{"id":"https://openalex.org/W4291020924","doi":"https://doi.org/10.1038/s41467-022-32346-5","title":"Synthesis of bioactive (1\u21926)-\u03b2-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages","display_name":"Synthesis of bioactive (1\u21926)-\u03b2-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages","publication_year":2022,"publication_date":"2022-08-09","ids":{"openalex":"https://openalex.org/W4291020924","doi":"https://doi.org/10.1038/s41467-022-32346-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/35945224","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9363418"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-32346-5","doi":"https://doi.org/10.1038/s41467-022-32346-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-32346-5","pdf_url":"https://www.nature.com/articles/s41467-022-32346-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-32346-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080020903","display_name":"Ruiqing Xiao","orcid":"https://orcid.org/0000-0001-7944-0508","observed_orcids":["https://orcid.org/0000-0001-7944-0508"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruiqing Xiao","raw_affiliation_strings":["David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","Department of Chemistry, Boston University, Boston, MA, 02215, USA","Shenzhen Middle School, Shenzhen, GD, 518001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Shenzhen Middle School, Shenzhen, GD, 518001, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018895606","display_name":"Jialiu Zeng","orcid":"https://orcid.org/0000-0001-7802-1432","observed_orcids":["https://orcid.org/0000-0001-7802-1432"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Jialiu Zeng","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA","Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore"],"raw_orcid":"https://orcid.org/0000-0001-7802-1432","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063594921","display_name":"Eric M. Bressler","orcid":"https://orcid.org/0000-0002-7076-7560","observed_orcids":["https://orcid.org/0000-0002-7076-7560"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Bressler","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073819021","display_name":"Wei Lu","orcid":"https://orcid.org/0000-0001-7460-098X","observed_orcids":["https://orcid.org/0000-0001-7460-098X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Lu","raw_affiliation_strings":["Tosoh Bioscience LLC, King of Prussia, PA, 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tosoh Bioscience LLC, King of Prussia, PA, 19406, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001975624","display_name":"Mark W. Grinstaff","orcid":"https://orcid.org/0000-0002-5453-3668","observed_orcids":["https://orcid.org/0000-0002-5453-3668"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark W. Grinstaff","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA. mgrin@bu.edu","Department of Chemistry, Boston University, Boston, MA, 02215, USA. mgrin@bu.edu","Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA"],"raw_orcid":"https://orcid.org/0000-0002-5453-3668","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA. mgrin@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, MA, 02215, USA. mgrin@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001975624"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":2.2497,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88876055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"4661","last_page":"4661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7509999871253967},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dectin-1","display_name":"Dectin-1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ring-opening-polymerization","display_name":"ring-opening polymerization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/branching-frequency","display_name":"branching frequency","score":0.6330000162124634},{"id":"https://openalex.org/keywords/molecular-weight-control","display_name":"molecular weight control","score":0.7730000019073486},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lentinan","display_name":"lentinan","score":0.6800000071525574},{"id":"https://openalex.org/keywords/laminarin","display_name":"laminarin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/curdlan","display_name":"curdlan","score":1.0}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7528698444366455},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6340267658233643},{"id":"https://openalex.org/C2776748855","wikidata":"https://www.wikidata.org/wiki/Q419019","display_name":"Lentinan","level":3,"score":0.5753098130226135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5329160690307617},{"id":"https://openalex.org/C2776123893","wikidata":"https://www.wikidata.org/wiki/Q416796","display_name":"Glucan","level":2,"score":0.48967674374580383},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.4884394705295563},{"id":"https://openalex.org/C2777726330","wikidata":"https://www.wikidata.org/wiki/Q320607","display_name":"Oligosaccharide","level":2,"score":0.4627769887447357},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.45917582511901855},{"id":"https://openalex.org/C2779929572","wikidata":"https://www.wikidata.org/wiki/Q616242","display_name":"Curdlan","level":3,"score":0.44307440519332886},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36066871881484985},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12970668077468872},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.10352352261543274}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047071","descriptor_name":"beta-Glucans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-022-32346-5","doi":"https://doi.org/10.1038/s41467-022-32346-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-32346-5","pdf_url":"https://www.nature.com/articles/s41467-022-32346-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9363418","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9363418","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:35945224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35945224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32346-5","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-32346-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bac951bb9a3442e0aef620756bb3e231","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bac951bb9a3442e0aef620756bb3e231","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)","raw_type":"article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/170856","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/170856","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-32346-5","doi":"https://doi.org/10.1038/s41467-022-32346-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-32346-5","pdf_url":"https://www.nature.com/articles/s41467-022-32346-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1274943346","display_name":"Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma","funder_award_id":"R01EB017722","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G2752085301","display_name":null,"funder_award_id":"F30 