{"id":"https://openalex.org/W4289878737","doi":"https://doi.org/10.1093/noajnl/vdac078.060","title":"MMAP-04 CYTOTOXIC, TUMOR-HOMING INDUCED NEURAL STEM CELLS AS AN ADJUVANT TO RADIATION IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER LEPTOMENINGEAL METASTASES","display_name":"MMAP-04 CYTOTOXIC, TUMOR-HOMING INDUCED NEURAL STEM CELLS AS AN ADJUVANT TO RADIATION IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER LEPTOMENINGEAL METASTASES","publication_year":2022,"publication_date":"2022-08-01","ids":{"openalex":"https://openalex.org/W4289878737","doi":"https://doi.org/10.1093/noajnl/vdac078.060"},"language":"en","primary_location":{"id":"doi:10.1093/noajnl/vdac078.060","doi":"https://doi.org/10.1093/noajnl/vdac078.060","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdac078.060","pdf_url":"https://academic.oup.com/noa/article-pdf/4/Supplement_1/i15/45223521/vdac078.060.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/noa/article-pdf/4/Supplement_1/i15/45223521/vdac078.060.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087096736","display_name":"Alison R. Mercer-Smith","orcid":"https://orcid.org/0000-0001-9571-2219","observed_orcids":["https://orcid.org/0000-0001-9571-2219"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Mercer-Smith","raw_affiliation_strings":["University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019988483","display_name":"Wulin Jiang","orcid":"https://orcid.org/0000-0002-7183-1616","observed_orcids":["https://orcid.org/0000-0002-7183-1616"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wulin Jiang","raw_affiliation_strings":["University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007283338","display_name":"Alain Valdivia","orcid":"https://orcid.org/0000-0003-0985-3475","observed_orcids":["https://orcid.org/0000-0003-0985-3475"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alain Valdivia","raw_affiliation_strings":["University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108877427","display_name":"Noah Bell","orcid":"https://orcid.org/0009-0004-4134-5563","observed_orcids":["https://orcid.org/0009-0004-4134-5563"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah Bell","raw_affiliation_strings":["University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031833745","display_name":"Alex S. Woodell","orcid":"https://orcid.org/0000-0001-9429-7295","observed_orcids":["https://orcid.org/0000-0001-9429-7295"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Woodell","raw_affiliation_strings":["University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007348475","display_name":"Scott Floyd","orcid":"https://orcid.org/0000-0002-8067-2426","observed_orcids":["https://orcid.org/0000-0002-8067-2426"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Floyd","raw_affiliation_strings":["Duke University , Durham, NC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC , USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086220759","display_name":"Shawn Hingtgen","orcid":"https://orcid.org/0000-0003-4355-2377","observed_orcids":["https://orcid.org/0000-0003-4355-2377"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn Hingtgen","raw_affiliation_strings":["University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina \u2013 Chapel Hill , Chapel Hill, NC , USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2371,"currency":"USD","value_usd":2371},"apc_paid":{"value":2371,"currency":"USD","value_usd":2371},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"Supplement_1","first_page":"i15","last_page":"i15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.3230000138282776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.3230000138282776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.2809999883174896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.22280000150203705,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/induced-neural-stem-cells","display_name":"induced neural stem cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.7239999771118164},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5080000162124634},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5040000081062317},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.714826762676239},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6315359473228455},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.598869264125824},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5508806109428406},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5364903211593628},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.45882463455200195},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45313164591789246},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4366624057292938},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3958902657032013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.339487761259079},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33459433913230896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1728515923023224},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16281116008758545},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/noajnl/vdac078.060","doi":"https://doi.org/10.1093/noajnl/vdac078.060","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdac078.060","pdf_url":"https://academic.oup.com/noa/article-pdf/4/Supplement_1/i15/45223521/vdac078.060.