{"id":"https://openalex.org/W4290805624","doi":"https://doi.org/10.1097/mnm.0000000000001596","title":"Role of dynamic and parametric whole-body FDG PET/CT imaging in molecular characterization of primary breast cancer: a single institution experience","display_name":"Role of dynamic and parametric whole-body FDG PET/CT imaging in molecular characterization of primary breast cancer: a single institution experience","publication_year":2022,"publication_date":"2022-08-10","ids":{"openalex":"https://openalex.org/W4290805624","doi":"https://doi.org/10.1097/mnm.0000000000001596","pmid":"https://pubmed.ncbi.nlm.nih.gov/35950356"},"language":"en","primary_location":{"id":"doi:10.1097/mnm.0000000000001596","doi":"https://doi.org/10.1097/mnm.0000000000001596","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mnm.0000000000001596","pdf_url":null,"source":{"id":"https://openalex.org/S108023290","display_name":"Nuclear Medicine Communications","issn_l":"0143-3636","issn":["0143-3636","1473-5628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022256945","display_name":"Sumati Sundaraiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1300678687","display_name":"Madras Institute of Orthopaedics and Traumatology","ror":"https://ror.org/0037zb552","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1300678687"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sumati Sundaraiya","raw_affiliation_strings":["Department of Nuclear Medicine, MIOT International"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, MIOT International","institution_ids":["https://openalex.org/I1300678687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014581740","display_name":"Thirumalairaj Raja","orcid":"https://orcid.org/0009-0009-7164-1255","observed_orcids":["https://orcid.org/0009-0009-7164-1255"]},"institutions":[{"id":"https://openalex.org/I4210130696","display_name":"Apollo Hospitals","ror":"https://ror.org/035fmf715","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210130696"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Raja T","raw_affiliation_strings":["Department of Medical Oncology, Apollo cancer hospitals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Apollo cancer hospitals","institution_ids":["https://openalex.org/I4210130696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047547148","display_name":"Sapna Nangia","orcid":"https://orcid.org/0000-0003-1712-7879","observed_orcids":["https://orcid.org/0000-0003-1712-7879"]},"institutions":[{"id":"https://openalex.org/I4210154769","display_name":"Apollo Proton Cancer Centre","ror":"https://ror.org/04sve9e90","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210154769"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sapna Nangia","raw_affiliation_strings":["Department of Radiation Oncology, Apollo Proton Cancer Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Apollo Proton Cancer Centre","institution_ids":["https://openalex.org/I4210154769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012687354","display_name":"Bhawna Sirohi","orcid":"https://orcid.org/0000-0001-8093-1531","observed_orcids":["https://orcid.org/0000-0001-8093-1531"]},"institutions":[{"id":"https://openalex.org/I4210154769","display_name":"Apollo Proton Cancer Centre","ror":"https://ror.org/04sve9e90","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210154769"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhawna Sirohi","raw_affiliation_strings":["Department of Medical Oncology, Apollo Proton Cancer Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Apollo Proton Cancer Centre","institution_ids":["https://openalex.org/I4210154769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105471258","display_name":"Sushama Patil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154769","display_name":"Apollo Proton Cancer Centre","ror":"https://ror.org/04sve9e90","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210154769"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sushama Patil","raw_affiliation_strings":["Department of Pathology, Apollo Proton Cancer Centre, Chennai, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Apollo Proton Cancer