269"],"related_works":["https://openalex.org/W3019475159","https://openalex.org/W2024427337","https://openalex.org/W2994806190","https://openalex.org/W1517690457","https://openalex.org/W4414356332","https://openalex.org/W1601964977","https://openalex.org/W109442298","https://openalex.org/W7120468579","https://openalex.org/W1888391017","https://openalex.org/W2056762578"],"abstract_inverted_index":{"Abstract":[0],"Calgranulin":[1],"C":[2],"performs":[3],"antimicrobial":[4,172],"activity":[5,173],"in":[6,85,96,124],"the":[7,20,50,86,97,101,104,118,148,171],"human":[8],"immune":[9],"response":[10],"by":[11,58,157],"sequestering":[12],"Zn(II).":[13],"This":[14,79],"biological":[15],"function":[16],"is":[17],"afforded":[18],"with":[19],"aid":[21],"of":[22,32,52,55,120,134,140,174],"two":[23],"structurally":[24],"distinct":[25],"Ca(II)\u2010binding":[26],"EF":[27,106,164],"hand":[28],"motifs,":[29],"wherein":[30],"one":[31],"which":[33,158],"bears":[34],"an":[35],"unusual":[36],"amino":[37],"acid":[38],"sequence.":[39],"Here,":[40],"we":[41,66],"utilize":[42],"solution":[43],"state":[44,73,88],"NMR":[45],"relaxation":[46],"measurements":[47],"to":[48,93,161],"investigate":[49],"mechanism":[51,156],"Ca(II)\u2010modulated":[53],"enhancement":[54],"Zn(II)":[56,149],"sequestration":[57],"calgranulin":[59,175],"C.":[60,176],"Using":[61],"C13/N15":[62],"CPMG":[63],"dispersion":[64],"experiments":[65],"have":[67],"measured":[68],"pH\u2010dependent":[69,121],"major":[70],"and":[71,89,100,142,169],"minor":[72],"populations":[74],"exchanging":[75],"on":[76],"micro\u2010to\u2010millisecond":[77],"timescale.":[78],"conformational":[80],"exchange":[81],"takes":[82],"place":[83],"exclusively":[84],"Ca(II)\u2010bound":[87],"can":[90],"be":[91],"mapped":[92],"residues":[94],"located":[95],"EF\u2010I":[98],"loop":[99,165],"linker":[102],"between":[103],"tandem":[105],"hands.":[107],"Molecular":[108],"dynamics":[109],"(MD)":[110],"simulations":[111],"spanning":[112],"nano\u2010to\u2010microsecond":[113],"timescale":[114],"offer":[115],"insights":[116],"into":[117],"role":[119],"electrostatic":[122],"interactions":[123],"EF\u2010hand":[125],"dynamics.":[126],"Our":[127],"results":[128],"suggest":[129],"a":[130,138,154,162],"pH\u2010regulated":[131],"dynamic":[132],"equilibrium":[133],"conformations":[135],"that":[136],"explore":[137],"range":[139],"\u201cclosed\u201d":[141],"partially":[143],"\u201copen\u201d":[144],"sidechain":[145],"configurations":[146],"within":[147],"binding":[150,160],"site.":[151],"We":[152],"propose":[153],"novel":[155],"Ca(II)":[159],"non\u2010canonical":[163],"regulates":[166],"its":[167],"flexibility":[168],"tunes":[170]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-08-13T00:00:00"}