{"id":"https://openalex.org/W4290829809","doi":"https://doi.org/10.1136/jnnp-2022-abn2.183","title":"139 Characterising DARC (Detecting Apoptosing Retinal Cells) spots in optic neuritis","display_name":"139 Characterising DARC (Detecting Apoptosing Retinal Cells) spots in optic neuritis","publication_year":2022,"publication_date":"2022-08-12","ids":{"openalex":"https://openalex.org/W4290829809","doi":"https://doi.org/10.1136/jnnp-2022-abn2.183"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp-2022-abn2.183","doi":"https://doi.org/10.1136/jnnp-2022-abn2.183","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2022-abn2.183","pdf_url":null,"source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100785289","display_name":"Soyoung Choi","orcid":"https://orcid.org/0000-0001-8229-0248","observed_orcids":["https://orcid.org/0000-0001-8229-0248"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Soyoung Choi","raw_affiliation_strings":["UCL Institute of Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Ophthalmology","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103128040","display_name":"John Maddison","orcid":"https://orcid.org/0000-0001-8692-8878","observed_orcids":["https://orcid.org/0000-0001-8692-8878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Maddison","raw_affiliation_strings":["Novai Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novai Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019481679","display_name":"Richard S. Nicholas","orcid":"https://orcid.org/0000-0003-0414-1225","observed_orcids":["https://orcid.org/0000-0003-0414-1225"]},"institutions":[{"id":"https://openalex.org/I39586589","display_name":"Swansea University","ror":"https://ror.org/053fq8t95","country_code":"GB","type":"education","lineage":["https://openalex.org/I39586589"]},{"id":"https://openalex.org/I4210136817","display_name":"Western Eye Hospital","ror":"https://ror.org/04g0t2d47","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I4210136817"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Nicholas","raw_affiliation_strings":["ICORG Imperial College London and Western Eye Hospital ICHNT","Swansea University","UCL Institute of Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICORG Imperial College London and Western Eye Hospital ICHNT","institution_ids":["https://openalex.org/I4210136817","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Swansea University","institution_ids":["https://openalex.org/I39586589"]},{"raw_affiliation_string":"UCL Institute of Ophthalmology","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044451478","display_name":"Maria Francesca Cordeiro","orcid":"https://orcid.org/0000-0001-8663-6525","observed_orcids":["https://orcid.org/0000-0001-8663-6525"]},"institutions":[{"id":"https://openalex.org/I4210136817","display_name":"Western Eye Hospital","ror":"https://ror.org/04g0t2d47","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I4210136817"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francesca Cordeiro","raw_affiliation_strings":["ICORG Imperial College London and Western Eye Hospital ICHNT","UCL Institute of Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICORG Imperial College London and Western Eye Hospital ICHNT","institution_ids":["https://openalex.org/I4210136817","https://openalex.org/I47508984"]},{"raw_affiliation_string":"UCL Institute of Ophthalmology","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1428,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.40230296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"93","issue":"9","first_page":"e2.94","last_page":"e2.94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.10170000046491623,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optic-neuritis","display_name":"optic neuritis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/duffy-antigen-receptor-for-chemokines","display_name":"DARC","score":0.8640000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.36899998784065247},{"id":"https://openalex.org/keywords/retinal-imaging","display_name":"retinal imaging","score":0.8009999990463257},{"id":"https://openalex.org/keywords/annexin-v","display_name":"annexin V","score":0.7850000262260437},{"id":"https://openalex.org/keywords/convolutional-neural-networks","display_name":"convolutional