{"id":"https://openalex.org/W4290342699","doi":"https://doi.org/10.1177/02611929221114383","title":"Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance","display_name":"Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4290342699","doi":"https://doi.org/10.1177/02611929221114383","pmid":"https://pubmed.ncbi.nlm.nih.gov/35938181"},"language":"en","primary_location":{"id":"doi:10.1177/02611929221114383","doi":"https://doi.org/10.1177/02611929221114383","is_oa":false,"landing_page_url":"https://doi.org/10.1177/02611929221114383","pdf_url":null,"source":{"id":"https://openalex.org/S35160907","display_name":"Alternatives to Laboratory Animals","issn_l":"0261-1929","issn":["0261-1929","2632-3559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternatives to Laboratory Animals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079240159","display_name":"Holger Peter Behrsing","orcid":"https://orcid.org/0000-0001-7284-9837","observed_orcids":["https://orcid.org/0000-0001-7284-9837"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Holger P. Behrsing","raw_affiliation_strings":["IIVS, Inc., Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIVS, Inc., Gaithersburg, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086588644","display_name":"Adam Wahab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Wahab","raw_affiliation_strings":["IIVS, Inc., Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIVS, Inc., Gaithersburg, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078270748","display_name":"Lindsey Ukishima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lindsey Ukishima","raw_affiliation_strings":["IIVS, Inc., Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIVS, Inc., Gaithersburg, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087576901","display_name":"Chad Grodi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chad Grodi","raw_affiliation_strings":["IIVS, Inc., Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIVS, Inc., Gaithersburg, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059517509","display_name":"Stefan Frentzel","orcid":"https://orcid.org/0000-0001-8999-8679","observed_orcids":["https://orcid.org/0000-0001-8999-8679"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stefan Frentzel","raw_affiliation_strings":["Phillip Morris International, Neuchatel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phillip Morris International, Neuchatel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058978889","display_name":"St\u00e9phanie Johne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephanie Johne","raw_affiliation_strings":["Phillip Morris International, Neuchatel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phillip Morris International, Neuchatel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038105587","display_name":"Shinkichi Ishikawa","orcid":"https://orcid.org/0000-0001-9501-6096","observed_orcids":["https://orcid.org/0000-0001-9501-6096"]},"institutions":[{"id":"https://openalex.org/I4210108598","display_name":"Japan Tobacco (Japan)","ror":"https://ror.org/01xdq1k91","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210108598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinkichi Ishikawa","raw_affiliation_strings":["Japan Tobacco, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Tobacco, Yokohama, Japan","institution_ids":["https://openalex.org/I4210108598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081535885","display_name":"Shigeaki Ito","orcid":"https://orcid.org/0000-0002-0079-7510","observed_orcids":["https://orcid.org/0000-0002-0079-7510"]},"institutions":[{"id":"https://openalex.org/I4210108598","display_name":"Japan Tobacco (Japan)","ror":"https://ror.org/01xdq1k91","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210108598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeaki Ito","raw_affiliation_strings":["Japan Tobacco, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Tobacco, Yokohama, Japan","institution_ids":["https://openalex.org/I4210108598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044888783","display_name":"Roman Wieczorek","orcid":"https://orcid.org/0000-0003-2826-1539","observed_orcids":["https://orcid.org/0000-0003-2826-1539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman Wieczorek","raw_affiliation_strings":["Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2826-1539","affiliations":[{"raw_affiliation_string":"Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075236619","display_name":"Jessica Budde","orcid":"https://orcid.org/0000-0002-0484-6826","observed_orcids":["https://orcid.org/0000-0002-0484-6826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Budde","raw_affiliation_strings":["Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0484-6826","affiliations":[{"raw_affiliation_string":"Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036121921","display_name":"Brian M. Keyser","orcid":"https://orcid.org/0000-0002-7493-1073","observed_orcids":["https://orcid.org/0000-0002-7493-1073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian M. Keyser","raw_affiliation_strings":["RAI Services Company, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RAI Services Company, Winston-Salem, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025603160","display_name":"Linsey Ellen Haswell","orcid":"https://orcid.org/0000-0002-5663-8834","observed_orcids":["https://orcid.org/0000-0002-5663-8834"]},"institutions":[{"id":"https://openalex.org/I1701708","display_name":"British American Tobacco (United