{"id":"https://openalex.org/W4290052559","doi":"https://doi.org/10.1016/j.cjco.2022.07.013","title":"Sex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics?","display_name":"Sex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics?","publication_year":2022,"publication_date":"2022-08-06","ids":{"openalex":"https://openalex.org/W4290052559","doi":"https://doi.org/10.1016/j.cjco.2022.07.013","pmid":"https://pubmed.ncbi.nlm.nih.gov/36444366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9700217"},"language":"en","primary_location":{"id":"doi:10.1016/j.cjco.2022.07.013","doi":"https://doi.org/10.1016/j.cjco.2022.07.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cjco.2022.07.013","pdf_url":"http://www.cjcopen.ca/article/S2589790X22001548/pdf","source":{"id":"https://openalex.org/S4210204950","display_name":"CJC Open","issn_l":"2589-790X","issn":["2589-790X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CJC Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cjcopen.ca/article/S2589790X22001548/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101997662","display_name":"Amanpreet Kaur","orcid":"https://orcid.org/0000-0001-5004-7614","observed_orcids":["https://orcid.org/0000-0001-5004-7614"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amanpreet Kaur","raw_affiliation_strings":["Centre for Outcomes Research and Evaluation, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Outcomes Research and Evaluation, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070286977","display_name":"Rachel P. Dreyer","orcid":"https://orcid.org/0000-0003-2861-1383","observed_orcids":["https://orcid.org/0000-0003-2861-1383"]},"institutions":[{"id":"https://openalex.org/I1323778983","display_name":"Yale New Haven Hospital","ror":"https://ror.org/05tszed37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1323778983","https://openalex.org/I4210117499"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel P. Dreyer","raw_affiliation_strings":["Centre for Outcomes Research and Evaluation (CORE), Yale-New Haven Hospital, New Haven, Connecticut, USA","Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Outcomes Research and Evaluation (CORE), Yale-New Haven Hospital, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I1323778983"]},{"raw_affiliation_string":"Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088617695","display_name":"Thomas W. Marsh","orcid":"https://orcid.org/0000-0001-8565-3788","observed_orcids":["https://orcid.org/0000-0001-8565-3788"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas W. Marsh","raw_affiliation_strings":["Department of Human Genetics, McGill University, Montreal, Quebec, Canada","Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034080261","display_name":"George Thanassoulis","orcid":"https://orcid.org/0000-0002-9930-7189","observed_orcids":["https://orcid.org/0000-0002-9930-7189"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"George Thanassoulis","raw_affiliation_strings":["Centre for Outcomes Research and Evaluation, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada","Department of Medicine, McGill University, Montreal, Quebec, Canada","Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Outcomes Research and Evaluation, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283"]},{"raw_affiliation_string":"Department of Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074660968","display_name":"Valeria Raparelli","orcid":"https://orcid.org/0000-0002-2100-5682","observed_orcids":["https://orcid.org/0000-0002-2100-5682"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["CA","IT"],"is_corresponding":false,"raw_author_name":"Valeria Raparelli","raw_affiliation_strings":["Department of Translational Medicine, University of Ferrara, Ferrara, Italy","Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025601376","display_name":"Gail D\u2019Onofrio","orcid":"https://orcid.org/0000-0002-3833-1871","observed_orcids":["https://orcid.org/0000-0002-3833-1871"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail D\u2019Onofrio","raw_affiliation_strings":["Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080707052","display_name":"James C. Engert","orcid":"https://orcid.org/0000-0001-8411-4790","observed_orcids":["https://orcid.org/0000-0001-8411-4790"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James C. Engert","raw_affiliation_strings":["Department of Human Genetics, McGill University, Montreal, Quebec, Canada","Department of Medicine, McGill University, Montreal, Quebec, Canada","Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017235084","display_name":"Louise Pilote","orcid":"https://orcid.org/0000-0002-6159-0628","observed_orcids":["https://orcid.org/0000-0002-6159-0628"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Louise