{"id":"https://openalex.org/W4289952202","doi":"https://doi.org/10.3760/cma.j.cn121430-20220223-00170","title":"[Role and mechanism of signal transducer and activator of transcription protein STAT1/3/5 in hyperoxia-induced acute lung injury].","display_name":"[Role and mechanism of signal transducer and activator of transcription protein STAT1/3/5 in hyperoxia-induced acute lung injury].","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4289952202","doi":"https://doi.org/10.3760/cma.j.cn121430-20220223-00170","pmid":"https://pubmed.ncbi.nlm.nih.gov/35924515"},"language":"zh","primary_location":{"id":"pmid:35924515","doi":"https://doi.org/10.3760/cma.j.cn121430-20220223-00170","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35924515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua wei zhong bing ji jiu yi xue","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039100779","display_name":"Hong Mei","orcid":"https://orcid.org/0000-0001-8848-5580","observed_orcids":["https://orcid.org/0000-0001-8848-5580"]},"institutions":[{"id":"https://openalex.org/I4210164192","display_name":"Affiliated Hospital of Zunyi Medical College","ror":"https://ror.org/05mzh9z59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164192"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Mei","raw_affiliation_strings":["The Second Ward, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Ward, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I4210164192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087560855","display_name":"Banghai Feng","orcid":"https://orcid.org/0009-0006-5543-6196","observed_orcids":["https://orcid.org/0009-0006-5543-6196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Banghai Feng","raw_affiliation_strings":["Department of Critical Care Medicine, Zunyi Hospital of Traditional Chinese Medicine, Zunyi 563000, Guizhou, China. Corresponding author: Qin Song, Email: 120647053@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Zunyi Hospital of Traditional Chinese Medicine, Zunyi 563000, Guizhou, China. Corresponding author: Qin Song, Email: 120647053@qq.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055552186","display_name":"Junya Liu","orcid":"https://orcid.org/0000-0001-6651-2509","observed_orcids":["https://orcid.org/0000-0001-6651-2509"]},"institutions":[{"id":"https://openalex.org/I4210164192","display_name":"Affiliated Hospital of Zunyi Medical College","ror":"https://ror.org/05mzh9z59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164192"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junya Liu","raw_affiliation_strings":["The Second Ward, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Ward, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I4210164192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100382076","display_name":"Miao Chen","orcid":"https://orcid.org/0000-0001-9560-6934","observed_orcids":["https://orcid.org/0000-0001-9560-6934"]},"institutions":[{"id":"https://openalex.org/I4210164192","display_name":"Affiliated Hospital of Zunyi Medical College","ror":"https://ror.org/05mzh9z59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164192"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Chen","raw_affiliation_strings":["The Second Ward, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Ward, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I4210164192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086889596","display_name":"Song Qin","orcid":"https://orcid.org/0000-0002-8226-6923","observed_orcids":["https://orcid.org/0000-0002-8226-6923"]},"institutions":[{"id":"https://openalex.org/I4210164192","display_name":"Affiliated Hospital of Zunyi Medical College","ror":"https://ror.org/05mzh9z59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164192"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Qin","raw_affiliation_strings":["The Second Ward, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Ward, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I4210164192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3192,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.50921894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"34","issue":"6","first_page":"602","last_page":"607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.36570000648498535,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.8270000219345093},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat3-inhibitor","display_name":"STAT3 inhibitor","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.8949999809265137},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8510000109672546},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/lung-permeability","display_name":"lung permeability","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.7749999761581421},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.6159999966621399},{"id":"https://openalex.org/keywords/stat-phosphorylation","display_name":"STAT