{"id":"https://openalex.org/W4290730200","doi":"https://doi.org/10.3389/fmed.2022.970423","title":"RAGE pathway activation and function in chronic kidney disease and COVID-19","display_name":"RAGE pathway activation and function in chronic kidney disease and COVID-19","publication_year":2022,"publication_date":"2022-08-09","ids":{"openalex":"https://openalex.org/W4290730200","doi":"https://doi.org/10.3389/fmed.2022.970423","pmid":"https://pubmed.ncbi.nlm.nih.gov/36017003","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9395689"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2022.970423","doi":"https://doi.org/10.3389/fmed.2022.970423","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2022.970423","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2022.970423/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmed.2022.970423/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019048294","display_name":"Colleen S. Curran","orcid":"https://orcid.org/0000-0002-4517-6494","observed_orcids":["https://orcid.org/0000-0002-4517-6494"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Colleen S. Curran","raw_affiliation_strings":["Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044494633","display_name":"Jeffrey B. Kopp","orcid":"https://orcid.org/0000-0001-9052-186X","observed_orcids":["https://orcid.org/0000-0001-9052-186X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey B. Kopp","raw_affiliation_strings":["Kidney Disease Section, NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases), National Institutes of Health, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kidney Disease Section, NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases), National Institutes of Health, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019048294"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.7858,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.64917127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"970423","last_page":"970423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.7599999904632568},{"id":"https://openalex.org/keywords/rage-ligands","display_name":"RAGE ligands","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":1.0},{"id":"https://openalex.org/keywords/long-covid","display_name":"long COVID","score":0.9629999995231628},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8740000128746033},{"id":"https://openalex.org/keywords/thrombotic-disorders","display_name":"thrombotic disorders","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9800000190734863},{"id":"https://openalex.org/keywords/rage-antagonists","display_name":"RAGE antagonists","score":0.9470000267028809},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.9233366847038269},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.6155126690864563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5817080736160278},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5372737646102905},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5077677965164185},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5046659708023071},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49444127082824707},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4842671751976013},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4760201573371887},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.4379105865955353},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4124499559402466},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3242822289466858},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2635331451892853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23038989305496216},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19957461953163147}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmed.2022.970423","doi":"https://doi.org/10.3389/fmed.2022.970423","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2022.970423","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2022.970423/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9395689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9395689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmid:36017003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36017003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:26808b9d61384426bce85fd7107ce21a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/26808b9d61384426bce85fd7107ce21a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2022.970423","doi":"https://doi.org/10.3389/fmed.2022.970423","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2022.970423","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2022.970423/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290730200.pdf","grobid_xml":"https://content.openalex.org/works/W4290730200.grobid-xml"},"referenced_works_count":154,"referenced_works":["https://openalex.org/W1671871957","https://openalex.org/W1829893638","https://openalex.org/W1899472065","https://openalex.org/W1964082919","https://openalex.org/W1966813043","https://openalex.org/W1967303459","https://openalex.org/W1967982666","https://openalex.org/W1975089978","https://openalex.org/W1984830754","https://openalex.org/W1990586999","https://openalex.org/W1990596307","https://openalex.org/W1991148912","https://openalex.org/W2000551327","https://openalex.org/W2001930522","https://openalex.org/W2009130750","https://openalex.org/W2010032252","https://openalex.org/W2016649530","https://openalex.org/W2021061364","https://openalex.org/W2022267544","https://openalex.org/W2024306433","https://openalex.org/W2029227372","https://openalex.org/W2029331129","https://openalex.org/W2034427444","https://openalex.org/W2045724747","https://openalex.org/W2045883983","https://openalex.org/W2046401692","https://openalex.org/W2052746932","https://openalex.org/W2058016077","https://openalex.org/W2059580890","https://openalex.org/W2062273929","https://openalex.org/W2063349565","https://openalex.org/W2065764145","https://openalex.org/W2073625973","https://openalex.org/W2076362159","https://openalex.org/W2083419397","https://openalex.org/W2083997441","https://openalex.org/W2085060090","https://openalex.org/W2088845292","https://openalex.org/W2102319255","https://openalex.org/W2104611418","https