{"id":"https://openalex.org/W4289922038","doi":"https://doi.org/10.1615/oncotherap.2022045040","title":"Anti-cancer Pectins and Their Role in Colorectal Cancer Treatment","display_name":"Anti-cancer Pectins and Their Role in Colorectal Cancer Treatment","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4289922038","doi":"https://doi.org/10.1615/oncotherap.2022045040"},"language":"en","primary_location":{"id":"doi:10.1615/oncotherap.2022045040","doi":"https://doi.org/10.1615/oncotherap.2022045040","is_oa":false,"landing_page_url":"https://doi.org/10.1615/oncotherap.2022045040","pdf_url":null,"source":{"id":"https://openalex.org/S4210197020","display_name":"Onco Therapeutics","issn_l":"2694-4642","issn":["2694-4642","2694-4650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onco Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017286092","display_name":"Andrea Cedillo Ornelas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Cedillo Ornelas","raw_affiliation_strings":["Department of Neuroscience, Rice University, Houston, TX 77005"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rice University, Houston, TX 77005","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sam Ferguson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam Ferguson","raw_affiliation_strings":["Department of Biomedical Engineering, University of Oklahoma, Norman, OK 73019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Oklahoma, Norman, OK 73019","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071965852","display_name":"Maya DePlaza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maya DePlaza","raw_affiliation_strings":["Texas College of osteopathic Medicine, The University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas College of osteopathic Medicine, The University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044442739","display_name":"Tkai Adekunle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159289790","display_name":"Savannah State University","ror":"https://ror.org/00mns7k70","country_code":"US","type":"education","lineage":["https://openalex.org/I159289790"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tkai Adekunle","raw_affiliation_strings":["Department of Biology, Savannah State University, Savannah, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Savannah State University, Savannah, GA","institution_ids":["https://openalex.org/I159289790"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007695569","display_name":"Riyaz M. Basha","orcid":"https://orcid.org/0000-0002-4071-0993","observed_orcids":["https://orcid.org/0000-0002-4071-0993","https://orcid.org/0000-0002-6955-5448"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riyaz Basha","raw_affiliation_strings":["The University of North Texas Health Science Center at Fort Worth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of North Texas Health Science Center at Fort Worth","institution_ids":["https://openalex.org/I165139151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.06830228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.1168999969959259,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pectin","display_name":"pectin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/plant-polysaccharides","display_name":"plant polysaccharides","score":0.8939999938011169},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.9470000267028809},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8619999885559082},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9649999737739563},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7459999918937683},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8640000224113464},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.9359999895095825},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.734000027179718},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2780756937","wikidata":"https://www.wikidata.org/wiki/Q188154","display_name":"Pectin","level":2,"score":0.819054365158081},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6066452264785767},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49597296118736267},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4676764905452728},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4562548100948334},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4561227858066559},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43918728828430176},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.43218719959259033},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4227280616760254},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4207325577735901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38458120822906494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33719778060913086},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31277740001678467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28624427318573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15944823622703552}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1615/oncotherap.2022045040","doi":"https://doi.org/10.1615/oncotherap.2022045040","is_oa":false,"landing_page_url":"https://doi.org/10.1615/oncotherap.2022045040","pdf_url":null,"source":{"id":"https://openalex.org/S4210197020","display_name":"Onco Therapeutics","issn_l":"2694-4642","issn":["2694-4642","2694-4650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onco Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4307776626","https://openalex.org/W7171681371","https://openalex.org/W4293070901","https://openalex.org/W4383890645","https://openalex.org/W4384816295","https://openalex.org/W4413889967","https://openalex.org/W2971756683","https://openalex.org/W2086947055","https://openalex.org/W4282596625","https://openalex.org/W966223094"],"abstract_inverted_index":{"A":[0],"class":[1],"of":[2,29,61,202,219],"plant":[3],"polysaccharides,":[4],"pectin":[5,21,55,123,132,147,203,220],"is":[6,17,148,207],"known":[7],"to":[8,34,78,88,111,128,150,160,215],"display":[9],"several":[10],"medicinal":[11],"properties":[12],"including":[13],"in":[14,43,188,195,204,229],"cancer.":[15],"There":[16],"some":[18,23,173,183,196],"evidence":[19,184],"that":[20,54,109,146],"from":[22],"fruits":[24],"can":[25,74,124,133,157],"reduce":[26,169],"the":[27,44,199,217],"severity":[28],"colorectal":[30],"cancer":[31,71,90],"(CRC)":[32],"due":[33],"antiproliferative,":[35],"anti-inflammatory,":[36],"antimetastatic,":[37],"and":[38,65,101,104,119,137,141,168,192],"pro-apoptotic":[39],"properties.":[40],"Pectin":[41,73,93,156],"fermentation":[42],"colon":[45],"induces":[46],"antiproliferative":[47],"activity":[48],"via":[49],"butyrate.":[50],"Research":[51,143],"also":[52,134,144],"showed":[53],"acts":[56],"as":[57,222],"a":[58,223],"potent":[59],"inducer":[60],"programmed":[62],"cell":[63,91],"death":[64],"cell-cycle":[66],"arrest,":[67],"thereby,":[68],"selectively":[69],"target":[70],"cells.":[72],"limit":[75],"oxidative":[76],"stress":[77],"maintain":[79],"cellular":[80],"homeostasis":[81],"while":[82],"increasing":[83],"reactive":[84],"oxygen":[85],"species":[86],"damage":[87],"activate":[89],"death.":[92],"regulates":[94],"various":[95],"signaling":[96,118],"cascades,":[97],"e.g.,":[98],"Signal":[99],"transduction":[100],"transcriptional":[102],"activator":[103],"Mitogen-activated":[105],"protein":[106],"kinase":[107],"signaling,":[108],"contribute":[110],"its":[112,129],"anticancer":[113],"activity.":[114],"By":[115],"curbing":[116],"inflammation-activated":[117],"bolstering":[120],"immunoprotective":[121],"mechanisms":[122],"mediate":[125],"CRC.":[126],"Due":[127],"chemical":[130],"structure,":[131],"inhibit":[135],"galectin-3":[136],"suppress":[138],"tumor":[139,189],"growth":[140,190],"metastasis.":[142],"suggested":[145],"beneficial":[149],"use":[151,201],"alongside":[152],"CRC":[153,162,205,228],"standard":[154],"care.":[155],"increase":[158],"sensitivity":[159],"conventional":[161],"drugs,":[163],"alleviate":[164],"unwanted":[165],"side":[166],"effects,":[167],"drug":[170],"resistance.":[171],"While":[172],"preclinical":[174],"studies":[175,212],"are":[176,181,213],"promising,":[177],"early":[178],"clinical":[179,200,225],"trials":[180],"showing":[182],"for":[185,227],"pectin\u2019s":[186],"efficacy":[187,218],"inhibition":[191],"preventing":[193],"metastasis":[194],"cancers,":[197],"still":[198],"therapy":[206,226],"not":[208],"well":[209],"established.":[210],"Further":[211],"needed":[214],"confirm":[216],"treatment":[221],"valid":[224],"humans.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2022-08-06T00:00:00"}
