{"id":"https://openalex.org/W4290759902","doi":"https://doi.org/10.3390/polym14153223","title":"Novel Immobilized Biocatalysts Based on Cysteine Proteases Bound to 2-(4-Acetamido-2-sulfanilamide) Chitosan and Research on Their Structural Features","display_name":"Novel Immobilized Biocatalysts Based on Cysteine Proteases Bound to 2-(4-Acetamido-2-sulfanilamide) Chitosan and Research on Their Structural Features","publication_year":2022,"publication_date":"2022-08-08","ids":{"openalex":"https://openalex.org/W4290759902","doi":"https://doi.org/10.3390/polym14153223","pmid":"https://pubmed.ncbi.nlm.nih.gov/35956736","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9370924"},"language":"en","primary_location":{"id":"doi:10.3390/polym14153223","doi":"https://doi.org/10.3390/polym14153223","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym14153223","pdf_url":"https://www.mdpi.com/2073-4360/14/15/3223/pdf?version=1659965928","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4360/14/15/3223/pdf?version=1659965928","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058794130","display_name":"\u0421\u0432\u0435\u0442\u043b\u0430\u043d\u0430 \u0421\u0435\u0440\u0433\u0435\u0435\u0432\u043d\u0430 \u041e\u043b\u044c\u0448\u0430\u043d\u043d\u0438\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-3381-2008","observed_orcids":["https://orcid.org/0000-0003-3381-2008"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Svetlana S. Olshannikova","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084582772","display_name":"N. V. Malykhina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nataliya V. Malykhina","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030290568","display_name":"Maria S. Lavlinskaya","orcid":"https://orcid.org/0000-0001-9058-027X","observed_orcids":["https://orcid.org/0000-0001-9058-027X"]},"institutions":[{"id":"https://openalex.org/I4210106771","display_name":"Voronezh State University of Engineering Technologies","ror":"https://ror.org/01mebf576","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210106771"]},{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria S. Lavlinskaya","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","Metagenomics and Food Biotechnologies Laboratory, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia"],"raw_orcid":"https://orcid.org/0000-0001-9058-027X","affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]},{"raw_affiliation_string":"Metagenomics and Food Biotechnologies Laboratory, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia","institution_ids":["https://openalex.org/I4210106771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082270519","display_name":"\u0410. \u0412. \u0421\u043e\u0440\u043e\u043a\u0438\u043d","orcid":"https://orcid.org/0000-0001-5268-9557","observed_orcids":["https://orcid.org/0000-0001-5268-9557"]},"institutions":[{"id":"https://openalex.org/I4210106771","display_name":"Voronezh State University of Engineering Technologies","ror":"https://ror.org/01mebf576","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210106771"]},{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey V. Sorokin","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","Metagenomics and Food Biotechnologies Laboratory, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia","Polymer Science and Colloid Chemistry Department, Voronezh State University, 394018 Voronezh, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]},{"raw_affiliation_string":"Metagenomics and Food Biotechnologies Laboratory, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia","institution_ids":["https://openalex.org/I4210106771"]},{"raw_affiliation_string":"Polymer Science and Colloid Chemistry Department, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073703613","display_name":"Nikolay E. Yudin","orcid":"https://orcid.org/0000-0001-5667-0319","observed_orcids":["https://orcid.org/0000-0001-5667-0319"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikolay E. Yudin","raw_affiliation_strings":["Polymer Science and Colloid Chemistry Department, Voronezh State University, 394018 Voronezh, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polymer Science and Colloid Chemistry Department, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014679262","display_name":"Yulia M. Vyshkvorkina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yulia M. Vyshkvorkina","raw_affiliation_strings":["Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141701 Dolgoprudnyi, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141701 