{"id":"https://openalex.org/W4290804033","doi":"https://doi.org/10.1158/0008-5472.can-22-0698","title":"A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer","display_name":"A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4290804033","doi":"https://doi.org/10.1158/0008-5472.can-22-0698","pmid":"https://pubmed.ncbi.nlm.nih.gov/35950923","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588738"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-22-0698","doi":"https://doi.org/10.1158/0008-5472.can-22-0698","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-22-0698","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/82/20/3830/3213034/3830.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/82/20/3830/3213034/3830.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081244737","display_name":"Kristin Ann Altwegg","orcid":"https://orcid.org/0000-0002-3439-0655","observed_orcids":["https://orcid.org/0000-0002-3439-0655"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin A. Altwegg","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0002-3439-0655","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043867874","display_name":"Suryavathi Viswanadhapalli","orcid":"https://orcid.org/0000-0002-7381-6962","observed_orcids":["https://orcid.org/0000-0002-7381-6962"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suryavathi Viswanadhapalli","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0002-7381-6962","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087746790","display_name":"Monica Mann","orcid":"https://orcid.org/0000-0003-4974-7511","observed_orcids":["https://orcid.org/0000-0003-4974-7511"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Mann","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0003-4974-7511","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053377661","display_name":"Dimple Chakravarty","orcid":"https://orcid.org/0000-0002-5021-4440","observed_orcids":["https://orcid.org/0000-0002-5021-4440"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimple Chakravarty","raw_affiliation_strings":["3Department of Urology, Weill Cornell Medical School, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-5021-4440","affiliations":[{"raw_affiliation_string":"3Department of Urology, Weill Cornell Medical School, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052982585","display_name":"Samaya Rajeshwari Krishnan","orcid":"https://orcid.org/0000-0003-0498-6404","observed_orcids":["https://orcid.org/0000-0003-0498-6404"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samaya Krishnan","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0003-0498-6404","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045699506","display_name":"Zexuan Liu","orcid":"https://orcid.org/0000-0002-1475-2217","observed_orcids":["https://orcid.org/0000-0002-1475-2217"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zexuan Liu","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","4Department of Oncology, Xiangya Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-1475-2217","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"4Department of Oncology, Xiangya Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan, P.R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725197","display_name":"Junhao Liu","orcid":"https://orcid.org/0000-0002-2545-7176","observed_orcids":["https://orcid.org/0000-0002-2545-7176"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Junhao Liu","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","4Department of Oncology, Xiangya Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-2545-7176","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"4Department of Oncology, Xiangya Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan, P.R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064393266","display_name":"Uday P. Pratap","orcid":"https://orcid.org/0000-0003-2973-0210","observed_orcids":["https://orcid.org/0000-0003-2973-0210"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uday P. Pratap","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0003-2973-0210","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079514337","display_name":"Behnam Ebrahimi","orcid":"https://orcid.org/0000-0003-4588-7525","observed_orcids":["https://orcid.org/0000-0003-4588-7525"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Behnam Ebrahimi","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0003-4588-7525","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022585394","display_name":"John R. Sanchez","orcid":"https://orcid.org/0000-0002-5362-1025","observed_orcids":["https://orcid.org/0000-0002-5362-1025"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Sanchez","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0002-5362-1025","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047633611","display_name":"Xiaonan