Kingdom)","ror":"https://ror.org/01znsh139","country_code":"GB","type":"company","lineage":["https://openalex.org/I1701708"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Linsey E. Haswell","raw_affiliation_strings":["British American Tobacco, R&D, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British American Tobacco, R&D, Southampton, UK","institution_ids":["https://openalex.org/I1701708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000160763","display_name":"David Thorne","orcid":"https://orcid.org/0000-0002-6002-6507","observed_orcids":["https://orcid.org/0000-0002-6002-6507"]},"institutions":[{"id":"https://openalex.org/I1701708","display_name":"British American Tobacco (United Kingdom)","ror":"https://ror.org/01znsh139","country_code":"GB","type":"company","lineage":["https://openalex.org/I1701708"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Thorne","raw_affiliation_strings":["British American Tobacco, R&D, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British American Tobacco, R&D, Southampton, UK","institution_ids":["https://openalex.org/I1701708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033093150","display_name":"Emma Bishop","orcid":"https://orcid.org/0000-0002-9048-1527","observed_orcids":["https://orcid.org/0000-0002-9048-1527"]},"institutions":[{"id":"https://openalex.org/I1701708","display_name":"British American Tobacco (United Kingdom)","ror":"https://ror.org/01znsh139","country_code":"GB","type":"company","lineage":["https://openalex.org/I1701708"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma Bishop","raw_affiliation_strings":["British American Tobacco, R&D, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British American Tobacco, R&D, Southampton, UK","institution_ids":["https://openalex.org/I1701708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010390963","display_name":"Damien Breheny","orcid":"https://orcid.org/0000-0001-5786-4369","observed_orcids":["https://orcid.org/0000-0001-5786-4369"]},"institutions":[{"id":"https://openalex.org/I1701708","display_name":"British American Tobacco (United Kingdom)","ror":"https://ror.org/01znsh139","country_code":"GB","type":"company","lineage":["https://openalex.org/I1701708"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Damien Breheny","raw_affiliation_strings":["British American Tobacco, R&D, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British American Tobacco, R&D, Southampton, UK","institution_ids":["https://openalex.org/I1701708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102024986","display_name":"Xuefei Cao","orcid":"https://orcid.org/0000-0002-1823-5102","observed_orcids":["https://orcid.org/0000-0002-1823-5102"]},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuefei Cao","raw_affiliation_strings":["National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, AR, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680083","display_name":"Qin Qin","orcid":"https://orcid.org/0000-0002-6432-2944","observed_orcids":["https://orcid.org/0000-0002-6432-2944"]},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qin Qin","raw_affiliation_strings":["Current Affiliation: L\u2019Or\u00e9al, R&D, Shanghai, PR China","National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current Affiliation: L\u2019Or\u00e9al, R&D, Shanghai, PR China","institution_ids":[]},{"raw_affiliation_string":"National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, AR, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052876785","display_name":"Vivek Patel","orcid":"https://orcid.org/0000-0001-8583-1548","observed_orcids":["https://orcid.org/0000-0001-8583-1548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vivek Patel","raw_affiliation_strings":["IIVS, Inc., Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIVS, Inc., Gaithersburg, MD, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079240159"],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.459,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.77923955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"50","issue":"4","first_page":"293","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciliary-beat-frequency","display_name":"ciliary beat frequency","score":1.0},{"id":"https://openalex.org/keywords/mucociliary-clearance","display_name":"mucociliary clearance","score":0.902999997138977},{"id":"https://openalex.org/keywords/interlaboratory-comparison","display_name":"interlaboratory comparison","score":0.6010000109672546},{"id":"https://openalex.org/keywords/interlaboratory-variability","display_name":"inter-laboratory variability","score":0.8240000009536743},{"id":"https://openalex.org/keywords/video-analysis-software","display_name":"video analysis software","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mucilair","display_name":"MucilAir","score":0.7730000019073486},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.8460000157356262},{"id":"https://openalex.org/keywords/procaterol","display_name":"procaterol","score":0.9190000295639038},{"id":"https://openalex.org/keywords/respiratory-toxicology","display_name":"respiratory toxicology","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C114682108","wikidata":"https://www.wikidata.org/wiki/Q1952044","display_name":"Mucociliary