{"id":"https://openalex.org/W4290852192","doi":"https://doi.org/10.1371/journal.ppat.1010771","title":"The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness","display_name":"The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness","publication_year":2022,"publication_date":"2022-08-12","ids":{"openalex":"https://openalex.org/W4290852192","doi":"https://doi.org/10.1371/journal.ppat.1010771","pmid":"https://pubmed.ncbi.nlm.nih.gov/35960766","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9401124"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1010771","doi":"https://doi.org/10.1371/journal.ppat.1010771","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1010771","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010771&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010771&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060130159","display_name":"Marion Lagune","orcid":"https://orcid.org/0000-0001-9600-5719","observed_orcids":["https://orcid.org/0000-0001-9600-5719"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4390039363","display_name":"Infection et inflammation","ror":"https://ror.org/021sh3243","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marion Lagune","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089641764","display_name":"Vincent Le Moigne","orcid":"https://orcid.org/0000-0003-2012-1750","observed_orcids":["https://orcid.org/0000-0003-2012-1750"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4390039363","display_name":"Infection et inflammation","ror":"https://ror.org/021sh3243","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Le Moigne","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013175164","display_name":"Matt D. Johansen","orcid":"https://orcid.org/0000-0001-5553-5270","observed_orcids":["https://orcid.org/0000-0001-5553-5270"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Matt D. Johansen","raw_affiliation_strings":["Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Universit\u00e9 de Montpellier, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Universit\u00e9 de Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017649537","display_name":"Flor V\u00e1squez Sotomayor","orcid":"https://orcid.org/0000-0003-1695-0409","observed_orcids":["https://orcid.org/0000-0003-1695-0409"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Flor V\u00e1squez Sotomayor","raw_affiliation_strings":["National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003862643","display_name":"Wassim Daher","orcid":"https://orcid.org/0000-0001-9026-5333","observed_orcids":["https://orcid.org/0000-0001-9026-5333"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wassim Daher","raw_affiliation_strings":["Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Universit\u00e9 de Montpellier, Montpellier, France","INSERM, IRIM, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Universit\u00e9 de Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]},{"raw_affiliation_string":"INSERM, IRIM, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210140640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108015339","display_name":"C\u00e9cile Petit","orcid":"https://orcid.org/0000-0002-1864-6630","observed_orcids":["https://orcid.org/0000-0002-1864-6630"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C\u00e9cile Petit","raw_affiliation_strings":["European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033836195","display_name":"Gina Cosentino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4390039363","display_name":"Infection et inflammation","ror":"https://ror.org/021sh3243","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gina Cosentino","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061614023","display_name":"Laura Paulowski","orcid":"https://orcid.org/0000-0002-6662-4196","observed_orcids":["https://orcid.org/0000-0002-6662-4196"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Paulowski","raw_affiliation_strings":["National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083044115","display_name":"Thomas Gutsmann","orcid":"https://orcid.org/0000-0001-5061-7891","observed_orcids":["https://orcid.org/0000-0001-5061-7891"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Gutsmann","raw_affiliation_strings":["Research Center Borstel, Leibniz Lung Center, Division of Biophysics, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center Borstel, Leibniz Lung Center, Division of Biophysics, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088714014","display_name":"Matthias Wilmanns","orcid":"https://orcid.org/0000-0002-4643-5435","observed_orcids":["https://orcid.org/0000-0002-4643-5435","https://orcid.org/0000-0003-2486-5239"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Wilmanns","raw_affiliation_strings":["European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019449593","display_name":"Florian