Li","orcid":"https://orcid.org/0000-0002-7732-4922","observed_orcids":["https://orcid.org/0000-0002-7732-4922"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaonan Li","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0002-7732-4922","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039009031","display_name":"Shihong Ma","orcid":"https://orcid.org/0000-0001-5903-2785","observed_orcids":["https://orcid.org/0000-0001-5903-2785"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shihong Ma","raw_affiliation_strings":["5Department of Urology, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":"https://orcid.org/0000-0001-5903-2785","affiliations":[{"raw_affiliation_string":"5Department of Urology, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091723009","display_name":"Ben Ho Park","orcid":"https://orcid.org/0000-0001-8119-2291","observed_orcids":["https://orcid.org/0000-0001-8119-2291"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben H. Park","raw_affiliation_strings":["6Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":"https://orcid.org/0000-0001-8119-2291","affiliations":[{"raw_affiliation_string":"6Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077133681","display_name":"Bindu Santhamma","orcid":"https://orcid.org/0000-0002-5569-2185","observed_orcids":["https://orcid.org/0000-0002-5569-2185"]},"institutions":[{"id":"https://openalex.org/I4210165651","display_name":"Evestra (United States)","ror":"https://ror.org/05e0mbv58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bindu Santhamma","raw_affiliation_strings":["7Evestra.Inc, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0002-5569-2185","affiliations":[{"raw_affiliation_string":"7Evestra.Inc, San Antonio, Texas","institution_ids":["https://openalex.org/I4210165651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100689057","display_name":"Yidong Chen","orcid":"https://orcid.org/0000-0001-6806-2185","observed_orcids":["https://orcid.org/0000-0001-6806-2185"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yidong Chen","raw_affiliation_strings":["8Department of Population Health Sciences, UT Health San Antonio, San Antonio, Texas","9Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0001-6806-2185","affiliations":[{"raw_affiliation_string":"8Department of Population Health Sciences, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"9Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015534740","display_name":"Zhao Lai","orcid":"https://orcid.org/0000-0002-3543-5376","observed_orcids":["https://orcid.org/0000-0002-3543-5376"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhao Lai","raw_affiliation_strings":["10Department of Molecular Medicine, UT Health San Antonio, San Antonio, Texas","9Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0002-3543-5376","affiliations":[{"raw_affiliation_string":"10Department of Molecular Medicine, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"9Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053069471","display_name":"Ganesh V. Raj","orcid":"https://orcid.org/0000-0001-5098-6347","observed_orcids":["https://orcid.org/0000-0001-5098-6347"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ganesh V. Raj","raw_affiliation_strings":["5Department of Urology, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":"https://orcid.org/0000-0001-5098-6347","affiliations":[{"raw_affiliation_string":"5Department of Urology, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046581115","display_name":"Yaxia Yuan","orcid":"https://orcid.org/0000-0001-7094-4419","observed_orcids":["https://orcid.org/0000-0001-7094-4419"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaxia Yuan","raw_affiliation_strings":["11Department of Biochemistry and Structural Biology, and Center for Innovative Drug Discovery, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0001-7094-4419","affiliations":[{"raw_affiliation_string":"11Department of Biochemistry and Structural Biology, and Center for Innovative Drug Discovery, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781093","display_name":"Daohong Zhou","orcid":"https://orcid.org/0000-0002-2400-6461","observed_orcids":["https://orcid.org/0000-0002-2400-6461","https://orcid.org/0000-0002-7771-6299"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daohong Zhou","raw_affiliation_strings":["11Department of Biochemistry and Structural Biology, and Center for Innovative Drug Discovery, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0002-2400-6461","affiliations":[{"raw_affiliation_string":"11Department of Biochemistry and Structural Biology, and Center for Innovative Drug Discovery, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060877175","display_name":"Gangadhara R. Sareddy","orcid":"https://orcid.org/0000-0001-9977-3932","observed_orcids":["https://orcid.org/0000-0001-9977-3932"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gangadhara