{"id":"https://openalex.org/W4291019872","doi":"https://doi.org/10.1111/bcp.15477","title":"A population pharmacokinetic model based on HPTN 077 of long\u2010acting injectable cabotegravir for HIV PrEP","display_name":"A population pharmacokinetic model based on HPTN 077 of long\u2010acting injectable cabotegravir for HIV PrEP","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4291019872","doi":"https://doi.org/10.1111/bcp.15477","pmid":"https://pubmed.ncbi.nlm.nih.gov/35949044","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10077525"},"language":"en","primary_location":{"id":"doi:10.1111/bcp.15477","doi":"https://doi.org/10.1111/bcp.15477","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bcp.15477","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.authorea.com/doi/pdf/10.22541/au.165332770.01944469","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056455411","display_name":"Yifan Yu","orcid":"https://orcid.org/0009-0004-7897-9906","observed_orcids":["https://orcid.org/0009-0004-7897-9906","https://orcid.org/0009-0002-5291-9003"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yifan Yu","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083617820","display_name":"Kristin L. Bigos","orcid":"https://orcid.org/0000-0002-5738-9008","observed_orcids":["https://orcid.org/0000-0002-5738-9008"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin L. Bigos","raw_affiliation_strings":["Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082007029","display_name":"Mark A. Marzinke","orcid":"https://orcid.org/0000-0003-1670-8786","observed_orcids":["https://orcid.org/0000-0003-1670-8786"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Marzinke","raw_affiliation_strings":["Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":"https://orcid.org/0000-0003-1670-8786","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045910681","display_name":"Raphael J. Landovitz","orcid":"https://orcid.org/0000-0002-1442-714X","observed_orcids":["https://orcid.org/0000-0002-1442-714X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raphael J. Landovitz","raw_affiliation_strings":["Los Angeles, Center for Clinical AIDS Research and Education, The University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, Center for Clinical AIDS Research and Education, The University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046756577","display_name":"Marybeth McCauley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290866511","display_name":"Family Health International 360","ror":"https://ror.org/007kp6q87","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290866511"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marybeth McCauley","raw_affiliation_strings":["FHI 360, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FHI 360, Durham, NC, USA","institution_ids":["https://openalex.org/I1290866511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009272615","display_name":"Susan L. Ford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Ford","raw_affiliation_strings":["GlaxoSmithKline, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053567182","display_name":"Craig W. Hendrix","orcid":"https://orcid.org/0000-0002-5696-8665","observed_orcids":["https://orcid.org/0000-0002-5696-8665"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig W. Hendrix","raw_affiliation_strings":["Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","Department of Medicine, Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074303161","display_name":"Robert R. Bies","orcid":"https://orcid.org/0000-0003-3818-2252","observed_orcids":["https://orcid.org/0000-0003-3818-2252"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. Bies","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060676573","display_name":"Ethel  Derby Weld","orcid":"https://orcid.org/0000-0002-9519-3348","observed_orcids":["https://orcid.org/0000-0002-9519-3348","https://orcid.org/0000-0002-5016-4586"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ethel D. Weld","raw_affiliation_strings":["Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","Department of Medicine, Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-9519-3348","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":null,"display_name":"the HPTN 077 Study Team","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the HPTN 077 Study Team","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5060676573"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.1616,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78823216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"88","issue":"10","first_page":"4623","last_page":"4632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.16279999911785126,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cabotegravir","display_name":"cabotegravir","score":0.996999979019165},{"id":"https://openalex.org/keywords/population-pharmacokinetic-model","display_name":"population pharmacokinetic model","score":0.8339999914169312},{"id":"https://openalex.org/keywords/absorption-rate","display_name":"absorption rate","score":0.7639999985694885},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7509999871253967},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.9359999895095825},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.7870000004768372},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.7179999947547913},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7930610179901123},{"id":"https://openalex.org/C2779778239","wikidata":"https://www.wikidata.org/wiki/Q422604","display_name":"Emtricitabine","level":5,"score":0.7066724300384521},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6213400959968567},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5404255390167236},{"id":"https://openalex.org/C2776291583","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Intramuscular injection","level":2,"score":0.5387870073318481},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4793027937412262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44034069776535034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2773068845272064},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.25723832845687866},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09262964129447937},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.06375816464424133},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0632680356502533}],"mesh":[{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054659","descriptor_name":"Diketopiperazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/bcp.15477","doi":"https://doi.org/10.1111/bcp.15477","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bcp.15477","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"doi:10.22541/au.165332770.01944469/v1","doi":"https://doi.org/10.22541/au.165332770.01944469/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.165332770.01944469/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.165332770.01944469","source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:35949044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35949044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10077525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10077525","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10077525/pdf/nihms-1874649.