{"id":"https://openalex.org/W4290973267","doi":"https://doi.org/10.1002/cbic.202200332","title":"Post\u2010Assembly Modification of Protein Cages by Ubc9\u2010Mediated Lysine Acylation","display_name":"Post\u2010Assembly Modification of Protein Cages by Ubc9\u2010Mediated Lysine Acylation","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4290973267","doi":"https://doi.org/10.1002/cbic.202200332","pmid":"https://pubmed.ncbi.nlm.nih.gov/35951442","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9826087"},"language":"en","primary_location":{"id":"doi:10.1002/cbic.202200332","doi":"https://doi.org/10.1002/cbic.202200332","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.202200332","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.202200332","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.202200332","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033313650","display_name":"Mikail D. Levasseur","orcid":"https://orcid.org/0000-0003-4228-0875","observed_orcids":["https://orcid.org/0000-0003-4228-0875"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mikail D. Levasseur","raw_affiliation_strings":["Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","These authors contributed equally to this work"],"raw_orcid":"https://orcid.org/0000-0003-4228-0875","affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039269554","display_name":"Raphael Hofmann","orcid":"https://orcid.org/0000-0002-9769-6555","observed_orcids":["https://orcid.org/0000-0002-9769-6555"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Raphael Hofmann","raw_affiliation_strings":["Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","These authors contributed equally to this work"],"raw_orcid":"https://orcid.org/0000-0002-9769-6555","affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008271985","display_name":"Thomas G. W. Edwardson","orcid":"https://orcid.org/0000-0001-8661-8036","observed_orcids":["https://orcid.org/0000-0001-8661-8036"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas G. W. Edwardson","raw_affiliation_strings":["Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8661-8036","affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025784822","display_name":"Svenja Hehn","orcid":"https://orcid.org/0000-0002-3591-9354","observed_orcids":["https://orcid.org/0000-0002-3591-9354"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Svenja Hehn","raw_affiliation_strings":["Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3591-9354","affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054803960","display_name":"Manutsawee Thanaburakorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manutsawee Thanaburakorn","raw_affiliation_strings":["Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058457451","display_name":"Jeffrey W. Bode","orcid":"https://orcid.org/0000-0001-8394-8910","observed_orcids":["https://orcid.org/0000-0001-8394-8910"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Jeffrey W. Bode","raw_affiliation_strings":["Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8394-8910","affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044029247","display_name":"Donald Hilvert","orcid":"https://orcid.org/0000-0002-3941-621X","observed_orcids":["https://orcid.org/0000-0002-3941-621X"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Donald Hilvert","raw_affiliation_strings":["Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3941-621X","affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135/10 8093 Zurich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044029247","https://openalex.org/A5058457451"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.2444,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.40108144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"20","first_page":"e202200332","last_page":"e202200332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.7103999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.7103999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-cages","display_name":"protein cages","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lace","display_name":"lace","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ube2i","display_name":"Ubc9","score":0.925000011920929},{"id":"https://openalex.org/keywords/post-assembly-modification","display_name":"post-assembly modification","score":0.8220000267028809},{"id":"https://openalex.org/keywords/virus-like-particles","display_name":"virus-like particles","score":0.7350000143051147},{"id":"https://openalex.org/keywords/site-specific-conjugation","display_name":"site-specific conjugation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ligand-conjugation","display_name":"ligand conjugation","score":0.5170000195503235},{"id":"https://openalex.org/keywords/synthetic-peptides","display_name":"synthetic peptides","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C23963754","wikidata":"https://www.wikidata.org/wiki/Q4914729","display_name":"Bioconjugation","level":2,"score":0.9361138343811035},{"id":"https://openalex.org/C193557335","wikidata":"https://www.wikidata.org/wiki/Q61424","display_name":"Acylation","level":3,"score":0.7096648216247559},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.701307475566864},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5851643085479736},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.56376051902771},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5528035163879395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5498034954071045},{"id":"https://openalex.org/C184133267","wikidata":"https://www.wikidata.org/wiki/Q5090480","display_name":"Chemical modification","level":2,"score":0.471076637506485},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4614509344100952},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44894149899482727},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.43204888701438904},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.4301034212112427},{"id":"https://openalex.org/C2780430158","wikidata":"https://www.wikidata.org/wiki/Q7685902","display_name":"Target