{"id":"https://openalex.org/W4290141863","doi":null,"title":"[The yeast test: an alternative method for determination of acute toxicity of drugs and environmental chemicals].","display_name":"[The yeast test: an alternative method for determination of acute toxicity of drugs and environmental chemicals].","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W4290141863","mag":"49530646","pmid":"https://pubmed.ncbi.nlm.nih.gov/1518900"},"language":"de","primary_location":{"id":"pmid:1518900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1518900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113383536","display_name":"H. P. Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"H P Koch","raw_affiliation_strings":["Institut f\u00fcr Pharmazeutische Chemie, Universit\u00e4t Wien, Osterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmazeutische Chemie, Universit\u00e4t Wien, Osterreich","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113383536"],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55852696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"47","issue":"7","first_page":"531","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9269999861717224},{"id":"https://openalex.org/keywords/acute-toxicity-testing","display_name":"acute toxicity testing","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alternatives-to-animal-testing","display_name":"alternatives to animal testing","score":0.8140000104904175},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/environmental-chemicals","display_name":"environmental chemicals","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.8553750514984131},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.6259051561355591},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5977461338043213},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.5796404480934143},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5537869334220886},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4730250835418701},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.43920090794563293},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.41923853754997253},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.33324235677719116},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33001768589019775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3271424174308777},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30259695649147034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20394667983055115},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09464439749717712},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08556658029556274},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1518900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1518900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"Comparative Study"},{"id":"mag:49530646","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/1518900","pdf_url":null,"source":{"id":"https://openalex.org/S175310056","display_name":"Die Pharmazie","issn_l":"0031-7144","issn":["0031-7144","3053-691X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320695","host_organization_name":"Avoxa","host_organization_lineage":["https://openalex.org/P4310320695"],"host_organization_lineage_names":["Avoxa"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0098Die \u009cPharmazie","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W143585376","https://openalex.org/W2083105829","https://openalex.org/W6990848542","https://openalex.org/W2952521657","https://openalex.org/W7011513868","https://openalex.org/W2095211801","https://openalex.org/W1971757130","https://openalex.org/W7044362416","https://openalex.org/W2936350461","https://openalex.org/W2268106654"],"abstract_inverted_index":{"Starting":[0],"point":[1],"for":[2,9],"this":[3,40],"study":[4],"was":[5],"the":[6,12,72,142],"urgent":[7],"need":[8],"replacement":[10],"of":[11,15,19,145],"contemporary":[13],"mode":[14],"acute":[16,146],"toxicity":[17,147],"testing":[18,43,54],"chemicals":[20],"in":[21,66,75,102,131],"vertebrates":[22],"(LD50-test)":[23],"by":[24,141],"an":[25,83],"experimental":[26],"model":[27],"with":[28,88,138],"equal":[29],"power":[30,69],"that":[31,56],"can":[32,98,125],"be":[33,47,100,126],"performed":[34],"on":[35],"non-pain":[36],"sensitive":[37],"matter.":[38],"For":[39],"purpose,":[41],"a":[42,50],"procedure":[44,106],"ought":[45],"to":[46,63,71],"developed":[48],"using":[49],"non-pathogenic":[51],"microorganism":[52],"as":[53,109],"object":[55],"is":[57,116],"available":[58],"at":[59],"any":[60],"time,":[61],"easy":[62],"cultivate,":[64],"and":[65,78,123],"its":[67],"indicative":[68],"equivalent":[70],"LD50":[73],"test":[74],"mice,":[76],"rats,":[77],"other":[79],"laboratory":[80],"animals.":[81],"Such":[82],"organism":[84],"has":[85],"been":[86],"found":[87],"ordinary":[89],"yeast":[90],"(baker's":[91],"yeast,":[92,94],"brewer's":[93],"Saccharomyces":[95],"cerevisiae)":[96],"which":[97],"always":[99],"obtained":[101],"good":[103],"quality.":[104],"This":[105],"(shortly":[107],"denominated":[108],"'yeast":[110],"test'":[111],"offers":[112],"several":[113],"advantages:":[114],"It":[115],"rather":[117],"simple,":[118],"inexpensive,":[119],"outstandingly":[120],"well":[121,137],"reproducible,":[122],"it":[124],"carried":[127],"out":[128],"conveniently":[129],"also":[130],"routine":[132],"experiments.":[133],"The":[134],"results":[135],"correlate":[136],"those":[139],"furnished":[140],"customary":[143],"methods":[144],"testing.":[148]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-08-07T00:00:00"}