R. Sareddy","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0001-9977-3932","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054763940","display_name":"RAJESHWAR RAO TEKMAL","orcid":"https://orcid.org/0000-0002-3770-6811","observed_orcids":["https://orcid.org/0000-0002-3770-6811"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeshwar R. Tekmal","raw_affiliation_strings":["1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0002-3770-6811","affiliations":[{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109690851","display_name":"Stan McHardy","orcid":"https://orcid.org/0000-0003-0070-4924","observed_orcids":["https://orcid.org/0000-0003-0070-4924"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stan McHardy","raw_affiliation_strings":["12Department of Chemistry and Center for Innovative Drug Discovery, University of Texas San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0003-0070-4924","affiliations":[{"raw_affiliation_string":"12Department of Chemistry and Center for Innovative Drug Discovery, University of Texas San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049119185","display_name":"Tim H.\u2010M. Huang","orcid":"https://orcid.org/0000-0001-5985-9176","observed_orcids":["https://orcid.org/0000-0001-5985-9176"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim H.-M. Huang","raw_affiliation_strings":["10Department of Molecular Medicine, UT Health San Antonio, San Antonio, Texas","2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0001-5985-9176","affiliations":[{"raw_affiliation_string":"10Department of Molecular Medicine, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060628869","display_name":"Manjeet K. Rao","orcid":"https://orcid.org/0000-0001-7573-2677","observed_orcids":["https://orcid.org/0000-0001-7573-2677"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manjeet K. Rao","raw_affiliation_strings":["2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","9Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0001-7573-2677","affiliations":[{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]},{"raw_affiliation_string":"9Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081486992","display_name":"Hariprasad Vankayalapati","orcid":"https://orcid.org/0000-0002-5477-2124","observed_orcids":["https://orcid.org/0000-0002-5477-2124"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hariprasad Vankayalapati","raw_affiliation_strings":["13Utah Health Huntsman Cancer Institute, Salt Lake City, Utah"],"raw_orcid":"https://orcid.org/0000-0002-5477-2124","affiliations":[{"raw_affiliation_string":"13Utah Health Huntsman Cancer Institute, Salt Lake City, Utah","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090010000","display_name":"Ratna K. Vadlamudi","orcid":"https://orcid.org/0000-0003-2849-4076","observed_orcids":["https://orcid.org/0000-0003-2849-4076"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I2802109968","display_name":"Audie L. Murphy Memorial VA Hospital","ror":"https://ror.org/035xhk118","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802109968","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]},{"id":"https://openalex.org/I4210144081","display_name":"South Texas Veterans Health Care System","ror":"https://ror.org/03n2ay196","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ratna K. Vadlamudi","raw_affiliation_strings":["14Audie L. Murphy South Texas Veterans Health Care System, San Antonio, Texas","1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas"],"raw_orcid":"https://orcid.org/0000-0003-2849-4076","affiliations":[{"raw_affiliation_string":"14Audie L. Murphy South Texas Veterans Health Care System, San Antonio, Texas","institution_ids":["https://openalex.org/I2802109968","https://openalex.org/I4210144081"]},{"raw_affiliation_string":"1Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"2Mays Cancer Center, UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5090010000"],"corresponding_institution_ids":["https://openalex.org/I165951966","https://openalex.org/I2802109968","https://openalex.org/I4210144081","https://openalex.org/I4390039360"],"apc_list":null,"apc_paid":null,"fwci":3.3181,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.93414872,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"82","issue":"20","first_page":"3830","last_page":"3844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pelp1","display_name":"PELP1","score":1.0},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha-positive-breast-cancer","display_name":"estrogen receptor alpha-positive breast cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/peptide-inhibitors","display_name":"peptide inhibitors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/proteasome-pathway","display_name":"proteasome