{"id":"https://openalex.org/W4290803974","doi":"https://doi.org/10.1042/bcj20220161","title":"Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding","display_name":"Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4290803974","doi":"https://doi.org/10.1042/bcj20220161","pmid":"https://pubmed.ncbi.nlm.nih.gov/35950872","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9472821"},"language":"en","primary_location":{"id":"doi:10.1042/bcj20220161","doi":"https://doi.org/10.1042/bcj20220161","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20220161","pdf_url":"https://portlandpress.com/biochemj/article-pdf/479/17/1759/936843/bcj-2022-0161.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://portlandpress.com/biochemj/article-pdf/479/17/1759/936843/bcj-2022-0161.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000257912","display_name":"Alexia F. Kalogeropulou","orcid":"https://orcid.org/0000-0001-5185-7694","observed_orcids":["https://orcid.org/0000-0001-5185-7694"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Alexia F. Kalogeropulou","raw_affiliation_strings":["1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","2Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]},{"raw_affiliation_string":"2Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A","institution_ids":["https://openalex.org/I4387154804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002947066","display_name":"Elena Purlyte","orcid":"https://orcid.org/0000-0001-7291-1549","observed_orcids":["https://orcid.org/0000-0001-7291-1549"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elena Purlyte","raw_affiliation_strings":["1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029388712","display_name":"Francesca Tonelli","orcid":"https://orcid.org/0000-0002-4600-6630","observed_orcids":["https://orcid.org/0000-0002-4600-6630"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Francesca Tonelli","raw_affiliation_strings":["1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","2Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]},{"raw_affiliation_string":"2Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A","institution_ids":["https://openalex.org/I4387154804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044370251","display_name":"Sven M. Lange","orcid":"https://orcid.org/0000-0002-6011-8647","observed_orcids":["https://orcid.org/0000-0002-6011-8647"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sven M. Lange","raw_affiliation_strings":["1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017025792","display_name":"Melanie Wightman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melanie Wightman","raw_affiliation_strings":["1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027617773","display_name":"Alan R. Prescott","orcid":"https://orcid.org/0000-0002-0747-7317","observed_orcids":["https://orcid.org/0000-0002-0747-7317"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan R. Prescott","raw_affiliation_strings":["3Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037379163","display_name":"Shalini Padmanabhan","orcid":"https://orcid.org/0000-0002-6933-416X","observed_orcids":["https://orcid.org/0000-0002-6933-416X"]},"institutions":[{"id":"https://openalex.org/I2802508227","display_name":"Michael J. Fox Foundation","ror":"https://ror.org/03arq3225","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802508227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shalini Padmanabhan","raw_affiliation_strings":["4The Michael J. Fox Foundation for Parkinson's Research, New York, NY, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4The Michael J. Fox Foundation for Parkinson's Research, New York, NY, U.S.A","institution_ids":["https://openalex.org/I2802508227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067865589","display_name":"Esther M. Sammler","orcid":"https://orcid.org/0000-0003-3218-7116","observed_orcids":["https://orcid.org/0000-0003-3218-7116"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Esther Sammler","raw_affiliation_strings":["1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","2Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A","5Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]},{"raw_affiliation_string":"2Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A","institution_ids":["https://openalex.org/I4387154804"]},{"raw_affiliation_string":"5Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054181982","display_name":"Dario R. Alessi","orcid":"https://orcid.org/0000-0002-2140-9185","observed_orcids":["https://orcid.org/0000-0002-2140-9185"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Dario R. Alessi","raw_affiliation_strings":["1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","2Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-2140-9185","affiliations":[{"raw_affiliation_string":"1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]},{"raw_affiliation_string":"2Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A","institution_ids":["https://openalex.org/I4387154804"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054181982"],"corresponding_institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201","https://openalex.org/I4387154804"],"apc_list":null,"apc_paid":null,"fwci":12.9717,"has_fulltext":true,"cited_by_count":136,"citation_normalized_percentile":{"value":0.9937176,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"479","issue":"17","first_page":"1759","last_page":"1783"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/kinase-activity","display_name":"kinase