P. Maurer","orcid":"https://orcid.org/0000-0001-8353-5964","observed_orcids":["https://orcid.org/0000-0001-8353-5964"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florian P. Maurer","raw_affiliation_strings":["Institute of Medical Microbiology, Virology and Hospital Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, Virology and Hospital Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029558296","display_name":"Jean\u2010Louis Herrmann","orcid":"https://orcid.org/0000-0003-2347-6418","observed_orcids":["https://orcid.org/0000-0003-2347-6418","https://orcid.org/0000-0001-5907-5793"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210134648","display_name":"H\u00f4pital Raymond-Poincar\u00e9","ror":"https://ror.org/03pef0w96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210134648"]},{"id":"https://openalex.org/I4390039363","display_name":"Infection et inflammation","ror":"https://ror.org/021sh3243","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Louis Herrmann","raw_affiliation_strings":["APHP, GHU Paris-Saclay, H\u00f4pital Raymond Poincar\u00e9, Service de Microbiologie, Garches, France","Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France"],"raw_orcid":"https://orcid.org/0000-0003-2347-6418","affiliations":[{"raw_affiliation_string":"APHP, GHU Paris-Saclay, H\u00f4pital Raymond Poincar\u00e9, Service de Microbiologie, Garches, France","institution_ids":["https://openalex.org/I4210134648"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071037321","display_name":"Fabienne Girard\u2010Misguich","orcid":"https://orcid.org/0000-0002-7571-6519","observed_orcids":["https://orcid.org/0000-0002-7571-6519"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4390039363","display_name":"Infection et inflammation","ror":"https://ror.org/021sh3243","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fabienne Girard-Misguich","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et inflammation, Montigny-Le-Bretonneux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4390039363"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056305582","display_name":"Laurent Kremer","orcid":"https://orcid.org/0000-0002-6604-4458","observed_orcids":["https://orcid.org/0000-0002-6604-4458"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Laurent Kremer","raw_affiliation_strings":["Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Universit\u00e9 de Montpellier, Montpellier, France","INSERM, IRIM, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Universit\u00e9 de Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]},{"raw_affiliation_string":"INSERM, IRIM, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210140640"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5019449593","https://openalex.org/A5029558296","https://openalex.org/A5056305582","https://openalex.org/A5071037321","https://openalex.org/A5088714014"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I19894307","https://openalex.org/I277688954","https://openalex.org/I4210108711","https://openalex.org/I4210128097","https://openalex.org/I4210134648","https://openalex.org/I4210138560","https://openalex.org/I4210140640","https://openalex.org/I4210153543","https://openalex.org/I4390039363"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2466,"currency":"EUR","value_usd":2659},"fwci":3.2934,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.93316832,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"18","issue":"8","first_page":"e1010771","last_page":"e1010771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.11620000004768372,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-abscessus","display_name":"Mycobacterium abscessus","score":0.949999988079071},{"id":"https://openalex.org/keywords/type-vii-secretion-system","display_name":"type VII secretion system","score":0.8999999761581421},{"id":"https://openalex.org/keywords/effector-proteins","display_name":"effector proteins","score":0.8009999990463257},{"id":"https://openalex.org/keywords/heterodimer","display_name":"heterodimer","score":0.7070000171661377},{"id":"https://openalex.org/keywords/membrane-permeabilization","display_name":"membrane permeabilization","score":0.8420000076293945},{"id":"https://openalex.org/keywords/intracellular-survival","display_name":"intracellular survival","score":0.7929999828338623},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.5690000057220459},{"id":"https://openalex.org/keywords/macrophage-infection","display_name":"macrophage infection","score":0.6690000295639038},{"id":"https://openalex.org/keywords/bacterial-persistence","display_name":"bacterial