Dolgoprudnyi, Russia","institution_ids":["https://openalex.org/I153845743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057042224","display_name":"\u0410. \u041d. \u041b\u0443\u043a\u0438\u043d","orcid":"https://orcid.org/0000-0001-6521-8009","observed_orcids":["https://orcid.org/0000-0001-6521-8009"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Anatoliy N. Lukin","raw_affiliation_strings":["Research Core Center of Voronezh State University, Voronezh State University, 394018 Voronezh, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Core Center of Voronezh State University, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046821470","display_name":"M. G. Holyavka","orcid":"https://orcid.org/0000-0002-1390-4119","observed_orcids":["https://orcid.org/0000-0002-1390-4119"]},"institutions":[{"id":"https://openalex.org/I4405278832","display_name":"Sevastopol State University","ror":"https://ror.org/00m88tr89","country_code":"UA","type":"education","lineage":["https://openalex.org/I4405278832"]},{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU","UA"],"is_corresponding":true,"raw_author_name":"Marina G. Holyavka","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","Physics Department, Sevastopol State University, 299053 Sevastopol, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1390-4119","affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]},{"raw_affiliation_string":"Physics Department, Sevastopol State University, 299053 Sevastopol, Russia","institution_ids":["https://openalex.org/I4405278832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107049402","display_name":"Valeriy G. Artyukhov","orcid":"https://orcid.org/0000-0002-8264-3784","observed_orcids":["https://orcid.org/0000-0002-8264-3784"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Valeriy G. Artyukhov","raw_affiliation_strings":["Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics and Biotechnology Department, Voronezh State University, 394018 Voronezh, Russia","institution_ids":["https://openalex.org/I71305448"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5046821470","https://openalex.org/A5057042224"],"corresponding_institution_ids":["https://openalex.org/I4405278832","https://openalex.org/I71305448"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":1.313,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.78626246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"15","first_page":"3223","last_page":"3223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-immobilization","display_name":"enzyme immobilization","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cysteine-protease","display_name":"cysteine protease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/chitosan-derivatives","display_name":"chitosan derivatives","score":0.8669999837875366},{"id":"https://openalex.org/keywords/ficin","display_name":"ficin","score":0.7509999871253967},{"id":"https://openalex.org/keywords/papain","display_name":"papain","score":1.0},{"id":"https://openalex.org/keywords/bromelain","display_name":"bromelain","score":1.0},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6899999976158142},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/specific-activity","display_name":"specific activity","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2779832904","wikidata":"https://www.wikidata.org/wiki/Q410420","display_name":"Papain","level":3,"score":0.8986474871635437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8215087652206421},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.813956618309021},{"id":"https://openalex.org/C2779056493","wikidata":"https://www.wikidata.org/wiki/Q423423","display_name":"Sulfanilamide","level":2,"score":0.6690916419029236},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.46623775362968445},{"id":"https://openalex.org/C3019223276","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Proteolytic enzymes","level":3,"score":0.4207681119441986},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.32463526725769043},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27457112073898315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21674084663391113}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/polym14153223","doi":"https://doi.org/10.3390/polym14153223","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym14153223","pdf_url":"https://www.mdpi.com/2073-4360/14/15/3223/pdf?version=1659965928","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},{"id":"pmid:35956736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35956736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9370924","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9370924/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3cc2733d3f4647f781ff4db5f9be78b2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3cc2733d3f4647f781ff4db5f9be78b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Polymers, Vol 14, Iss 15, p 3223 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/polym14153223","doi":"https://doi.org/10.3390/polym14153223","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym14153223","pdf_url":"https://www.mdpi.com/2073-4360/14/15/3223/pdf?version=1659965928","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1751974251","display_name":null,"funder_award_id":"21-74-20053","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G8395089297","display_name":null,"funder_award_id":"N 075-15-2021-1351","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290759902.pdf","grobid_xml":"https://content.openalex.org/works/W4290759902.