{"id":"https://openalex.org/W4289912940","doi":"https://doi.org/10.3389/fonc.2022.933446","title":"Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status","display_name":"Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status","publication_year":2022,"publication_date":"2022-08-05","ids":{"openalex":"https://openalex.org/W4289912940","doi":"https://doi.org/10.3389/fonc.2022.933446","pmid":"https://pubmed.ncbi.nlm.nih.gov/35992795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9389462"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2022.933446","doi":"https://doi.org/10.3389/fonc.2022.933446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.933446","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fonc.2022.933446","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037604746","display_name":"Rati Lama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rati Lama","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100701750","display_name":"Chao Xu","orcid":"https://orcid.org/0000-0001-8462-8337","observed_orcids":["https://orcid.org/0000-0001-8462-8337"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao Xu","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079810755","display_name":"Samuel L. Galster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel L. Galster","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, United States","Department of Chemistry, University at Buffalo, The State University of New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, United States","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008116086","display_name":"Javier Querol-Garc\u00eda","orcid":"https://orcid.org/0009-0006-6667-9556","observed_orcids":["https://orcid.org/0009-0006-6667-9556"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Querol-Garc\u00eda","raw_affiliation_strings":["Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]},{"raw_affiliation_string":"Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109358277","display_name":"Scott M. Portwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Portwood","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Medicine, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001862108","display_name":"Cory K. Mavis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cory K. Mavis","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Medicine, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050006350","display_name":"Federico M. Ruiz","orcid":"https://orcid.org/0000-0002-0385-7777","observed_orcids":["https://orcid.org/0000-0002-0385-7777"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Federico M. Ruiz","raw_affiliation_strings":["Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]},{"raw_affiliation_string":"Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064539581","display_name":"Diana L Martin","orcid":"https://orcid.org/0000-0003-3065-2870","observed_orcids":["https://orcid.org/0000-0003-3065-2870"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Diana Martin","raw_affiliation_strings":["Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]},{"raw_affiliation_string":"Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074898112","display_name":"Jin Wu","orcid":"https://orcid.org/0000-0001-9926-0993","observed_orcids":["https://orcid.org/0000-0001-9926-0993"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Wu","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088416158","display_name":"Marianna Giorgi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianna C. Giorgi","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Medicine, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050128762","display_name":"Jill Bargonetti","orcid":"https://orcid.org/0000-0003-2692-0991","observed_orcids":["https://orcid.org/0000-0003-2692-0991"]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I39694355","display_name":"Hunter College","ror":"https://ror.org/00g2xk477","country_code":"US","type":"education","lineage":["https://openalex.org/I39694355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Bargonetti","raw_affiliation_strings":["The Department of Biological Sciences, Hunter College, City University of New York, New York, NY, United States","The Department of Biological Sciences, Hunter College, City University of New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biological Sciences, Hunter College, City University of New York, New York, NY, United States","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I39694355"]},{"raw_affiliation_string":"The Department of Biological Sciences, Hunter College, City University of New York, United States","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I39694355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038660651","display_name":"Eunice S. Wang","orcid":"https://orcid.org/0000-0002-8644-0968","observed_orcids":["https://orcid.org/0000-0002-8644-0968"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eunice S. Wang","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Medicine, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066598802","display_name":"Francisco J. Hernandez\u2010Ilizaliturri","orcid":"https://orcid.org/0000-0001-8054-3539","observed_orcids":["https://orcid.org/0000-0001-8054-3539"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco J. Hernandez-Ilizaliturri","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Medicine, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047846728","display_name":"Gerald B. Koudelka","orcid":"https://orcid.org/0000-0001-6280-0837","observed_orcids":["https://orcid.org/0000-0001-6280-0837"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald B. Koudelka","raw_affiliation_strings":["Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States","Department of Biological Sciences, University at Buffalo, The State University of New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Biological Sciences, University at Buffalo, The State University of New York, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061360791","display_name":"Sherry R. Chemler","orcid":"https://orcid.org/0000-0001-6702-5032","observed_orcids":["https://orcid.org/0000-0001-6702-5032"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherry R. Chemler","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, United States","Department of Chemistry, University at Buffalo, The State University of New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, United States","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023575655","display_name":"In\u00e9s G. Mu\u00f1oz","orcid":"https://orcid.org/0000-0001-6732-4059","observed_orcids":["https://orcid.org/0000-0001-6732-4059"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"In\u00e9s G. Mu\u00f1oz","raw_affiliation_strings":["Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]},{"raw_affiliation_string":"Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059138390","display_name":"Xinjiang Wang","orcid":"https://orcid.org/0000-0002-1347-4112","observed_orcids":["https://orcid.org/0000-0002-1347-4112"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xinjiang Wang","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, United