pathway","score":0.796999990940094},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.7379999756813049},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.6579999923706055},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7154053449630737},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6654840111732483},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.609740674495697},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.60928875207901},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5118374228477478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4579346179962158},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4267627000808716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32587286829948425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2830049693584442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10161226987838745}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056970","descriptor_name":"Co-Repressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D056970","descriptor_name":"Co-Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-22-0698","doi":"https://doi.org/10.1158/0008-5472.can-22-0698","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-22-0698","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/82/20/3830/3213034/3830.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:35950923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35950923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9588738","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588738","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-22-0698","doi":"https://doi.org/10.1158/0008-5472.can-22-0698","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-22-0698","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/82/20/3830/3213034/3830.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1143455775","display_name":null,"funder_award_id":"CA-054174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1143696820","display_name":null,"funder_award_id":"I01 BX004545","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G1184699508","display_name":"FoXM1 inhibition: a novel therapeutic avenue to treat breast cancers","funder_award_id":"R01CA239227","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1221135887","display_name":"Mays Cancer Center at UT Health SA","funder_award_id":"P30CA054174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1638716746","display_name":"Development of Small Molecule Inhibitor of PELP1 for Treating Advanced Breast Cancer","funder_award_id":"F31CA257298","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3037622341","display_name":"High Throughput DNA Sequencer: Illumina HiSeq 3000 Sequencer","funder_award_id":"1s10od021805-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3281894257","display_name":"UTHealth-LINK- A PREP program","funder_award_id":"R25GM130437","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4411463291","display_name":null,"funder_award_id":"CA239227","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4699559005","display_name":"PELP1, a Novel Regulator of Estrogen Receptor","funder_award_id":"R01CA095681","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4864431264","display_name":"UTHSCSA Cancer Genome Sequencing and Computation Core","funder_award_id":"RP160732","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G5746677394","display_name":null,"funder_award_id":"RP160844","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5827286289","display_name":null,"funder_award_id":"CA054174","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G7190250055","display_name":null,"funder_award_id":"CA0095681","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7666586120","display_name":"Center for Innovative Drug Discovery: Enhancement of a Shared Cancer Resource for South Texas","funder_award_id":"RP160844","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G7934259991","display_name":"miRNAs:Safe and effective therapeutic adjuvants for treating drug resistant TNBC","funder_award_id":"R01CA179120","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8922965079","display_name":null,"funder_award_id":"1 101 BX004545-01","funder_id":"https://openalex.org/F4320333312","funder_display_name":"Office of Academic Affiliations, Department of Veterans Affairs"},{"id":"https://openalex.org/G9000324485","display_name":null,"funder_award_id":"CA054174","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000905965","display_name":"Advancing Cancer Research Through Next Generation Sequencing at Mays Cancer Center of UT Health San Antonio","funder_award_id":"R50CA265339","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333312","display_name":"Office of Academic Affiliations, Department of Veterans Affairs","ror":"https://ror.org/0442kw503"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290804033.pdf","grobid_xml":"https://content.openalex.org/works/W4290804033.