{"id":"https://openalex.org/W4290700360","doi":"https://doi.org/10.1038/s41467-022-32043-3","title":"A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis","display_name":"A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis","publication_year":2022,"publication_date":"2022-08-08","ids":{"openalex":"https://openalex.org/W4290700360","doi":"https://doi.org/10.1038/s41467-022-32043-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/35941109","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360445"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-32043-3","doi":"https://doi.org/10.1038/s41467-022-32043-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-32043-3","pdf_url":"https://www.nature.com/articles/s41467-022-32043-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-32043-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006288691","display_name":"Manse Kim","orcid":"https://orcid.org/0000-0001-8159-4012","observed_orcids":["https://orcid.org/0000-0001-8159-4012"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manse Kim","raw_affiliation_strings":["Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Claire E. Johnson","orcid":"https://orcid.org/0000-0003-0048-6592","observed_orcids":["https://orcid.org/0000-0003-0048-6592"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire E. Johnson","raw_affiliation_strings":["Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0003-0048-6592","affiliations":[{"raw_affiliation_string":"Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008419334","display_name":"Alan A. Schmalstig","orcid":"https://orcid.org/0000-0002-9100-4431","observed_orcids":["https://orcid.org/0000-0002-9100-4431"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan A. Schmalstig","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069717609","display_name":"Ayano Annis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayano Annis","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021139038","display_name":"Sarah E. Wessel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. Wessel","raw_affiliation_strings":["Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006853122","display_name":"Brian Van Horn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Van Horn","raw_affiliation_strings":["UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026144247","display_name":"Amanda P. Schauer","orcid":"https://orcid.org/0000-0002-7026-7224","observed_orcids":["https://orcid.org/0000-0002-7026-7224"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Schauer","raw_affiliation_strings":["UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066766358","display_name":"Agata A. Exner","orcid":"https://orcid.org/0000-0003-3913-7066","observed_orcids":["https://orcid.org/0000-0003-3913-7066"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agata A. Exner","raw_affiliation_strings":["Department of Radiology, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021760244","display_name":"Jason E. Stout","orcid":"https://orcid.org/0000-0002-6698-8176","observed_orcids":["https://orcid.org/0000-0002-6698-8176"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason E. Stout","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020131744","display_name":"Richard Hafner","orcid":"https://orcid.org/0000-0002-3587-9559","observed_orcids":["https://orcid.org/0000-0002-3587-9559"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Wahl","raw_affiliation_strings":["Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017514393","display_name":"Miriam Braunstein","orcid":"https://orcid.org/0000-0003-1180-0030","observed_orcids":["https://orcid.org/0000-0003-1180-0030"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Braunstein","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045466674","display_name":"J. V\u00edctor Garc\u00eda","orcid":"https://orcid.org/0000-0003-3726-0482","observed_orcids":["https://orcid.org/0000-0003-3726-0482"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Victor Garcia","raw_affiliation_strings":["Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. victor_garcia@med.unc.edu","Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. victor_garcia@med.unc.edu","International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. victor_garcia@med.unc.edu","Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0003-3726-0482","affiliations":[{"raw_affiliation_string":"Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. victor_garcia@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. victor_garcia@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. victor_garcia@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045677417","display_name":"Martina Kov\u00e1\u0159ov\u00e1","orcid":"https://orcid.org/0000-0001-7152-1709","observed_orcids":["https://orcid.org/0000-0001-7152-1709"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martina