{"id":"https://openalex.org/W4290802302","doi":"https://doi.org/10.1093/jnen/nlac068","title":"Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository","display_name":"Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4290802302","doi":"https://doi.org/10.1093/jnen/nlac068","pmid":"https://pubmed.ncbi.nlm.nih.gov/35950950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487643"},"language":"en","primary_location":{"id":"doi:10.1093/jnen/nlac068","doi":"https://doi.org/10.1093/jnen/nlac068","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnen/nlac068","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487643","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081733290","display_name":"Elan D. Louis","orcid":"https://orcid.org/0000-0003-2062-362X","observed_orcids":["https://orcid.org/0000-0003-2062-362X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elan D Louis","raw_affiliation_strings":["From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022578476","display_name":"Daniella Iglesias Hernandez","orcid":"https://orcid.org/0000-0001-8407-0230","observed_orcids":["https://orcid.org/0000-0001-8407-0230"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniella Iglesias-Hernandez","raw_affiliation_strings":["From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050014671","display_name":"Nora C. Hernandez","orcid":"https://orcid.org/0000-0001-7038-1492","observed_orcids":["https://orcid.org/0000-0001-7038-1492"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora C Hernandez","raw_affiliation_strings":["From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012650292","display_name":"Xena E. Flowers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xena Flowers","raw_affiliation_strings":["Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University , New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University , New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057371223","display_name":"Sheng\u2010Han Kuo","orcid":"https://orcid.org/0000-0002-9412-931X","observed_orcids":["https://orcid.org/0000-0002-9412-931X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheng-Han Kuo","raw_affiliation_strings":["Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113345804","display_name":"Jean Paul Vonsattel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Paul G Vonsattel","raw_affiliation_strings":["Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital , New York, New York, USA","Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University , New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital , New York, New York, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University , New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112131875","display_name":"Phyllis L. Faust","orcid":"https://orcid.org/0000-0001-6533-7921","observed_orcids":["https://orcid.org/0000-0001-6533-7921"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phyllis L Faust","raw_affiliation_strings":["Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital , New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital , New York, New York, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081733290"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":3.6858,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.94695395,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"81","issue":"10","first_page":"796","last_page":"806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-tremor","display_name":"essential tremor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lewy-body-pathology","display_name":"Lewy body pathology","score":0.9919999837875366},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.6959999799728394},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cerebellar-pathology","display_name":"cerebellar pathology","score":0.9399999976158142},{"id":"https://openalex.org/keywords/neurodegenerative-disease-comorbidity","display_name":"neurodegenerative disease comorbidity","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2780112193","wikidata":"https://www.wikidata.org/wiki/Q693519","display_name":"Essential tremor","level":2,"score":0.8606960773468018},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6147913336753845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.463655561208725},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3346811830997467},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3223647475242615}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020329","descriptor_name":"Essential Tremor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020329","descriptor_name":"Essential Tremor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020329","descriptor_name":"Essential Tremor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020329","descriptor_name":"Essential Tremor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jnen/nlac068","doi":"https://doi.org/10.1093/jnen/nlac068","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnen/nlac068","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9487643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487643","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuropathol Exp Neurol","raw_type":"Text"},{"id":"pmid:35950950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35950950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9487643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487643","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuropathol Exp Neurol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2439782326","display_name":"Clinical Pathological Study of Cognitive Impairment in Essential