{"id":"https://openalex.org/W4291148462","doi":"https://doi.org/10.1111/adb.13223","title":"Betel quid: New insights into an ancient addiction","display_name":"Betel quid: New insights into an ancient addiction","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4291148462","doi":"https://doi.org/10.1111/adb.13223","pmid":"https://pubmed.ncbi.nlm.nih.gov/36001424","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9552247"},"language":"en","primary_location":{"id":"doi:10.1111/adb.13223","doi":"https://doi.org/10.1111/adb.13223","is_oa":false,"landing_page_url":"https://doi.org/10.1111/adb.13223","pdf_url":null,"source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9552247","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060252649","display_name":"Clare A. Stokes","orcid":"https://orcid.org/0000-0002-4076-5361","observed_orcids":["https://orcid.org/0000-0002-4076-5361"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clare Stokes","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057217712","display_name":"Jos\u00e9 A. Pino","orcid":"https://orcid.org/0000-0002-1542-0660","observed_orcids":["https://orcid.org/0000-0002-1542-0660"]},"institutions":[{"id":"https://openalex.org/I201487725","display_name":"University of Atacama","ror":"https://ror.org/022yres73","country_code":"CL","type":"education","lineage":["https://openalex.org/I201487725"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Jose A. Pino","raw_affiliation_strings":["Department of Medicine, School of Medicine University of Atacama  Copiap\u00f3 Chile"],"raw_orcid":"https://orcid.org/0000-0002-1542-0660","affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine University of Atacama  Copiap\u00f3 Chile","institution_ids":["https://openalex.org/I201487725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022009265","display_name":"D. Walker Hagan","orcid":"https://orcid.org/0000-0002-8679-1995","observed_orcids":["https://orcid.org/0000-0002-8679-1995"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Walker Hagan","raw_affiliation_strings":["Department of Biomedical Engineering University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052902495","display_name":"Gonzalo E. Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gonzalo E. Torres","raw_affiliation_strings":["Department of Molecular, Cellular, and Biomedical Sciences, City University of New York School of Medicine at City College, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Biomedical Sciences, City University of New York School of Medicine at City College, New York, New York, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030187984","display_name":"Edward A. Phelps","orcid":"https://orcid.org/0000-0001-8666-805X","observed_orcids":["https://orcid.org/0000-0001-8666-805X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward A. Phelps","raw_affiliation_strings":["Department of Biomedical Engineering University of Florida, Gainesville, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0001-8666-805X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063185042","display_name":"Nicole A. Horenstein","orcid":"https://orcid.org/0000-0001-7505-1230","observed_orcids":["https://orcid.org/0000-0001-7505-1230"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole A. Horenstein","raw_affiliation_strings":["Department of Chemistry, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077039646","display_name":"Roger L. Papke","orcid":"https://orcid.org/0000-0002-4468-8658","observed_orcids":["https://orcid.org/0000-0002-4468-8658"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roger L. Papke","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0002-4468-8658","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5077039646"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":4050,"currency":"USD","value_usd":4050},"apc_paid":null,"fwci":3.1883,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.9196515,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"5","first_page":"e13223","last_page":"e13223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.350600004196167,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.350600004196167,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.30000001192092896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.1559000015258789,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betel-quid","display_name":"betel quid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/areca-nut","display_name":"areca nut","score":0.9490000009536743},{"id":"https://openalex.org/keywords/arecoline","display_name":"arecoline","score":0.9179999828338623},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.5450000166893005},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9169999957084656},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gaba-receptors","display_name":"GABA receptors","score":0.968999981880188},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.9229999780654907},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.9990000128746033},{"id":"https://openalex.org/keywords/psychoactive-substances","display_name":"psychoactive substances","score":0.7580000162124634},{"id":"https://openalex.org/keywords/oral-cancer-risk","display_name":"oral cancer risk","score":0.7210000157356262},{"id":"https://openalex.org/keywords/oral-diseases","display_name":"oral diseases","score":0.6710000038146973},{"id":"https://openalex.org/keywords/physical-dependence","display_name":"physical