{"id":"https://openalex.org/W4290931343","doi":"https://doi.org/10.1021/jacs.2c02937","title":"Distinct Reactivity Modes of a Copper Hydride Enabled by an Intramolecular Lewis Acid","display_name":"Distinct Reactivity Modes of a Copper Hydride Enabled by an Intramolecular Lewis Acid","publication_year":2022,"publication_date":"2022-08-12","ids":{"openalex":"https://openalex.org/W4290931343","doi":"https://doi.org/10.1021/jacs.2c02937","pmid":"https://pubmed.ncbi.nlm.nih.gov/35960993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10291504"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.2c02937","doi":"https://doi.org/10.1021/jacs.2c02937","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.2c02937","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10291504/pdf/nihms-1904032.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030656860","display_name":"Emily E. Norwine","orcid":"https://orcid.org/0000-0001-5329-6229","observed_orcids":["https://orcid.org/0000-0001-5329-6229"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily E. Norwine","raw_affiliation_strings":["University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081979759","display_name":"John J. Kiernicki","orcid":"https://orcid.org/0000-0002-6240-5156","observed_orcids":["https://orcid.org/0000-0002-6240-5156"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Kiernicki","raw_affiliation_strings":["University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States"],"raw_orcid":"https://orcid.org/0000-0002-6240-5156","affiliations":[{"raw_affiliation_string":"University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025944326","display_name":"Mat\u00adthias Zeller","orcid":"https://orcid.org/0000-0002-3305-852X","observed_orcids":["https://orcid.org/0000-0002-3305-852X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias Zeller","raw_affiliation_strings":["Herbert C. Brown Laboratory, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States"],"raw_orcid":"https://orcid.org/0000-0002-3305-852X","affiliations":[{"raw_affiliation_string":"Herbert C. Brown Laboratory, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009251963","display_name":"Nathaniel K. Szymczak","orcid":"https://orcid.org/0000-0002-1296-1445","observed_orcids":["https://orcid.org/0000-0002-1296-1445"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nathaniel K. Szymczak","raw_affiliation_strings":["University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States"],"raw_orcid":"https://orcid.org/0000-0002-1296-1445","affiliations":[{"raw_affiliation_string":"University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009251963"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.1884,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.88232762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"144","issue":"33","first_page":"15038","last_page":"15046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.4083999991416931,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.4083999991416931,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11441","display_name":"Organoboron and organosilicon chemistry","score":0.19840000569820404,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.13050000369548798,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper-hydride","display_name":"copper hydride","score":0.8349999785423279},{"id":"https://openalex.org/keywords/boron-lewis-acids","display_name":"boron Lewis acids","score":0.8790000081062317},{"id":"https://openalex.org/keywords/1-4-7-triazacyclononane","display_name":"1,4,7-triazacyclononane","score":0.9710000157356262},{"id":"https://openalex.org/keywords/copper-i-complexes","display_name":"copper(I) complexes","score":0.7250000238418579},{"id":"https://openalex.org/keywords/hydrogen-evolution-reaction","display_name":"hydrogen evolution reaction","score":0.8939999938011169},{"id":"https://openalex.org/keywords/alkyne-reduction","display_name":"alkyne reduction","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9668511152267456},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.8410625457763672},{"id":"https://openalex.org/C2777961443","wikidata":"https://www.wikidata.org/wiki/Q106520","display_name":"Hydride","level":3,"score":0.820073664188385},{"id":"https://openalex.org/C2775855785","wikidata":"https://www.wikidata.org/wiki/Q2270356","display_name":"Metalation","level":2,"score":0.8180199861526489},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.7525240778923035},{"id":"https://openalex.org/C2779012754","wikidata":"https://www.wikidata.org/wiki/Q159226","display_name":"Alkyne","level":3,"score":0.6909750699996948},{"id":"https://openalex.org/C163638829","wikidata":"https://www.wikidata.org/wiki/Q900337","display_name":"Lewis acids and bases","level":3,"score":0.675022542476654},{"id":"https://openalex.org/C501308230","wikidata":"https://www.wikidata.org/wiki/Q618","display_name":"Boron","level":2,"score":0.5980483293533325},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.5887799263000488},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4343542158603668},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.41495952010154724},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4051823318004608},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3476649522781372},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.284795880317688},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22317776083946228},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.15806961059570312},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0821402370929718},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001895","descriptor_name":"Boron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058116","descriptor_name":"Lewis Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/jacs.2c02937","doi":"https://doi.org/10.1021/jacs.2c02937","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.2c02937","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:35960993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35960993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10291504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10291504","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10291504/pdf/nihms-1904032.