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1984789514","https://openalex.org/W2000547215","https://openalex.org/W2006921208","https://openalex.org/W2011510434","https://openalex.org/W2014121368","https://openalex.org/W2029218412","https://openalex.org/W2077300098","https://openalex.org/W2079013207","https://openalex.org/W2079745748","https://openalex.org/W2084981771","https://openalex.org/W2125577596","https://openalex.org/W2142343447","https://openalex.org/W2280376243","https://openalex.org/W2750170631","https://openalex.org/W2792944996","https://openalex.org/W2915084240","https://openalex.org/W2944180353","https://openalex.org/W2956853805","https://openalex.org/W2968870571","https://openalex.org/W2969389119","https://openalex.org/W2991083474","https://openalex.org/W3037516797","https://openalex.org/W3081687669","https://openalex.org/W3084226867","https://openalex.org/W3114903295","https://openalex.org/W3116320510","https://openalex.org/W3120246889","https://openalex.org/W3132655242","https://openalex.org/W3134740255","https://openalex.org/W3137553411","https://openalex.org/W3141349465","https://openalex.org/W3167742053","https://openalex.org/W3216174645","https://openalex.org/W4200205094","https://openalex.org/W4205934519","https://openalex.org/W4205965662","https://openalex.org/W4211020829","https://openalex.org/W4214878519","https://openalex.org/W4245942108","https://openalex.org/W4282936475"],"related_works":["https://openalex.org/W4401757736","https://openalex.org/W3134740255","https://openalex.org/W4310037814","https://openalex.org/W4417326657","https://openalex.org/W4224443410","https://openalex.org/W3112440513","https://openalex.org/W4281711815","https://openalex.org/W4281658979","https://openalex.org/W3112960312","https://openalex.org/W2148343186"],"abstract_inverted_index":{"Briefly,":[0],"2-(4-Acetamido-2-sulfanilamide)":[1],"chitosan,":[2],"which":[3],"is":[4],"a":[5,152,206],"chitosan":[6,41,64,204],"water-soluble":[7],"derivative,":[8],"with":[9,33,42,89,121,151,205],"molecular":[10,153,207],"weights":[11],"of":[12,23,39,62,80,84,145,155,172,179,186,194,209],"200,":[13],"350,":[14],"and":[15,26,45,59,109,113,141,188],"600":[16],"kDa,":[17],"was":[18,28,47,53,129,196],"successfully":[19],"synthesized.":[20],"The":[21,36,111,169],"immobilization":[22,91],"ficin,":[24,44],"papain,":[25],"bromelain":[27,108],"carried":[29],"out":[30],"by":[31],"complexation":[32,69],"these":[34],"polymers.":[35],"interaction":[37],"mechanism":[38],"2-(4-acetamido-2-sulfanilamide)":[40,63,203],"bromelain,":[43],"papain":[46,85,128,146],"studied":[48],"using":[49],"FTIR":[50],"spectroscopy.":[51],"It":[52],"found":[54],"that":[55,75],"the":[56,68,81,90,104,122,134,139,149,162,167,199],"hydroxy,":[57],"thionyl,":[58],"amino":[60,77,98],"groups":[61],"were":[65,117,158],"involved":[66],"in":[67,103,114,118],"process.":[70],"Molecular":[71],"docking":[72],"research":[73],"showed":[74],"all":[76],"acid":[78,99],"residues":[79,100],"active":[82,131],"site":[83],"formed":[86],"hydrogen":[87],"bonds":[88],"matrix,":[92],"while":[93],"only":[94],"two":[95],"catalytically":[96],"valuable":[97],"took":[101],"part":[102],"H-bond":[105],"formation":[106],"for":[107,198],"ficin.":[110],"spectral":[112],"silico":[115],"data":[116],"good":[119],"agreement":[120],"catalytic":[123],"activity":[124,144,182,190],"evaluation":[125],"data.":[126],"Immobilized":[127],"more":[130],"compared":[132,160],"to":[133,161,166],"other":[135],"immobilized":[136,147,201],"proteases.":[137],"Moreover,":[138],"total":[140,181],"specific":[142,189],"proteolytic":[143],"on":[148,202],"carrier":[150],"weight":[154,208],"350":[156,210],"kDa":[157],"higher":[159],"native":[163],"one":[164],"due":[165],"hyperactivation.":[168],"optimal":[170],"ratio":[171],"protein":[173],"content":[174],"(mg":[175],"\u00d7":[176,184,192],"g":[177],"\u22121":[178],"carrier),":[180],"(U":[183,191],"mL\u22121":[185],"solution),":[187],"mg\u22121":[193],"protein)":[195],"determined":[197],"enzymes":[200],"kDa.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-09T00:00:00"}