activity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/microtubule-binding","display_name":"microtubule binding","score":0.9729999899864197},{"id":"https://openalex.org/keywords/variants-of-uncertain-significance","display_name":"variants of uncertain significance","score":0.7250000238418579},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.30300000309944153},{"id":"https://openalex.org/keywords/rab10-phosphorylation","display_name":"Rab10 phosphorylation","score":0.777999997138977},{"id":"https://openalex.org/keywords/lrrk2-inhibitors","display_name":"LRRK2 inhibitors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.3659999966621399},{"id":"https://openalex.org/keywords/rare-variants","display_name":"rare variants","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.960127592086792},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7371463179588318},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.601610004901886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5448408722877502},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.4141862094402313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4005054831504822},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39554932713508606},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.38253241777420044},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.34374070167541504},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.30059319734573364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1324862539768219}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1042/bcj20220161","doi":"https://doi.org/10.1042/bcj20220161","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20220161","pdf_url":"https://portlandpress.com/biochemj/article-pdf/479/17/1759/936843/bcj-2022-0161.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"doi:10.1101/2022.04.01.486724","doi":"https://doi.org/10.1101/2022.04.01.486724","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.04.01.486724","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/04/01/2022.04.01.486724.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:35950872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35950872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9472821","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9472821/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/4a394bae-b0c5-47b3-8900-4ad53f44ff50","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/4a394bae-b0c5-47b3-8900-4ad53f44ff50","pdf_url":"https://discovery.dundee.ac.uk/ws/files/80544669/bcj_2022_0161.pdf","source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Kalogeropulou, A F, Purlyte, E, Tonelli, F, Lange, S M, Wightman, M, Prescott, A R, Padmanabhan, S, Sammler, E & Alessi, D R 2022, 'Impact of 100 LRRK2 variants linked to Parkinson\u2019s Disease on kinase activity and microtubule binding', Biochemical Journal, vol. 479, no. 17, pp. 1759-1783. https://doi.org/10.1042/BCJ20220161","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1042/bcj20220161","doi":"https://doi.org/10.1042/bcj20220161","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20220161","pdf_url":"https://portlandpress.com/biochemj/article-pdf/479/17/1759/936843/bcj-2022-0161.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2035955455","display_name":null,"funder_award_id":"H-1701","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"},{"id":"https://openalex.org/G6158515048","display_name":null,"funder_award_id":"ASAP\u2010000463","funder_id":"https://openalex.org/F4320306136","funder_display_name":"Michael J. Fox Foundation for Parkinson's Research"},{"id":"https://openalex.org/G6291034611","display_name":"Understanding Signalling Pathways Mutated in Inherited Disorders","funder_award_id":"MC_UU_00018/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320311647","display_name":"Merck KGaA","ror":"https://ror.org/04b2dty93"},{"id":"https://openalex.org/F4320320021","display_name":"Parkinson's UK","ror":"https://ror.org/02417p338"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290803974.pdf","grobid_xml":"https://content.openalex.org/works/W4290803974.