Pilote","raw_affiliation_strings":["Centre for Outcomes Research and Evaluation, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada","Department of Medicine, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Outcomes Research and Evaluation, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283"]},{"raw_affiliation_string":"Department of Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5017235084"],"corresponding_institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.8627,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71652312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"4","issue":"11","first_page":"970","last_page":"978"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.8500000238418579},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5429999828338623},{"id":"https://openalex.org/keywords/loss-of-function-alleles","display_name":"loss-of-function alleles","score":0.6930000185966492},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.7929999828338623},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.9515302181243896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8208419680595398},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7778326272964478},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.7403732538223267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6303267478942871},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5909348130226135},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4748181104660034},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47430041432380676},{"id":"https://openalex.org/C2777265216","wikidata":"https://www.wikidata.org/wiki/Q721432","display_name":"Antiplatelet drug","level":4,"score":0.4666901230812073},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.34917938709259033},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3234095275402069}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.cjco.2022.07.013","doi":"https://doi.org/10.1016/j.cjco.2022.07.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cjco.2022.07.013","pdf_url":"http://www.cjcopen.ca/article/S2589790X22001548/pdf","source":{"id":"https://openalex.org/S4210204950","display_name":"CJC Open","issn_l":"2589-790X","issn":["2589-790X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CJC Open","raw_type":"journal-article"},{"id":"pmid:36444366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36444366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CJC open","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9700217","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9700217/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CJC Open","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bfaf344b39844129b7bb48f0b5e59711","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bfaf344b39844129b7bb48f0b5e59711","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CJC Open, Vol 4, Iss 11, Pp 970-978 (2022)","raw_type":"article"},{"id":"pmh:oai:iris.unife.it:11392/2499558","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11392/2499558","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1706603","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1706603","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sfera.unife.it:11392/2499558","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11392/2499558","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.cjco.2022.07.013","doi":"https://doi.org/10.1016/j.cjco.2022.07.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cjco.2022.07.013","pdf_url":"http://www.cjcopen.ca/article/S2589790X22001548/pdf","source":{"id":"https://openalex.org/S4210204950","display_name":"CJC Open","issn_l":"2589-790X","issn":["2589-790X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CJC Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4531977775","display_name":null,"funder_award_id":"385400","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320314794","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4290052559.pdf","grobid_xml":"https://content.openalex.org/works/W4290052559.