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9354154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9354154","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurooncol Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/noajnl/vdac078.060","doi":"https://doi.org/10.1093/noajnl/vdac078.060","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdac078.060","pdf_url":"https://academic.oup.com/noa/article-pdf/4/Supplement_1/i15/45223521/vdac078.060.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4289878737.pdf","grobid_xml":"https://content.openalex.org/works/W4289878737.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3217355244","https://openalex.org/W4224240377","https://openalex.org/W3111517120","https://openalex.org/W3046962221","https://openalex.org/W6962888945","https://openalex.org/W2967762988","https://openalex.org/W3112109723","https://openalex.org/W2983514516","https://openalex.org/W4378194894","https://openalex.org/W3195925679"],"abstract_inverted_index":{"Abstract":[0],"INTRODUCTION":[1],"Non-small":[2],"cell":[3],"lung":[4],"cancer":[5,11],"(NSCLC)":[6],"is":[7,22],"the":[8,15,20,65,71,91,110,115,130,147,168,232,265,276],"most":[9],"common":[10],"to":[12,14,19,63,78,184,203,218,250,273],"spread":[13,18],"brain,":[16],"and":[17,93,128,135,156,172,207,221,229,243],"leptomeninges":[21],"particularly":[23],"devastating,":[24],"with":[25,97,102,127,152,167,193,255],"a":[26,74,176,211,270],"median":[27,215],"survival":[28,94,200,216],"of":[29,95,112,118,132,150,170,234,253,267,278],"only":[30],"months.":[31],"While":[32],"radiation":[33,113,274],"may":[34],"offer":[35],"symptomatic":[36],"relief,":[37],"new":[38],"adjuvant":[39,272],"therapies":[40],"are":[41,58],"needed":[42],"for":[43,73],"more":[44],"durable":[45],"tumor":[46,116,180],"kill.":[47],"Spheroidal,":[48],"human":[49],"induced":[50],"neural":[51],"stem":[52],"cells":[53],"(hiNeuroS)":[54],"transdifferentiated":[55],"from":[56],"fibroblasts":[57],"inherently":[59],"tumoritropic.":[60],"When":[61],"engineered":[62],"secrete":[64],"cytotoxic":[66],"protein":[67],"TRAIL,":[68],"they":[69,244],"provide":[70],"potential":[72,266],"personalized,":[75],"targeted":[76],"approach":[77],"NSCLC":[79,98,133,154,235,256],"leptomeningeal":[80,99,279],"metastases.":[81],"METHODS":[82],"hiNeuroS-TRAIL":[83,171,268],"in":[84,139,214,231,236,260,275],"vivo":[85,140],"efficacy":[86],"was":[87,141,257],"determined":[88,142],"by":[89,143],"tracking":[90],"progression":[92],"mice":[96,151,209],"tumors":[100,155],"treated":[101,166,192],"intracerebroventricular":[103],"hiNeuroS,":[104,119],"radiation,":[105],"or":[106,187],"both.":[107],"To":[108],"determine":[109],"impact":[111],"on":[114,125],"tropism":[117],"we":[120],"performed":[121],"2-dimensional":[122,237],"motion":[123,238],"assays":[124],"hiNeuroS":[126,145,158,225,254],"without":[129],"presence":[131,233],"pre-":[134],"post-radiation.":[136],"Migrational":[137],"capacity":[138],"infusing":[144],"into":[146],"lateral":[148],"ventricles":[149],"established":[153],"monitoring":[157],"accumulation":[159],"using":[160],"post-mortem":[161],"fluorescent":[162],"analysis.":[163],"RESULTS/CONCLUSION":[164],"Mice":[165,191],"combination":[169,206],"2":[173,188,194],"Gy":[174,195],"showed":[175,197,210,226],"significantly":[177],"reduced":[178],"mean":[179],"signal":[181],"(2.7%)":[182],"compared":[183,202,217],"controls":[185,219],"(100%)":[186],"Gy-only":[189],"(54.9%).":[190],"alone":[196],"no":[198],"significant":[199,212],"difference":[201],"controls.":[204],"Both":[205],"hiNeuroS-TRAIL-only-treated":[208],"improvement":[213],"(36.6%":[220],"46.3%":[222],"improvement,":[223],"respectively).":[224],"enhanced":[227],"directionality":[228],"displacement":[230],"assays,":[239],"indicating":[240],"directional":[241],"migration,":[242],"maintained":[245],"this":[246],"ability":[247],"following":[248],"exposure":[249],"radiation.":[251],"Co-localization":[252],"also":[258],"observed":[259],"vivo.":[261],"These":[262],"results":[263],"suggest":[264],"as":[269],"powerful":[271],"treatment":[277],"NSCLC.":[280]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-05T00:00:00"}