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1564467880","https://openalex.org/W1967900265","https://openalex.org/W1972097907","https://openalex.org/W1977283973","https://openalex.org/W1977391806","https://openalex.org/W1979460584","https://openalex.org/W2004536040","https://openalex.org/W2025949276","https://openalex.org/W2046398127","https://openalex.org/W2051978340","https://openalex.org/W2063127941","https://openalex.org/W2086072858","https://openalex.org/W2099111846","https://openalex.org/W2100300726","https://openalex.org/W2103739667","https://openalex.org/W2120262230","https://openalex.org/W2127068865","https://openalex.org/W2133869385","https://openalex.org/W2134541041","https://openalex.org/W2167552109","https://openalex.org/W2253950023","https://openalex.org/W2271257475","https://openalex.org/W2272666074","https://openalex.org/W2321209857","https://openalex.org/W2325989705","https://openalex.org/W2376573086","https://openalex.org/W2521967673","https://openalex.org/W2609407882","https://openalex.org/W2767998367","https://openalex.org/W2768016303","https://openalex.org/W2770997070","https://openalex.org/W2771688344","https://openalex.org/W2774127993","https://openalex.org/W2782592927","https://openalex.org/W2795590254","https://openalex.org/W2899593101","https://openalex.org/W2901203581","https://openalex.org/W2909123291","https://openalex.org/W2910972593","https://openalex.org/W2936990364","https://openalex.org/W2960012086","https://openalex.org/W2976101375","https://openalex.org/W2982613077","https://openalex.org/W2997426905","https://openalex.org/W3001241789","https://openalex.org/W3004019902","https://openalex.org/W3004823952","https://openalex.org/W3004855290","https://openalex.org/W3006593399","https://openalex.org/W3029661147","https://openalex.org/W3048909661","https://openalex.org/W3068292362","https://openalex.org/W3092460711","https://openalex.org/W3098923693","https://openalex.org/W3113414713","https://openalex.org/W3118577024","https://openalex.org/W3123326768","https://openalex.org/W3127263423","https://openalex.org/W3134999369","https://openalex.org/W3136294075","https://openalex.org/W3165747523","https://openalex.org/W3166052330","https://openalex.org/W3171048111","https://openalex.org/W3177828909","https://openalex.org/W3196071261","https://openalex.org/W3200383688","https://openalex.org/W4213439607","https://openalex.org/W4214648160","https://openalex.org/W4296793671","https://openalex.org/W4311901922","https://openalex.org/W4390046099"],"related_works":["https://openalex.org/W4399786281","https://openalex.org/W7166140440","https://openalex.org/W1992069488","https://openalex.org/W2897825499","https://openalex.org/W3166052330","https://openalex.org/W7220832751","https://openalex.org/W4417157025","https://openalex.org/W2100894616","https://openalex.org/W7154936739","https://openalex.org/W2019238415"],"abstract_inverted_index":{"Mutations":[0],"enhancing":[1],"the":[2,39,75,94,122,125,135,202,236],"kinase":[3,19,70,127,140,159,173,180,208],"activity":[4,20,141,181],"of":[5,30,137,150,165,182,204],"leucine-rich":[6],"repeat":[7],"kinase-2":[8],"(LRRK2)":[9],"cause":[10],"Parkinson's":[11],"disease":[12],"(PD)":[13],"and":[14,105,172,192,223,243,254],"therapies":[15],"that":[16,67,124,134,189],"reduce":[17],"LRRK2":[18,44,52,65,115,191,256],"are":[21],"being":[22],"tested":[23],"in":[24,178,201,252],"clinical":[25,32,258],"trials.":[26,259],"Numerous":[27],"rare":[28],"variants":[29,53,66,73,90,113,138,167,186,240],"unknown":[31],"significance":[33],"have":[34,193],"been":[35,194],"reported,":[36],"but":[37],"how":[38],"vast":[40],"majority":[41],"impact":[42,136,241],"on":[43,139],"function":[45],"is":[46,142],"unknown.":[47],"Here,":[48],"we":[49],"investigate":[50],"100":[51],"linked":[54,195],"to":[55,92,196,233],"PD,":[56,197],"including":[57,72,187],"previously":[58],"described":[59],"pathogenic":[60],"mutations.":[61],"We":[62,132],"identify":[63],"23":[64],"robustly":[68],"stimulate":[69,231],"activity,":[71],"within":[74],"N-terminal":[76],"non-catalytic":[77],"regions":[78],"(ARM":[79,210],"(E334K,":[80],"A419V),":[81],"ANK":[82],"(R767H),":[83],"LRR":[84,212],"(R1067Q,":[85],"R1325Q)),":[86],"as":[87,89,161],"well":[88],"predicted":[91],"destabilize":[93],"ROC:CORB":[95],"interface":[96,108],"(ROC":[97],"(A1442P,":[98,215],"V1447M),":[99],"CORA":[100,218],"(R1628P)":[101],"CORB":[102,220],"(S1761R,":[103],"L1795F))":[104],"COR:COR":[106],"dimer":[107],"(CORB":[109,168],"(R1728H/L)).":[110],"Most":[111],"activating":[112,166],"decrease":[114],"biomarker":[116],"site":[117],"phosphorylation":[118],"(pSer935/pSer955/pSer973),":[119],"consistent":[120],"with":[121,156],"notion":[123],"active":[126],"conformation":[128],"blocks":[129],"their":[130],"phosphorylation.":[131],"conclude":[133],"best":[143],"evaluated":[144],"by":[145,238],"deploying":[146],"a":[147,157,163,205],"cellular":[148],"assay":[149],"LRRK2-dependent":[151],"Rab10":[152],"substrate":[153],"phosphorylation,":[154],"compared":[155],"biochemical":[158],"assay,":[160],"only":[162],"minority":[164],"(Y1699C,":[169,221],"R1728H/L,":[170],"S1761R)":[171],"(G2019S,":[174],"I2020T,":[175],"T2031S)),":[176],"enhance":[177],"vitro":[179],"immunoprecipitated":[183],"LRRK2.":[184],"Twelve":[185],"several":[188],"activate":[190],"suppress":[198],"microtubule":[199],"association":[200],"presence":[203],"Type":[206],"I":[207],"inhibitor":[209,257],"(M712V),":[211],"(R1320S),":[213],"ROC":[214],"K1468E,":[216],"S1508R),":[217],"(A1589S),":[219],"R1728H/L)":[222],"WD40":[224],"(R2143M,":[225],"S2350I,":[226],"G2385R)).":[227],"Our":[228],"findings":[229],"will":[230],"work":[232],"better":[234],"understand":[235],"mechanisms":[237],"which":[239],"biology":[242],"provide":[244],"rationale":[245],"for":[246],"variant":[247],"carrier":[248],"inclusion":[249],"or":[250],"exclusion":[251],"ongoing":[253],"future":[255]},"counts_by_year":[{"year":2026,"cited_by_count":42},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-08-12T00:00:00"}