Centre, Chennai, Tamilnadu, India","institution_ids":["https://openalex.org/I4210154769"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014581740","https://openalex.org/A5022256945"],"corresponding_institution_ids":["https://openalex.org/I1300678687","https://openalex.org/I4210130696"],"apc_list":null,"apc_paid":null,"fwci":1.0871,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.71219903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"43","issue":"9","first_page":"1015","last_page":"1025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-breast-cancer","display_name":"primary breast cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/fdg-pet-ct","display_name":"FDG PET/CT","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dynamic-pet","display_name":"dynamic PET","score":0.6570000052452087},{"id":"https://openalex.org/keywords/parametric-imaging","display_name":"parametric imaging","score":0.8790000081062317},{"id":"https://openalex.org/keywords/patlak-plot","display_name":"Patlak plot","score":0.9160000085830688},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.9779999852180481},{"id":"https://openalex.org/keywords/standardized-uptake-value","display_name":"standardized uptake value","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.871999979019165},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tumor-staging","display_name":"tumor staging","score":0.4059999883174896},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/molecular-characterization","display_name":"molecular characterization","score":0.43299999833106995},{"id":"https://openalex.org/keywords/list-mode-acquisition","display_name":"list-mode acquisition","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7736690640449524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.704100489616394},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6335918307304382},{"id":"https://openalex.org/C199374082","wikidata":"https://www.wikidata.org/wiki/Q907080","display_name":"Standardized uptake value","level":3,"score":0.576063871383667},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.488398015499115},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.46750956773757935},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4655851423740387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31729423999786377},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2493440806865692}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051598","descriptor_name":"Whole Body Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mnm.0000000000001596","doi":"https://doi.org/10.1097/mnm.0000000000001596","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mnm.0000000000001596","pdf_url":null,"source":{"id":"https://openalex.org/S108023290","display_name":"Nuclear Medicine Communications","issn_l":"0143-3636","issn":["0143-3636","1473-5628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine Communications","raw_type":"journal-article"},{"id":"pmid:35950356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35950356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear medicine communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1533336328","https://openalex.org/W1924227990","https://openalex.org/W1969411880","https://openalex.org/W1979750265","https://openalex.org/W1981954633","https://openalex.org/W1985650368","https://openalex.org/W1990159346","https://openalex.org/W1990434772","https://openalex.org/W2007346130","https://openalex.org/W2010871781","https://openalex.org/W2012440256","https://openalex.org/W2022293767","https://openalex.org/W2034877326","https://openalex.org/W2042752379","https://openalex.org/W2049420719","https://openalex.org/W2054270840","https://openalex.org/W2065877493","https://openalex.org/W2072326013","https://openalex.org/W2089631910","https://openalex.org/W2090816843","https://openalex.org/W2098896768","https://openalex.org/W2105656190","https://openalex.org/W2121412644","https://openalex.org/W2129487338","https://openalex.org/W2144183889","https://openalex.org/W2152210952","https://openalex.org/W2159489835","https://openalex.org/W2166467219","https://openalex.org/W2168021523","https://openalex.org/W2190593755","https://openalex.org/W2313621585","https://openalex.org/W2749123167","https://openalex.org/W2767351057","https://openalex.org/W2767634354","https://openalex.org/W2892892233","https://openalex.org/W2926696132","https://openalex.org/W2996073893","https://openalex.org/W3026410403","https://openalex.org/W6663140