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10291504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10291504","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10291504/pdf/nihms-1904032.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1124212407","display_name":null,"funder_award_id":"CHE1625543","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G1930378340","display_name":"The Role of Secondary Interactions Relevant to Biological Reductions of Small Molecules","funder_award_id":"R35GM136360","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3078950143","display_name":"MRI:  Acquisition of an X-ray Diffractometer at Purdue University","funder_award_id":"1625543","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4267811985","display_name":null,"funder_award_id":"1625543","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306315","display_name":"Camille and Henry Dreyfus Foundation","ror":"https://ror.org/019p8h045"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290931343.pdf","grobid_xml":"https://content.openalex.org/works/W4290931343.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1906318094","https://openalex.org/W1965428201","https://openalex.org/W1970416686","https://openalex.org/W1977055582","https://openalex.org/W1979736846","https://openalex.org/W1985548752","https://openalex.org/W1999582957","https://openalex.org/W1999687041","https://openalex.org/W2002096928","https://openalex.org/W2002892929","https://openalex.org/W2012742825","https://openalex.org/W2023630158","https://openalex.org/W2057960152","https://openalex.org/W2058229775","https://openalex.org/W2059019886","https://openalex.org/W2059290973","https://openalex.org/W2066747456","https://openalex.org/W2075132776","https://openalex.org/W2087699935","https://openalex.org/W2088241536","https://openalex.org/W2095029118","https://openalex.org/W2107081186","https://openalex.org/W2127373955","https://openalex.org/W2131073880","https://openalex.org/W2134657215","https://openalex.org/W2149850909","https://openalex.org/W2159794836","https://openalex.org/W2160244611","https://openalex.org/W2161555085","https://openalex.org/W2162449746","https://openalex.org/W2165056068","https://openalex.org/W2165753513","https://openalex.org/W2178175437","https://openalex.org/W2191239964","https://openalex.org/W2199017923","https://openalex.org/W2243663245","https://openalex.org/W2265252028","https://openalex.org/W2285239204","https://openalex.org/W2294180076","https://openalex.org/W2315795462","https://openalex.org/W2316353842","https://openalex.org/W2321396989","https://openalex.org/W2325128343","https://openalex.org/W2325573195","https://openalex.org/W2329999676","https://openalex.org/W2330703182","https://openalex.org/W2331937820","https://openalex.org/W2333094183","https://openalex.org/W2343656461","https://openalex.org/W2429119539","https://openalex.org/W2463228036","https://openalex.org/W2476839356","https://openalex.org/W2482236566","https://openalex.org/W2482975889","https://openalex.org/W2518629815","https://openalex.org/W2550399556","https://openalex.org/W2619886577","https://openalex.org/W2773751703","https://openalex.org/W2779196338","https://openalex.org/W2794637900","https://openalex.org/W2795397166","https://openalex.org/W2893297271","https://openalex.org/W2905566536","https://openalex.org/W2908938395","https://openalex.org/W2944783027","https://openalex.org/W2951427984","https://openalex.org/W2967550406","https://openalex.org/W2971640787","https://openalex.org/W2973927592","https://openalex.org/W2999935086","https://openalex.org/W3005475928","https://openalex.org/W3089671819","https://openalex.org/W3116179859","https://openalex.org/W3128225784","https://openalex.org/W3136950785","https://openalex.org/W3163418898","https://openalex.org/W3182661134","https://openalex.org/W3184165198","https://openalex.org/W3186047504","https://openalex.org/W4200623428","https://openalex.org/W4213335899","https://openalex.org/W4286212480","https://openalex.org/W4397615933","https://openalex.org/W4397677189"],"related_works":["https://openalex.org/W4400355077","https://openalex.org/W4225611559","https://openalex.org/W2161338373","https://openalex.org/W3013211804","https://openalex.org/W2042353641","https://openalex.org/W3128225784","https://openalex.org/W2587544431","https://openalex.org/W2952231802","https://openalex.org/W1976731171","https://openalex.org/W3013416615"],"abstract_inverted_index":{"We":[0,26],"disclose":[1],"a":[2,16,22,32],"1,4,7-triazacyclononane":[3],"(TACN)":[4],"ligand":[5],"featuring":[6],"an":[7],"appended":[8],"boron":[9],"Lewis":[10],"acid.":[11],"Metalation":[12],"with":[13],"Cu(I)":[14],"affords":[15],"series":[17],"of":[18,34],"tetrahedral":[19],"complexes":[20],"including":[21],"boron-capped":[23],"cuprous":[24],"hydride.":[25],"demonstrate":[27],"distinct":[28],"reactivity":[29],"modes":[30],"as":[31,51,53],"function":[33],"chemical":[35],"oxidation:":[36],"hydride":[37],"transfer":[38],"to":[39],"CO":[40],"2":[41,49],"in":[42],"the":[43],"copper(I)":[44],"state":[45],"and":[46],"oxidant-induced":[47],"H":[48],"evolution":[50],"well":[52],"alkyne":[54],"reduction.":[55]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-13T00:00:00"}