phosphorylation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.7880253791809082},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.6509634256362915},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5903982520103455},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5578855276107788},{"id":"https://openalex.org/C2779391668","wikidata":"https://www.wikidata.org/wiki/Q4210018","display_name":"STAT5","level":3,"score":0.5503430366516113},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4840390086174011},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.47379371523857117},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4238802194595337},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.41675978899002075},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.4149261713027954},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.41483911871910095},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3698350191116333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3693692982196808},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.35498249530792236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3423129916191101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33260881900787354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33249178528785706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31834152340888977},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2168005406856537},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2128339409828186},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.15790480375289917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1334100365638733},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:35924515","doi":"https://doi.org/10.3760/cma.j.cn121430-20220223-00170","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35924515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua wei zhong bing ji jiu yi xue","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2105912583","https://openalex.org/W7103143159","https://openalex.org/W2152698731","https://openalex.org/W4413961662","https://openalex.org/W7223048824","https://openalex.org/W3215829268","https://openalex.org/W3032737932","https://openalex.org/W4387647260","https://openalex.org/W2531652270","https://openalex.org/W3035730359"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"whether":[3],"signal":[4],"transducer":[5],"and":[6,21,39,78,83,100,122,148,173,243],"activator":[7],"of":[8,73,116,134,156,177,190,204,238,252,269,287],"transcription":[9],"(STAT1/3/5)":[10],"have":[11],"a":[12],"protective":[13],"effect":[14],"on":[15],"hyperoxia-induced":[16],"acute":[17],"lung":[18,157,165,178,197,281,291],"injury":[19,179],"(HALI)":[20],"its":[22],"mechanism.":[23],"METHODS:":[24],"Seventy":[25],"C57BL/6J":[26],"mice":[27,45,119,208],"were":[28,68,94,167,212,247],"randomly":[29,95],"divided":[30],"into":[31],"five":[32],"groups:":[33],"normoxia":[34],"control":[35],"group,":[36,38,99],"HALI":[37,50,254],"STAT1/3/5":[40],"inhibitor":[41,66,75,80,85,241,245],"groups,":[42],"with":[43],"14":[44],"in":[46,164,196,209,293],"each":[47,98,210],"group.":[48],"The":[49,153,161,199],"model":[51],"was":[52,104,120,128,159,180,184],"established":[53],"by":[54,70,106],"exposure":[55],"to":[56,130,186],"more":[57],"than":[58,250],"90%":[59],"hyperoxia":[60],"for":[61,88],"48":[62],"hours;":[63],"three":[64],"STAT":[65,192],"groups":[67],"pretreated":[69],"intraperitoneal":[71],"injection":[72],"STAT1":[74],"40":[76],"mg/kg":[77,87],"STAT3":[79,240,270],"5":[81],"mg/kg,":[82],"STAT5":[84,244],"10":[86],"1":[89],"week.":[90],"Six":[91],"blood":[92],"samples":[93],"collected":[96],"from":[97],"microRNA-21":[101],"(miR-21)":[102],"expression":[103,189,286],"measured":[105],"quantitative":[107],"real-time":[108],"reverse":[109],"transcription-polymerase":[110],"chain":[111],"reaction":[112],"(RT-PCR).":[113],"Lung":[114],"tissue":[115,158,166],"the":[117,132,170,174,188,205,233,239,253,274,285],"sacrificed":[118],"obtained,":[121],"enzyme":[123],"linked":[124],"immunosorbent":[125],"assay":[126],"(ELISA)":[127],"used":[129,185],"detect":[131,187],"contents":[133],"tumor":[135],"necrosis":[136],"factor-\u03b1":[137],"(TNF-\u03b1),":[138],"interleukins":[139],"(IL-6,":[140],"IL-1\u03b2),":[141],"superoxide":[142],"dismutase":[143],"(SOD),":[144],"malonic":[145],"dialdehyde":[146],"(MDA),":[147],"matrix":[149],"metalloproteinase":[150],"9":[151],"(MMP9).":[152],"water":[154],"content":[155],"calculated.":[160],"pathological":[162,175],"changes":[163],"observed":[168],"under":[169],"light":[171],"microscope,":[172],"score":[176],"performed.":[181],"Western":[182],"blotting":[183],"phosphorylated":[191],"(p-STAT1,":[193],"p-STAT3,":[194],"p-STAT5)":[195],"tissue.":[198],"7-day":[200,234],"cumulative":[201,235],"survival":[202,216,228,236],"rates":[203,237],"remaining":[206],"8":[207],"group":[211,242,246,255],"analyzed":[213],"using":[214],"Kaplan-Meier":[215,227],"curves.":[217],"RESULTS:":[218],"):":[219],"0.550\u00b10.018":[220],"vs.":[221,260],"0.316\u00b10.037,":[222],"all":[223],"P":[224,264],"<":[225,265],"0.05].":[226,266],"curve":[229],"analysis":[230],"showed":[231],"that":[232],"significantly":[248],"higher":[249],"those":[251],"[62.5%":[256],"(5/8),":[257],"37.5%":[258],"(3/8)":[259],"12.5%":[261],"(1/8),":[262],"both":[263],"CONCLUSIONS:":[267],"Inhibition":[268],"hyperactivation":[271],"may":[272],"suppress":[273],"inflammatory":[275],"response,":[276],"regulate":[277],"oxidative":[278],"stress,":[279],"improve":[280],"permeability":[282],"through":[283],"regulating":[284],"miR-21,":[288],"which":[289],"exert":[290],"protection":[292],"HALI.":[294]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-06T00:00:00"}