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3p19h592","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3p19h592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Clinical Pharmacology, vol 88, iss 10","raw_type":"article"}],"best_oa_location":{"id":"doi:10.22541/au.165332770.01944469/v1","doi":"https://doi.org/10.22541/au.165332770.01944469/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.165332770.01944469/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.165332770.01944469","source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G155233325","display_name":"Optimizing the Use of Long-Acting Antiretrovirals for Youth Living withHIV","funder_award_id":"K23AI165290","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000860452","display_name":"The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)","funder_award_id":"P30HD106451","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000874350","display_name":"The Johns Hopkins Center for AIDS Research (JHU CFAR)","funder_award_id":"P30AI094189","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000895738","display_name":"LC: HIV PREVENTION TRIALS NETWORK","funder_award_id":"UM1AI068613","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320312382","display_name":"ViiV Healthcare","ror":"https://ror.org/01cc9yk21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291019872.pdf","grobid_xml":"https://content.openalex.org/works/W4291019872.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1612898398","https://openalex.org/W1906145619","https://openalex.org/W1995101760","https://openalex.org/W2024823439","https://openalex.org/W2035387023","https://openalex.org/W2072686355","https://openalex.org/W2081607626","https://openalex.org/W2153935691","https://openalex.org/W2219812044","https://openalex.org/W2298072787","https://openalex.org/W2502670554","https://openalex.org/W2617514227","https://openalex.org/W2898368813","https://openalex.org/W2899917447","https://openalex.org/W2911991742","https://openalex.org/W2914123147","https://openalex.org/W2982150070","https://openalex.org/W3009494891","https://openalex.org/W3030616052","https://openalex.org/W3080975608","https://openalex.org/W3137354410","https://openalex.org/W3178349831","https://openalex.org/W3190424399"],"related_works":["https://openalex.org/W4282570584","https://openalex.org/W6892212641","https://openalex.org/W4396659463","https://openalex.org/W3030006426","https://openalex.org/W7204988348","https://openalex.org/W7162100891","https://openalex.org/W4403685285","https://openalex.org/W4414630990","https://openalex.org/W7168295758","https://openalex.org/W7202398831"],"abstract_inverted_index":{"Aims":[0],"Cabotegravir":[1,21],"delivered":[2],"as":[3,15,118,150],"a":[4,82,119,140,176,192,198,201,226],"long\u2010acting":[5,28,51],"intramuscular":[6,163],"injection":[7,37,114,164],"has":[8],"shown":[9],"superior":[10],"efficacy":[11],"to":[12,45,80,115,132,182,200,234],"oral":[13],"tenofovir\u2010emtricitabine":[14],"pre\u2010exposure":[16],"prophylaxis":[17],"(PrEP)":[18],"for":[19],"HIV.":[20],"pharmacokinetics":[22,49],"(PK),":[23],"like":[24],"those":[25],"of":[26,41,50,130,142,160,209,219,229,239],"other":[27],"depot":[29],"preparations,":[30],"exhibit":[31],"variability":[32,103,134],"between":[33,36],"individuals":[34],"and":[35,145,157,168,194,212,224],"occasions.":[38],"The":[39,99,216],"aim":[40],"this":[42,220],"study":[43],"is":[44],"describe":[46],"the":[47,63,96,116,123,136,154,183,204,236],"population":[48,83],"cabotegravir":[52],"(CAB\u2010LA).":[53],"Methods":[54],"Using":[55],"available":[56],"PK":[57,74,84,108,133],"measurements":[58],"from":[59,112],"133":[60],"participants":[61,171],"in":[62,107,203],"HIV":[64],"Prevention":[65],"Trials":[66],"Network":[67],"(HPTN)":[68],"077":[69],"trial,":[70],"we":[71],"analysed":[72],"CAB\u2010LA":[73,97,161],"data":[75],"using":[76],"nonlinear":[77],"mixed\u2010effects":[78],"modelling":[79],"develop":[81],"model.":[85],"Results":[86],"A":[87],"two\u2010compartment":[88],"model":[89,184,221],"with":[90,126],"first":[91],"order":[92],"absorption":[93,124,137,155],"best":[94],"described":[95],"PK.":[98],"analysis":[100],"identified":[101,149],"between\u2010occasion":[102],"(BOV,":[104],"i.e.,":[105],"differences":[106],"within":[109],"one":[110,113],"individual":[111],"next)":[117],"significant":[120,151],"covariate":[121],"affecting":[122],"rate,":[125],"an":[127],"estimated":[128],"contribution":[129],"BOV":[131,195],"on":[135,187,190,196],"rate":[138,156],"(k":[139],")":[141],"38.5%.":[143],"Sex":[144],"body":[146,185],"weight":[147,186],"were":[148],"covariates":[152],"influencing":[153],"apparent":[158],"clearance":[159],"after":[162],"at":[165],"various":[166],"doses":[167],"frequencies.":[169],"Male":[170],"had":[172],"67%":[173],"higher":[174],"k":[175,191,197],"than":[177],"female":[178],"participants.":[179],"Serially":[180],"adding":[181],"clearance,":[188],"sex":[189],",":[193],"led":[199],"decrease":[202],"objective":[205],"function":[206],"value":[207],"(OFV)":[208],"24.4,":[210],"36":[211],"321.4,":[213],"respectively.":[214],"Conclusion":[215],"public":[217],"availability":[218],"will":[222],"facilitate":[223],"enable":[225],"wide":[227],"variety":[228],"future":[230],"clinically":[231],"relevant":[232],"simulations":[233],"inform":[235],"optimal":[237],"use":[238],"CAB\u2010LA.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-08-13T00:00:00"}