neural networks","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hu-moments","display_name":"Hu moments","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2781255879","wikidata":"https://www.wikidata.org/wiki/Q7580087","display_name":"Spots","level":2,"score":0.799428403377533},{"id":"https://openalex.org/C166963901","wikidata":"https://www.wikidata.org/wiki/Q287251","display_name":"Kurtosis","level":2,"score":0.7632268667221069},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6322695016860962},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5559934973716736},{"id":"https://openalex.org/C2776572573","wikidata":"https://www.wikidata.org/wiki/Q972514","display_name":"Optic neuritis","level":3,"score":0.5508562922477722},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.4117926359176636},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35530489683151245},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.3380630612373352},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2146834135055542},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10797694325447083},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07676342129707336}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jnnp-2022-abn2.183","doi":"https://doi.org/10.1136/jnnp-2022-abn2.183","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2022-abn2.183","pdf_url":null,"source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409970686","https://openalex.org/W2549916719","https://openalex.org/W2770149207","https://openalex.org/W2920313371","https://openalex.org/W7211879949","https://openalex.org/W4295014903","https://openalex.org/W7197022540","https://openalex.org/W2237493820","https://openalex.org/W4402364106","https://openalex.org/W4406688126"],"abstract_inverted_index":{"Purpose":[0],"Optic":[1],"neuritis":[2],"(ON)":[3],"is":[4,13],"a":[5,49,174],"common":[6],"feature":[7],"of":[8,44,94,127,167,197],"Multiple":[9],"Sclerosis":[10],"(MS).":[11],"DARC":[12,33,45,56,62,159,198],"an":[14],"intravenous":[15],"fluo-":[16],"rescent-tagged":[17],"annexin":[18],"V":[19],"(ANX776)":[20],"identifying":[21],"cell":[22],"stress":[23],"and":[24,70,105,116,140,145,147,163,182,193,202],"apoptosis":[25],"with":[26,207],"retinal":[27],"imaging.":[28],"We":[29],"aimed":[30],"to":[31,154,213],"differentiate":[32],"spots":[34,46,57,160,184,199],"in":[35,161],"ON":[36,66,112,162,181,201,209],"from":[37,60,65,99],"healthy":[38,71,117,164,183,203],"subjects":[39],"using":[40,79,122,132],"descriptive":[41],"measures":[42],"(DM)":[43],"identified":[47,59],"by":[48],"convolutional":[50],"neural":[51],"network-aided":[52],"algorithm":[53],"(CNN-AA).":[54],"Methods":[55],"were":[58,109,130,152],"anonymised":[61],"images":[63],"obtained":[64],"(n=12;":[67],"mean":[68,73],"age=46)":[69],"(n=68;":[72],"age=48)":[74],"participants":[75],"after":[76],"ANX776":[77],"administration":[78],"the":[80,100,106,168,186],"CNN-AA":[81],"(":[82],"ISRCTN10751859":[83],").":[84],"DM":[85,170,196],"characteristics:":[86],"mean,":[87,138],"standard":[88],"deviation":[89],"(std),":[90],"skew,":[91],"kurtosis,":[92,191],"coefficient":[93],"variation":[95],"(cv),":[96],"Euclidean":[97],"distance":[98],"nearest":[101],"blood":[102],"vessel":[103],"(bvdist)":[104],"7Hu":[107],"moments,":[108],"analysed":[110,131],"on":[111],"(n":[113,118],"=":[114,119],"357)":[115],"2457)":[120],"eyes":[121],"two-tailed":[123],"student":[124],"t-tests.":[125],"Distributions":[126,166],"spot":[128],"metrics":[129,171],"two-sample":[133],"Kolmogorov-Smirnov":[134],"test.":[135],"Results":[136],"The":[137],"cv":[139],"kurtosis":[141],"(p":[142,149,177],"\u00a3":[143,150,178],"0.0001)":[144,179],"hu1":[146,192],"std":[148],"0.001)":[151],"found":[153],"be":[155],"significantly":[156],"different":[157],"between":[158,180],"controls.":[165],"individual":[169],"analysed,":[172],"showed":[173],"significant":[175],"difference":[176],"for":[185],"same":[187],"variables":[188],"(mean,":[189],"cv,":[190],"std).":[194],"Conclusion":[195],"distinguish":[200],"subjects.":[204],"Further":[205],"studies":[206],"larger":[208],"groups":[210],"are":[211],"needed":[212],"replicate":[214],"this":[215],"finding.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-08-12T00:00:00"}