://openalex.org/W2105327109","https://openalex.org/W2105677438","https://openalex.org/W2105678207","https://openalex.org/W2117783767","https://openalex.org/W2124272802","https://openalex.org/W2125308882","https://openalex.org/W2131900085","https://openalex.org/W2147068335","https://openalex.org/W2158006372","https://openalex.org/W2163351331","https://openalex.org/W2163464980","https://openalex.org/W2171663865","https://openalex.org/W2183521979","https://openalex.org/W2200298303","https://openalex.org/W2289862791","https://openalex.org/W2296739687","https://openalex.org/W2405578377","https://openalex.org/W2415134141","https://openalex.org/W2492431655","https://openalex.org/W2509253412","https://openalex.org/W2511512465","https://openalex.org/W2575079226","https://openalex.org/W2610585610","https://openalex.org/W2624318920","https://openalex.org/W2734651019","https://openalex.org/W2743010525","https://openalex.org/W2753937739","https://openalex.org/W2765658889","https://openalex.org/W2774139999","https://openalex.org/W2799395660","https://openalex.org/W2805557676","https://openalex.org/W2808305854","https://openalex.org/W2886211455","https://openalex.org/W2886755849","https://openalex.org/W2888707342","https://openalex.org/W2898211100","https://openalex.org/W2905097831","https://openalex.org/W2917813883","https://openalex.org/W2923882829","https://openalex.org/W2943619559","https://openalex.org/W2945886406","https://openalex.org/W2947621199","https://openalex.org/W2949887030","https://openalex.org/W2954623327","https://openalex.org/W2976486272","https://openalex.org/W2977705058","https://openalex.org/W2985421076","https://openalex.org/W2986566812","https://openalex.org/W3004063856","https://openalex.org/W3018996899","https://openalex.org/W3024585410","https://openalex.org/W3039284170","https://openalex.org/W3040531409","https://openalex.org/W3041376106","https://openalex.org/W3043729847","https://openalex.org/W3047890217","https://openalex.org/W3048128444","https://openalex.org/W3049168405","https://openalex.org/W3080435317","https://openalex.org/W3081607505","https://openalex.org/W3087732369","https://openalex.org/W3091023692","https://openalex.org/W3091632316","https://openalex.org/W3095779196","https://openalex.org/W3108492836","https://openalex.org/W3112030505","https://openalex.org/W3113136031","https://openalex.org/W3113301600","https://openalex.org/W3116204181","https://openalex.org/W3122323246","https://openalex.org/W3126459824","https://openalex.org/W3126728711","https://openalex.org/W3134702367","https://openalex.org/W3135576732","https://openalex.org/W3137224373","https://openalex.org/W3137841630","https://openalex.org/W3139126471","https://openalex.org/W3141671875","https://openalex.org/W3147393950","https://openalex.org/W3156315735","https://openalex.org/W3157093074","https://openalex.org/W3157628415","https://openalex.org/W3158025673","https://openalex.org/W3163336620","https://openalex.org/W3163999468","https://openalex.org/W3168089974","https://openalex.org/W3173551239","https://openalex.org/W3173999719","https://openalex.org/W3177394872","https://openalex.org/W3178514404","https://openalex.org/W3185516914","https://openalex.org/W3190218425","https://openalex.org/W3191110339","https://openalex.org/W3191772277","https://openalex.org/W3194821704","https://openalex.org/W3196529166","https://openalex.org/W3199260195","https://openalex.org/W3200437319","https://openalex.org/W3206577402","https://openalex.org/W3209954062","https://openalex.org/W3214488270","https://openalex.org/W3214821684","https://openalex.org/W3215732862","https://openalex.org/W3216189891","https://openalex.org/W4200517301","https://openalex.org/W4200535194","https://openalex.org/W4200545848","https://openalex.org/W4206241615","https://openalex.org/W4206958645","https://openalex.org/W4213325369","https://openalex.org/W4220883003","https://openalex.org/W4223517816","https://openalex.org/W4224267135","https://openalex.org/W4313333668"],"related_works":["https://openalex.org/W2009897371","https://openalex.org/W4221087933","https://openalex.org/W193268008","https://openalex.org/W2038676563","https://openalex.org/W3038419469","https://openalex.org/W4286794519","https://openalex.org/W4220894256","https://openalex.org/W4205818196","https://openalex.org/W3169208133","https://openalex.org/W3106951869"],"abstract_inverted_index":{"The":[0,76],"multi-ligand":[1],"receptor":[2],"for":[3,151],"advanced":[4],"glycation":[5],"end-products":[6],"(RAGE)":[7],"and":[8,17,29,42,66,71,85,100,110,114,120],"its":[9,134,137],"ligands":[10,68,116,138],"are":[11,155],"contributing":[12],"factors":[13],"in":[14,24,46,55,88,94,117,129],"autoimmunity,":[15],"cancers,":[16],"infectious":[18],"disease.":[19],"RAGE":[20,52,64,67,74,113,115,127],"activation":[21],"is":[22,53],"increased":[23],"chronic":[25],"kidney":[26,58,95,119,149],"disease":[27,31],"(CKD)":[28],"coronavirus":[30],"2019":[32],"(COVID-19).":[33],"CKD":[34,70],"may":[35,43,139],"increase":[36],"the":[37,47,108,118],"risk":[38],"of":[39,49,63,112],"COVID-19":[40,72],"severity":[41],"also":[44],"develop":[45],"form":[48],"long":[50],"COVID.":[51],"expressed":[54],"essentially":[56],"all":[57],"cell":[59],"types.":[60],"Increased":[61],"production":[62],"isoforms":[65],"during":[69],"promotes":[73],"activity.":[75],"downstream":[77],"effects":[78],"include":[79],"cellular":[80],"dysfunction,":[81],"tissue":[82],"injury,":[83],"fibrosis,":[84],"inflammation,":[86],"which":[87,152],"turn":[89],"contribute":[90],"to":[91,144],"a":[92],"decline":[93],"function,":[96],"hypertension,":[97],"thrombotic":[98],"disorders,":[99],"cognitive":[101],"impairment.":[102],"In":[103],"this":[104],"review,":[105],"we":[106],"discuss":[107],"forms":[109],"mechanisms":[111],"COVID-19.":[121],"Because":[122],"various":[123],"small":[124],"molecules":[125],"antagonize":[126],"activity":[128],"animal":[130],"models,":[131],"targeting":[132],"RAGE,":[133],"co-receptors,":[135],"or":[136,146],"offer":[140],"novel":[141],"therapeutic":[142],"approaches":[143],"slowing":[145],"halting":[147],"progressive":[148],"disease,":[150],"current":[153],"therapies":[154],"often":[156],"inadequate.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-08-09T00:00:00"}