CA257566","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2978348425","display_name":"Development of a Surgical Drug Delivery System for Enhancement of CAR T Cell Activity","funder_award_id":"F30CA257566","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3084778278","display_name":null,"funder_award_id":"R01EB017722","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3693778541","display_name":"Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program","funder_award_id":"T32GM130546","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4019682062","display_name":null,"funder_award_id":"T32 GM130546","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291020924.pdf","grobid_xml":"https://content.openalex.org/works/W4291020924.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W1484817497","https://openalex.org/W1967532637","https://openalex.org/W1971695057","https://openalex.org/W1973018387","https://openalex.org/W1976723993","https://openalex.org/W1976987509","https://openalex.org/W1978841484","https://openalex.org/W1980335302","https://openalex.org/W1980588029","https://openalex.org/W1987051998","https://openalex.org/W1988940275","https://openalex.org/W1992071813","https://openalex.org/W1992104357","https://openalex.org/W1992494622","https://openalex.org/W1996736315","https://openalex.org/W2000860870","https://openalex.org/W2002337697","https://openalex.org/W2006352924","https://openalex.org/W2020969008","https://openalex.org/W2023173466","https://openalex.org/W2028624353","https://openalex.org/W2029718281","https://openalex.org/W2035659210","https://openalex.org/W2037789217","https://openalex.org/W2042433863","https://openalex.org/W2043717195","https://openalex.org/W2048331155","https://openalex.org/W2049136865","https://openalex.org/W2052528277","https://openalex.org/W2055090334","https://openalex.org/W2055211432","https://openalex.org/W2066222426","https://openalex.org/W2066505604","https://openalex.org/W2068498799","https://openalex.org/W2072196793","https://openalex.org/W2077058827","https://openalex.org/W2078727684","https://openalex.org/W2083284507","https://openalex.org/W2089573250","https://openalex.org/W2093608891","https://openalex.org/W2097568210","https://openalex.org/W2104440842","https://openalex.org/W2104650194","https://openalex.org/W2107531246","https://openalex.org/W2108522845","https://openalex.org/W2111773358","https://openalex.org/W2118154718","https://openalex.org/W2121878520","https://openalex.org/W2124059797","https://openalex.org/W2128856207","https://openalex.org/W2130699389","https://openalex.org/W2137205222","https://openalex.org/W2140767513","https://openalex.org/W2144136142","https://openalex.org/W2145399009","https://openalex.org/W2149200346","https://openalex.org/W2159195476","https://openalex.org/W2164052164","https://openalex.org/W2169499736","https://openalex.org/W2169658842","https://openalex.org/W2285025442","https://openalex.org/W2317160467","https://openalex.org/W2320505478","https://openalex.org/W2323853830","https://openalex.org/W2343821326","https://openalex.org/W2485848175","https://openalex.org/W2735527928","https://openalex.org/W2740308755","https://openalex.org/W2746521754","https://openalex.org/W2754115562","https://openalex.org/W2773495508","https://openalex.org/W2782783651","https://openalex.org/W2791825614","https://openalex.org/W2793597042","https://openalex.org/W2807846077","https://openalex.org/W2884587975","https://openalex.org/W2900179161","https://openalex.org/W2900911743","https://openalex.org/W2903613218","https://openalex.org/W2910383202","https://openalex.org/W2942814658","https://openalex.org/W2946952192","https://openalex.org/W2953107858","https://openalex.org/W2953531820","https://openalex.org/W2973940795","https://openalex.org/W3003884092","https://openalex.org/W3025871179","https://openalex.org/W3041545489","https://openalex.org/W3086057753"],"related_works":["https://openalex.org/W2807846077","https://openalex.org/W4392344150","https://openalex.org/W2741559286","https://openalex.org/W2791680860","https://openalex.org/W2043717195","https://openalex.org/W4328053104","https://openalex.org/W2087389362","https://openalex.org/W7095811226","https://openalex.org/W1980335302","https://openalex.org/W4389008210"],"abstract_inverted_index":{"Abstract":[0],"\u03b2-Glucans":[1],"are":[2],"of":[3,27,40,44,54,76,79,91,103,119],"significant":[4],"interest":[5],"due":[6],"to":[7,32,127,142],"their":[8],"potent":[9],"antitumor":[10],"and":[11,21,30,59,74,88,100,110,149],"immunomodulatory":[12],"activities.":[13],"Nevertheless,":[14],"the":[15,25,38,117],"difficulty":[16],"in":[17,93,106,122],"purification,":[18],"structural":[19],"heterogenicity,":[20],"limited":[22],"solubility":[23],"impede":[24],"development":[26],"structure-property":[28],"relationships":[29],"translation":[31],"therapeutic":[33],"applications.":[34],"Here,":[35],"we":[36],"report":[37],"synthesis":[39],"a":[41,55,63,107,123],"new":[42],"class":[43],"(1\u21926)-\u03b2-glucose-branched":[45],"poly-amido-saccharides":[46],"(PASs)":[47],"as":[48,146],"\u03b2-glucan":[49],"mimetics":[50],"by":[51,67,84],"ring-opening":[52],"polymerization":[53],"gentiobiose-based":[56],"disaccharide":[57],"\u03b2-lactam":[58],"its":[60],"copolymerization":[61],"with":[62],"glucose-based":[64],"\u03b2-lactam,":[65],"followed":[66],"post-polymerization":[68],"deprotection.":[69],"The":[70,113,130],"molecular":[71],"weight":[72],"(Mn)":[73],"frequency":[75],"branching":[77],"(FB)":[78],"PASs":[80,96],"is":[81],"readily":[82],"tuned":[83],"adjusting":[85],"monomer-to-initiator":[86],"ratio":[87],"mole":[89],"fraction":[90],"gentiobiose-lactam":[92],"copolymerization.":[94],"Branched":[95],"stimulate":[97],"mouse":[98],"macrophages,":[99],"enhance":[101],"production":[102],"pro-inflammatory":[104],"cytokines":[105],"FB-,":[108],"dose-,":[109],"Mn-dependent":[111],"manner.":[112],"stimulation":[114],"proceeds":[115],"via":[116],"activation":[118],"NF-\u03baB/AP-1":[120],"pathway":[121],"Dectin-1-dependent":[124],"manner,":[125],"similar":[126],"natural":[128],"\u03b2-glucans.":[129],"lead":[131],"PAS":[132],"significantly":[133],"polarizes":[134],"primary":[135],"human":[136],"macrophages":[137],"towards":[138],"M1":[139],"phenotype":[140],"compared":[141],"other":[143],"\u03b2-glucans":[144],"such":[145],"lentinan,":[147],"laminarin,":[148],"curdlan.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-13T00:00:00"}