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W7166862","https://openalex.org/W1229126436","https://openalex.org/W1523938956","https://openalex.org/W1711243152","https://openalex.org/W1977317212","https://openalex.org/W1978054736","https://openalex.org/W1986526442","https://openalex.org/W1993617982","https://openalex.org/W2002010237","https://openalex.org/W2010427019","https://openalex.org/W2019242459","https://openalex.org/W2050457541","https://openalex.org/W2104549677","https://openalex.org/W2109964634","https://openalex.org/W2111180428","https://openalex.org/W2112380741","https://openalex.org/W2113212108","https://openalex.org/W2113730370","https://openalex.org/W2148895117","https://openalex.org/W2149011208","https://openalex.org/W2157191905","https://openalex.org/W2158615904","https://openalex.org/W2164704288","https://openalex.org/W2168355902","https://openalex.org/W2193552914","https://openalex.org/W2256016639","https://openalex.org/W2256539200","https://openalex.org/W2331820709","https://openalex.org/W2336778042","https://openalex.org/W2460117772","https://openalex.org/W2522162268","https://openalex.org/W2522209380","https://openalex.org/W2532281394","https://openalex.org/W2572771135","https://openalex.org/W2583926287","https://openalex.org/W2605348885","https://openalex.org/W2735586517","https://openalex.org/W2735960192","https://openalex.org/W2776894078","https://openalex.org/W2777744478","https://openalex.org/W2779604619","https://openalex.org/W2793753528","https://openalex.org/W2806298612","https://openalex.org/W2829010272","https://openalex.org/W2885923307","https://openalex.org/W2901728784","https://openalex.org/W2914095387","https://openalex.org/W2936489929","https://openalex.org/W2971988395","https://openalex.org/W3009673715","https://openalex.org/W3031845473","https://openalex.org/W3135139936","https://openalex.org/W3160579173","https://openalex.org/W3184597490","https://openalex.org/W4293372203","https://openalex.org/W6751641871","https://openalex.org/W6775838077"],"related_works":["https://openalex.org/W2919131998","https://openalex.org/W2092566126","https://openalex.org/W6887705159","https://openalex.org/W1257077020","https://openalex.org/W2885923307","https://openalex.org/W1985059672","https://openalex.org/W2564637961","https://openalex.org/W2159858918","https://openalex.org/W2021341882","https://openalex.org/W56261390"],"abstract_inverted_index":{"Background":[0],"Poorer":[1],"health":[2],"outcomes":[3,61],"experienced":[4],"by":[5],"young":[6],"women":[7,63,205],"with":[8,80,138,246],"acute":[9,117],"coronary":[10,118],"syndrome":[11],"may":[12],"be":[13],"related":[14],"to":[15,49,57,73,135,142,226],"sex":[16,79,124,267],"differences":[17,268],"in":[18,30,47,62,169,265,269],"the":[19,45,155,161,173,189,227,232,253,260],"safety":[20],"and":[21,88,125,133],"efficacy":[22],"of":[23,55,78,86,106,149,157,163,172,188,196,210,259,262],"antiplatelet":[24],"agents,":[25],"such":[26],"as":[27],"clopidogrel.":[28,50],"Polymorphisms":[29],"drug":[31,270],"metabolism":[32],"enzyme":[33],"(cytochrome":[34],"P450":[35],"[":[36],"CYP":[37,81,126],"]":[38],"family)":[39],"genes":[40],"are":[41],"independent":[42],"factors":[43],"for":[44,116,194,229,255],"variability":[46],"response":[48],"However,":[51],"a":[52,103,239],"sex-specific":[53],"impact":[54,92],"genetics":[56],"explain":[58],"worse":[59],"clinical":[60,96],"has":[64],"not":[65,244],"been":[66],"explored":[67],"extensively.":[68],"Therefore,":[69],"our":[70],"objective":[71],"was":[72,167],"determine":[74],"whether":[75],"an":[76,164,256],"interaction":[77],"variants":[82,127],"occurs":[83],"among":[84,128],"users":[85,130,195],"clopidogrel,":[87],"if":[89],"so,":[90],"its":[91],"on":[93,152],"1-year":[94,139,247],"adverse":[95],"outcomes.":[97],"Methods":[98],"We":[99,120],"used":[100],"data":[101],"from":[102],"combined":[104],"cohort":[105],"2272":[107],"patients":[108],"(median":[109],"age":[110],"49":[111],"years;":[112],"56%":[113],"female)":[114],"hospitalized":[115],"syndrome.":[119],"examined":[121],"interactions":[122,264],"between":[123],"clopidogrel":[129,153,197],"at":[131,154,198,213],"admission":[132],"discharge":[134,199],"assess":[136],"associations":[137],"readmission":[140],"due":[141],"cardiac":[143],"events.":[144],"Results":[145],"The":[146,186],"case-only":[147],"analysis":[148],"177":[150],"participants":[151],"time":[156],"presentation":[158],"showed":[159],"that":[160,204],"risk":[162,209,228,241],"atherothrombotic":[165,211],"event":[166],"greater":[168],"female":[170],"carriers":[171],"CYP2C9\u22173":[174],"loss-of-function":[175,233],"allele":[176],"(odds":[177,216],"ratio":[178,217],"=":[179,184,201,218,223],"3.77,":[180],"95%":[181,220],"confidence":[182,221],"interval":[183,222],"1.54-9.24).":[185],"results":[187],"multivariable":[190],"logistic":[191],"regression":[192],"model":[193],"(n":[200],"1733)":[202],"indicated":[203],"had":[206],"significantly":[207],"higher":[208],"readmissions":[212],"1":[214],"year":[215],"1.55,":[219],"1.16-2.07),":[224],"compared":[225],"men,":[230],"but":[231],"alleles,":[234],"either":[235],"individually":[236],"or":[237],"through":[238],"genetic":[240],"score,":[242],"were":[243],"associated":[245],"readmissions.":[248],"Conclusion":[249],"This":[250],"study":[251],"highlights":[252],"need":[254],"improved":[257],"understanding":[258],"role":[261],"sex-by-gene":[263],"causing":[266],"metabolism.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-06T00:00:00"}