States","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059138390"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.1522,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79150302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"933446","last_page":"933446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ring-finger-domain","display_name":"RING domain","score":0.7680000066757202},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5299999713897705},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.7809900641441345},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6580864191055298},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.578156054019928},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5523423552513123},{"id":"https://openalex.org/C2777221213","wikidata":"https://www.wikidata.org/wiki/Q10322346","display_name":"MDMX","level":4,"score":0.5078573822975159},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.48699837923049927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46459364891052246},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.45634517073631287},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.44543883204460144},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42129838466644287},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4020461142063141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30455389618873596},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1139569878578186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2022.933446","doi":"https://doi.org/10.3389/fonc.2022.933446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.933446","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9389462","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9389462","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:35992795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35992795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ac45ea6ffa8a496fa654d17db6618c95","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ac45ea6ffa8a496fa654d17db6618c95","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2022.933446","doi":"https://doi.org/10.3389/fonc.2022.933446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.933446","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3629554841","display_name":"Targeting Mdm2-MdmX E3 Ligase for Treatment of Drug-Resistant Lymphoma","funder_award_id":"R01CA208352","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G543394214","display_name":"New Methods for Nitrogen and Oxygen Heterocycle Synthesis","funder_award_id":"R01GM078383","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8858395165","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306497","display_name":"Roswell Park Cancer Institute","ror":"https://ror.org/0499dwk57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W152522539","https://openalex.org/W1483201954","https://openalex.org/W1591166893","https://openalex.org/W1963872465","https://openalex.org/W1976633722","https://openalex.org/W2014563476","https://openalex.org/W2025533271","https://openalex.org/W2026140625","https://openalex.org/W2039108801","https://openalex.org/W2043018999","https://openalex.org/W2052516738","https://openalex.org/W2081953771","https://openalex.org/W2103562758","https://openalex.org/W2106718280","https://openalex.org/W2109619078","https://openalex.org/W2117692326","https://openalex.org/W2143351237","https://openalex.org/W2151665323","https://openalex.org/W2153871559","https://openalex.org/W2167291962","https://openalex.org/W2171224722","https://openalex.org/W2196605452","https://openalex.org/W2269475590","https://openalex.org/W2304376138","https://openalex.org/W2412183643","https://openalex.org/W2467734182","https://openalex.org/W2515257886","https://openalex.org/W2584524963","https://openalex.org/W2587664043","https://openalex.org/W2626160990","https://openalex.org/W2729108853","https://openalex.org/W2747995240","https://openalex.org/W2768768130","https://openalex.org/W2887425009","https://openalex.org/W2887798331","https://openalex.org/W2894673269","https://openalex.org/W3041100082","https://openalex.org/W3133950868","https://openalex.org/W4206841660","https://openalex.org/W4210566084","https://openalex.org/W4210837665","https://openalex.org/W4224290890","https://openalex.org/W4225282908","https://openalex.org/W4229374919","https://openalex.org/W4280538061","https://openalex.org/W4281796269","https://openalex.org/W4283586361","https://openalex.org/W4285744152","https://openalex.org/W6682673941"],"related_works":["https://openalex.org/W4308532065","https://openalex.org/W4406103180","https://openalex.org/W2196605452","https://openalex.org/W2886880203","https://openalex.org/W4405691901","https://openalex.org/W2945441925","https://openalex.org/W4405201652","https://openalex.org/W4282962245","https://openalex.org/W4310112154","https://openalex.org/W4289034584"],"abstract_inverted_index":{"their":[0],"RING":[1,42,83,142],"domains":[2],"and":[3,30,62,69,93,128,145,157,176],"form":[4],"a":[5,141,172,188],"heterodimer":[6,17,143],"polyubiquitin":[7],"E3":[8,18,152],"ligase":[9],"essential":[10],"for":[11],"p53":[12,29,123,134,198],"degradation.":[13],"MDM4":[14,31,91,96,184],"also":[15],"forms":[16],"ligases":[19],"with":[20,110],"MDM2":[21],"isoforms":[22],"that":[23,47,178],"lack":[24],"p53-binding":[25],"domains,":[26],"which":[27],"regulate":[28],"stability.":[32],"We":[33],"are":[34],"working":[35],"to":[36,81,107,133,159,192],"identify":[37],"small-molecule":[38],"inhibitors":[39],"targeting":[40],"the":[41,50,60,87,150],"domain":[43,84],"of":[44,54,64,103,149,182],"MDM2-MDM4":[45,55,151],"(MMRi)":[46],"can":[48],"inactivate":[49],"total":[51],"oncogenic":[52],"activity":[53,102,156],"heterodimers.":[56],"Here,":[57],"we":[58],"describe":[59],"identification":[61],"characterization":[63],"MMRi62":[65,79,104,118,170],"as":[66,140,171],"an":[67,146],"MDM4-degrader":[68,101,155],"apoptosis":[70,112,121,161],"inducer":[71],"in":[72,76,98,114,122,131,162],"leukemia":[73,115,126,194],"cells.":[74,99,116,136,164],"Biochemically,":[75],"our":[77],"experiments,":[78],"bound":[80],"preformed":[82],"heterodimers":[85],"altered":[86],"substrate":[88],"preference":[89],"toward":[90],"ubiquitination":[92],"promoted":[94],"MDM2-dependent":[95],"degradation":[97,185],"This":[100],"was":[105],"found":[106],"be":[108,187],"associated":[109],"potent":[111],"induction":[113],"Interestingly,":[117],"effectively":[119],"induced":[120],"mutant,":[124],"multidrug-resistant":[125],"cells":[127,195],"patient":[129],"samples":[130],"addition":[132],"wild-type":[135],"In":[137,165],"contrast,":[138],"MMRi67":[139],"disruptor":[144],"enzymatic":[147],"inhibitor":[148],"complex":[153],"lacked":[154],"failed":[158],"induce":[160],"these":[163],"summary,":[166],"this":[167],"study":[168],"identifies":[169],"novel":[173],"MDM2-MDM4-targeting":[174],"agent":[175],"suggests":[177],"small":[179],"molecules":[180],"capable":[181],"promoting":[183],"may":[186],"viable":[189],"new":[190],"approach":[191],"killing":[193],"bearing":[196],"non-functional":[197],"by":[199],"apoptosis.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-06T00:00:00"}