clearance","level":3,"score":0.6955400109291077},{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.46215420961380005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42237597703933716},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.420375794172287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4020515978336334},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3403138816356659},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3331948518753052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20789769291877747},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1638377606868744},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12924078106880188},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007753","descriptor_name":"Laboratories","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009079","descriptor_name":"Mucociliary Clearance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/02611929221114383","doi":"https://doi.org/10.1177/02611929221114383","is_oa":false,"landing_page_url":"https://doi.org/10.1177/02611929221114383","pdf_url":null,"source":{"id":"https://openalex.org/S35160907","display_name":"Alternatives to Laboratory Animals","issn_l":"0261-1929","issn":["0261-1929","2632-3559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternatives to Laboratory Animals","raw_type":"journal-article"},{"id":"pmid:35938181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35938181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternatives to laboratory animals : ATLA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W61220348","https://openalex.org/W79119690","https://openalex.org/W1556188016","https://openalex.org/W1848749243","https://openalex.org/W1976148540","https://openalex.org/W2007770546","https://openalex.org/W2024543029","https://openalex.org/W2028175803","https://openalex.org/W2030109546","https://openalex.org/W2044466667","https://openalex.org/W2122111590","https://openalex.org/W2171253100","https://openalex.org/W2524637378","https://openalex.org/W2990326782","https://openalex.org/W2997814633","https://openalex.org/W3033853693","https://openalex.org/W3104976980","https://openalex.org/W4237911065","https://openalex.org/W4298371813"],"related_works":["https://openalex.org/W1805999094","https://openalex.org/W4392824186","https://openalex.org/W3212535321","https://openalex.org/W2321066337","https://openalex.org/W7131640474","https://openalex.org/W3200566767","https://openalex.org/W2494652097","https://openalex.org/W2344583821","https://openalex.org/W2171253100","https://openalex.org/W2062864099"],"abstract_inverted_index":{"The":[0,51,215],"use":[1],"of":[2,44,53,90,100,118,180,186,261],"reconstituted":[3],"human":[4],"airway":[5],"(RHuA)":[6],"epithelial":[7],"tissues":[8],"to":[9,38,82,136,142,168,207,223],"assess":[10,143],"functional":[11],"endpoints":[12,227],"is":[13],"highly":[14],"relevant":[15],"in":[16,57,62,87],"respiratory":[17],"toxicology,":[18],"but":[19,220,246],"standardised":[20,263],"methods":[21],"are":[22],"lacking.":[23],"In":[24,30],"June":[25],"2015,":[26],"the":[27,40,58,70,74,80,88,98,178,184,242,257],"Institute":[28],"for":[29,42,85,97,126],"Vitro":[31],"Sciences":[32],"(IIVS)":[33],"held":[34],"a":[35,54,63,91,262],"technical":[36],"workshop":[37,59],"evaluate":[39],"potential":[41],"standardisation":[43],"methods,":[45],"including":[46],"ciliary":[47],"beat":[48],"frequency":[49],"(CBF).":[50],"applicability":[52],"protocol":[55],"suggested":[56],"was":[60],"assessed":[61],"multi-laboratory":[64],"ring":[65],"study.":[66],"This":[67],"report":[68],"summarises":[69],"findings,":[71],"and":[72,76,114,134,157,164,189,198,236,259],"uses":[73],"similarities":[75],"differences":[77],"identified":[78],"between":[79],"laboratories":[81],"make":[83],"recommendations":[84],"researchers":[86],"absence":[89],"validated":[92],"method.":[93],"Two":[94,146],"software":[95],"platforms":[96],"assessment":[99],"CBF":[101,194,202,210,226,264],"were":[102,124,151,166,218,221,228],"used":[103,167],"-":[104],"Sisson-Ammons":[105],"Video":[106],"Analysis":[107],"(SAVA;":[108],"Ammons":[109],"Engineering,":[110],"Clio,":[111],"MI,":[112],"USA)":[113],"ciliaFA":[115,199,205],"(National":[116],"Institutes":[117],"Health,":[119],"Bethesda,":[120],"MD,":[121],"USA).":[122,162],"Both":[123,196],"utilised":[125],"multiple":[127],"read":[128],"temperatures,":[129],"one":[130],"objective":[131,190,234],"strength":[132],"(10\u00d7)":[133],"up":[135],"four":[137],"video":[138],"captures":[139],"per":[140],"tissue,":[141],"their":[144],"utility.":[145],"commercial":[147],"RHuA":[148],"tissue":[149,181,239],"cultures":[150],"used:":[152],"MucilAir\u2122":[153],"(Epithelix,":[154],"Geneva,":[155],"Switzerland)":[156],"EpiAirway\u2122":[158],"(MatTek,":[159],"Ashland,":[160],"MA,":[161],"IL-13":[163],"procaterol":[165],"induce":[169],"CBF-specific":[170],"responses":[171],"as":[172],"positive":[173,216],"controls.":[174],"Further":[175],"testing":[176],"addressed":[177],"impact":[179,249],"acclimation":[182,240],"duration,":[183],"number":[185],"capture":[187],"fields":[188],"strengths":[191,235],"on":[192,250],"baseline":[193],"readings.":[195],"SAVA":[197],"reliably":[200],"collected":[201],"data.":[203],"However,":[204],"failed":[206],"generate":[208],"accurate":[209],"measurements":[211],"above":[212],"\u223c10":[213],"Hz.":[214],"controls":[217],"effective,":[219],"subject":[222],"inter-laboratory":[224],"variability.":[225],"generally":[229],"uniform":[230],"across":[231],"replicate":[232],"tissues,":[233],"laboratories.":[237],"Longer":[238],"increased":[241],"percentage":[243],"active":[244],"area,":[245],"had":[247],"minimal":[248],"CBF.":[251],"Taken":[252],"together,":[253],"these":[254],"findings":[255],"support":[256],"development":[258],"validation":[260],"measurement":[265],"protocol.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-08-07T00:00:00"}