Kovarova","raw_affiliation_strings":["Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. martina_kovarova@med.unc.edu","Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. martina_kovarova@med.unc.edu","International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. martina_kovarova@med.unc.edu","Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0001-7152-1709","affiliations":[{"raw_affiliation_string":"Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. martina_kovarova@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. martina_kovarova@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. martina_kovarova@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045466674","https://openalex.org/A5045677417"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":2.2078,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86553611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"4455","last_page":"4455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.4088999927043915,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifabutin","display_name":"rifabutin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/long-acting-drug-delivery","display_name":"long-acting drug delivery","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/injectable-implants","display_name":"injectable implants","score":0.7770000100135803},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.9779999852180481},{"id":"https://openalex.org/keywords/subcutaneous-injection","display_name":"subcutaneous injection","score":0.7070000171661377},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7609999775886536},{"id":"https://openalex.org/keywords/amphiphilic-molecules","display_name":"amphiphilic molecules","score":0.7749999761581421},{"id":"https://openalex.org/keywords/drug-solubility","display_name":"drug solubility","score":0.9340000152587891},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.4959999918937683},{"id":"https://openalex.org/keywords/tuberculosis-prevention","display_name":"tuberculosis prevention","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2780867798","wikidata":"https://www.wikidata.org/wiki/Q1135705","display_name":"Rifabutin","level":4,"score":0.9677062034606934},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7223941087722778},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7183140516281128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5478892922401428},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.48267820477485657},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3707563281059265},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32584667205810547},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3251153230667114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2831125855445862},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16334572434425354},{"id":"https://openalex.org/C2776962512","wikidata":"https://www.wikidata.org/wiki/Q118551","display_name":"Clarithromycin","level":3,"score":0.08414193987846375}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017828","descriptor_name":"Rifabutin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017828","descriptor_name":"Rifabutin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-022-32043-3","doi":"https://doi.org/10.1038/s41467-022-32043-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-32043-3","pdf_url":"https://www.nature.com/articles/s41467-022-32043-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9360445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360445","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:35941109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35941109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:ns064m021","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/z06h-8s18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 13(1)","raw_type":"Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32043-3","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-32043-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:78ca0bb18972453d8ccd4f196de8996e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/78ca0bb18972453d8ccd4f196de8996e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)","raw_type":"article"},{"id":"doi:10.17615/z06h-8s18","doi":"https://doi.org/10.17615/z06h-8s18","is_oa":true,"landing_page_url":"https://doi.org/10.17615/z06h-8s18","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-32043-3","doi":"https://doi.org/10.1038/s41467-022-32043-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-32043-3","pdf_url":"https://www.nature.com/articles/s41467-022-32043-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G107801735","display_name":null,"funder_award_id":"R01AI40799","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4527619190","display_name":null,"funder_award_id":"R01AI40799","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5469885365","display_name":"The Role of Human Gut Microbiota in HIV-1 Rectal Acquisition, Replication, and Pathogenesis","funder_award_id":"R01AI123010","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5881149655","display_name":null,"funder_award_id":"R01AI123010","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G644726313","display_name":"Next generation ultra-long acting antiretroviral formulations for HIV treatment and