{"id":"https://openalex.org/W4290988604","doi":"https://doi.org/10.7759/cureus.27837","title":"Is Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) Effective in Ovarian Cancer With Peritoneal Metastasis?","display_name":"Is Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) Effective in Ovarian Cancer With Peritoneal Metastasis?","publication_year":2022,"publication_date":"2022-08-09","ids":{"openalex":"https://openalex.org/W4290988604","doi":"https://doi.org/10.7759/cureus.27837","pmid":"https://pubmed.ncbi.nlm.nih.gov/36110443","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9462586"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.27837","doi":"https://doi.org/10.7759/cureus.27837","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.27837","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/105406/20220909-28329-1ylrgjz.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://assets.cureus.com/uploads/review_article/pdf/105406/20220909-28329-1ylrgjz.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043403825","display_name":"Amad Mohammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134359838","display_name":"Alfaisal University","ror":"https://ror.org/00cdrtq48","country_code":"SA","type":"education","lineage":["https://openalex.org/I134359838"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["SA","US"],"is_corresponding":true,"raw_author_name":"Amad Mohammad","raw_affiliation_strings":["Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA",". General Internal Medicine, Mansoura General Hospital, Mansoura, EGY",". Internal Medicine, Alfaisal University, Riyadh, SAU",". Ophthalmology, Palestinian Medical Council, Ramallah, PSE",". Research, Fresno Clinical Research Center, Fresno, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":". General Internal Medicine, Mansoura General Hospital, Mansoura, EGY","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Alfaisal University, Riyadh, SAU","institution_ids":["https://openalex.org/I134359838"]},{"raw_affiliation_string":". Ophthalmology, Palestinian Medical Council, Ramallah, PSE","institution_ids":[]},{"raw_affiliation_string":". Research, Fresno Clinical Research Center, Fresno, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000166689","display_name":"Mosab Hor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134359838","display_name":"Alfaisal University","ror":"https://ror.org/00cdrtq48","country_code":"SA","type":"education","lineage":["https://openalex.org/I134359838"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mosab Hor","raw_affiliation_strings":["Ophthalmology, Palestinian Medical Council, Ramallah, PSE",". General Internal Medicine, Mansoura General Hospital, Mansoura, EGY",". Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA",". Internal Medicine, Alfaisal University, Riyadh, SAU",". Research, Fresno Clinical Research Center, Fresno, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Palestinian Medical Council, Ramallah, PSE","institution_ids":[]},{"raw_affiliation_string":". General Internal Medicine, Mansoura General Hospital, Mansoura, EGY","institution_ids":[]},{"raw_affiliation_string":". Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Alfaisal University, Riyadh, SAU","institution_ids":["https://openalex.org/I134359838"]},{"raw_affiliation_string":". Research, Fresno Clinical Research Center, Fresno, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038448587","display_name":"Ahmed M Baradeiya","orcid":"https://orcid.org/0009-0008-4022-3934","observed_orcids":["https://orcid.org/0009-0008-4022-3934"]},"institutions":[{"id":"https://openalex.org/I134359838","display_name":"Alfaisal University","ror":"https://ror.org/00cdrtq48","country_code":"SA","type":"education","lineage":["https://openalex.org/I134359838"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ahmed  M Baradeiya","raw_affiliation_strings":["Research, Fresno Clinical Research Center, Fresno, USA",". General Internal Medicine, Mansoura General Hospital, Mansoura, EGY",". Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA",". Internal Medicine, Alfaisal University, Riyadh, SAU",". Ophthalmology, Palestinian Medical Council, Ramallah, PSE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research, Fresno Clinical Research Center, Fresno, USA","institution_ids":[]},{"raw_affiliation_string":". General Internal Medicine, Mansoura General Hospital, Mansoura, EGY","institution_ids":[]},{"raw_affiliation_string":". Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Alfaisal University, Riyadh, SAU","institution_ids":["https://openalex.org/I134359838"]},{"raw_affiliation_string":". Ophthalmology, Palestinian Medical Council, Ramallah, PSE","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042141853","display_name":"Hodan Qasim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134359838","display_name":"Alfaisal University","ror":"https://ror.org/00cdrtq48","country_code":"SA","type":"education","lineage":["https://openalex.org/I134359838"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hodan Qasim","raw_affiliation_strings":["Internal Medicine, Alfaisal University, Riyadh, SAU",". General Internal Medicine, Mansoura General Hospital, Mansoura, EGY",". Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA",". Ophthalmology, Palestinian Medical Council, Ramallah, PSE",". Research, Fresno Clinical Research Center, Fresno, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Alfaisal University, Riyadh, SAU","institution_ids":["https://openalex.org/I134359838"]},{"raw_affiliation_string":". General Internal Medicine, Mansoura General Hospital, Mansoura, EGY","institution_ids":[]},{"raw_affiliation_string":". Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA","institution_ids":[]},{"raw_affiliation_string":". Ophthalmology, Palestinian Medical Council, Ramallah, PSE","institution_ids":[]},{"raw_affiliation_string":". Research, Fresno Clinical Research Center, Fresno, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Mohamed Nasr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134359838","display_name":"Alfaisal University","ror":"https://ror.org/00cdrtq48","country_code":"SA","type":"education","lineage":["https://openalex.org/I134359838"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohamed Nasr","raw_affiliation_strings":["General Internal Medicine, Mansoura General Hospital, Mansoura, EGY",". Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA",". Internal Medicine, Alfaisal University, Riyadh, SAU",". Ophthalmology, Palestinian Medical Council, Ramallah, PSE",". Research, Fresno Clinical Research Center, Fresno, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Internal Medicine, Mansoura General Hospital, Mansoura, EGY","institution_ids":[]},{"raw_affiliation_string":". Hematology and Oncology, Saint James School of Medicine (SJSM), New York, USA","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Alfaisal University, Riyadh, SAU","institution_ids":["https://openalex.org/I134359838"]},{"raw_affiliation_string":". Ophthalmology, Palestinian Medical Council, Ramallah, PSE","institution_ids":[]},{"raw_affiliation_string":". Research, Fresno Clinical Research Center, Fresno, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043403825"],"corresponding_institution_ids":["https://openalex.org/I134359838","https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":1.2776,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.78808257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"8","first_page":"e27837","last_page":"e27837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13279","display_name":"Safe Handling of Antineoplastic Drugs","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pressurized-intraperitoneal-aerosol-chemotherapy","display_name":"PIPAC","score":0.953000009059906},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intraperitoneal-chemotherapy","display_name":"intraperitoneal chemotherapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7670000195503235},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9543040990829468},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7466732859611511},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6805925369262695},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6713880896568298},{"id":"https://openalex.org/C2776001837","wikidata":"https://www.wikidata.org/wiki/Q9629","display_name":"Peritoneum","level":2,"score":0.6035672426223755},{"id":"https://openalex.org/C3019901188","wikidata":"https://www.wikidata.org/wiki/Q612526","display_name":"Intraperitoneal chemotherapy","level":4,"score":0.5171546339988708},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.48453301191329956},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4296555817127228},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42737385630607605},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4062527120113373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38327401876449585},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.27837","doi":"https://doi.org/10.7759/cureus.27837","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.27837","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/105406/20220909-28329-1ylrgjz.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9462586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9462586","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:36110443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36110443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7759/cureus.27837","doi":"https://doi.org/10.7759/cureus.27837","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.27837","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/105406/20220909-28329-1ylrgjz.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290988604.pdf","grobid_xml":"https://content.openalex.org/works/W4290988604.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W171868192","https://openalex.org/W1979911466","https://openalex.org/W1980661013","https://openalex.org/W2051099595","https://openalex.org/W2080853165","https://openalex.org/W2087230876","https://openalex.org/W2161579588","https://openalex.org/W2344894825","https://openalex.org/W2524247262","https://openalex.org/W2757519722","https://openalex.org/W2769284793","https://openalex.org/W2799675510","https://openalex.org/W2806804067","https://openalex.org/W2896259582","https://openalex.org/W2898330049","https://openalex.org/W2944802824","https://openalex.org/W2954661925","https://openalex.org/W2963704932","https://openalex.org/W2971767883","https://openalex.org/W2996375301","https://openalex.org/W3065944417","https://openalex.org/W3152843110","https://openalex.org/W3183971326","https://openalex.org/W3194600479","https://openalex.org/W4211185980","https://openalex.org/W4211203170","https://openalex.org/W4292528108"],"related_works":["https://openalex.org/W7164928227","https://openalex.org/W4392634540","https://openalex.org/W4361283346","https://openalex.org/W4206554228","https://openalex.org/W7129670036","https://openalex.org/W4414261149","https://openalex.org/W3065944417","https://openalex.org/W2919614454","https://openalex.org/W4387135032","https://openalex.org/W4312239173"],"abstract_inverted_index":{"Ovarian":[0,21],"cancer":[1,22],"is":[2,14,40,47,99],"one":[3],"of":[4,9,37,53,67,108],"the":[5,45,106],"most":[6,29],"common":[7],"causes":[8],"mortality":[10],"in":[11,71],"women":[12],"and":[13,80],"frequently":[15,55],"diagnosed":[16],"at":[17],"an":[18],"advanced":[19],"stage.":[20],"has":[23,82],"a":[24,64,91],"high":[25],"recurrence":[26],"rate,":[27],"with":[28],"cases":[30],"being":[31],"peritoneal":[32,38,112],"metastasis.":[33],"The":[34],"standard":[35,52],"treatment":[36,54,110],"metastasis":[39,113],"systemic":[41],"chemotherapy,":[42],"but":[43],"naturally,":[44],"peritoneum":[46],"poorly":[48],"vascularized,":[49],"making":[50],"this":[51],"ineffective.":[56],"Hence,":[57],"pressurized":[58],"intraperitoneal":[59,68],"aerosol":[60],"chemotherapy":[61,69],"(PIPAC)":[62],"introduced":[63],"new":[65,92],"type":[66],"(IPC)":[70],"November":[72],"2011.":[73],"Positive":[74],"feedback":[75],"on":[76,105],"its":[77],"feasibility,":[78],"tolerance,":[79],"efficacy":[81,107],"encouraged":[83],"medical":[84],"communities":[85],"worldwide":[86],"to":[87,100],"adopt":[88],"PIPAC":[89,109],"as":[90],"drug":[93],"delivery":[94],"technique.":[95],"This":[96],"study's":[97],"objective":[98],"review":[101],"previously":[102],"conducted":[103],"research":[104],"for":[111],"from":[114],"ovarian":[115],"cancer.":[116]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-08-13T00:00:00"}