742"],"related_works":["https://openalex.org/W2926696132","https://openalex.org/W7223439627","https://openalex.org/W2734533713","https://openalex.org/W7166562204","https://openalex.org/W4392375462","https://openalex.org/W3126362037","https://openalex.org/W3026902415","https://openalex.org/W4231061941","https://openalex.org/W2275858470","https://openalex.org/W4284879764"],"abstract_inverted_index":{"AIM:":[0],"The":[1,72,92,157,303],"aim":[2],"of":[3,12,23,69,107,313,329,363],"this":[4],"pilot":[5],"study":[6],"was":[7,98,160,213,322],"to":[8,162,216,233,262,307,324,327,339,379],"assess":[9],"the":[10,20,62,103,108,120,220,229,234,253,291,314,334,380],"role":[11],"dynamic":[13,51,109],"whole-body":[14,50],"PET":[15,57],"and":[16,80,88,115,127,137,142,153,182,199,204,242,256,277,285,383],"parametric":[17,74,85],"imaging":[18,75],"in":[19,39,61,166,192,331,359,372],"biological":[21,315,384],"characterization":[22],"primary":[24,35,374],"breast":[25,36,364,375],"cancer.":[26],"MATERIALS":[27],"AND":[28],"METHOD:":[29],"In":[30],"total":[31,67],"24":[32],"histologically":[33],"proven":[34],"cancer":[37,365,376],"lesions":[38,171,206,377],"21":[40],"consecutive":[41],"patients":[42,366],"were":[43,59,90,117,351],"retrospectively":[44],"analyzed.":[45],"Each":[46],"patient":[47],"underwent":[48],"18F-fluoro-deoxyglucose":[49],"PET-CT":[52],"before":[53],"any":[54,309,312],"treatment.":[55],"Dynamic":[56],"images":[58],"acquired":[60],"list":[63],"mode":[64],"for":[65,219,240,246,342],"a":[66,360],"duration":[68],"70":[70],"min.":[71],"reconstructed":[73],"generated":[76],"Patlak":[77],"plot-based":[78],"'Slope'":[79],"'Intercept'":[81],"images,":[82],"from":[83],"which":[84],"indices":[86],"ki":[87,159,212,261,321,369],"DV":[89,241,305],"obtained.":[91],"standard":[93],"uptake":[94],"value":[95],"(SUV)":[96],"metric":[97],"also":[99,259],"obtained":[100],"by":[101],"summing":[102],"last":[104],"few":[105],"frames":[106],"study.":[110],"ki,":[111],"distribution":[112],"volume":[113],"(DV)":[114],"SUV":[116,330],"correlated":[118],"with":[119,147,290,311],"histological":[121],"tumor":[122,148,264,381],"grade,":[123],"biomarkers":[124],"[hormone":[125],"receptors":[126,222,293,345],"human":[128],"epidermal":[129],"growth":[130],"factor":[131],"receptor":[132],"2":[133],"(HER-2)":[134],"neu":[135,176,275],"expression]":[136],"molecular":[138,183,278],"subtypes":[139,279],"(A,":[140],"B":[141,185],"C)":[143],"as":[144,146,189,191],"well":[145,190],"size,":[149],"regional":[150],"nodal":[151],"metastases":[152],"distant":[154],"metastases.":[155],"RESULTS:":[156],"mean":[158,211,304],"found":[161,215,323],"be":[163,217,325,340],"significantly":[164],"higher":[165],"grade":[167,265,382],"III":[168],"than":[169,194],"II":[170],"(P":[172,179,186,207,224,237],"=":[173,180,187,197,201,208,225,238,244,269,272,283,287,298,301],"0.005),":[174],"HER-2":[175,274],"positive":[177],"status":[178,223,276,294,346],"0.04)":[181,188],"subtype":[184],"greater":[193],"T1":[195],"lesions(P":[196],"0.0003":[198],"P":[200,243,271,286,300],"0.04,":[202],"respectively)":[203],"node-positive":[205],"0.009).":[209],"Though":[210,320],"not":[214,352],"significant":[218],"hormone":[221,292,344],"0.08),":[226],"it":[227,337],"showed":[228],"best":[230],"correlation":[231,249],"compared":[232],"other":[235],"parameters":[236,350],"0.8":[239],"0.1":[245],"SUV).":[247],"Spearman's":[248],"test,":[250],"area":[251],"under":[252],"curve":[254],"(AUC)":[255],"mismatch":[257],"percentage":[258],"revealed":[260],"predict":[263],"(AUC,":[266,280,295],"0.95;":[267],"r":[268,282,297],"0.7;":[270],"0.0001),":[273],"0.81;":[281],"0.49":[284],"0.01)":[288],"along":[289],"0.83;":[296],"0.32;":[299],"0.1).":[302],"failed":[306],"show":[308],"association":[310],"or":[316],"anatomical":[317],"staging":[318],"parameters.":[319],"comparable":[326],"that":[328,368],"almost":[332],"all":[333],"assessed":[335],"parameters,":[336],"appeared":[338],"better":[341],"predicting":[343],"even":[347],"though":[348],"both":[349],"statistically":[353],"significant.":[354],"CONCLUSION:":[355],"Our":[356],"initial":[357],"observation":[358],"small":[361],"cohort":[362],"suggests":[367],"is":[370],"promising":[371],"stratifying":[373],"according":[378],"characteristics.":[385]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-08-12T00:00:00"}