persistence","score":0.6050000190734863},{"id":"https://openalex.org/keywords/zebrafish-infection-model","display_name":"zebrafish infection model","score":0.7480000257492065},{"id":"https://openalex.org/keywords/mouse-model-of-infection","display_name":"mouse infection model","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8282831907272339},{"id":"https://openalex.org/C2776111603","wikidata":"https://www.wikidata.org/wiki/Q6946978","display_name":"Mycobacterium abscessus","level":4,"score":0.8224079608917236},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7112196087837219},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6778308749198914},{"id":"https://openalex.org/C161478664","wikidata":"https://www.wikidata.org/wiki/Q901955","display_name":"Phagosome","level":3,"score":0.6467596292495728},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6060183048248291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5941686630249023},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.5923647284507751},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5797422528266907},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5628741979598999},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5611417889595032},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.47885772585868835},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47884535789489746},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.31177401542663574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2912936210632324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20190557837486267},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19234561920166016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11006942391395569}],"mesh":[{"descriptor_ui":"D000069377","descriptor_name":"Type VII Secretion Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000069377","descriptor_name":"Type VII Secretion Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000073358","descriptor_name":"Mycobacterium abscessus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019910","descriptor_name":"Mycobacterium marinum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.ppat.1010771","doi":"https://doi.org/10.1371/journal.ppat.1010771","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1010771","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010771&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmid:35960766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35960766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9401124","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9401124/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-03751522v1","doi":null,"is_oa":true,"landing_page_url":"https://uvsq.hal.science/hal-03751522","pdf_url":"https://uvsq.hal.science/hal-03751522v1/file/journal.ppat.1010771.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 2022, 18 (8), pp.e1010771. ⟨10.1371/journal.ppat.1010771⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f4437e588dda4b4387ffeba73b917254","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f4437e588dda4b4387ffeba73b917254","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 18, Iss 8, p e1010771 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1010771","doi":"https://doi.org/10.1371/journal.ppat.1010771","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1010771","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010771&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G102179115","display_name":null,"funder_award_id":"ANR-10-LABX-12-01","funder_id":"https://openalex.org/F4320330081","funder_display_name":"Laboratoire d'Excellence EpiGenMed"},{"id":"https://openalex.org/G2337407410","display_name":null,"funder_award_id":"10-LABX-12-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2465067033","display_name":null,"funder_award_id":"ANR-10-LABX-12-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4463643225","display_name":null,"funder_award_id":"grant agreement n\u00b0RIF20190502522","funder_id":"https://openalex.org/F4320323786","funder_display_name":"Association Vaincre la Mucoviscidose"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7376787254","display_name":null,"funder_award_id":"ANR-10-LABX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G793941223","display_name":"From Genome and Epigenome to Molecular Medicine: turning new paradigms in biology into the therapeutic strategies of tomorrow","funder_award_id":"ANR-10-LABX-0012","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G993277415","display_name":"Structure/function of a prototypic type VII secretion system from a fast-growing pathogenic mycobacteria","funder_award_id":"846476","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320310697","display_name":"Joachim Herz Stiftung","ror":"https://ror.org/01j8qgg43"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320323786","display_name":"Association Vaincre la Mucoviscidose","ror":"https://ror.org/00gp9bw49"},{"id":"https://openalex.org/F4320330081","display_name":"Laboratoire d'Excellence EpiGenMed","ror":null},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290852192.pdf","grobid_xml":"https://content.openalex.org/works/W4290852192.