prevention","funder_award_id":"R01AI140799","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7366156696","display_name":null,"funder_award_id":"CA016086","funder_id":"https://openalex.org/F4320337594","funder_display_name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill"},{"id":"https://openalex.org/G9000033364","display_name":null,"funder_award_id":"CA016086","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000894295","display_name":"The University of North Carolina Center for AIDS Research","funder_award_id":"P30AI050410","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000913976","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G958207224","display_name":null,"funder_award_id":"P30-CA016086","funder_id":"https://openalex.org/F4320337594","funder_display_name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320331265","display_name":"Partenariat Canadien Contre Le Cancer","ror":"https://ror.org/0488wxv90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337594","display_name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290700360.pdf","grobid_xml":"https://content.openalex.org/works/W4290700360.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W149836168","https://openalex.org/W1546289395","https://openalex.org/W1606638524","https://openalex.org/W1975455625","https://openalex.org/W1992801092","https://openalex.org/W1993801112","https://openalex.org/W2003429874","https://openalex.org/W2007793290","https://openalex.org/W2019087919","https://openalex.org/W2022340002","https://openalex.org/W2025330324","https://openalex.org/W2042562804","https://openalex.org/W2043179283","https://openalex.org/W2043279962","https://openalex.org/W2048567398","https://openalex.org/W2059539025","https://openalex.org/W2059786651","https://openalex.org/W2060490180","https://openalex.org/W2061534137","https://openalex.org/W2068228356","https://openalex.org/W2068847419","https://openalex.org/W2083674054","https://openalex.org/W2083886631","https://openalex.org/W2087496871","https://openalex.org/W2122510226","https://openalex.org/W2140993748","https://openalex.org/W2150559484","https://openalex.org/W2172990556","https://openalex.org/W2174905232","https://openalex.org/W2290466312","https://openalex.org/W2304970015","https://openalex.org/W2404394069","https://openalex.org/W2420893966","https://openalex.org/W2623158620","https://openalex.org/W2790642604","https://openalex.org/W2793825585","https://openalex.org/W2806401002","https://openalex.org/W2886632226","https://openalex.org/W2893259841","https://openalex.org/W2894851276","https://openalex.org/W2908949990","https://openalex.org/W2910058835","https://openalex.org/W2953312173","https://openalex.org/W2957013022","https://openalex.org/W2958974345","https://openalex.org/W2963372854","https://openalex.org/W2969249031","https://openalex.org/W2974040532","https://openalex.org/W2979728016","https://openalex.org/W3042180409","https://openalex.org/W3049689840","https://openalex.org/W3101947576","https://openalex.org/W3190903956","https://openalex.org/W4210627381","https://openalex.org/W4245878836"],"related_works":["https://openalex.org/W2790642604","https://openalex.org/W4413426654","https://openalex.org/W7203645196","https://openalex.org/W2964245485","https://openalex.org/W2881931961","https://openalex.org/W2102969949","https://openalex.org/W7135054989","https://openalex.org/W2953312173","https://openalex.org/W4200151401","https://openalex.org/W1940811086"],"abstract_inverted_index":{"Tuberculosis":[0],"(TB)":[1],"is":[2,12,120],"a":[3,13],"communicable":[4],"disease":[5],"caused":[6],"by":[7,122],"Mycobacterium":[8],"tuberculosis":[9],"(Mtb)":[10],"and":[11,18,62,106,138,147],"major":[14],"cause":[15],"of":[16,31,48,53,59,71,114,135],"morbidity":[17],"mortality.":[19],"Successful":[20],"treatment":[21],"requires":[22],"strict":[23],"adherence":[24],"to":[25,40,78],"drug":[26,51,56,75,82,95,109,127],"regimens":[27],"for":[28,129],"prolonged":[29],"periods":[30],"time.":[32],"Long-acting":[33],"(LA)":[34],"delivery":[35],"systems":[36],"have":[37,86],"the":[38,46,54,145],"potential":[39],"improve":[41],"adherence.":[42],"Here,":[43],"we":[44],"show":[45],"development":[47],"LA":[49],"injectable":[50],"formulations":[52],"anti-TB":[55],"rifabutin":[57],"made":[58],"biodegradable":[60],"polymers":[61],"biocompatible":[63],"solvents":[64],"that":[65,89,102],"solidifies":[66],"after":[67],"subcutaneous":[68],"injection.":[69],"Addition":[70],"amphiphilic":[72],"compounds":[73],"increases":[74],"solubility,":[76],"allowing":[77],"significantly":[79],"increase":[80],"formulation":[81,92],"load.":[83],"Solidified":[84],"implants":[85],"organized":[87],"microstructures":[88],"change":[90],"with":[91],"composition.":[93],"Higher":[94],"load":[96],"results":[97],"in":[98,117],"smaller":[99],"pore":[100],"size":[101],"alters":[103],"implant":[104],"erosion":[105],"allows":[107],"sustained":[108],"release.":[110],"The":[111],"translational":[112],"relevance":[113],"these":[115],"observations":[116],"BALB/c":[118],"mice":[119],"demonstrated":[121],"(1)":[123],"delivering":[124],"high":[125],"plasma":[126],"concentrations":[128],"16":[130],"weeks,":[131],"(2)":[132],"preventing":[133],"acquisition":[134],"Mtb":[136,142],"infection,":[137],"(3)":[139],"clearing":[140],"acute":[141],"infection":[143],"from":[144],"lung":[146],"other":[148],"tissues.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-09T00:00:00"}
