{"id":"https://openalex.org/W4290785293","doi":"https://doi.org/10.1016/j.ekir.2022.08.001","title":"Factors Associated With Reduced Anti-SARS-CoV-2 Antibody Responses After mRNA Vaccination in Kidney Transplant Recipients on Belatacept","display_name":"Factors Associated With Reduced Anti-SARS-CoV-2 Antibody Responses After mRNA Vaccination in Kidney Transplant Recipients on Belatacept","publication_year":2022,"publication_date":"2022-08-09","ids":{"openalex":"https://openalex.org/W4290785293","doi":"https://doi.org/10.1016/j.ekir.2022.08.001","pmid":"https://pubmed.ncbi.nlm.nih.gov/35968509","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9361626"},"language":"en","primary_location":{"id":"doi:10.1016/j.ekir.2022.08.001","doi":"https://doi.org/10.1016/j.ekir.2022.08.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2022.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ekir.2022.08.001","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061761191","display_name":"Leela Moren\u00e1","orcid":"https://orcid.org/0000-0001-8295-1026","observed_orcids":["https://orcid.org/0000-0001-8295-1026"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leela Morena","raw_affiliation_strings":["Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078668547","display_name":"Ayman Al Jurdi","orcid":"https://orcid.org/0000-0002-7652-3399","observed_orcids":["https://orcid.org/0000-0002-7652-3399","https://orcid.org/0000-0002-7957-137X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayman Al Jurdi","raw_affiliation_strings":["Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043563275","display_name":"Jamil R. Azzi","orcid":"https://orcid.org/0000-0002-6909-4645","observed_orcids":["https://orcid.org/0000-0002-6909-4645"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamil Azzi","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019427610","display_name":"Jay Alan Fishman","orcid":"https://orcid.org/0000-0002-2671-3311","observed_orcids":["https://orcid.org/0000-0002-2671-3311"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Fishman","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083826351","display_name":"Leonardo V. Riella","orcid":"https://orcid.org/0000-0002-7636-3196","observed_orcids":["https://orcid.org/0000-0002-7636-3196"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonardo V. Riella","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083826351"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":2625,"currency":"USD","value_usd":2625},"apc_paid":{"value":2625,"currency":"USD","value_usd":2625},"fwci":0.4889,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63417855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"7","issue":"11","first_page":"2513","last_page":"2516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/belatacept","display_name":"belatacept","score":0.9359999895095825},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.9620000123977661},{"id":"https://openalex.org/keywords/covid-19-vaccines","display_name":"COVID-19 vaccines","score":0.7509999871253967},{"id":"https://openalex.org/keywords/mrna-vaccines","display_name":"mRNA vaccines","score":0.9039999842643738},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.7760000228881836},{"id":"https://openalex.org/keywords/costimulation-blockade","display_name":"costimulation blockade","score":0.8029999732971191},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9520000219345093},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.8040000200271606},{"id":"https://openalex.org/keywords/vaccine-response-predictors","display_name":"vaccine response predictors","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2780743877","wikidata":"https://www.wikidata.org/wiki/Q4881990","display_name":"Belatacept","level":5,"score":0.9848662614822388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9436731338500977},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.7277226448059082},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5634708404541016},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5420206189155579},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5318431854248047},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.4989018440246582},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4764445424079895},{"id":"https://openalex.org/C2779605438","wikidata":"https://www.wikidata.org/wiki/Q2697833","display_name":"Abatacept","level":4,"score":0.4447910785675049},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.43857431411743164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.430366188287735},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.4123663008213043},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3670074939727783},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.30573761463165283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26951146125793457},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.04637995362281799},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ekir.2022.08.001","doi":"https://doi.org/10.1016/j.ekir.2022.08.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2022.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9361626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9361626","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney Int Rep","raw_type":"Text"},{"id":"pmid:35968509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35968509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ekir.2022.08.001","doi":"https://doi.org/10.1016/j.ekir.2022.08.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2022.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2317185835","https://openalex.org/W3149188151","https://openalex.org/W3188171413","https://openalex.org/W3194809099","https://openalex.org/W4214601934"],"related_works":["https://openalex.org/W3149188151","https://openalex.org/W3165852176","https://openalex.org/W3194809099","https://openalex.org/W3188171413","https://openalex.org/W4292553412","https://openalex.org/W4220672556","https://openalex.org/W3214226177","https://openalex.org/W4229024696","https://openalex.org/W3209102696","https://openalex.org/W4200101051"],"abstract_inverted_index":{"Belatacept":[0],"is":[1],"a":[2,43],"costimulation":[3],"blocker":[4],"used":[5],"for":[6],"maintenance":[7],"immunosuppression":[8],"in":[9,25,32],"kidney":[10],"transplant":[11],"recipients":[12],"(KTRs)":[13],"as":[14],"an":[15],"alternative":[16],"to":[17,59],"calcineurin":[18],"inhibitors.1":[19],"Studies":[20],"evaluating":[21],"SARS-CoV-2":[22],"vaccine":[23],"responses":[24,31],"KTRs":[26,33],"have":[27],"shown":[28],"reduced":[29],"antibody":[30,67],"on":[34,48],"belatacept.2-4":[35],"Nevertheless,":[36],"many":[37],"of":[38,46,54,66],"these":[39],"studies":[40],"included":[41],"only":[42],"small":[44],"number":[45],"patients":[47],"belatacept,5":[49],"and":[50],"had":[51],"low":[52],"rates":[53],"seroconversion,":[55],"limiting":[56],"the":[57,64],"ability":[58],"evaluate":[60],"factors":[61],"associated":[62],"with":[63],"development":[65],"responses.":[68]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-08-09T00:00:00"}