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W211351290","https://openalex.org/W617372667","https://openalex.org/W779403461","https://openalex.org/W804992752","https://openalex.org/W1977781463","https://openalex.org/W1984535299","https://openalex.org/W1995573963","https://openalex.org/W2004822259","https://openalex.org/W2013956549","https://openalex.org/W2016047921","https://openalex.org/W2027657101","https://openalex.org/W2030781089","https://openalex.org/W2056922853","https://openalex.org/W2072613049","https://openalex.org/W2073367400","https://openalex.org/W2078374001","https://openalex.org/W2088502199","https://openalex.org/W2097599440","https://openalex.org/W2101163638","https://openalex.org/W2101599992","https://openalex.org/W2106665718","https://openalex.org/W2110951751","https://openalex.org/W2129309277","https://openalex.org/W2135247786","https://openalex.org/W2138220879","https://openalex.org/W2141289004","https://openalex.org/W2141312827","https://openalex.org/W2144285753","https://openalex.org/W2146177487","https://openalex.org/W2147934525","https://openalex.org/W2153539494","https://openalex.org/W2154478723","https://openalex.org/W2155871333","https://openalex.org/W2300860717","https://openalex.org/W2559423762","https://openalex.org/W2560409587","https://openalex.org/W2565707423","https://openalex.org/W2619213753","https://openalex.org/W2745290453","https://openalex.org/W2941041091","https://openalex.org/W2955341169","https://openalex.org/W2997462523","https://openalex.org/W3030054993","https://openalex.org/W3109568790","https://openalex.org/W3211795435"],"related_works":["https://openalex.org/W4282963707","https://openalex.org/W3079150579","https://openalex.org/W3133418421","https://openalex.org/W3013130861","https://openalex.org/W2001738003","https://openalex.org/W4377010624","https://openalex.org/W3180019320","https://openalex.org/W2001121499","https://openalex.org/W4396590599","https://openalex.org/W2886899594"],"abstract_inverted_index":{"Most":[0],"patients":[1],"with":[2,18,78,170],"estrogen":[3,171],"receptor":[4],"alpha-positive":[5],"(ER+)":[6],"breast":[7,38,118,144,190,216,236],"cancers":[8],"initially":[9],"respond":[10],"to":[11,80,93,115],"treatment":[12,163],"but":[13,137],"eventually":[14],"develop":[15],"therapy":[16],"resistance":[17],"disease":[19],"progression.":[20,40,200],"Overexpression":[21],"of":[22,43,64,72,87,100,104,132,167,184,210,220,224],"oncogenic":[23,83,211,225],"ER":[24],"coregulators,":[25],"including":[26],"proline,":[27],"glutamic":[28],"acid,":[29],"and":[30,96,107,142,175,181,187,196],"leucine-rich":[31],"protein":[32],"1":[33],"(PELP1),":[34],"are":[35],"implicated":[36],"in":[37,125,147,214],"cancer":[39,119,145,191],"The":[41],"lack":[42],"small":[44],"molecules":[45],"that":[46,70,111,161],"inhibits":[47],"PELP1":[48,65,79,82,151,212,226],"represents":[49],"a":[50,56,101,126,207,221],"major":[51],"knowledge":[52],"gap.":[53],"Here,":[54],"using":[55],"yeast-two-hybrid":[57],"screen,":[58],"we":[59],"identified":[60],"novel":[61,222],"peptide":[62],"inhibitors":[63],"(PIP).":[66],"Biochemical":[67],"assays":[68],"demonstrated":[69],"one":[71],"these":[73,202],"peptides,":[74],"PIP1,":[75],"directly":[76,113],"interacted":[77],"block":[81],"functions.":[84],"Computational":[85],"modeling":[86],"PIP1":[88],"revealed":[89],"key":[90],"residues":[91],"contributing":[92],"its":[94],"activity":[95],"facilitated":[97],"the":[98,154,165],"development":[99],"small-molecule":[102],"inhibitor":[103,209,223],"PELP1,":[105],"SMIP34,":[106],"further":[108],"analyses":[109,159],"confirmed":[110],"SMIP34":[112,121,129,162,193,205],"bound":[114],"PELP1.":[116],"In":[117,178],"cells,":[120,146],"reduced":[122,194],"cell":[123,173,179],"growth":[124],"dose-dependent":[127],"manner.":[128],"inhibited":[130],"proliferation":[131,195],"not":[133],"only":[134],"wild-type":[135],"(WT)":[136],"also":[138],"mutant":[139],"(MT)":[140],"ER+":[141,189,235],"therapy-resistant":[143],"part":[148],"by":[149],"inducing":[150],"degradation":[152],"via":[153],"proteasome":[155],"pathway.":[156],"RNA":[157],"sequencing":[158],"showed":[160],"altered":[164],"expression":[166],"genes":[168],"associated":[169],"response,":[172],"cycle,":[174],"apoptosis":[176],"pathways.":[177],"line-derived":[180],"patient-derived":[182],"xenografts":[183],"both":[185],"WT":[186],"MT":[188],"models,":[192],"significantly":[197],"suppressed":[198],"tumor":[199],"Collectively,":[201],"results":[203],"demonstrate":[204],"as":[206],"first-in-class":[208],"signaling":[213],"advanced":[215,234],"cancer.":[217,237],"SIGNIFICANCE:":[218],"Development":[219],"provides":[227],"potential":[228],"therapeutic":[229],"avenues":[230],"for":[231],"treating":[232],"therapy-resistant,":[233]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-12T00:00:00"}