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1418640045","https://openalex.org/W1548106543","https://openalex.org/W1898863040","https://openalex.org/W1920434477","https://openalex.org/W1971536912","https://openalex.org/W1992799735","https://openalex.org/W1996230675","https://openalex.org/W2000472417","https://openalex.org/W2012451546","https://openalex.org/W2015648468","https://openalex.org/W2051792510","https://openalex.org/W2057740405","https://openalex.org/W2074401088","https://openalex.org/W2075187364","https://openalex.org/W2078178166","https://openalex.org/W2098107406","https://openalex.org/W2101358576","https://openalex.org/W2112473074","https://openalex.org/W2118978296","https://openalex.org/W2141115207","https://openalex.org/W2155181416","https://openalex.org/W2160239525","https://openalex.org/W2223993952","https://openalex.org/W2225338927","https://openalex.org/W2300801912","https://openalex.org/W2315325009","https://openalex.org/W2328653408","https://openalex.org/W2329943654","https://openalex.org/W2413218470","https://openalex.org/W2479871546","https://openalex.org/W2535274628","https://openalex.org/W2558222949","https://openalex.org/W2580358075","https://openalex.org/W2592510217","https://openalex.org/W2607240190","https://openalex.org/W2783698286","https://openalex.org/W2784014905","https://openalex.org/W2883128367","https://openalex.org/W2897003522","https://openalex.org/W2979491247","https://openalex.org/W2986136624","https://openalex.org/W2997527981","https://openalex.org/W3009004529","https://openalex.org/W3014829746","https://openalex.org/W3049333657","https://openalex.org/W3123875335","https://openalex.org/W3133923741","https://openalex.org/W3155223672","https://openalex.org/W3163944831","https://openalex.org/W3199370352","https://openalex.org/W3211775897","https://openalex.org/W4200038919","https://openalex.org/W4220940287"],"related_works":["https://openalex.org/W4407096258","https://openalex.org/W7214250744","https://openalex.org/W7151030173","https://openalex.org/W2783698286","https://openalex.org/W7163650268","https://openalex.org/W7125688699","https://openalex.org/W7151369476","https://openalex.org/W4393910996","https://openalex.org/W4200038919","https://openalex.org/W4416410480"],"abstract_inverted_index":{"ESX":[0],"type":[1],"VII":[2],"secretion":[3,7,46],"systems":[4],"are":[5,90],"complex":[6],"machineries":[8],"spanning":[9],"across":[10],"the":[11,28,53,62,70,136,163],"mycobacterial":[12],"membrane":[13,125],"and":[14,23,57,59,76,80,88,94,108,150,154,167,171],"play":[15],"an":[16,119,132],"important":[17],"role":[18,29],"in":[19,32,78,81,112,118,131,152],"pathogenicity,":[20],"nutrient":[21],"uptake":[22],"conjugation.":[24],"We":[25],"previously":[26],"reported":[27],"of":[30,40,47,72,92,106,165,173],"ESX-4":[31,93],"modulating":[33],"Mycobacterium":[34],"abscessus":[35,74,130,175],"intracellular":[36],"survival.":[37],"The":[38],"loss":[39],"EccB4":[41],"was":[42,110,139],"associated":[43,140],"with":[44,141],"limited":[45],"two":[48],"effector":[49],"proteins":[50],"belonging":[51],"to":[52,68],"WXG-100":[54],"family,":[55],"EsxU":[56,75,87,166],"EsxT,":[58],"encoded":[60],"by":[61,146],"esx-4":[63],"locus.":[64],"This":[65],"prompted":[66],"us":[67],"investigate":[69],"function":[71],"M.":[73,113,129,174],"EsxT":[77,89,168],"vitro":[79],"vivo.":[82],"Herein,":[83],"we":[84],"show":[85],"that":[86,100,162],"substrates":[91],"form":[95],"a":[96,142],"stable":[97],"1:1":[98],"heterodimer":[99],"permeabilizes":[101],"artificial":[102],"membranes.":[103],"While":[104],"expression":[105],"esxU":[107],"esxT":[109],"up-regulated":[111],"abscessus-infected":[114],"macrophages,":[115],"their":[116],"absence":[117],"esxUT":[120,137],"deletion":[121,138],"mutant":[122],"prevented":[123],"phagosomal":[124],"disruption":[126],"while":[127],"maintaining":[128],"unacidified":[133],"phagosome.":[134],"Unexpectedly,":[135],"hyper-virulent":[143],"phenotype,":[144],"characterised":[145],"increased":[147],"bacterial":[148],"loads":[149],"mortality":[151],"mouse":[153],"zebrafish":[155],"infection":[156],"models.":[157],"Collectively,":[158],"these":[159],"results":[160],"demonstrate":[161],"presence":[164],"dampens":[169],"survival":[170],"persistence":[172],"during":[176],"infection.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-12T00:00:00"}