Tremor","funder_award_id":"R01NS086736","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G48354126","display_name":"PATHOLOG-OMICS - ESSENTIAL TREMOR IN THE BROADER CONTEXT OF","funder_award_id":"R01NS088257","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7900876767","display_name":"Design of Genetically Encoded Ca2+ Indicators for in Vivo Application","funder_award_id":"R01GM086736","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000863210","display_name":"Deep Dive: Mapping the Neuropathology of Essential Tremor and Exploring the Molecular Underpinnings of Neurodegeneration","funder_award_id":"R01NS117745","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W57510132","https://openalex.org/W139984142","https://openalex.org/W1479935944","https://openalex.org/W1490420159","https://openalex.org/W1591728422","https://openalex.org/W1917565734","https://openalex.org/W1970417678","https://openalex.org/W1971032265","https://openalex.org/W1971431571","https://openalex.org/W1980724929","https://openalex.org/W1984891398","https://openalex.org/W1992476268","https://openalex.org/W1993023011","https://openalex.org/W1995607576","https://openalex.org/W1996703740","https://openalex.org/W2005331929","https://openalex.org/W2006465787","https://openalex.org/W2007822621","https://openalex.org/W2015020748","https://openalex.org/W2023992844","https://openalex.org/W2025930115","https://openalex.org/W2029563691","https://openalex.org/W2029704191","https://openalex.org/W2032090553","https://openalex.org/W2044747395","https://openalex.org/W2052742260","https://openalex.org/W2057931238","https://openalex.org/W2059183482","https://openalex.org/W2064284597","https://openalex.org/W2067235747","https://openalex.org/W2069397705","https://openalex.org/W2073449985","https://openalex.org/W2073958007","https://openalex.org/W2074146584","https://openalex.org/W2082429191","https://openalex.org/W2088395870","https://openalex.org/W2091624804","https://openalex.org/W2094697534","https://openalex.org/W2102572922","https://openalex.org/W2121393176","https://openalex.org/W2128011583","https://openalex.org/W2128228199","https://openalex.org/W2132123623","https://openalex.org/W2136235944","https://openalex.org/W2137794576","https://openalex.org/W2149857081","https://openalex.org/W2151171937","https://openalex.org/W2157206772","https://openalex.org/W2163245612","https://openalex.org/W2165038358","https://openalex.org/W2326740308","https://openalex.org/W2327675986","https://openalex.org/W2340869043","https://openalex.org/W2343262276","https://openalex.org/W2410916134","https://openalex.org/W2736170441","https://openalex.org/W2901725597","https://openalex.org/W2943828894","https://openalex.org/W2958658085","https://openalex.org/W3000326778","https://openalex.org/W3049297382","https://openalex.org/W3179092049","https://openalex.org/W3190515001","https://openalex.org/W3197866882","https://openalex.org/W4280514249"],"related_works":["https://openalex.org/W4367305235","https://openalex.org/W4328048638","https://openalex.org/W2137608988","https://openalex.org/W1970417678","https://openalex.org/W4389447178","https://openalex.org/W4411358290","https://openalex.org/W2258043093","https://openalex.org/W1996703740","https://openalex.org/W2059183482","https://openalex.org/W4399519297"],"abstract_inverted_index":{"The":[0],"Essential":[1],"Tremor":[2],"Centralized":[3],"Brain":[4],"Repository":[5],"is":[6,39],"the":[7,40,72],"largest":[8],"repository":[9],"of":[10,31,42,74,79,106,130,140,193],"prospectively":[11],"collected":[12],"essential":[13],"tremor":[14],"(ET)":[15],"brains":[16],"(n":[17],"=":[18,89],"231).":[19],"Hence,":[20],"we":[21],"are":[22],"uniquely":[23],"poised":[24],"to":[25,50,69,103,198],"address":[26],"several":[27],"questions:":[28],"What":[29,38],"proportion":[30,160],"ET":[32,144,156,179,183,194],"cases":[33,116,145,157],"has":[34],"Lewy":[35],"pathology":[36,44,81,142],"(LP)?":[37],"nature":[41],"that":[43,161],"and":[45,98,148,180,182,195],"how":[46],"does":[47],"it":[48],"relate":[49],"other":[51,199],"comorbidities?":[52],"Each":[53],"brain":[54],"had":[55,96,101,158],"a":[56,65,128,137],"complete":[57],"neuropathological":[58],"assessment,":[59],"including":[60],"\u03b1-synuclein":[61],"immunostaining.":[62],"We":[63],"created":[64],"10-category":[66],"classification":[67],"scheme":[68],"fully":[70],"encapsulate":[71],"patterns":[73],"LP":[75,97,110,173],"observed.":[76],"Four":[77],"metrics":[78],"cerebellar":[80,141],"were":[82],"also":[83],"quantified.":[84],"Mean":[85],"age":[86],"at":[87],"death":[88],"89.0":[90],"\u00b1":[91],"6.4":[92],"years.":[93,134],"Fifty-eight":[94],"(25.1%)":[95],"46":[99],"(19.9%)":[100],"early":[102],"late":[104],"stages":[105],"Parkinson":[107],"disease":[108],"(PD).":[109],"was":[111,136],"very":[112],"heterogeneous.":[113],"Of":[114],"58":[115],"with":[117,147,184],"LP,":[118],"14":[119],"(24.1%)":[120],"clinically":[121],"developed":[122],"possible":[123],"PD":[124,126],"or":[125,132],"after":[127],"latency":[129],"5":[131],"more":[133],"There":[135],"similar":[138],"degree":[139],"in":[143,154],"both":[146],"without":[149],"LP.":[150],"In":[151],"summary,":[152],"1":[153],"4":[155],"LP-a":[159],"seems":[162],"higher":[163],"than":[164],"expected":[165],"based":[166],"on":[167],"studies":[168],"among":[169],"control":[170],"populations.":[171],"Heterogeneous":[172],"likely":[174],"reflects":[175],"clinical":[176],"associations":[177],"between":[178],"PD,":[181],"Alzheimer":[185],"disease-type":[186],"neuropathology.":[187],"These":[188],"data":[189],"further":[190],"our":[191],"understanding":[192],"its":[196],"relatedness":[197],"degenerative":[200],"diseases.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-08-12T00:00:00"}
