{"id":"https://openalex.org/W4291000786","doi":"https://doi.org/10.1007/s13402-022-00702-8","title":"Telomerase-targeting compounds Imetelstat and 6-thio-dG act synergistically with chemotherapy in high-risk neuroblastoma models","display_name":"Telomerase-targeting compounds Imetelstat and 6-thio-dG act synergistically with chemotherapy in high-risk neuroblastoma models","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4291000786","doi":"https://doi.org/10.1007/s13402-022-00702-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/35953764","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9579108"},"language":"en","primary_location":{"id":"doi:10.1007/s13402-022-00702-8","doi":"https://doi.org/10.1007/s13402-022-00702-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-022-00702-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13402-022-00702-8.pdf","source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s13402-022-00702-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Janina Fischer-Mertens","orcid":"https://orcid.org/0000-0001-6240-2417","observed_orcids":["https://orcid.org/0000-0001-6240-2417"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janina Fischer-Mertens","raw_affiliation_strings":["Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6240-2417","affiliations":[{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091706777","display_name":"Felix Otte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix Otte","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010827105","display_name":"Andrea Roderwieser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Roderwieser","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210153755"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064486746","display_name":"Carolina Rosswog","orcid":"https://orcid.org/0000-0002-8855-6198","observed_orcids":["https://orcid.org/0000-0002-8855-6198"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolina Rosswog","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084357587","display_name":"Yvonne Kahlert","orcid":"https://orcid.org/0009-0006-0556-0439","observed_orcids":["https://orcid.org/0009-0006-0556-0439"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yvonne Kahlert","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044635759","display_name":"Lisa Werr","orcid":"https://orcid.org/0000-0002-3697-4136","observed_orcids":["https://orcid.org/0000-0002-3697-4136"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa Werr","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086064651","display_name":"Anna\u2010Maria Hellmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna-Maria Hellmann","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089966977","display_name":"Maya Berding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maya Berding","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051281026","display_name":"Bill Chiu","orcid":"https://orcid.org/0000-0002-6540-4538","observed_orcids":["https://orcid.org/0000-0002-6540-4538"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bill Chiu","raw_affiliation_strings":["Pediatric Surgery, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Surgery, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062364819","display_name":"Christoph Bartenhagen","orcid":"https://orcid.org/0000-0002-2522-1454","observed_orcids":["https://orcid.org/0000-0002-2522-1454"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Bartenhagen","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061831442","display_name":"Matthias Fischer","orcid":"https://orcid.org/0000-0003-1363-1242","observed_orcids":["https://orcid.org/0000-0003-1363-1242"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Fischer","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. matthias.fischer@uk-koeln.de","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany. matthias.fischer@uk-koeln.de","Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1363-1242","affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. matthias.fischer@uk-koeln.de","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany. matthias.fischer@uk-koeln.de","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061831442"],"corresponding_institution_ids":["https://openalex.org/I180923762"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.4785,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.90690178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"45","issue":"5","first_page":"991","last_page":"1003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.10220000147819519,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/imetelstat","display_name":"imetelstat","score":0.9639999866485596},{"id":"https://openalex.org/keywords/6-thio-2-deoxyguanosine","display_name":"6-thio-2'-deoxyguanosine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/telomerase-inhibitors","display_name":"telomerase inhibitors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5009999871253967},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.8429999947547913},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/ceritinib","display_name":"ceritinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7400000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.996999979019165},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.7795863151550293},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.7718775272369385},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5711341500282288},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5569868087768555},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5071125030517578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.460495263338089},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45448848605155945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33812153339385986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2245381474494934},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.17088773846626282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09829917550086975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07323047518730164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013872","descriptor_name":"Thionucleosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s13402-022-00702-8","doi":"https://doi.org/10.1007/s13402-022-00702-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-022-00702-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13402-022-00702-8.pdf","source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9579108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9579108","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Oncol (Dordr)","raw_type":"Text"},{"id":"pmid:35953764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35953764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular oncology (Dordrecht, Netherlands)","raw_type":"Journal Article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:67105","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/67105/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"}],"best_oa_location":{"id":"doi:10.1007/s13402-022-00702-8","doi":"https://doi.org/10.1007/s13402-022-00702-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-022-00702-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13402-022-00702-8.pdf","source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1479270331","display_name":null,"funder_award_id":"2020-EKFK19","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G3658512782","display_name":null,"funder_award_id":"FI 2376/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4031778708","display_name":null,"funder_award_id":"110122","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"},{"id":"https://openalex.org/G4388033244","display_name":null,"funder_award_id":"BA 6984/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5277190150","display_name":null,"funder_award_id":"473/2018","funder_id":"https://openalex.org/F4320324811","funder_display_name":"Universit\u00e4t zu K\u00f6ln"},{"id":"https://openalex.org/G6645292354","display_name":"Focal Sustained Release Chemotherapy-Loaded Biomaterials at Tumor Sites","funder_award_id":"R01NS094218","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G838213719","display_name":null,"funder_award_id":"NS094218","funder_id":"https://openalex.org/F4320337364","funder_display_name":"National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"},{"id":"https://openalex.org/F4320322889","display_name":"Elternverein f\u00fcr Leuk\u00e4mie- und Krebskranke Kinder, Gie\u00dfen","ror":"https://ror.org/017a3va29"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320324811","display_name":"Universit\u00e4t zu K\u00f6ln","ror":"https://ror.org/00rcxh774"},{"id":"https://openalex.org/F4320335423","display_name":"Center for Molecular Medicine Cologne, University of Cologne","ror":null},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291000786.pdf","grobid_xml":"https://content.openalex.org/works/W4291000786.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1915238740","https://openalex.org/W2010978319","https://openalex.org/W2022354436","https://openalex.org/W2024963052","https://openalex.org/W2028714796","https://openalex.org/W2050694674","https://openalex.org/W2060275730","https://openalex.org/W2077945404","https://openalex.org/W2096387850","https://openalex.org/W2096982451","https://openalex.org/W2103562758","https://openalex.org/W2113618284","https://openalex.org/W2117692326","https://openalex.org/W2140360759","https://openalex.org/W2156509269","https://openalex.org/W2530482928","https://openalex.org/W2565108495","https://openalex.org/W2617103357","https://openalex.org/W2774112395","https://openalex.org/W2790510662","https://openalex.org/W2790598964","https://openalex.org/W2797193399","https://openalex.org/W2802944621","https://openalex.org/W2890666478","https://openalex.org/W2898695740","https://openalex.org/W2902229746","https://openalex.org/W2944363197","https://openalex.org/W2974263766","https://openalex.org/W3039849639","https://openalex.org/W3097251831","https://openalex.org/W3113191048","https://openalex.org/W4211031423"],"related_works":["https://openalex.org/W7151729944","https://openalex.org/W7130487536","https://openalex.org/W7106806023","https://openalex.org/W2323581146","https://openalex.org/W2114859007","https://openalex.org/W2041884820","https://openalex.org/W7095253005","https://openalex.org/W3023848683","https://openalex.org/W7043776246","https://openalex.org/W2974263766"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"majority":[2],"of":[3,23,53,56,80,102,114,134,139,156,162,242],"high-risk":[4,255],"neuroblastomas":[5],"harbor":[6],"telomerase":[7,96,169,222,247],"activity,":[8],"and":[9,116,124,141,147,174,213,230],"telomerase-interacting":[10,236],"compounds,":[11],"such":[12,34],"as":[13],"6-thio-2'-deoxyguanosine":[14],"(6-thio-dG),":[15],"have":[16],"been":[17],"found":[18,205],"to":[19,191,206,209],"impair":[20],"the":[21,94,201,240],"growth":[22,78,146],"telomerase-positive":[24,69,127,228],"neuroblastoma":[25,48,70,128,256],"cell":[26,71,86,129,158,214],"lines.":[27],"It":[28],"has":[29],"remained":[30],"unclear,":[31],"however,":[32],"how":[33],"drugs":[35],"can":[36],"be":[37,207],"combined":[38],"with":[39,60,73,92,137,186],"other":[40],"compounds":[41,237],"used":[42],"in":[43,58,67,126,131,154,180,197,227,254],"current":[44],"treatment":[45,91,185],"concepts":[46],"for":[47,112,122],"patients.":[49,257],"METHODS:":[50],"Growth-inhibitory":[51],"effects":[52,109],"varying":[54],"concentrations":[55],"6-thio-dG":[57,115,123,140],"combination":[59,233],"etoposide,":[61,99],"doxorubicin":[62],"or":[63,100,118],"ceritinib":[64],"were":[65,110],"determined":[66],"eight":[68],"lines":[72,87,130],"distinct":[74],"genetic":[75],"backgrounds.":[76],"Tumor":[77],"inhibition":[79],"subcutaneous":[81],"xenografts":[82,136],"from":[83],"three":[84,157,182],"different":[85],"was":[88,204],"assessed":[89],"upon":[90],"6-thio-dG,":[93],"competitive":[95],"inhibitor":[97],"imetelstat,":[98],"combinations":[101,113,138],"these":[103],"compounds.":[104],"RESULTS:":[105],"Robust":[106],"synergistic":[107,202],"anti-tumor":[108],"observed":[111],"etoposide":[117,142,152,189,195],"doxorubicin,":[119],"but":[120],"not":[121],"ceritinib,":[125],"vitro.":[132],"Treatment":[133,161],"mouse":[135,149],"significantly":[143,175],"attenuated":[144],"tumor":[145],"improved":[148,176],"survival":[150,177,193],"over":[151,178,194],"alone":[153],"two":[155],"line":[159],"models.":[160],"xenograft":[163],"tumors":[164],"by":[165,171],"imetelstat":[166,187],"monotherapy":[167,196],"decreased":[168],"activity":[170],"roughly":[172],"50%":[173],"control":[179],"all":[181],"models,":[183],"whereas":[184],"plus":[188],"led":[190],"enhanced":[192],"one":[198],"model.":[199],"Mechanistically,":[200],"effect":[203],"due":[208],"both":[210],"increased":[211],"apoptosis":[212],"cycle":[215],"arrest.":[216],"CONCLUSION:":[217],"Our":[218],"study":[219],"indicates":[220],"that":[221,232],"is":[223],"an":[224],"actionable":[225],"target":[226],"neuroblastoma,":[229],"demonstrates":[231],"therapies":[234],"including":[235],"may":[238,248],"improve":[239],"efficacy":[241],"established":[243],"cytotoxic":[244],"drugs.":[245],"Targeting":[246],"thus":[249],"represent":[250],"a":[251],"therapeutic":[252],"option":[253]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-13T00:00:00"}