protein","level":3,"score":0.41906577348709106},{"id":"https://openalex.org/C2775954774","wikidata":"https://www.wikidata.org/wiki/Q899401","display_name":"Intein","level":5,"score":0.4184541404247284},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.41461390256881714},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3730051517486572},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3671107292175293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28221264481544495},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.09263864159584045},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.08545398712158203},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0841202437877655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08192774653434753},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000215","descriptor_name":"Acylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/cbic.202200332","doi":"https://doi.org/10.1002/cbic.202200332","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.202200332","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.202200332","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9826087","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9826087","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chembiochem","raw_type":"Text"},{"id":"pmid:35951442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35951442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chembiochem : a European journal of chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/572234","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/572234","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ChemBioChem, 23 (20)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000572234","doi":"https://doi.org/10.3929/ethz-b-000572234","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000572234","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/cbic.202200332","doi":"https://doi.org/10.1002/cbic.202200332","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.202200332","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.202200332","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2016294362","display_name":"Mineral microparticle-organic macromolecule-heavy metal interactions in natural waters: speciation at the nanoscale with analytical electron microscopies","funder_award_id":"42250","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G5511077943","display_name":null,"funder_award_id":"42250.1","funder_id":"https://openalex.org/F4320327931","funder_display_name":"Innosuisse - Schweizerische Agentur f\u00fcr Innovationsf\u00f6rderung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320327931","display_name":"Innosuisse - Schweizerische Agentur f\u00fcr Innovationsf\u00f6rderung","ror":"https://ror.org/05a2bhn71"},{"id":"https://openalex.org/F4320336859","display_name":"Functional Genomics Center Zurich","ror":"https://ror.org/04tgr1802"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290973267.pdf","grobid_xml":"https://content.openalex.org/works/W4290973267.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1964708816","https://openalex.org/W1966012201","https://openalex.org/W1970108447","https://openalex.org/W2000260992","https://openalex.org/W2040415740","https://openalex.org/W2083146987","https://openalex.org/W2088357489","https://openalex.org/W2134450909","https://openalex.org/W2317947423","https://openalex.org/W2406359775","https://openalex.org/W2406900093","https://openalex.org/W2491008760","https://openalex.org/W2779505132","https://openalex.org/W2799961143","https://openalex.org/W2887243151","https://openalex.org/W2913578359","https://openalex.org/W2936645928","https://openalex.org/W2989728684","https://openalex.org/W3007582551","https://openalex.org/W3010723488","https://openalex.org/W3015742158","https://openalex.org/W3025532812","https://openalex.org/W3081110541","https://openalex.org/W3086598145","https://openalex.org/W3092680773","https://openalex.org/W3093768976","https://openalex.org/W3152922933","https://openalex.org/W3158191005","https://openalex.org/W3160834656","https://openalex.org/W4210871186","https://openalex.org/W4213380054","https://openalex.org/W4223484160","https://openalex.org/W4225138738","https://openalex.org/W4230408684"],"related_works":["https://openalex.org/W3092680773","https://openalex.org/W2787695425","https://openalex.org/W4232871314","https://openalex.org/W7167268241","https://openalex.org/W2065591786","https://openalex.org/W3086598145","https://openalex.org/W2913578359","https://openalex.org/W2807313219","https://openalex.org/W1645960006","https://openalex.org/W4413840594"],"abstract_inverted_index":{"Although":[0],"viruses":[1],"have":[2],"been":[3],"successfully":[4],"repurposed":[5],"as":[6,99,101],"vaccines,":[7],"antibiotics,":[8],"and":[9,19,23,72,88,91,124],"anticancer":[10],"therapeutics,":[11],"they":[12],"also":[13],"raise":[14],"concerns":[15],"regarding":[16],"genome":[17],"integration":[18],"immunogenicity.":[20],"Virus-like":[21],"particles":[22],"non-viral":[24],"protein":[25,58,65,119],"cages":[26],"represent":[27],"a":[28,43,68],"potentially":[29],"safer":[30],"alternative":[31],"but":[32],"often":[33],"lack":[34],"desired":[35],"functionality.":[36],"Here,":[37],"we":[38],"investigated":[39],"the":[40,83,108,115],"utility":[41],"of":[42,85,107,110,121],"new":[44,130],"enzymatic":[45],"bioconjugation":[46],"method,":[47],"called":[48],"lysine":[49],"acylation":[50],"using":[51],"conjugating":[52],"enzymes":[53],"(LACE),":[54],"to":[55,117],"chemoenzymatically":[56],"modify":[57],"cages.":[59],"We":[60],"equipped":[61],"two":[62],"structurally":[63],"distinct":[64],"capsules":[66],"with":[67,76,96,104,129],"LACE-reactive":[69],"peptide":[70],"tag":[71],"demonstrated":[73],"their":[74,135],"modification":[75,95],"diverse":[77],"ligands.":[78],"This":[79,112],"modular":[80],"approach":[81],"combines":[82],"advantages":[84],"chemical":[86],"conjugation":[87],"genetic":[89],"fusion":[90],"allows":[92],"for":[93],"site-specific":[94],"recombinant":[97],"proteins":[98],"well":[100],"synthetic":[102],"peptides":[103],"facile":[105],"control":[106],"extent":[109],"labeling.":[111],"strategy":[113],"has":[114],"potential":[116],"fine-tune":[118],"containers":[120],"different":[122],"shape":[123],"size":[125],"by":[126],"providing":[127],"them":[128],"properties":[131],"that":[132],"go":[133],"beyond":[134],"biologically":[136],"native":[137],"functions.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-08-13T00:00:00"}