dependence","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2781277053","wikidata":"https://www.wikidata.org/wiki/Q423515","display_name":"Arecoline","level":4,"score":0.9166887998580933},{"id":"https://openalex.org/C2779741799","wikidata":"https://www.wikidata.org/wiki/Q157289","display_name":"Areca","level":3,"score":0.9124942421913147},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6716095805168152},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5860608816146851},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.5060383677482605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3650423288345337},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.3538537323474884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26964759826660156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24465912580490112},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.244014173746109},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21286094188690186},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16039374470710754},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C206391251","wikidata":"https://www.wikidata.org/wiki/Q1186738","display_name":"Nut","level":2,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001114","descriptor_name":"Areca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001115","descriptor_name":"Arecoline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/adb.13223","doi":"https://doi.org/10.1111/adb.13223","is_oa":false,"landing_page_url":"https://doi.org/10.1111/adb.13223","pdf_url":null,"source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},{"id":"pmid:36001424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36001424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9552247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9552247","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Addict Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9552247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9552247","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Addict Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4321876468","display_name":null,"funder_award_id":"GM57481","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5094043252","display_name":"Targeting of Alpha7 nAChR for therapeutic effects","funder_award_id":"R01GM057481","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000877143","display_name":"Mechanism and dynamics of islet GABA signaling","funder_award_id":"R01DK124267","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W150861114","https://openalex.org/W1481700503","https://openalex.org/W1922357690","https://openalex.org/W1934459076","https://openalex.org/W1978891587","https://openalex.org/W1984039810","https://openalex.org/W1999957169","https://openalex.org/W2001097084","https://openalex.org/W2004330896","https://openalex.org/W2006726629","https://openalex.org/W2011106578","https://openalex.org/W2015508129","https://openalex.org/W2032251095","https://openalex.org/W2033982388","https://openalex.org/W2037646583","https://openalex.org/W2040720735","https://openalex.org/W2049996304","https://openalex.org/W2056914236","https://openalex.org/W2058024825","https://openalex.org/W2060582131","https://openalex.org/W2064130080","https://openalex.org/W2064687417","https://openalex.org/W2069584242","https://openalex.org/W2083157947","https://openalex.org/W2089463406","https://openalex.org/W2093292871","https://openalex.org/W2118964451","https://openalex.org/W2127241683","https://openalex.org/W2135601854","https://openalex.org/W2147968873","https://openalex.org/W2167748491","https://openalex.org/W2179660749","https://openalex.org/W2181819230","https://openalex.org/W2328937666","https://openalex.org/W2397377945","https://openalex.org/W2418507128","https://openalex.org/W2521139797","https://openalex.org/W2584100491","https://openalex.org/W2593018740","https://openalex.org/W2773997905","https://openalex.org/W2794318971","https://openalex.org/W2952144217","https://openalex.org/W2984694456","https://openalex.org/W2998722354","https://openalex.org/W3008666126","https://openalex.org/W3026789862","https://openalex.org/W3036083259","https://openalex.org/W3047597757","https://openalex.org/W3134391605","https://openalex.org/W3176439361","https://openalex.org/W3193710897","https://openalex.org/W3214649305"],"related_works":["https://openalex.org/W2762933329","https://openalex.org/W2179660749","https://openalex.org/W2952144217","https://openalex.org/W3036083259","https://openalex.org/W2912724651","https://openalex.org/W2189208075","https://openalex.org/W2331104147","https://openalex.org/W4224138000","https://openalex.org/W3035893098","https://openalex.org/W1957746868"],"abstract_inverted_index":{"The":[0],"use":[1,82],"of":[2,9,63,80,85,95,105,115,130,137,142,151,167,171,183,209,220,234,240,247],"areca":[3,81,120,147,155,192],"nuts":[4],"(areca)":[5],"in":[6,18,146,175,191],"the":[7,13,19,45,55,61,64,93,123,128,149,165,181,197,216,237,244],"form":[8],"betel":[10,221],"quids":[11],"constitutes":[12],"fourth":[14],"most":[15],"common":[16],"addiction":[17],"world,":[20],"associated":[21,43],"with":[22,44,92,140],"high":[23,143,169,210],"risk":[24],"for":[25,196],"oral":[26,217],"disease":[27],"and":[28,47,88,112,134,148,160,173,186,200,236],"cancer.":[29],"Areca":[30],"is":[31,51,59,70],"a":[32,168,184],"complex":[33],"natural":[34],"product,":[35],"making":[36],"it":[37],"difficult":[38],"to":[39,74,157,215,243],"identify":[40],"specific":[41],"components":[42,230],"addictive":[46],"carcinogenic":[48],"properties.":[49],"It":[50],"commonly":[52],"believed":[53,73],"that":[54,193,206],"muscarinic":[56,67],"agonist":[57],"arecoline":[58,111,241],"at":[60],"core":[62],"addiction.":[65,248],"However,":[66],"receptor":[68],"activation":[69],"not":[71],"generally":[72],"support":[75],"drug-taking":[76],"behaviour.":[77],"Subjective":[78],"accounts":[79],"include":[83],"descriptions":[84],"both":[86],"sedative":[87],"stimulatory":[89],"effects,":[90],"consistent":[91],"presence":[94,166,182],"multiple":[96],"psychoactive":[97],"agents.":[98],"We":[99,163],"have":[100],"previously":[101],"reported":[102,198],"partial":[103],"agonism":[104],"\u03b14-containing":[106],"nicotinic":[107,131,238],"acetylcholine":[108,132],"receptors":[109,117,133,139],"by":[110,118],"subsequent":[113],"inhibition":[114,129],"those":[116],"whole":[119],"broth.":[121],"In":[122],"present":[124],"study,":[125],"we":[126],"report":[127],"other":[135],"types":[136],"neurotransmitter":[138],"compounds":[141],"molecular":[144,153,211,228],"weight":[145,154,212,229],"ability":[150],"low":[152,227],"extract":[156],"activate":[158],"GABA":[159,172],"glutamate":[161,174],"receptors.":[162],"confirm":[164],"concentration":[170],"areca.":[176],"Additionally,":[177],"data":[178,204],"also":[179],"indicate":[180],"dopamine":[185],"serotonin":[187],"transporter":[188],"blocking":[189],"activity":[190,239],"could":[194],"account":[195],"stimulant":[199],"antidepressant":[201],"activity.":[202],"Our":[203],"suggest":[205],"toxic":[207],"elements":[208,233],"may":[213,231],"contribute":[214],"health":[218],"liability":[219],"quid":[222],"use,":[223],"while":[224],"two":[225],"distinct":[226],"provide":[232],"reward,":[235],"contributes":[242],"physical":[245],"dependence":[246]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-13T00:00:00"}
